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Conserved domains on  [gi|815890897|ref|NP_001295065|]
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protein archease isoform 3 [Homo sapiens]

Protein Classification

archease( domain architecture ID 10487813)

archease catalyzes the activation of the RNA ligase RtcB, which joins RNA molecules to form phosphodiester bonds

CATH:  3.55.10.10
Gene Ontology:  GO:0006388|GO:0046872|GO:0072669
SCOP:  4003521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 43-136 1.35e-40

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


:

Pssm-ID: 426527  Cd Length: 136  Bit Score: 132.65  E-value: 1.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890897   43 YEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFfiprV 122
Cdd:pfam01951   1 YEYLDHTADVGIEAWGPTLEEAFENAALAMFELMTDLSKVEPKEEREIEVEGEDLEDLLVDWLDELLYLFDTEGL----V 76

                          90
                  ....*....|....
gi 815890897  123 GRRIFIVQAPSGNR 136
Cdd:pfam01951  77 FSRFEIEEEEDGYR 90
 
Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 43-136 1.35e-40

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 426527  Cd Length: 136  Bit Score: 132.65  E-value: 1.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890897   43 YEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFfiprV 122
Cdd:pfam01951   1 YEYLDHTADVGIEAWGPTLEEAFENAALAMFELMTDLSKVEPKEEREIEVEGEDLEDLLVDWLDELLYLFDTEGL----V 76

                          90
                  ....*....|....
gi 815890897  123 GRRIFIVQAPSGNR 136
Cdd:pfam01951  77 FSRFEIEEEEDGYR 90
ARCH COG1371
Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and ...
 41-117 4.18e-30

Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440982  Cd Length: 139  Bit Score: 106.03  E-value: 4.18e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 815890897  41 RKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEF 117
Cdd:COG1371    1 MGYEFLDHTADVGIEAYGPTLEEAFANAALALFALMVDTSKVEPREEREIEVEAEDLEDLLVDWLNELLYLFDTEGL 77
Archease PRK00407
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 41-110 2.84e-23

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 179008  Cd Length: 139  Bit Score: 88.54  E-value: 2.84e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890897  41 RKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLY 110
Cdd:PRK00407   2 RSYEFFEHTADIGIRAYGRTLEEAFENAALAVFDVITDTSKVEPKEEREIEIEGYDLENLLYRWLEELLY 71
 
Name Accession Description Interval E-value
Archease pfam01951
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 43-136 1.35e-40

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 426527  Cd Length: 136  Bit Score: 132.65  E-value: 1.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890897   43 YEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFfiprV 122
Cdd:pfam01951   1 YEYLDHTADVGIEAWGPTLEEAFENAALAMFELMTDLSKVEPKEEREIEVEGEDLEDLLVDWLDELLYLFDTEGL----V 76

                          90
                  ....*....|....
gi 815890897  123 GRRIFIVQAPSGNR 136
Cdd:pfam01951  77 FSRFEIEEEEDGYR 90
ARCH COG1371
Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and ...
 41-117 4.18e-30

Archease, activates RNA ligation by RtcB (tRNA splicing) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440982  Cd Length: 139  Bit Score: 106.03  E-value: 4.18e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 815890897  41 RKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEF 117
Cdd:COG1371    1 MGYEFLDHTADVGIEAYGPTLEEAFANAALALFALMVDTSKVEPREEREIEVEAEDLEDLLVDWLNELLYLFDTEGL 77
Archease PRK00407
Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 ...
 41-110 2.84e-23

Archease protein family (MTH1598/TM1083); This archease family of proteins, has two SHS2 domains, with one inserted into another. It is predicted to be an enzyme. It is predicted to act as a chaperone in DNA/RNA metabolism.


Pssm-ID: 179008  Cd Length: 139  Bit Score: 88.54  E-value: 2.84e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890897  41 RKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLY 110
Cdd:PRK00407   2 RSYEFFEHTADIGIRAYGRTLEEAFENAALAVFDVITDTSKVEPKEEREIEIEGYDLENLLYRWLEELLY 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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