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Conserved domains on  [gi|808355742|ref|NP_001293655|]
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Rho-GAP domain-containing protein [Caenorhabditis elegans]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138230)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 106-307 1.78e-125

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239860  Cd Length: 196  Bit Score: 372.50  E-value: 1.78e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 106 VLGVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDsvdlskVESLDPRWRDVN 185
Cdd:cd04395    1 TFGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFD------IDLQDPRWRDVN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 186 VVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRN 265
Cdd:cd04395   75 VVSSLLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRN 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 808355742 266 LALMFGPSIVRPSDDNMATMVTHMSDQCKIIETLIHYNLWMF 307
Cdd:cd04395  155 LAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQHYDWFF 196
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 106-307 1.78e-125

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 372.50  E-value: 1.78e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 106 VLGVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDsvdlskVESLDPRWRDVN 185
Cdd:cd04395    1 TFGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFD------IDLQDPRWRDVN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 186 VVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRN 265
Cdd:cd04395   75 VVSSLLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRN 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 808355742 266 LALMFGPSIVRPSDDNMATMVTHMSDQCKIIETLIHYNLWMF 307
Cdd:cd04395  155 LAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQHYDWFF 196
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 121-302 2.99e-65

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 214.44  E-value: 2.99e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742   121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSkvesldprWRDVNVVSSLLKMFLRKLPE 200
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLS--------EYDVHDVAGLLKLFLRELPE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742   201 PLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDD 280
Cdd:smart00324  73 PLITYELYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDG 152

                          170       180
                   ....*....|....*....|..
gi 808355742   281 NMATMvTHMSDQCKIIETLIHY 302
Cdd:smart00324 153 EVASL-KDIRHQNTVIEFLIEN 173
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 124-279 1.32e-61

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 203.55  E-value: 1.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742  124 PMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLsnrgfdsvDLSKVESLDPRWRDVNVVSSLLKMFLRKLPEPLL 203
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAF--------DRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808355742  204 TDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSD 279
Cdd:pfam00620  73 TFELYEEFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 106-307 1.78e-125

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 372.50  E-value: 1.78e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 106 VLGVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDsvdlskVESLDPRWRDVN 185
Cdd:cd04395    1 TFGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFD------IDLQDPRWRDVN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 186 VVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRN 265
Cdd:cd04395   75 VVSSLLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRN 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 808355742 266 LALMFGPSIVRPSDDNMATMVTHMSDQCKIIETLIHYNLWMF 307
Cdd:cd04395  155 LAIVFGPTLVRTSDDNMETMVTHMPDQCKIVETLIQHYDWFF 196
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 121-302 2.99e-65

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 214.44  E-value: 2.99e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742   121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSkvesldprWRDVNVVSSLLKMFLRKLPE 200
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLS--------EYDVHDVAGLLKLFLRELPE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742   201 PLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDD 280
Cdd:smart00324  73 PLITYELYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDG 152

                          170       180
                   ....*....|....*....|..
gi 808355742   281 NMATMvTHMSDQCKIIETLIHY 302
Cdd:smart00324 153 EVASL-KDIRHQNTVIEFLIEN 173
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 124-279 1.32e-61

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 203.55  E-value: 1.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742  124 PMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLsnrgfdsvDLSKVESLDPRWRDVNVVSSLLKMFLRKLPEPLL 203
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAF--------DRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808355742  204 TDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSD 279
Cdd:pfam00620  73 TFELYEEFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 124-300 1.92e-53

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 182.12  E-value: 1.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 124 PMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSvdlskveslDPRWRDVNVVSSLLKMFLRKLPEPLL 203
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDID---------DLEDYDVHDVASLLKLYLRELPEPLI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 204 TDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNMa 283
Cdd:cd00159   72 PFELYDEFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDD- 150

                        170
                 ....*....|....*..
gi 808355742 284 TMVTHMSDQCKIIETLI 300
Cdd:cd00159  151 ELLEDIKKLNEIVEFLI 167
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 121-302 1.49e-52

