|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
630-852 |
3.21e-172 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 528.08 E-value: 3.21e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 789
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 790 LQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
630-852 |
1.50e-95 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 308.66 E-value: 1.50e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQGWTKPN------AFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 783
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNlytrdaPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 784 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
633-919 |
2.36e-95 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 310.77 E-value: 2.36e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 633 YQHIGLDWLVTMYEK-KLNGILADEMGLGKTIQTISLLAHLACEKGNWG-PHLIIVPTSVMLNWEMELKRWC--PSFKIL 708
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 709 TYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGT 788
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 789 PLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHV 868
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIE------RGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYI 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 747019224 869 IRCRLSKRQRCLYDDFMAQTTTKETLAT----GHFMSVINILMQLRKVCNHPNLF 919
Cdd:pfam00176 235 LFCRLSKLQRKLYQTFLLKKDLNAIKTGeggrEIKASLLNILMRLRKICNHPGLI 289
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
417-921 |
9.85e-93 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 317.94 E-value: 9.85e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 417 AAEEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYACDASAPASGDSEDEDEVEANSSDGELEETVEEAAQEDSSSQ 496
Cdd:COG0553 28 ALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLALLLLALLLLLAGLLALA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 497 SDSAEECSEDEEDEHSEEEMSGSSQSEESESDESEDAQSQSQADEEQDDEGEDDDVDDDDDDGFGVEYLLARDDERSEVD 576
Cdd:COG0553 108 LLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 577 GGSGPPTPGPTTTLGPKKEITDIAAAAESLQPKGYTLAT-TQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILAD 655
Cdd:COG0553 188 ALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRlREALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLAD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 656 EMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAqKERKLKRQGWtkpNAFHVCIT 735
Cdd:COG0553 268 DMGLGKTIQALALLLELK-ERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT-RERAKGANPF---EDADLVIT 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 736 SYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREF 815
Cdd:COG0553 343 SYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAF 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 816 KEWFSNPLtgmiegsQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLA 895
Cdd:COG0553 423 RERFARPI-------EKGDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGA 495
|
490 500
....*....|....*....|....*...
gi 747019224 896 TG--HFMSVINILMQLRKVCNHPNLFDP 921
Cdd:COG0553 496 EGirRRGLILAALTRLRQICSHPALLLE 523
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
628-854 |
1.22e-92 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 300.01 E-value: 1.22e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 628 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 707
Cdd:cd17997 2 GTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 708 LTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTG 787
Cdd:cd17997 82 VVLIGDKEERADIIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTG 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 747019224 788 TPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNpltgmiEGSQEYNEGLVKRLHKVLRPFLLRRVK 854
Cdd:cd17997 162 TPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNV------NNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
623-930 |
2.42e-92 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 326.37 E-value: 2.42e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 623 PLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWC 702
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFC 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 703 PSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRR 782
Cdd:PLN03142 243 PVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 783 LLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNpltgmieGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMP 862
Cdd:PLN03142 323 LLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI-------SGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLP 395
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 747019224 863 KKYEHVIRCRLSKRQRCLYDDFMaQTTTKETLATGHFMSVINILMQLRKVCNHPNLF---DPRPvtsPFIT 930
Cdd:PLN03142 396 PKKETILKVGMSQMQKQYYKALL-QKDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFqgaEPGP---PYTT 462
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
628-854 |
5.75e-87 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 284.26 E-value: 5.75e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 628 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 707
Cdd:cd17996 2 GTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 708 LTYYGAQKERKlKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLN-FNSQRRLLLT 786
Cdd:cd17996 82 IVYKGTPDVRK-KLQSQIRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 787 GTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGM-----IEGSQEYNEGLVKRLHKVLRPFLLRRVK 854
Cdd:cd17996 161 GTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTgeqvkIELNEEETLLIIRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
630-809 |
8.98e-85 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 275.98 E-value: 8.98e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKlKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 789
Cdd:cd17919 81 YHGSQRERA-QIRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159
