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Conserved domains on  [gi|752293514|ref|NP_001291403|]
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chordin isoform 3 [Homo sapiens]

Protein Classification

follistatin-related protein 1( domain architecture ID 10654732)

follistatin-related protein 1 is an extracellular calcium-binding protein belonging to the BM-40/SPARC/osteonectin family and containing Kazal-type serine protease inhibitor/follistatin-like and EF-hand domains, that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
162-276 1.15e-29

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 113.21  E-value: 1.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514   162 DTLPVPLAGALVLPPVKSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGTPGP--RRLLKGF--YGSE 236
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPvvRIPLPNPtsREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 752293514   237 AQGVVKDLEPELLRHLAKGMASLMITTKGSPRGELRGQVH 276
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
34-151 3.31e-27

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 106.28  E-value: 3.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514    34 DVLQSVLCGADALIPVQTGAAGSASLTLLGNGSLIYQVQVVGTSSEVVAMTLETKPQRRD---QRTVLCHMaglQPGGHT 110
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 752293514   111 AVGICPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAA 151
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
VWC smart00214
von Willebrand factor (vWF) type C domain;
414-480 1.39e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.58  E-value: 1.39e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752293514   414 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGGTgEVHCEKVQCPR-LACAQPVRVNPTD-CCKQC 480
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 335-392 1.34e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 40.10  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514  335 CFFEGQQRPHGARWAPNydpLCSLCTCQRRTVICDPVVCPPPSCPHP--VQAPDQCCPVC 392
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 502-562 5.27e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 38.17  E-value: 5.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752293514  502 CRFAGQWFPESQSWHPSvppfgemSCITCRCGAGVPHCERDDCSlPLSCGSGKES----RCCSRC 562
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICP-PLDCPNPRLEippgECCPVC 57
 
Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
162-276 1.15e-29

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 113.21  E-value: 1.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514   162 DTLPVPLAGALVLPPVKSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGTPGP--RRLLKGF--YGSE 236
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPvvRIPLPNPtsREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 752293514   237 AQGVVKDLEPELLRHLAKGMASLMITTKGSPRGELRGQVH 276
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
34-151 3.31e-27

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 106.28  E-value: 3.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514    34 DVLQSVLCGADALIPVQTGAAGSASLTLLGNGSLIYQVQVVGTSSEVVAMTLETKPQRRD---QRTVLCHMaglQPGGHT 110
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 752293514   111 AVGICPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAA 151
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 164-275 1.40e-15

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 73.28  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514  164 LPVPLAGALVLPP-VKSQAAGHAWLSLDTHCH-LHYEVLLAGLggseQGTVTAHL-LGPPGTPGPrrLLKGFYG------ 234
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLDDTENtLHYTLTFSGL----SVPTAAHIhAGAAGFNGP--VVVPLEGgprktt 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 752293514  235 -SEAQGVVKDLEPELLRHL--AKGMASLMITTKGSPRGELRGQV 275
Cdd:pfam07452  75 lLAVPEGLATLTAAQLAALlaQQGELYVNVHTEGNPGGEIRGQI 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 36-149 2.99e-13

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 66.35  E-value: 2.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514   36 LQSVLCGADALIP-VQTGAAGSASLTL-LGNGSLIYQVQVVGTS--------------SEVVAMTLETKPQRRDqrtvlc 99
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLdDTENTLHYTLTFSGLSvptaahihagaagfNGPVVVPLEGGPRKTT------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 752293514  100 hmaglqpgGHTAVGICPGLGARGAHMLLQN--ELFLNVGTKDFPDGELRGHV 149
Cdd:pfam07452  75 --------LLAVPEGLATLTAAQLAALLAQqgELYVNVHTEGNPGGEIRGQI 118
VWC smart00214
von Willebrand factor (vWF) type C domain;
414-480 1.39e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.58  E-value: 1.39e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752293514   414 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGGTgEVHCEKVQCPR-LACAQPVRVNPTD-CCKQC 480
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 335-392 1.34e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.10  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514  335 CFFEGQQRPHGARWAPNydpLCSLCTCQRRTVICDPVVCPPPSCPHP--VQAPDQCCPVC 392
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 502-562 5.27e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.17  E-value: 5.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752293514  502 CRFAGQWFPESQSWHPSvppfgemSCITCRCGAGVPHCERDDCSlPLSCGSGKES----RCCSRC 562
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICP-PLDCPNPRLEippgECCPVC 57
 
Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
162-276 1.15e-29

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 113.21  E-value: 1.15e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514   162 DTLPVPLAGALVLPPVKSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGTPGP--RRLLKGF--YGSE 236
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPvvRIPLPNPtsREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 752293514   237 AQGVVKDLEPELLRHLAKGMASLMITTKGSPRGELRGQVH 276
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
34-151 3.31e-27

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 106.28  E-value: 3.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514    34 DVLQSVLCGADALIPVQTGAAGSASLTLLGNGSLIYQVQVVGTSSEVVAMTLETKPQRRD---QRTVLCHMaglQPGGHT 110
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 752293514   111 AVGICPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAA 151
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 164-275 1.40e-15

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 73.28  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514  164 LPVPLAGALVLPP-VKSQAAGHAWLSLDTHCH-LHYEVLLAGLggseQGTVTAHL-LGPPGTPGPrrLLKGFYG------ 234
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLDDTENtLHYTLTFSGL----SVPTAAHIhAGAAGFNGP--VVVPLEGgprktt 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 752293514  235 -SEAQGVVKDLEPELLRHL--AKGMASLMITTKGSPRGELRGQV 275
Cdd:pfam07452  75 lLAVPEGLATLTAAQLAALlaQQGELYVNVHTEGNPGGEIRGQI 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 36-149 2.99e-13

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 66.35  E-value: 2.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514   36 LQSVLCGADALIP-VQTGAAGSASLTL-LGNGSLIYQVQVVGTS--------------SEVVAMTLETKPQRRDqrtvlc 99
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLdDTENTLHYTLTFSGLSvptaahihagaagfNGPVVVPLEGGPRKTT------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 752293514  100 hmaglqpgGHTAVGICPGLGARGAHMLLQN--ELFLNVGTKDFPDGELRGHV 149
Cdd:pfam07452  75 --------LLAVPEGLATLTAAQLAALLAQqgELYVNVHTEGNPGGEIRGQI 118
VWC smart00214
von Willebrand factor (vWF) type C domain;
414-480 1.39e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.58  E-value: 1.39e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752293514   414 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGGTgEVHCEKVQCPR-LACAQPVRVNPTD-CCKQC 480
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 335-392 1.34e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.10  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 752293514  335 CFFEGQQRPHGARWAPNydpLCSLCTCQRRTVICDPVVCPPPSCPHP--VQAPDQCCPVC 392
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 502-562 5.27e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.17  E-value: 5.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752293514  502 CRFAGQWFPESQSWHPSvppfgemSCITCRCGAGVPHCERDDCSlPLSCGSGKES----RCCSRC 562
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICP-PLDCPNPRLEippgECCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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