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 180.68  E-value: 1.49e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDSVDLSKVESLDprwRDVNVVSSLLKMFLRKLPE 200
Cdd:cd04398   14 DNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDK-DPLNVLLISPEDYE---SDIHSVASLLKLFFRELPE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 201 PLLTDKLYPFFIDANRI---STHHNRLHKLRNllrKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRP 277
Cdd:cd04398   90 PLLTKALSREFIEAAKIedeSRRRDALHGLIN---DLPDANYATLRALMFHLARIKEHESVNRMSVNNLAIIWGPTLMNA 166

                        170       180
                 ....*....|....*....|....*
gi 808355742 278 SDDNMAtmvtHMSDQCKIIETLIHY 302
Cdd:cd04398  167 APDNAA----DMSFQSRVIETLLDN 187
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-300 1.32e-44

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 158.83  E-value: 1.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 124 PMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGfDSVDLSKVesldpRWRDVNVVSSLLKMFLRKLPEPLL 203
Cdd:cd04372   17 PMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDG-EKADISAT-----VYPDINVITGALKLYFRDLPIPVI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 204 TDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNMA 283
Cdd:cd04372   91 TYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSAL 170

                        170
                 ....*....|....*..
gi 808355742 284 TMVTHMSDQCKIIETLI 300
Cdd:cd04372  171 TTLNDMRYQILIVQLLI 187
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 119-301 4.93e-43

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 154.09  E-value: 4.93e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 119 CE---DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKeslsnrgFDSVDLSKVESLDPRWRDVNVVSSLLKMFL 195
Cdd:cd04403    9 CQrenSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLR-------FAVDHDEKLDLDDSKWEDIHVITGALKLFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 196 RKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV 275
Cdd:cd04403   82 RELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLL 161

                        170       180
                 ....*....|....*....|....*.
gi 808355742 276 RPSDDNmATMVTHMSDQCKIIETLIH 301
Cdd:cd04403  162 RPEQET-GNIAVHMVYQNQIVELILL 186
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 121-302 4.29e-40

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 146.41  E-value: 4.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDSVDLSKVESLDprwrdvnvVSSLLKMFLRKLPE 200
Cdd:cd04378   14 DEVPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFEN-GKDLVELSELSPHD--------ISSVLKLFLRQLPE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 201 PLLTDKLYPFFID--------------ANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNL 266
Cdd:cd04378   85 PLILFRLYNDFIAlakeiqrdteedkaPNTPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNL 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 808355742 267 ALMFGPSIVRPSDDNMATMVTHMSD---QCKIIETLIHY 302
Cdd:cd04378  165 GIVFGPTLIRPRPGDADVSLSSLVDygyQARLVEFLITN 203
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 121-302 1.21e-36

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 135.90  E-value: 1.21e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSN--RGFdsvdlskveSLDPRWRDVNVVSSLLKMFLRKL 198
Cdd:cd04385   13 NDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdaRSV---------QLREGEYTVHDVADVLKRFLRDL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 199 PEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPS 278
Cdd:cd04385   84 PDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTD 163

                        170       180
                 ....*....|....*....|....
gi 808355742 279 DDnmatMVTHMSDQCKIIETLIHY 302
Cdd:cd04385  164 EH----SVGQTSHEVKVIEDLIDN 183
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 123-301 1.33e-35

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 133.19  E-value: 1.33e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSnRGFDSVDLSKVesldprwrDVNVVSSLLKMFLRKLPEPL 202
Cdd:cd04382   17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFL-RGKTVPNLSKV--------DIHVICGCLKDFLRSLKEPL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 203 LTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKhSDVNKMECRNLALMFGPSIVRPSDDN- 281
Cdd:cd04382   88 ITFALWKEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTIVGYSVPNp 166

                        170       180
                 ....*....|....*....|.
gi 808355742 282 -MATMVTHMSDQCKIIETLIH 301
Cdd:cd04382  167 dPMTILQDTVRQPRVVERLLE 187
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 121-302 4.17e-35

