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Conserved domains on  [gi|815891066|ref|NP_001295126|]
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translocon-associated protein subunit gamma isoform 1 [Homo sapiens]

Protein Classification

TRAP-gamma domain-containing protein( domain architecture ID 10537207)

TRAP-gamma domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAP-gamma pfam07074
Translocon-associated protein, gamma subunit (TRAP-gamma); This family consists of several ...
 12-196 1.92e-99

Translocon-associated protein, gamma subunit (TRAP-gamma); This family consists of several eukaryotic translocon-associated protein, gamma subunit (TRAP-gamma) sequences. The translocation site (translocon), at which nascent polypeptides pass through the endoplasmic reticulum membrane, contains a component previously called 'signal sequence receptor' that is now renamed as 'translocon-associated protein' (TRAP). The TRAP complex is comprised of four membrane proteins alpha, beta, gamma and delta which are present in a stoichiometric relation, and are genuine neighbours in intact microsomes. The gamma subunit is predicted to span the membrane four times.


:

Pssm-ID: 399809  Cd Length: 170  Bit Score: 285.05  E-value: 1.92e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815891066   12 EEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQK 91
Cdd:pfam07074   1 EEELLLQDFSRNVSTKSSALFYGNAFIVSAIPIWLFWRIHQMELYDSLILFVIVTLLSTYLLAFAYKNVKFVLKHKIAVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815891066   92 REDAVSKEVTRKLseADNRKMSRKEKDERfdsclkyghhkrgILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILK 171
Cdd:pfam07074  81 REDAVTREMNRKL--ADDKKMSKKEKDER-------------ILWKKNEVADYEATTFSIFYNNALFLALVIVASFYLLK 145

                         170       180
                  ....*....|....*....|....*
gi 815891066  172 NFNPTVNYILSISASSGLIALLSTG 196
Cdd:pfam07074 146 SFSPTVNYILSTVGASGLVALLSTG 170
 
Name Accession Description Interval E-value
TRAP-gamma pfam07074
Translocon-associated protein, gamma subunit (TRAP-gamma); This family consists of several ...
 12-196 1.92e-99

Translocon-associated protein, gamma subunit (TRAP-gamma); This family consists of several eukaryotic translocon-associated protein, gamma subunit (TRAP-gamma) sequences. The translocation site (translocon), at which nascent polypeptides pass through the endoplasmic reticulum membrane, contains a component previously called 'signal sequence receptor' that is now renamed as 'translocon-associated protein' (TRAP). The TRAP complex is comprised of four membrane proteins alpha, beta, gamma and delta which are present in a stoichiometric relation, and are genuine neighbours in intact microsomes. The gamma subunit is predicted to span the membrane four times.


Pssm-ID: 399809  Cd Length: 170  Bit Score: 285.05  E-value: 1.92e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815891066   12 EEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQK 91
Cdd:pfam07074   1 EEELLLQDFSRNVSTKSSALFYGNAFIVSAIPIWLFWRIHQMELYDSLILFVIVTLLSTYLLAFAYKNVKFVLKHKIAVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815891066   92 REDAVSKEVTRKLseADNRKMSRKEKDERfdsclkyghhkrgILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILK 171
Cdd:pfam07074  81 REDAVTREMNRKL--ADDKKMSKKEKDER-------------ILWKKNEVADYEATTFSIFYNNALFLALVIVASFYLLK 145

                         170       180
                  ....*....|....*....|....*
gi 815891066  172 NFNPTVNYILSISASSGLIALLSTG 196
Cdd:pfam07074 146 SFSPTVNYILSTVGASGLVALLSTG 170
 
Name Accession Description Interval E-value
TRAP-gamma pfam07074
Translocon-associated protein, gamma subunit (TRAP-gamma); This family consists of several ...
 12-196 1.92e-99

Translocon-associated protein, gamma subunit (TRAP-gamma); This family consists of several eukaryotic translocon-associated protein, gamma subunit (TRAP-gamma) sequences. The translocation site (translocon), at which nascent polypeptides pass through the endoplasmic reticulum membrane, contains a component previously called 'signal sequence receptor' that is now renamed as 'translocon-associated protein' (TRAP). The TRAP complex is comprised of four membrane proteins alpha, beta, gamma and delta which are present in a stoichiometric relation, and are genuine neighbours in intact microsomes. The gamma subunit is predicted to span the membrane four times.


Pssm-ID: 399809  Cd Length: 170  Bit Score: 285.05  E-value: 1.92e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815891066   12 EEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQK 91
Cdd:pfam07074   1 EEELLLQDFSRNVSTKSSALFYGNAFIVSAIPIWLFWRIHQMELYDSLILFVIVTLLSTYLLAFAYKNVKFVLKHKIAVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815891066   92 REDAVSKEVTRKLseADNRKMSRKEKDERfdsclkyghhkrgILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILK 171
Cdd:pfam07074  81 REDAVTREMNRKL--ADDKKMSKKEKDER-------------ILWKKNEVADYEATTFSIFYNNALFLALVIVASFYLLK 145

                         170       180
                  ....*....|....*....|....*
gi 815891066  172 NFNPTVNYILSISASSGLIALLSTG 196
Cdd:pfam07074 146 SFSPTVNYILSTVGASGLVALLSTG 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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