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Conserved domains on  [gi|816197596|ref|NP_001295252|]
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zinc finger protein 51 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-82 1.78e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.78e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 816197596   42 LLTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSV 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-749 4.09e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 327 SCPECGREFHQLSHLRKHYRLHTGEKPYKCN--ECDRSFTHYASLRWHQKTHTPE-IHYECKECGKSFIELSHLKRHYRI 403
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpSDLNSKSLPLSNSKASSSSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 404 HTGEKPYKCEICDKSFTTTttlktHQKIHTGEKPYKCRECDKSFIHSSHlrrhqnvhtgerpyrcKECDKSFHESATLRE 483
Cdd:COG5048  115 SNSNDNNLLSSHSLPPSSR-----DPQLPDLLSISNLRNNPLPGNNSSS----------------VNTPQSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 484 HEKSHTGEKtykcrecdksftqrAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5048  174 NSLSKDPSS--------------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 564 SYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTGE-------KPYKCIECDKSFTQVSHLRTHQR--VHTGE-- 632
Cdd:COG5048  240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEsl 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 633 RPFRCTE--CDKSFIRSSHLREHQKIHSGEKPYKC--RDCDISFSQISNLRRHQKLH-----TGEKPYKCM--ECDKSFT 701
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFK 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 816197596 702 HNSNFRTHQRVHTGEKP--YRCAECDKSFTRCSYLRAHQKIHTGEKPYKC 749
Cdd:COG5048  400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.16e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  284 ALKSHQKLHTGEKPYKCKECDKSFAH 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.17e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  256 HLKIHQRRHTGEKPYKCKECEKSFVQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-82 1.78e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.78e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 816197596   42 LLTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSV 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
43-83 3.88e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.88e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 816197596    43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSVE 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 43-81 3.43e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 3.43e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 816197596  43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVS 81
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-749 4.09e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 327 SCPECGREFHQLSHLRKHYRLHTGEKPYKCN--ECDRSFTHYASLRWHQKTHTPE-IHYECKECGKSFIELSHLKRHYRI 403
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpSDLNSKSLPLSNSKASSSSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 404 HTGEKPYKCEICDKSFTTTttlktHQKIHTGEKPYKCRECDKSFIHSSHlrrhqnvhtgerpyrcKECDKSFHESATLRE 483
Cdd:COG5048  115 SNSNDNNLLSSHSLPPSSR-----DPQLPDLLSISNLRNNPLPGNNSSS----------------VNTPQSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 484 HEKSHTGEKtykcrecdksftqrAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5048  174 NSLSKDPSS--------------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 564 SYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTGE-------KPYKCIECDKSFTQVSHLRTHQR--VHTGE-- 632
Cdd:COG5048  240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEsl 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 633 RPFRCTE--CDKSFIRSSHLREHQKIHSGEKPYKC--RDCDISFSQISNLRRHQKLH-----TGEKPYKCM--ECDKSFT 701
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFK 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 816197596 702 HNSNFRTHQRVHTGEKP--YRCAECDKSFTRCSYLRAHQKIHTGEKPYKC 749
Cdd:COG5048  400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-702 2.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 816197596  677 NLRRHQKLHTGEKPYKCMECDKSFTH 702
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  284 ALKSHQKLHTGEKPYKCKECDKSFAH 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  256 HLKIHQRRHTGEKPYKCKECEKSFVQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 239-318 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 239 EKPYKCSV--CDKSFTQCTHLKIHqRRHtgekpykcKECEKSFVQLSALKSHQKLHTGEKPYKCKECDKSFAHYPNFRTH 316
Cdd:COG5189  347 GKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ..