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 132.62  E-value: 4.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDSVDLSKVESLDprwrdvnvVSSLLKMFLRKLPE 200
Cdd:cd04409   14 DGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFEN-GKDLVELSELSPHD--------ISNVLKLYLRQLPE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 201 PLLTDKLYPFFIDANRISTHHNR----------------------LHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDV 258
Cdd:cd04409   85 PLILFRLYNEFIGLAKESQHVNEtqeakknsdkkwpnmctelnriLLKSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEE 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 808355742 259 NKMECRNLALMFGPSIVRPSDDNMATMVTHMSD---QCKIIETLIHY 302
Cdd:cd04409  165 NKMSASNLGIIFGPTLIRPRPTDATVSLSSLVDyphQARLVELLITY 211
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 103-309 4.38e-35

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 132.20  E-value: 4.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 103 PQPVLGVriadcptgSCEDH-------VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSvdlskve 175
Cdd:cd04386    1 EKPVFGT--------PLEEHlkrtgreIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTFSL------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 176 SLDPRWRDVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKH 255
Cdd:cd04386   66 PLDEFYSDPHAVASALKSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQK 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 808355742 256 SDVNKMECRNLALMFGPSIVRPSDDNM-----ATMVTHMSdqcKIIETLIHYNLWMFDE 309
Cdd:cd04386  146 SDENKMSPSNIAIVLAPNLLWAKNEGSlaemaAGTSVHVV---AIVELIISHADWFFPG 201
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 105-277 9.66e-35

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 131.09  E-value: 9.66e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 105 PVLGVRIADCPTGSCEDhVPMIVQACVCVIETYGMDTvGIYRIPGNTAAVNALKeslsnRGFDS---VDLSKveslDPRW 181
Cdd:cd04384    1 RVFGCDLTEHLLNSGQD-VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLR-----HEFDSeqiPDLTK----DVYI 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 182 RDVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKM 261
Cdd:cd04384   70 QDIHSVSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNM 149

                        170
                 ....*....|....*.
gi 808355742 262 ECRNLALMFGPSIVRP 277
Cdd:cd04384  150 HAKNLAIVWAPNLLRS 165
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 123-291 1.67e-34

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 130.43  E-value: 1.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFD-SVDLSKVesldprwrDVNVVSSLLKMFLRKLPEP 201
Cdd:cd04387   16 VPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDvSVMLSEM--------DVNAIAGTLKLYFRELPEP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 202 LLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDN 281
Cdd:cd04387   88 LFTDELYPNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKE 167

                        170
                 ....*....|
gi 808355742 282 MATMVTHMSD 291
Cdd:cd04387  168 SKIPTNTMTD 177
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 117-282 1.38e-32

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 124.76  E-value: 1.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 117 GSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKEsLSNRGfDSVDLSKVEsldprwrDVNVVSSLLKMFLR 196
Cdd:cd04404   17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQ-KYNMG-EPVDFDQYE-------DVHLPAVILKTFLR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 197 KLPEPLLTDKLYPFFIDANRISTHhNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVR 276
Cdd:cd04404   88 ELPEPLLTFDLYDDIVGFLNVDKE-ERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLLW 166


                 ....*.
gi 808355742 277 PSDDNM 282
Cdd:cd04404  167 AKDASM 172
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 125-300 1.65e-32

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 124.81  E-value: 1.65e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 125 MIVQACVCVIETYGMDTVGIYRIPGNTAAVNalkeSLSNRGFDSVDLSKVE-SLDPRWRDVNVVSSLLKMFLRKLPEPLL 203
Cdd:cd04374   30 KFVRKCIEAVETRGINEQGLYRVVGVNSKVQ----KLLSLGLDPKTSTPGDvDLDNSEWEIKTITSALKTYLRNLPEPLM 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 204 TDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNMA 283
Cdd:cd04374  106 TYELHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEETVA 185

                        170
                 ....*....|....*..
gi 808355742 284 TMVtHMSDQCKIIETLI 300
Cdd:cd04374  186 AIM-DIKFQNIVVEILI 201
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 120-300 5.78e-32