|
170 180
....*....|....*....|
gi 747019224 790 LQNSLMELWSLMHFLMPHVF 809
Cdd:cd17919 160 LQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
628-854 |
9.88e-85 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 278.12 E-value: 9.88e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 628 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 707
Cdd:cd18009 2 GVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLR-ERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 708 LTYYGAQKERK-LKRQGWTKPNA---FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 783
Cdd:cd18009 81 LLYHGTKEERErLRKKIMKREGTlqdFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 747019224 784 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWF-----SNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVK 854
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfsslSDNAADISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
626-854 |
1.77e-77 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 256.34 E-value: 1.77e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 626 LRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSF 705
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK-EEGRKGPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 706 KILTYYGAQKERKLKRQgwtkPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLL 785
Cdd:cd18012 80 KVLVIHGTKRKREKLRA----LEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 786 TGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGSQeyNEGLVKRLHKVLRPFLLRRVK 854
Cdd:cd18012 156 TGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKP----IEKDG--DEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
628-864 |
3.10e-73 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 245.35 E-value: 3.10e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 628 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 707
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 708 LTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTG 787
Cdd:cd18064 94 VCLIGDKDQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 747019224 788 TPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSnplTGMIEGSQEynegLVKRLHKVLRPFLLRRVKVDVEKQMPKK 864
Cdd:cd18064 174 TPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD---TNNCLGDQK----LVERLHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
630-809 |
2.15e-69 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 231.89 E-value: 2.15e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLK-EIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQG-WTKPNAFHVCITSYKLVL---QDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLL 785
Cdd:cd17998 80 YYGSQEERKHLRYDiLKGLEDFDVIVTTYNLATsnpDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLL 159
|
170 180
....*....|....*....|....
gi 747019224 786 TGTPLQNSLMELWSLMHFLMPHVF 809
Cdd:cd17998 160 TGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
629-852 |
3.10e-69 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 233.02 E-value: 3.10e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 629 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKIL 708
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 709 TYYGAQKERKLKRQ-----GWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 783
Cdd:cd17993 81 VYLGDIKSRDTIREyefyfSQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 784 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKewfsnpltgmiEGSQEYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd17993 161 LITGTPLQNSLKELWALLHFLMPGKFDIWEEFE-----------EEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
628-854 |
2.48e-68 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 231.06 E-value: 2.48e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 628 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 707
Cdd:cd18065 14 GTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 708 LTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTG 787
Cdd:cd18065 94 VCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 747019224 788 TPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSnplTGMIEGSQEynegLVKRLHKVLRPFLLRRVK 854
Cdd:cd18065 174 TPLQNNLHELWALLNFLLPDVFNSADDFDSWFD---TKNCLGDQK----LVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
630-852 |
4.36e-66 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 224.05 E-value: 4.36e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPsFKILT 709
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQ-------GWTKPNA----FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 778
Cdd:cd17995 80 YHGSGESRQIIQQyemyfkdAQGRKKKgvykFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 779 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSnpltGMIEGSQeyneglVKRLHKVLRPFLLRR 852
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG----DLKTAEQ------VEKLQALLKPYMLRR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
2032-2167 |
1.15e-63 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 213.49 E-value: 1.15e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2032 FPDLRLIQYDcGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRI 2111
Cdd:cd18793 1 LPPKIEEVVS-GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 747019224 2112 FCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLI 2167
Cdd:cd18793 80 RVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
615-854 |
1.40e-61 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 212.21 E-value: 1.40e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 615 TTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNW 694
Cdd:cd18062 9 TEKVEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 695 EMELKRWCPSFKILTYYGAQKERK----LKRQGwtkpnAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQR 770
Cdd:cd18062 89 VYEFDKWAPSVVKVSYKGSPAARRafvpQLRSG-----KFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 771 WQSL-LNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNP--LTG-MIEGSQEYNEGLVKRLHKVLR 846
Cdd:cd18062 164 TQVLnTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGeKVDLNEEETILIIRRLHKVLR 243
|
....*...
