NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|887244241|ref|NP_001297462|]
View 

ankyrin repeat domain-containing protein 39 isoform 2 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-135 4.60e-31

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 4.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666  127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:COG0666  207 EAGADVNAKDNDGKTALD 224
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-135 4.60e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 4.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666  127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:COG0666  207 EAGADVNAKDNDGKTALD 224
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-127 3.29e-23

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 3.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241   38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESgAKCDAQTHGGaTALHRASYCGHTEIARLLL 117
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLL 81

                          90
                  ....*....|
gi 887244241  118 SHGSNPWLVD 127
Cdd:pfam12796  82 EKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-135 2.67e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.97  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:PHA02874 211 DHGNHIMNKCKNGFTPLH 228
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 1.26e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.26e-05
                           10        20
                   ....*....|....*....|....*....
gi 887244241    64 GYTALHYASRNGHYAVCQFLLESGAKCDA 92
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-120 5.93e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFI-QKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK-----CDAQTHGGATALHRASYCGHTE 111
Cdd:cd22192   24 AAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLN 103


                 ....*....
gi 887244241 112 IARLLLSHG 120
Cdd:cd22192  104 LVRELIARG 112
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-135 4.60e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 4.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666  127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:COG0666  207 EAGADVNAKDNDGKTALD 224
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-135 1.08e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.66  E-value: 1.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666   94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:COG0666  174 EAGADVNARDNDGETPLH 191
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-140 9.19e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.95  E-value: 9.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  30 DFDRGIWSAALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110
                 ....*....|....*....|....*....|.
gi 887244241 110 TEIARLLLSHGSNPWLVDNDGMTSLHKVCMS 140
Cdd:COG0666  133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-127 3.29e-23

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 3.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241   38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESgAKCDAQTHGGaTALHRASYCGHTEIARLLL 117
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLL 81

                          90
                  ....*....|
gi 887244241  118 SHGSNPWLVD 127
Cdd:pfam12796  82 EKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-136 2.72e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.40  E-value: 2.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666  160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         90
                 ....*....|....*....
gi 887244241 118 SHGSNPWLVDNDGMTSLHK 136
Cdd:COG0666  240 EAGADLNAKDKDGLTALLL 258
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-140 2.14e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 2.14e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 887244241   68 LHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNpwLVDNDGMTSLHKVCMS 140
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARS 71
Ank_4 pfam13637
Ankyrin repeats (many copies);
64-117 3.29e-13

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.75  E-value: 3.29e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 887244241   64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-135 5.70e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 5.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666   28 AALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL 107

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:COG0666  108 EAGADVNARDKDGETPLH 125
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-132 1.16e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:COG0666  193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272

                         90
                 ....*....|....*
gi 887244241 118 SHGSNPWLVDNDGMT 132
Cdd:COG0666  273 LALLLLAAALLDLLT 287
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-135 2.67e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.97  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLL 117
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210

                         90
                 ....*....|....*...
gi 887244241 118 SHGSNPWLVDNDGMTSLH 135
Cdd:PHA02874 211 DHGNHIMNKCKNGFTPLH 228
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 47-135 3.17e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.67  E-value: 3.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRNGHY--AVCQFLLESGAKCDAQT-------HG---------GATALHRASYCG 108
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNrvnyllsYGvpinikdvyGFTPLHYAVYNN 203

                         90       100
                 ....*....|....*....|....*..
gi 887244241 109 HTEIARLLLSHGSNPWLVDNDGMTSLH 135
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLH 230
Ank_4 pfam13637
Ankyrin repeats (many copies);
35-84 7.95e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 7.95e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 887244241   35 IWSAALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLL 84
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 46-122 1.45e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 887244241  46 RVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
Cdd:PHA03100 174 RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 83-134 2.49e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 2.49e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 887244241  83 LLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSL 134
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPL 152
PHA03095 PHA03095
ankyrin-like protein; Provisional
 41-140 1.26e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  41 NGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYA---VCQFLLESGAKCDAQTHGGATALHRASYCGHTE-IARLL 116
Cdd:PHA03095  24 NVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLL 103

                         90       100
                 ....*....|....*....|....
gi 887244241 117 LSHGSNPWLVDNDGMTSLHkVCMS 140
Cdd:PHA03095 104 IKAGADVNAKDKVGRTPLH-VYLS 126
Ank_4 pfam13637
Ankyrin repeats (many copies);
99-149 2.61e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 2.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 887244241   99 TALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLHKVCMSLPPSACIRL 149
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-147 3.48e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 3.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALH-YAS-RNGHYAVCQFLLESGAKCDAQTHGGATALH------RASycghTEIARLLLS 118
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLHvYLSgFNINPKVIRLLLRKGADVNALDLYGMTPLAvllksrNAN----VELLRLLID 175

                         90       100
                 ....*....|....*....|....*....
gi 887244241 119 HGSNPWLVDNDGMTSLHKVCMSLPPSACI 147
Cdd:PHA03095 176 AGADVYAVDDRFRSLLHHHLQSFKPRARI 204
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 38-121 4.16e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 4.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRA-SYCGHTEIARLL 116
Cdd:PHA02878 175 ATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLL 254


                 ....*
gi 887244241 117 LSHGS 121
Cdd:PHA02878 255 LEHGV 259
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 39-119 4.48e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 4.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  39 ALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169