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 122.55  E-value: 5.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 120 EDH-VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDSVDLSKVEsldprwrdVNVVSSLLKMFLRKL 198
Cdd:cd04377   11 EDRsVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT-DPDSVNLEDYP--------IHVITSVLKQWLREL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 199 PEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPS 278
Cdd:cd04377   82 PEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILRCP 161

                        170       180
                 ....*....|....*....|...
gi 808355742 279 DDNMATM-VTHMSDQCKIIETLI 300
Cdd:cd04377  162 DTADPLQsLQDVSKTTTCVETLI 184
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 120-301 2.01e-31

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 121.02  E-value: 2.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 120 EDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKeslsnRGFDSVDLSKVESLDprwRDVNVVSSLLKMFLRKLP 199
Cdd:cd04373   12 EKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQ-----KQFDQDHNLDLVSKD---FTVNAVAGALKSFFSELP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 200 EPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSD 279
Cdd:cd04373   84 DPLIPYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLMRPDF 163

                        170       180
                 ....*....|....*....|..
gi 808355742 280 DNMATMVTHMSDQcKIIETLIH 301
Cdd:cd04373  164 TSMEALSATRIYQ-TIIETFIQ 184
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 119-310 7.18e-31

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 119.71  E-value: 7.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 119 CEDH-VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLsNRGfDSVDLSKvESldprwrdVNVVSSLLKMFLRK 197
Cdd:cd04402   10 CEDDnLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKL-NSG-VEVDLKA-EP-------VLLLASVLKDFLRN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 198 LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRP 277
Cdd:cd04402   80 IPGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWP 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 808355742 278 SDDNMATMVThMSDQCKIIETLIHYNLWMFDES 310
Cdd:cd04402  160 PASSELQNED-LKKVTSLVQFLIENCQEIFGED 191
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 123-285 5.56e-29

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 114.46  E-value: 5.56e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESlsnrgFDSvdlSKVESLDpRWRDVNVVSSLLKMFLRKLPEPL 202
Cdd:cd04390   22 VPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDA-----FDA---GERPSFD-SDTDVHTVASLLKLYLRELPEPV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 203 LTDKLYPFFIDANRI--STHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDD 280
Cdd:cd04390   93 IPWAQYEDFLSCAQLlsKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPKVE 172


                 ....*
gi 808355742 281 NMATM 285
Cdd:cd04390  173 DPATI 177
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 121-300 8.02e-29

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 114.14  E-value: 8.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 121 DHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDSVDLSKVESLDprwrdvnvVSSLLKMFLRKLPE 200
Cdd:cd04408   14 EEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFEN-GRDLVDLSGHSPHD--------ITSVLKHFLKELPE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 201 PLLTDKLYPFFI------------DANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLAL 268
Cdd:cd04408   85 PVLPFQLYDDFIalakelqrdsekAAESPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGI 164

                        170       180       190
                 ....*....|....*....|....*....|....
gi 808355742 269 MFGPSIVRPSDDNMATMVTHM--SDQCKIIETLI 300
Cdd:cd04408  165 VFGPTLLRPLVGGDVSMICLLdtGYQAQLVEFLI 198
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-305 1.97e-28

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 113.59  E-value: 1.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLskvesldprWRDVNV--VSSLLKMFLRKLPE 200
Cdd:cd04391   22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFL---------WDQVKQhdAASLLKLFIRELPQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 201 PLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSI-----V 275
Cdd:cd04391   93 PLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVAMIMAPNLfpprgK 172

                        170       180       190
                 ....*....|....*....|....*....|...
gi 808355742 276 RPSDDNMATMVTHMSDQ-CKIIETLIHYN--LW 305
Cdd:cd04391  173 HSKDNESLQEEVNMAAGcANIMRLLIRYQdlLW 205
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 120-300 5.42e-28

