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Conserved domains on  [gi|808357266|ref|NP_001294161|]
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Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bravo_FIGEY super family cl16451
Bravo-like intracellular region; This is the very C-terminal intracellular region of neural ...
 159-235 1.24e-12

Bravo-like intracellular region; This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.


The actual alignment was detected with superfamily member pfam13882:

Pssm-ID: 464016  Cd Length: 88  Bit Score: 61.95  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266  159 RQRGQNYPVSQREREQGREPIL-----GKPDYkTDDDEKR------SLTGS---KAESETDSMAQYGDTDPGVFTEDGSF 224
Cdd:pfam13882   2 RNKGGKYSVKEKEDAHGDPEDQpmdedAFGEY-SDLDEKPlkssqpSLSSDsklVDSDSTDSLDDYGDGDGGQFNEDGSF 80

                          90
                  ....*....|.
gi 808357266  225 IavsGQYVPQK 235
Cdd:pfam13882  81 I---GQYGGKK 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 25-102 6.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 6.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266  25 PGVPSLVE-NAIGDKYFNVSFRPAKYDDesrAPVGNtYEVQYKPQDADEWETVKPAD-DGLTVHVDGLSPGTKYDVRVAA 102
Cdd:cd00063    1 PSPPTNLRvTDVTSTSVTLSWTPPEDDG---GPITG-YVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
Bravo_FIGEY pfam13882
Bravo-like intracellular region; This is the very C-terminal intracellular region of neural ...
 159-235 1.24e-12

Bravo-like intracellular region; This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.


Pssm-ID: 464016  Cd Length: 88  Bit Score: 61.95  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266  159 RQRGQNYPVSQREREQGREPIL-----GKPDYkTDDDEKR------SLTGS---KAESETDSMAQYGDTDPGVFTEDGSF 224
Cdd:pfam13882   2 RNKGGKYSVKEKEDAHGDPEDQpmdedAFGEY-SDLDEKPlkssqpSLSSDsklVDSDSTDSLDDYGDGDGGQFNEDGSF 80

                          90
                  ....*....|.
gi 808357266  225 IavsGQYVPQK 235
Cdd:pfam13882  81 I---GQYGGKK 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 25-102 6.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 6.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266  25 PGVPSLVE-NAIGDKYFNVSFRPAKYDDesrAPVGNtYEVQYKPQDADEWETVKPAD-DGLTVHVDGLSPGTKYDVRVAA 102
Cdd:cd00063    1 PSPPTNLRvTDVTSTSVTLSWTPPEDDG---GPITG-YVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 25-102 7.96e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 7.96e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808357266    25 PGVPSLVEN-AIGDKYFNVSFRPAKYDDESRAPVGntYEVQYKPQDaDEWETVKPADDGLTVHVDGLSPGTKYDVRVAA 102
Cdd:smart00060   1 PSPPSNLRVtDVTSTSVTLSWEPPPDDGITGYIVG--YRVEYREEG-SEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
34-112 2.12e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.02  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266   34 AIGDKYFNVSFRPAKYDDesrAPVgNTYEVQYKPQDADEWETVKPADDGL-TVHVDGLSPGTKYDVRVAALQVDPEGGET 112
Cdd:pfam00041  10 DVTSTSLTVSWTPPPDGN---GPI-TGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
PhoD COG3540
Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism];
73-116 8.58e-03

Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism];


Pssm-ID: 442761 [Multi-domain]  Cd Length: 482  Bit Score: 37.21  E-value: 8.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 808357266  73 WETVKPADDGlTVHVD--GLSPGTKYDVRVAALQVDPEGGeTTKTL 116
Cdd:COG3540   83 TVTATPERDH-TVKVDvtGLEPGTRYFYRFRAGGETSPVG-RFRTA 126
 
Name Accession Description Interval E-value
Bravo_FIGEY pfam13882
Bravo-like intracellular region; This is the very C-terminal intracellular region of neural ...
 159-235 1.24e-12

Bravo-like intracellular region; This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.


Pssm-ID: 464016  Cd Length: 88  Bit Score: 61.95  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266  159 RQRGQNYPVSQREREQGREPIL-----GKPDYkTDDDEKR------SLTGS---KAESETDSMAQYGDTDPGVFTEDGSF 224
Cdd:pfam13882   2 RNKGGKYSVKEKEDAHGDPEDQpmdedAFGEY-SDLDEKPlkssqpSLSSDsklVDSDSTDSLDDYGDGDGGQFNEDGSF 80

                          90
                  ....*....|.
gi 808357266  225 IavsGQYVPQK 235
Cdd:pfam13882  81 I---GQYGGKK 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 25-102 6.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 6.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266  25 PGVPSLVE-NAIGDKYFNVSFRPAKYDDesrAPVGNtYEVQYKPQDADEWETVKPAD-DGLTVHVDGLSPGTKYDVRVAA 102
Cdd:cd00063    1 PSPPTNLRvTDVTSTSVTLSWTPPEDDG---GPITG-YVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 25-102 7.96e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 7.96e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808357266    25 PGVPSLVEN-AIGDKYFNVSFRPAKYDDESRAPVGntYEVQYKPQDaDEWETVKPADDGLTVHVDGLSPGTKYDVRVAA 102
Cdd:smart00060   1 PSPPSNLRVtDVTSTSVTLSWEPPPDDGITGYIVG--YRVEYREEG-SEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
34-112 2.12e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.02  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357266   34 AIGDKYFNVSFRPAKYDDesrAPVgNTYEVQYKPQDADEWETVKPADDGL-TVHVDGLSPGTKYDVRVAALQVDPEGGET 112
Cdd:pfam00041  10 DVTSTSLTVSWTPPPDGN---GPI-TGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
PhoD COG3540
Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism];
73-116 8.58e-03

Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism];


Pssm-ID: 442761 [Multi-domain]  Cd Length: 482  Bit Score: 37.21  E-value: 8.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 808357266  73 WETVKPADDGlTVHVD--GLSPGTKYDVRVAALQVDPEGGeTTKTL 116
Cdd:COG3540   83 TVTATPERDH-TVKVDvtGLEPGTRYFYRFRAGGETSPVG-RFRTA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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