DUF3456 domain-containing protein [Caenorhabditis elegans]
Protein Classification
canopy family protein( domain architecture ID 37159)
canopy family protein is a DUF3456 domain-containing protein; similar to Homo sapiens protein canopy homolog 1 and marginal zone B- and B1-cell-specific protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| DUF3456 super family | cl13389 | TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ... |
1-50 | 1.32e-10 | ||
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family. The actual alignment was detected with superfamily member pfam11938: Pssm-ID: 463404 Cd Length: 151 Bit Score: 53.10 E-value: 1.32e-10
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| Name | Accession | Description | Interval | E-value | ||
| DUF3456 | pfam11938 | TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ... |
1-50 | 1.32e-10 | ||
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family. Pssm-ID: 463404 Cd Length: 151 Bit Score: 53.10 E-value: 1.32e-10
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| Name | Accession | Description | Interval | E-value | ||
| DUF3456 | pfam11938 | TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ... |
1-50 | 1.32e-10 | ||
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family. Pssm-ID: 463404 Cd Length: 151 Bit Score: 53.10 E-value: 1.32e-10
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