gi 747019224 847 PFLLRRVK 854
Cdd:cd18062 244 PFLLRRLK 251
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
630-852 |
7.65e-61 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 208.83 E-value: 7.65e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 789
Cdd:cd18006 81 YMGDKEKRLDLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 790 LQNSLMELWSLMHFLMPHVFQshREFKEWFSNPLTGMIEGSqeyneGLVKRLHKVLRPFLLRR 852
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFP--KDKLDDFIKAYSETDDES-----ETVEELHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
611-854 |
9.23e-61 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 209.92 E-value: 9.23e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 611 YTLA---TTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVP 687
Cdd:cd18063 2 YTVAhaiTERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 688 TSVMLNWEMELKRWCPSFKILTYYGAQKERK-LKRQgwTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNF 766
Cdd:cd18063 82 LSTLSNWTYEFDKWAPSVVKISYKGTPAMRRsLVPQ--LRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 767 KSQRWQSL-LNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNP--LTG-MIEGSQEYNEGLVKRLH 842
Cdd:cd18063 160 HCKLTQVLnTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGeRVDLNEEETILIIRRLH 239
|
250
....*....|..
gi 747019224 843 KVLRPFLLRRVK 854
Cdd:cd18063 240 KVLRPFLLRRLK 251
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
629-852 |
7.58e-59 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 204.08 E-value: 7.58e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 629 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKIL 708
Cdd:cd18054 20 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 709 TYYGAQKERKLKRQ-GWTKPNA----FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 783
Cdd:cd18054 100 VYIGDLMSRNTIREyEWIHSQTkrlkFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 784 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNpltGMIEGSQEyneglvkrLHKVLRPFLLRR 852
Cdd:cd18054 180 LITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGK---GRENGYQS--------LHKVLEPFLLRR 237
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
630-852 |
4.51e-55 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 192.95 E-value: 4.51e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWG-----PHLIIVPTSVMLNWEMELKRWCPS 704
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 705 F--KILTYYGAQKERKLKRQGWTKPNafhVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRR 782
Cdd:cd17999 81 AflKPLAYVGPPQERRRLREQGEKHN---VIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 747019224 783 LLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIE---GSQEYNEGL--VKRLHKVLRPFLLRR 852
Cdd:cd17999 158 LILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDskaSAKEQEAGAlaLEALHKQVLPFLLRR 232
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
2021-2192 |
2.26e-52 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 198.53 E-value: 2.26e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2021 LHRIVCNMRTQF-PDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQ 2099
Cdd:COG0553 510 RLRQICSHPALLlEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERD 589
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2100 ALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKK 2179
Cdd:COG0553 590 ELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILEL 669
|
170
....*....|...
gi 747019224 2180 ANQKRMLGDMAIE 2192
Cdd:COG0553 670 LEEKRALAESVLG 682
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
630-852 |
1.12e-51 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 182.96 E-value: 1.12e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMF-DSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQGWTKpNAFHVCITSYKLVL---QDHQAFRRKN--WRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLL 784
Cdd:cd18001 80 FHGTSKKERERNLERIQ-RGGGVLLTTYGMVLsntEQLSADDHDEfkWDYVILDEGHKIKNSKTKSAKSLREIPAKNRII 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 785 LTGTPLQNSLMELWSLMHFLMPH-VFQSHREFKEWFSNPLTGMIE-----GSQEYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd18001 159 LTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDkdatqGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
629-852 |
1.13e-50 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 180.25 E-value: 1.13e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 629 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKIL 708
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 709 TYYGAQKERKLKR-QGWTKPNA----FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 783
Cdd:cd18053 100 VYLGDINSRNMIRtHEWMHPQTkrlkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 784 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEwfsnpltgmiEGSQEYNEGLVKrLHKVLRPFLLRR 852
Cdd:cd18053 180 LITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEE----------EHGKGREYGYAS-LHKELEPFLLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
630-852 |
3.62e-50 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 177.25 E-value: 3.62e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAqkerklkrqgwtkpnafHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 789
Cdd:cd17994 81 YVGD-----------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 790 LQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmiegsqeYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd17994 144 LQNNLEELFHLLNFLTPERFNNLQGFLEEFADI----------SKEDQIKKLHDLLGPHMLRR 196
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
2043-2275 |
4.17e-50 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 196.17 E-value: 4.17e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2043 GKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNAD-KRIFCFILSTRSG 2121
Cdd:PLN03142 471 GKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAG 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2122 GVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTtayf 2201
Cdd:PLN03142 551 GLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLA---- 626
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2202 KQQTIR--ELFDM---PLEEPPGSSVSSVPEDEEEAVASK---QTHILEQALCRAEDEediraATQAKAEQVAELAEFNE 2273
Cdd:PLN03142 627 EQKTVNkdELLQMvryGAEMVFSSKDSTITDEDIDRIIAKgeeATAELDAKMKKFTED-----AIKFKMDDTAELYDFDD 701
|
..