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 112.15  E-value: 5.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 120 EDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLsNRGFDSVDLSKVESLDprwrdvnvVSSLLKMFLRKLP 199
Cdd:cd04376    6 ARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEF-DRGIDVVLDENHSVHD--------VAALLKEFFRDMP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 200 EPLLTDKLYPFFIDANRISThHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDV-----------NKMECRNLAL 268
Cdd:cd04376   77 DPLLPRELYTAFIGTALLEP-DEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLAT 155

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 808355742 269 MFGPSIVR---PSDDNMATMVTHMSD---QCKIIETLI 300
Cdd:cd04376  156 IFGPNLLHkqkSGEREFVQASLRIEEstaIINVVQTMI 193
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 123-282 4.39e-27

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 108.99  E-value: 4.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIE-TYGMDTVGIYRIPGNTAAVNALKESLsNRGFDsVDLSKveslDPRWRDVNVVSSLLKMFLRKLPEP 201
Cdd:cd04400   22 LPSVVYRCIEYLDkNRAIYEEGIFRLSGSASVIKQLKERF-NTEYD-VDLFS----SSLYPDVHTVAGLLKLYLRELPTL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 202 LLTDKLYPFFIDANRISTHH-NRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDD 280
Cdd:cd04400   96 ILGGELHNDFKRLVEENHDRsQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNVCIVFSPTLNIPAGI 175


                 ..
gi 808355742 281 NM 282
Cdd:cd04400  176 FV 177
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 117-282 9.66e-27

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 107.93  E-value: 9.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 117 GSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDsVDLSKVEsldprwrDVNVVSSLLKMFLR 196
Cdd:cd04393   14 GQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDS-GEE-VDLSKEA-------DVCSAASLLRLFLQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 197 KLPEPLLTDKLYPFFIdanRISTHHNR----LHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGP 272
Cdd:cd04393   85 ELPEGLIPASLQIRLM---QLYQDYNGedefGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFGP 161

                        170
                 ....*....|..
gi 808355742 273 SI--VRPSDDNM 282
Cdd:cd04393  162 DVfhVYTDVEDM 173
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 123-300 2.72e-26

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 106.35  E-value: 2.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSnRGFDSVdlskveSLDPRWRDVNVVSSLLKMFLRKLPEPL 202
Cdd:cd04383   18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFE-RGEDPL------ADDQNDHDINSVAGVLKLYFRGLENPL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 203 LTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVR-PSDDN 281
Cdd:cd04383   91 FPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLMPvPEGQD 170

                        170
                 ....*....|....*....
gi 808355742 282 MATMVTHMSDqckIIETLI 300
Cdd:cd04383  171 QVSCQAHVNE---LIKTII 186
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 119-274 4.72e-26

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 105.60  E-value: 4.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 119 CEDHV--PMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFdsvdlSKVESLDPrwrdvNVVSSLLKMFLR 196
Cdd:cd04381   14 CHDGIdlPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRES-----PNLEEYEP-----PTVASLLKQYLR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808355742 197 KLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSI 274
Cdd:cd04381   84 ELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPTV 161
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 123-279 1.78e-23

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 99.08  E-value: 1.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSnRGFDSVDLSkvESLDPrwrDVNVVSSLLKMFLRKLPEPL 202
Cdd:cd04379   18 VPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFE-RNSAAVELS--EELYP---DINVITGVLKDYLRELPEPL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 203 LTDKLYPFFIDA------NRISThhNRlHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVR 276
Cdd:cd04379   92 ITPQLYEMVLEAlavalpNDVQT--NT-HLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMF 168


                 ...
gi 808355742 277 PSD 279
Cdd:cd04379  169 CSQ 171
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 123-300 1.93e-21

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 92.36  E-value: 1.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNrGFDSVDLSKVEsldprwrdVNVVSSLLKMFLRKLPEPL 202
Cdd:cd04407   15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQA-DPENVKLENYP--------IHAITGLLKQWLRELPEPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 203 LTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDnm 282
Cdd:cd04407   86 MTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLRCPDS-- 163

                        170       180
                 ....*....|....*....|.
gi 808355742 283 ATMVTHMSDQCKI---IETLI 300
Cdd:cd04407  164 SDPLTSMKDVAKTttcVEMLI 184
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 118-279 3.64e-20