gi 816197596 317 QK 318
Cdd:COG5189  418 RK 419
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-82 1.78e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.78e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 816197596   42 LLTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSV 82
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
43-83 3.88e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.88e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 816197596    43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVSVE 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 43-81 3.43e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 3.43e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 816197596  43 LTFRDVAVDFPQEEWECLDSDQRALYIDVMLENYRNLVS 81
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-749 4.09e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 327 SCPECGREFHQLSHLRKHYRLHTGEKPYKCN--ECDRSFTHYASLRWHQKTHTPE-IHYECKECGKSFIELSHLKRHYRI 403
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpSDLNSKSLPLSNSKASSSSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 404 HTGEKPYKCEICDKSFTTTttlktHQKIHTGEKPYKCRECDKSFIHSSHlrrhqnvhtgerpyrcKECDKSFHESATLRE 483
Cdd:COG5048  115 SNSNDNNLLSSHSLPPSSR-----DPQLPDLLSISNLRNNPLPGNNSSS----------------VNTPQSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 484 HEKSHTGEKtykcrecdksftqrAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5048  174 NSLSKDPSS--------------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 564 SYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTGE-------KPYKCIECDKSFTQVSHLRTHQR--VHTGE-- 632
Cdd:COG5048  240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEsl 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 633 RPFRCTE--CDKSFIRSSHLREHQKIHSGEKPYKC--RDCDISFSQISNLRRHQKLH-----TGEKPYKCM--ECDKSFT 701
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFK 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 816197596 702 HNSNFRTHQRVHTGEKP--YRCAECDKSFTRCSYLRAHQKIHTGEKPYKC 749
Cdd:COG5048  400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-616 9.95e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 9.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 196 FSSAYSLMQPTAYIKEKPHQCGKCGKCFNTSSSLTVHHRIHTKEKPYKCSV--CDKSFTQCTHLKIHQRRHTGEKPYkck 273
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 274 ECEKSFVQLSALKSHQKL----HTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECGREFHQ-LSHLRKHYRLH 348
Cdd:COG5048   93 LNSKSLPLSNSKASSSSLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 349 TGEKPYKCNECDRSFTHyaslrwHQKTHTPEIHYECKECGKSFIELSHLKRHYRIHTgEKPYKCEICDKSFTTTTTLKTH 428
Cdd:COG5048  173 ANSLSKDPSSNLSLLIS------SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 429 QKIHTGEKPYKCRECDKSFIHSSHLRRHQNVHTGER-------PYRCKECDKSFHESATLREHEKS--HTGE--KTYKCR 497
Cdd:COG5048  246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCP 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 498 E--CDKSFTQRAYLRNHHnRVHTGERPYECK--ECGKSFTTCSTLRIHQTIHTGKKPYKCIE-------CGKSFTNNSYL 566
Cdd:COG5048  326 YslCGKLFSRNDALKRHI-LLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNL 404

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 816197596 567 RTHQKVHSGEKP--YRCKECDKSFTSCSTLKAHQNIHTGEKPYKCIECDKSF 616
Cdd:COG5048  405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-570 1.35e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 132 FRCCNNEDVSVDSSNQNRYKSTHTGEEP--CESKDCEKSLTLCSDISQDQRLYNAKQHR---QEVYDDYFSSAYSLMQPT 206
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPsqCSYSGCDKSFSRPLELSRHLRTHHNNPSDlnsKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 207 AYIKEKPHQCGKCGKCFNTSSSLTVHHRIHTKEKPYKCSVCDKSFTQCTH--LKIHQRRHTGEKPYKCKEceksfvqlSA 284
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnSLHPPLPANSLSKDPSSN--------LS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 285 LKSHQKLHTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECGREFHQLSHLRKHYRLHTGEKPYKCNECDRSFT 364
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 365 HYASLRWHQKTHTPE-------IHYECKECGKSFIELSHLKRHYR--IHTGE--KPYKC--EICDKSFTTTTTLKTHQKI 431
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 432 HTGEKPYKC--RECDKSFIHSSHLRRHQNVHtgerpyrckecdkSFHESATLREHEKSHTGektykcreCDKSFTQRAYL 509
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-------------QYKDLKNDKKSETLSNS--------CIRNFKRDSNL 404

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 816197596 510 RNhHNRVHTGERPYECK--ECGKSFTTCSTLRIHQTIHTGKKPYKCIECGKSFTNNSYLRTHQ 570
Cdd:COG5048  405 SL-HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
464-774 2.21e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 464 RPYRCKECDKSFHESATLREHEKSHTGEKTYKCR--ECDKSFTQRAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIH 541
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 542 QTIHTGKKPYKCieCGKSFTNNSYLRTHQKVHSGEKpYRCKECDKSFTSCSTLKAHQNIHtgeKPYKCIECDKSFTQVSH 621
Cdd:COG5048  112 SSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISN-LRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 622 LRTHQRVHTGERPFRCTECDKSFIRSSHLREHQKIHSGEKPYKCRDCDISFSQISNLRRHQKLHtgeKPYKCMECDKSFT 701
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS---SSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 702 HNSNFRTHQR---------VHTG-EKPYRCAECDKSFTRCSYLRAHQ--KIHTGE--KPYKCME--YDKPNTQDSNLKRH 765
Cdd:COG5048  263 SSLPTASSQSsspnesdssSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342


                 ....*....