gi 747019224 2274 ND 2275
Cdd:PLN03142 702 ED 703
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
630-852 |
5.61e-50 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 178.64 E-value: 5.61e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVtmyekKLNGILADEMGLGKTIQTISL-LAHLACEKGNWGPH----------------LIIVPTSVML 692
Cdd:cd18008 1 LLPYQKQGLAWML-----PRGGILADEMGLGKTIQALALiLATRPQDPKIPEELeenssdpkklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 693 NWEMELKR--WCPSFKILTYYGAQKERKLKrqgwtKPNAFHVCITSYKLVLQDHQAFRRKN----------------WRY 754
Cdd:cd18008 76 QWKDEIEKhtKPGSLKVYVYHGSKRIKSIE-----ELSDYDIVITTYGTLASEFPKNKKGGgrdskekeasplhrirWYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 755 LILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLtgmiegsQEYN 834
Cdd:cd18008 151 VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPF-------SKND 223
|
250
....*....|....*...
gi 747019224 835 EGLVKRLHKVLRPFLLRR 852
Cdd:cd18008 224 RKALERLQALLKPILLRR 241
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
630-806 |
9.85e-46 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 164.42 E-value: 9.85e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YY----GAQKERKLKRQGWTKP------NAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNS 779
Cdd:cd18000 81 LHssgsGTGSEEKLGSIERKSQlirkvvGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160
|
170 180
....*....|....*....|....*..
gi 747019224 780 QRRLLLTGTPLQNSLMELWSLMHFLMP 806
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
630-852 |
1.91e-45 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 165.63 E-value: 1.91e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGN--------------------WGPHLIIVPTS 689
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGKTGTrrdrennrprfkkkppassaKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 690 VMLNWEMELKRWcPSFKILTYYGAQKERKLkrQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQ 769
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDEL--EGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 770 RWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGSQEYN---------EGLVKR 840
Cdd:cd18005 158 LTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEP----IKRGQRHTatarelrlgRKRKQE 233
|
250
....*....|..