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 88.90  E-value: 3.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 118 SCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLsNRGFDSVDLSKVesldprwrDVNVVSSLLKMFLRK 197
Cdd:cd04406   10 SEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGL-DTDANSVNLDDY--------NIHVIASVFKQWLRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 198 LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRP 277
Cdd:cd04406   81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRC 160


                 ..
gi 808355742 278 SD 279
Cdd:cd04406  161 PD 162
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 122-303 3.90e-20

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 89.35  E-value: 3.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 122 HVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKvesldprwRDVNVVSSLLKMFLRKLPEP 201
Cdd:cd04397   26 RIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLSK--------ENPVQLAALLKKFLRELPDP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 202 LLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDV-----NKMECRNLALMFGPSIVR 276
Cdd:cd04397   98 LLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIdeetgSKMDIHNLATVITPNILY 177

                        170       180
                 ....*....|....*....|....*..
gi 808355742 277 PSDDNmATMVTHMSDQCKIIETLIHYN 303
Cdd:cd04397  178 SKTDN-PNTGDEYFLAIEAVNYLIENN 203
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 123-300 1.57e-19

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 87.06  E-value: 1.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACV-CVIETYGMDTVGIYRIPGNTAAVNALKESLsNRGfdSVDLSKVEsldprwrDVNVVSSLLKMFLRKLPEP 201
Cdd:cd04389   21 LPWILTFLSeKVLALGGFQTEGIFRVPGDIDEVNELKLRV-DQW--DYPLSGLE-------DPHVPASLLKLWLRELEEP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 202 LLTDKLYpffidaNRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDV--NKMECRNLALMFGPSIVRPSD 279
Cdd:cd04389   91 LIPDALY------QQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVahTKMDVSNLAMVFAPNILRCTS 164

                        170       180
                 ....*....|....*....|.
gi 808355742 280 DNMATMVTHMSDQCKIIETLI 300
Cdd:cd04389  165 DDPRVIFENTRKEMSFLRTLI 185
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 143-307 3.30e-19

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 86.75  E-value: 3.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 143 GIYRIPGNTAAVNALKESLsNRGFDsVDLSKVESldprwrDVNVVSSLLKMFLRKLPEPLLTDKLYP----------FFI 212
Cdd:cd04392   28 GLFRKPGNSARQQELRDLL-NSGTD-LDLESGGF------HAHDCATVLKGFLGELPEPLLTHAHYPahlqiadlcqFDE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 213 DANRIST--HHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRP---SDDNMATMVT 287
Cdd:cd04392  100 KGNKTSApdKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPrnlTPEDLHENAQ 179

                        170       180
                 ....*....|....*....|
gi 808355742 288 HMSDqckIIETLIHYNLWMF 307
Cdd:cd04392  180 KLNS---IVTFMIKHSQKLF 196
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 120-302 7.58e-19

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 85.60  E-value: 7.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 120 EDHVPMIVQACVCVIETYgMDTVGIYRIPGNTAAVNALKESLSNRGfdsVDLSKVESLDprwrdvnvVSSLLKMFLRKLP 199
Cdd:cd04394   17 YGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGE---ACLSSALPCD--------VAGLLKQFFRELP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 200 EPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVrPSD 279
Cdd:cd04394   85 EPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLF-QSE 163

                        170       180
                 ....*....|....*....|....*..
gi 808355742 280 DNMATMVTHMSD----QCKIIETLIHY 302
Cdd:cd04394  164 EGGEKMSSSTEKrlrlQAAVVQTLIDN 190
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-294 3.62e-14

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 72.45  E-value: 3.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGfDSVDLSKVESLDprwrdvnvVSSLLKMFLRKLPEPL 202
Cdd:cd04375   20 LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESST-DNVNYDGQQAYD--------VADMLKQYFRDLPEPL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 203 LTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNM 282
Cdd:cd04375   91 LTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPSLFHLNTSRR 170