gi 816197596 766 QRVHTGVKH 774
Cdd:COG5048  343 ILLHTSISP 351
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 406-489 2.06e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 406 GEKPYKCEI--CDKSFTTTTTLKTHQKI-HTGEKPYKCRECDKsfihsshlrrHQNVHTGERPYRCKECDKSFHESATLR 482
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 816197596 483 EHEKSHT 489
Cdd:COG5189  416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
677-702 2.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 816197596  677 NLRRHQKLHTGEKPYKCMECDKSFTH 702
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 350-430 5.66e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 350 GEKPYKCN--ECDRSFTHYASLRWHQKthtpEIHyeckeCGKSFIELSHLKRHYRIHTGEKPYKCEICDKSFTTTTTLKT 427
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGH-----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 816197596 428 HQK 430
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 6.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.97e-04
                          10        20
                  ....*....|....*....|....
gi 816197596  396 HLKRHYRIHTGEKPYKCEICDKSF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  284 ALKSHQKLHTGEKPYKCKECDKSFAH 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  256 HLKIHQRRHTGEKPYKCKECEKSFVQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 239-318 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 239 EKPYKCSV--CDKSFTQCTHLKIHqRRHtgekpykcKECEKSFVQLSALKSHQKLHTGEKPYKCKECDKSFAHYPNFRTH 316
Cdd:COG5189  347 GKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ..
gi 816197596 317 QK 318
Cdd:COG5189  418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-449 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*
gi 816197596  425 LKTHQKIHTGEKPYKCRECDKSFIH 449
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 3.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  340 HLRKHYRLHTGEKPYKCNECDRSFTH 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
621-646 3.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  621 HLRTHQRVHTGERPFRCTECDKSFIR 646
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
705-730 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  705 NFRTHQRVHTGEKPYRCAECDKSFTR 730
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 4.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 816197596  565 YLRTHQKVHSGEKPYRCKECDKSFTS 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 490-574 5.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 490 GEKTYKCR--ECDKSFTQRAYLRNH----HNRVHTGERPYECKecgksfttcstlriHQTIHTGKKPYKCIECGKSFTNN 563
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmlhgHQNQKLHENPSPEK--------------MNIFSAKDKPYRCEVCDKRYKNL 411

                         90
                 ....*....|.
gi 816197596 564 SYLRTHQKvHS 574
Cdd:COG5189  412 NGLKYHRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 547-625 5.18e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816197596 547 GKKPYKC--IECGKSFTNNSYLRTHQKvHSgekpyrckECDKSFTSCSTLKAHQNIHTGEKPYKCIECDKSFTQVSHLRT 624
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 816197596 625 H 625
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-475 5.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.48e-03
                          10        20
                  ....*....|....*....|....
gi 816197596  452 HLRRHQNVHTGERPYRCKECDKSF 475
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*
gi 816197596  481 LREHEKSHTGEKTYKCRECDKSFTQ 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
594-618 6.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.61e-03
                          10        20
                  ....*....|....*....|....*
gi 816197596  594 LKAHQNIHTGEKPYKCIECDKSFTQ 618
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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