                 .
gi 887244241 119 H 119
Cdd:PTZ00322 170 H 170
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-157 5.34e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 5.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYA--VCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPW 124
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                         90       100       110
                 ....*....|....*....|....*....|...
gi 887244241 125 LVDNDGMTslhkvCMSLppsACIRLRRRVTRTF 157
Cdd:PHA03095 285 AVSSDGNT-----PLSL---MVRNNNGRAVRAA 309
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 22-123 1.47e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.17  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  22 VQQTLEEMD--FDRGIWSAALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGAT 99
Cdd:PLN03192 514 GDNGGEHDDpnMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100
                 ....*....|....*....|....*.
gi 887244241 100 ALHRASYCGHTEIARLL--LSHGSNP 123
Cdd:PLN03192 594 ALWNAISAKHHKIFRILyhFASISDP 619
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-138 2.10e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD-AQTHGGATALHRASYCGHTEIARLL 116
Cdd:PHA02875 142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDyFGKNGCVAALCYAIENNKIDIVRLF 221

                         90       100
                 ....*....|....*....|....*
gi 887244241 117 LSHGSNP---WLVDNDGMTSLHKVC 138
Cdd:PHA02875 222 IKRGADCnimFMIEGEECTILDMIC 246
Ank_5 pfam13857
Ankyrin repeats (many copies);
56-104 2.91e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 2.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 887244241   56 DPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRA 104
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 47-122 3.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRN--GHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH--TEIARLLLSHGSN 122
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVD 168
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 1.26e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.26e-05
                           10        20
                   ....*....|....*....|....*....
gi 887244241    64 GYTALHYASRNGHYAVCQFLLESGAKCDA 92
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 64-135 1.27e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.10  E-value: 1.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 887244241  64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLH 135
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 64-92 1.92e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 1.92e-05
                          10        20
                  ....*....|....*....|....*....
gi 887244241   64 GYTALHYASRNGHYAVCQFLLESGAKCDA 92
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
90-135 2.40e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 2.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 887244241   90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLH 135
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 64-95 3.89e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 887244241   64 GYTALHYAS-RNGHYAVCQFLLESGAKCDAQTH 95
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 26-122 4.11e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 4.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  26 LEEMDFDRGIWSAALNG--DLGRVKYFIQKATDPSqpdsAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHR 103
Cdd:PLN03192 586 IRDANGNTALWNAISAKhhKIFRILYHFASISDPH----AAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQV 661

                         90
                 ....*....|....*....
gi 887244241 104 ASYCGHTEIARLLLSHGSN 122
Cdd:PLN03192 662 AMAEDHVDMVRLLIMNGAD 680
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 97-128 5.46e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 5.46e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 887244241   97 GATALHRASY-CGHTEIARLLLSHGSNPWLVDN 128
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-120 5.93e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  38 AALNGDLGRVKYFI-QKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK-----CDAQTHGGATALHRASYCGHTE 111
Cdd:cd22192   24 AAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLN 103


                 ....*....
gi 887244241 112 IARLLLSHG 120
Cdd:cd22192  104 LVRELIARG 112
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-135 1.04e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLV 126
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186


                 ....*....
gi 887244241 127 DNDGMTSLH 135
Cdd:PHA02874 187 DNNGESPLH 195
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 47-135 1.23e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYAVC-----QFLLESGAKCDAQTHGGATALHRASYC--GHTEIARLLLSH 119
Cdd:PHA03100  51 VKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDvkeivKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDN 130

                         90
                 ....*....|....*.
gi 887244241 120 GSNPWLVDNDGMTSLH 135
Cdd:PHA03100 131 GANVNIKNSDGENLLH 146
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 47-134 1.86e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLV 126
Cdd:PHA02875 118 MKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYF 197


                 ....*...
gi 887244241 127 DNDGMTSL 134
Cdd:PHA02875 198 GKNGCVAA 205
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 97-123 3.44e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 3.44e-04
                           10        20
                   ....*....|....*....|....*..
gi 887244241    97 GATALHRASYCGHTEIARLLLSHGSNP 123
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 64-139 7.60e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 38.97  E-value: 7.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHG--------------GATALHRASYCGHTEIARLLLSHGSNPWLV-DN 128
Cdd:cd22194  141 GQTALNIAIERRQGDIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTDITSqDS 220

                         90
                 ....*....|.
gi 887244241 129 DGMTSLHKVCM 139
Cdd:cd22194  221 RGNTVLHALVT 231
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-135 1.24e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.41  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 887244241  47 VKYFIQKATDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNpwLV 126
Cdd:PHA02874 173 IKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASIN--DQ 250


                 ....*....
gi 887244241 127 DNDGMTSLH 135
Cdd:PHA02874 251 DIDGSTPLH 259
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 79-136 2.26e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.55  E-value: 2.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 887244241  79 VCQFLLESGAKCDAQT-HGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLHK 136
Cdd:PHA02878 149 ITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHH 207
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 68-140 3.47e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 36.89  E-value: 3.47e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 887244241  68 LHYASRNGHYAVCQFLLESGAKCDAQTH-GGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSLHKVCMS 140
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMM 145
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 79-134 8.91e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 35.81  E-value: 8.91e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 887244241  79 VCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPWLVDNDGMTSL 134
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVL 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH