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Conserved domains on  [gi|808357194|ref|NP_001294125|]
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Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 143-233 6.82e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.85  E-value: 6.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  143 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 222
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 808357194  223 QDGLGHPSMSS 233
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
35-306 7.83e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 7.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   35 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 113
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  114 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 193
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  194 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 273
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 808357194  274 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 306
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 358-449 1.28e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  358 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 436
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 808357194  437 SGCSQPSPPSDFV 449
Cdd:cd00063    80 GGESPPSESVTVT 92
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 552-591 2.64e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 808357194   552 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 591
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 521-728 4.26e-07

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.34  E-value: 4.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  521 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 600
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  601 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 675
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 808357194  676 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 728
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 794-829 4.21e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.89  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 808357194   794 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 829
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 143-233 6.82e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.85  E-value: 6.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  143 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 222
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 808357194  223 QDGLGHPSMSS 233
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
35-306 7.83e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 7.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   35 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 113
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  114 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 193
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  194 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 273
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 808357194  274 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 306
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 143-227 5.89e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 5.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194    143 PLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVyGSRDWIVANEQlVQENVFTVESLRPNGVYEFRVRGKN 222
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 808357194    223 QDGLG 227
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 35-124 1.27e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   35 PSAPGVPDVVDAGIGEVTVVWSAPlQSNGGEVRGYQIEMREFPDGEWESMGVDHlLKDTTCRVTNLT-SHEVQFRVSAYG 113
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTP-GSETSYTLTGLKpGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 808357194  114 RTGFGPASNPS 124
Cdd:cd00063    79 GGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 358-449 1.28e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  358 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 436
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 808357194  437 SGCSQPSPPSDFV 449
Cdd:cd00063    80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
145-230 1.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   145 APGRPTVIAVDGQGVLLEWTPPvaDVHSSPPQGYQVEYR-VYGSRDWivaNEQLV--QENVFTVESLRPNGVYEFRVRGK 221
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRpKNSGEPW---NEITVpgTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 808357194   222 NQDGLGHPS 230
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 35-118 5.86e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 5.86e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194     35 PSAPGVPDVVDAGIGEVTVVWSAPLQSNG-GEVRGYQIEMREfPDGEWESMGVDHllKDTTCRVTNLT-SHEVQFRVSAY 112
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYRE-EGSEWKEVNVTP--SSTSYTLTGLKpGTEYEFRVRAV 77


                    ....*.
gi 808357194    113 GRTGFG 118
Cdd:smart00060   78 NGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 552-591 2.64e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 808357194   552 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 591
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 552-592 3.86e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 3.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 808357194    552 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSF 592
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 521-728 4.26e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.34  E-value: 4.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  521 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 600
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  601 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 675
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 808357194  676 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 728
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
fn3 pfam00041
Fibronectin type III domain;
258-337 5.01e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   258 PPGQPQMVEVGDDVVKLEWAPSVQN----ARYIVEYREVGDPE-WHTANyDPIVQNGIQVEGLHRNSTYEFCVISIVDNI 332
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEpWNEIT-VPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 808357194   333 ASQPS 337
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
356-443 1.01e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   356 PAPNILEapeFLEVDGDKITICWL-PAQSQLPVMGYDVEFRDL--QQDDRWYKVNDQPVFackMTVGDLIMDHDYQFRVL 432
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTpPPDGNGPITGYEVEYRPKnsGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 808357194   433 AHNASGCSQPS 443
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 364-440 1.58e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.58e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808357194    364 PEFLEVDGDKITICWLPAQSQlPVMGYDVEFR--DLQQDDRWYKVNDQPVfACKMTVGDLIMDHDYQFRVLAHNASGCS 440
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDD-GITGYIVGYRveYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 596-637 5.89e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 5.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 808357194   596 NDANKLAVMEADGVRLIAEVLRTThDASVKEEAAAALWNLSS 637
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
563-661 1.78e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  563 GGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANklAVMEADGVRLIAEVLrTTHDASVKEEAAAALWNLSSADMLK 642
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQ--AVIDANLIPPLIHLL-SSAEYKIKKEACWAISNATSGGLNR 403

                          90
                  ....*....|....*....
gi 808357194  643 PVILESateILSQQVIAPV 661
Cdd:COG5064   404 PDIIRY---LVSQGFIKPL 419
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 794-829 4.21e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.89  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 808357194   794 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 829
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 596-637 5.07e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.87  E-value: 5.07e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 808357194    596 NDANKLAVMEADGVRLIAEVLRTTHDaSVKEEAAAALWNLSS 637
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDE-EVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 143-233 6.82e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.85  E-value: 6.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  143 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 222
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 808357194  223 QDGLGHPSMSS 233
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
35-306 7.83e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 7.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   35 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 113
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  114 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 193
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  194 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 273
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 808357194  274 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 306
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 143-227 5.89e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 5.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194    143 PLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVyGSRDWIVANEQlVQENVFTVESLRPNGVYEFRVRGKN 222
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 808357194    223 QDGLG 227
Cdd:smart00060   79 GAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
106-343 7.91e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.73  E-value: 7.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  106 QFRVSAYGRTGFGPASNPslpvkipISETDLATsagAPLAPGRPTVIAVDGQGVLLEWTP-PVADVhssppQGYQVEYRV 184
Cdd:COG3401   206 YYRVAATDTGGESAPSNE-------VSVTTPTT---PPSAPTGLTATADTPGSVTLSWDPvTESDA-----TGYRVYRSN 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  185 YGSRDW-IVANeqlVQENVFTVESLRPNGVYEFRVRGKNQDGLghPSMSSGGVairpaapqrhvparKVSESVQPPGQPQ 263
Cdd:COG3401   271 SGDGPFtKVAT---VTTTSYTDTGLTNGTTYYYRVTAVDAAGN--ESAPSNVV--------------SVTTDLTPPAAPS 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  264 MVEV---GDDVVKLEWAPSVQN--ARYIVEYREVGDPEWHTANyDPIVQNGIQVEGLHRNSTYEFCVISI-VDNIASQPS 337
Cdd:COG3401   332 GLTAtavGSSSITLSWTASSDAdvTGYNVYRSTSGGGTYTKIA-ETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPS 410


                  ....*.
gi 808357194  338 ETSDII 343
Cdd:COG3401   411 EEVSAT 416
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 35-124 1.27e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   35 PSAPGVPDVVDAGIGEVTVVWSAPlQSNGGEVRGYQIEMREFPDGEWESMGVDHlLKDTTCRVTNLT-SHEVQFRVSAYG 113
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTP-GSETSYTLTGLKpGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 808357194  114 RTGFGPASNPS 124
Cdd:cd00063    79 GGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-343 8.73e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 8.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  258 PPGQPQMVEVGDDVVKLEWAPSVQNAR----YIVEYREVGDPEWHTANYDPIVQNGIQVEGLHRNSTYEFCVISIVDNIA 333
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGpitgYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|
gi 808357194  334 SQPSETSDII 343
Cdd:cd00063    83 SPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
44-466 1.00e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   44 VDAGIGEVTVVWSAPLQSNGGEVRGYQIEMREFPDGEWESMGVDHLLKDTTCRVTNLTSHEVQFRVSAYGRTGFGPASNP 123
Cdd:COG3401    34 KTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  124 SLPVKIPISETDLATSAGAPLAPGRPTVIAVDG-QGVLLEWTPPVADVHSSPPQGYQVEYRVYGSRDWIVANEQLVQENV 202
Cdd:COG3401   114 SDEVPSPAVGTATTATAVAGGAATAGTYALGAGlYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  203 FTVESLRPNGVYEFRVRGKNQDGLGHPSmssggvairpaapqrhvPARKVSESVQPPGQPQMVEV---GDDVVKLEWAPS 279
Cdd:COG3401   194 DGGGDIEPGTTYYYRVAATDTGGESAPS-----------------NEVSVTTPTTPPSAPTGLTAtadTPGSVTLSWDPV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  280 VQN--ARYIVEYREVGDPEW------HTANY-DPIVQNGiqveglhrnSTYEFCVISI-VDNIASQPSETSdiihlrpTC 349
Cdd:COG3401   257 TESdaTGYRVYRSNSGDGPFtkvatvTTTSYtDTGLTNG---------TTYYYRVTAVdAAGNESAPSNVV-------SV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  350 NTSALRPApnileAPEFLEV---DGDKITICWLPAqSQLPVMGYDVEfRDLQQDDRWYKVN---DQPVFackmTVGDLIM 423
Cdd:COG3401   321 TTDLTPPA-----APSGLTAtavGSSSITLSWTAS-SDADVTGYNVY-RSTSGGGTYTKIAetvTTTSY----TDTGLTP 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 808357194  424 DHDYQFRVLAHNASGCSqpSPPSDFVHIEPSTNRFSSDTMESP 466
Cdd:COG3401   390 GTTYYYKVTAVDAAGNE--SAPSEEVSATTASAASGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 358-449 1.28e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  358 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 436
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 808357194  437 SGCSQPSPPSDFV 449
Cdd:cd00063    80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
145-230 1.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   145 APGRPTVIAVDGQGVLLEWTPPvaDVHSSPPQGYQVEYR-VYGSRDWivaNEQLV--QENVFTVESLRPNGVYEFRVRGK 221
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRpKNSGEPW---NEITVpgTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 808357194   222 NQDGLGHPS 230
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 35-118 5.86e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 5.86e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194     35 PSAPGVPDVVDAGIGEVTVVWSAPLQSNG-GEVRGYQIEMREfPDGEWESMGVDHllKDTTCRVTNLT-SHEVQFRVSAY 112
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYRE-EGSEWKEVNVTP--SSTSYTLTGLKpGTEYEFRVRAV 77


                    ....*.
gi 808357194    113 GRTGFG 118
Cdd:smart00060   78 NGAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
8-225 6.62e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 6.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194    8 ASDHDSEDRSAPPPAPASRFLHEdsgipsapgVPDVVDAGIGEVTVV--WSAPLQSNGgevrgYQIEMREfPDGEWESMG 85
Cdd:COG4733   518 AIDAGAFDDVPPQWPPVNVTTSE---------SLSVVAQGTAVTTLTvsWDAPAGAVA-----YEVEWRR-DDGNWVSVP 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   86 VDHllkDTTCRVTNLTSHEVQFRVSAYGRtgFGPASNPSLPvkipiSETDLATSAGAPLAPGRPTVIAVDGqGVLLEWTP 165
Cdd:COG4733   583 RTS---GTSFEVPGIYAGDYEVRVRAINA--LGVSSAWAAS-----SETTVTGKTAPPPAPTGLTATGGLG-GITLSWSF 651

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808357194  166 PV-ADVhssppQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKNQDG 225
Cdd:COG4733   652 PVdADT-----LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 552-591 2.64e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 808357194   552 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 591
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 552-592 3.86e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 3.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 808357194    552 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSF 592
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 521-728 4.26e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.34  E-value: 4.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  521 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 600
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  601 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 675
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 808357194  676 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 728
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
fn3 pfam00041
Fibronectin type III domain;
258-337 5.01e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   258 PPGQPQMVEVGDDVVKLEWAPSVQN----ARYIVEYREVGDPE-WHTANyDPIVQNGIQVEGLHRNSTYEFCVISIVDNI 332
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEpWNEIT-VPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 808357194   333 ASQPS 337
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 258-328 2.43e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.43e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808357194    258 PPGQPQMVEVGDDVVKLEWAPSVQNA--RYIVEYREVG---DPEWHTANYDPIvQNGIQVEGLHRNSTYEFCVISI 328
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYreeGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
356-443 1.01e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   356 PAPNILEapeFLEVDGDKITICWL-PAQSQLPVMGYDVEFRDL--QQDDRWYKVNDQPVFackMTVGDLIMDHDYQFRVL 432
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTpPPDGNGPITGYEVEYRPKnsGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 808357194   433 AHNASGCSQPS 443
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
31-169 1.03e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   31 DSGIPSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGvdHLLKDTTCRVTNLTS-HEVQFRV 109
Cdd:COG3401   323 DLTPPAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNVYRSTSGGGTYTKIA--ETVTTTSYTDTGLTPgTTYYYKV 397

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  110 SAYGRTgfGPASNPSLPVKIPISETDLATSAGAPLAPGRPTVIAVDGQGVLLEWTPPVAD 169
Cdd:COG3401   398 TAVDAA--GNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSA 455
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 364-440 1.58e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.58e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808357194    364 PEFLEVDGDKITICWLPAQSQlPVMGYDVEFR--DLQQDDRWYKVNDQPVfACKMTVGDLIMDHDYQFRVLAHNASGCS 440
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDD-GITGYIVGYRveYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 596-637 5.89e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 5.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 808357194   596 NDANKLAVMEADGVRLIAEVLRTThDASVKEEAAAALWNLSS 637
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 136-221 1.20e-03

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 39.67  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194   136 LATSAGAPLAPGRPTVIAVDGQGVLlEWTPpvaDVHSSPPQGYQVEYRVYGSRDWI-VANEQLVQENV--FTVESLRPNG 212
Cdd:pfam01108   15 SAAGGPSLPAPQNVTFQSTNFKNIL-TWEP---GPNSPPDVVYTVQYKIYGSGDWKnVPNCTNITRTEcdLTDETSDLTE 90


                   ....*....
gi 808357194   213 VYEFRVRGK 221
Cdd:pfam01108   91 TYYARVRAV 99
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
563-661 1.78e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194  563 GGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANklAVMEADGVRLIAEVLrTTHDASVKEEAAAALWNLSSADMLK 642
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQ--AVIDANLIPPLIHLL-SSAEYKIKKEACWAISNATSGGLNR 403

                          90
                  ....*....|....*....
gi 808357194  643 PVILESateILSQQVIAPV 661
Cdd:COG5064   404 PDIIRY---LVSQGFIKPL 419
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 794-829 4.21e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.89  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 808357194   794 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 829
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 596-637 5.07e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.87  E-value: 5.07e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 808357194    596 NDANKLAVMEADGVRLIAEVLRTTHDaSVKEEAAAALWNLSS 637
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDE-EVVKEAAWALSNLSS 41
fn3 pfam00041
Fibronectin type III domain;
36-121 7.60e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.62  E-value: 7.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808357194    36 SAPGVPDVVDAGIGEVTVVWSAPLQSNgGEVRGYQIEMREfPDGEWESMgVDHLLKDT-TCRVTNLTSH-EVQFRVSAYG 113
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRP-KNSGEPWN-EITVPGTTtSVTLTGLKPGtEYEVRVQAVN 77


                   ....*...
gi 808357194   114 RTGFGPAS 121
Cdd:pfam00041   78 GGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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