                        170
                 ....*....|..
gi 808355742 283 ATMVTHMSDQCK 294
Cdd:cd04375  171 ENSSPARRMQRK 182
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 122-302 7.37e-14

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 71.67  E-value: 7.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 122 HVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSN-----RGFDsvdlskvesldprWRDVNV--VSSLLKMF 194
Cdd:cd04396   31 YIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTppdygKSFD-------------WDGYTVhdAASVLRRY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 195 LRKLPEPLLTDKLYPFF---------IDANRISTHHNRLHK--------LRNLLRKLPRPHYDTLRFLIVHLSEITKHSD 257
Cdd:cd04396   98 LNNLPEPLVPLDLYEEFrnplrkrprILQYMKGRINEPLNTdidqaikeYRDLITRLPNLNRQLLLYLLDLLAVFARNSD 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 808355742 258 VNKMECRNLALMFGPSIVRPSDDNMATMVTHMSDQckIIETLIHY 302
Cdd:cd04396  178 KNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSRL--VVEFLIEH 220
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 123-309 1.55e-10

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 61.58  E-value: 1.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 123 VPMIVQAcvcvIETYgMD-------------TVGIYRIPGNTaaVNALKESLSNRGFDSVDLSKVESLDPrwrdvNVVSS 189
Cdd:cd04399   16 VPLIVSA----ILSY-LDqlypdlindevrrNVWTDPVSLKE--THQLRNLLNKPKKPDKEVIILKKFEP-----STVAS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 190 LLKMFLRKLPEPLLTDK-------LYPFFIDANRISTHhNRLHKLRNLLRKLPRPHYDTLRFLIVHLS---EITKHSDVN 259
Cdd:cd04399   84 VLKLYLLELPDSLIPHDiydlirsLYSAYPPSQEDSDT-ARIQGLQSTLSQLPKSHIATLDAIITHFYrliEITKMGESE 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 808355742 260 KMECRNLALMFGPSIVRPSDDNMATMvtHMSDQCKIIETLIHYNLWMFDE 309
Cdd:cd04399  163 EEYADKLATSLSREILRPIIESLLTI--GDKHGYKFFRDLLTHKDQIFSE 210
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 186-300 3.37e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 54.65  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 186 VVSSLLKMFLRKLPEPLLTDKLYPFFIDAnriSTHHNRlhKLRNLLR-KLPRPHYDTLRFLIVHLSEITKHSDVNKMECR 264
Cdd:cd04380  106 SVAEALLLFLESLPDPIIPYSLYERLLEA---VANNEE--DKRQVIRiSLPPVHRNVFVYLCSFLRELLSESADRGLDEN 180

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 808355742 265 NLALMFGPSIVRPSDDNMATMVTHMSDQ-CKIIETLI 300
Cdd:cd04380  181 TLATIFGRVLLRDPPRAGGKERRAERDRkRAFIEQFL 217
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 121-300 3.17e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 51.41  E-value: 3.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 121 DHVPMIVQACVCVIETYGMDTVGIYR--IPGNTAAVNALKESLSNrgfdSVDLSKVesldprwrDVNVVSSLLKMFLRKL 198
Cdd:cd04388   13 DVAPPLLIKLVEAIEKKGLESSTLYRtqSSSSLTELRQILDCDAA----SVDLEQF--------DVAALADALKRYLLDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355742 199 PEPLLTDKLYPFFIdanRISTHHNRLHKLRNLLRKLPRP-----HYD-TLRFLIVHLSEITKHSDVNKMECRNLALMFGP 272
Cdd:cd04388   81 PNPVIPAPVYSEMI---SRAQEVQSSDEYAQLLRKLIRSpnlphQYWlTLQYLLKHFFRLCQSSSKNLLSARALAEIFSP 157

                        170       180       190
                 ....*....|....*....|....*....|.
gi 808355742 273 SIVR---PSDDNMATMVthmsdqcKIIETLI 300
Cdd:cd04388  158 LLFRfqpASSDSPEFHI-------RIIEVLI 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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