gi 747019224 841 LHKVLRPFLLRR 852
Cdd:cd18005 234 LAVKLSKFFLRR 245
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
630-852 |
2.66e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 164.44 E-value: 2.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACeKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 709
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFL-MGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKL---------KRQGWTKPN--AFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 778
Cdd:cd18058 79 YHGSQISRQMiqqyemyyrDEQGNPLSGifKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 779 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 852
Cdd:cd18058 159 LEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
630-852 |
1.88e-44 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 162.49 E-value: 1.88e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKER----------------------KLKRQGWTKpnaFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFK 767
Cdd:cd18055 81 YTGDKDSRaiirenefsfddnavkggkkafKMKREAQVK---FHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 768 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmiegsqeYNEGLVKRLHKVLRP 847
Cdd:cd18055 158 SKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----------SKEDQIKKLHDLLGP 227
|
....*
gi 747019224 848 FLLRR 852
Cdd:cd18055 228 HMLRR 232
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
630-852 |
4.05e-44 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 160.99 E-value: 4.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 709
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVY-NVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQ---------GWTKPNA--FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 778
Cdd:cd18060 79 YHGSLASRQMIQQyemyckdsrGRLIPGAykFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 779 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 852
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
630-852 |
2.83e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 155.99 E-value: 2.83e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKER----------------------KLKRQGWTKpnaFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFK 767
Cdd:cd18057 81 YTGDKESRsvirenefsfednairsgkkvfRMKKEAQIK---FHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 768 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmiegsqeYNEGLVKRLHKVLRP 847
Cdd:cd18057 158 SKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----------SKEDQIKKLHDLLGP 227
|
....*
gi 747019224 848 FLLRR 852
Cdd:cd18057 228 HMLRR 232
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
630-852 |
1.41e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 153.65 E-value: 1.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACeKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 709
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYL-KGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKR---------QGWTKPNA--FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 778
Cdd:cd18059 79 YHGSQASRRTIQlyemyfkdpQGRVIKGSykFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 779 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 852
Cdd:cd18059 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
630-852 |
2.08e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 153.68 E-value: 2.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 709
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKLKRQ-----------GWTKPN--------AFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQR 770
Cdd:cd18056 81 YVGDKDSRAIIREnefsfednairGGKKASrmkkeasvKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 771 WQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLtgmiegsqeyNEGLVKRLHKVLRPFLL 850
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIA----------KEDQIKKLHDMLGPHML 230
|
..
gi 747019224 851 RR 852
Cdd:cd18056 231 RR 232
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
630-852 |
1.17e-39 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 148.97 E-value: 1.17e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWlvtMYE-----KKLNG---ILADEMGLGKTIQTISLLAHLACEKGNWGPH----LIIVPTSVMLNWEME 697
Cdd:cd18004 1 LRPHQREGVQF---LYDcltgrRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 698 LKRWCPS--FKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLvlqdhqaFRRKNWRY--------LILDEAQNIKNFK 767
Cdd:cd18004 78 FDKWLGLrrIKVVTADGNAKDVKASLDFFSSASTYPVLIISYET-------LRRHAEKLskkisidlLICDEGHRLKNSE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 768 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLT-----GMIEGSQEYNEGLVKRLH 842
Cdd:cd18004 151 SKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILrsrdpDASEEDKELGAERSQELS 230
|
250
....*....|
gi 747019224 843 KVLRPFLLRR 852
Cdd:cd18004 231 ELTSRFILRR 240
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
630-846 |
1.24e-38 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 145.90 E-value: 1.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLD--W--LVTMYEKKLNG---ILADEMGLGKTIQTISLL-AHLACEKGNWGPhLIIVPTSVMLNWEMELKRW 701
Cdd:cd18007 1 LKPHQVEGVRflWsnLVGTDVGSDEGggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 702 CPS----FKILTYYGAQKERKLK----RQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRY-----------LILDEAQN 762
Cdd:cd18007 80 LPPdlrpLLVLVSLSASKRADARlrkiNKWHKEGGVLLIGYELFRNLASNATTDPRLKQEFiaalldpgpdlLVLDEGHR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 763 IKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGSQEYNEGLVKRLH 842
Cdd:cd18007 160 LKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKP----IEAGQCVDSTEEDVRL 235
|
....
gi 747019224 843 KVLR 846
Cdd:cd18007 236 MLKR 239
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
630-852 |
2.64e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 144.38 E-value: 2.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 709
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEIL-LTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 710 YYGAQKERKL---------KRQGWTKPNA--FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 778
Cdd:cd18061 79 YHGSLISRQMiqqyemyfrDSQGRIIRGAyrFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 779 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 852
Cdd:cd18061 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
652-852 |
6.68e-34 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 131.17 E-value: 6.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 652 ILADEMGLGKTIQTISLLAHLaceKGNWgPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKpnafh 731
Cdd:cd18010 20 LIADEMGLGKTVQAIAIAAYY---REEW-PLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKSKDGLRDGDAK----- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 732 VCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNF--NSQRRLLLTGTPLQNSLMELWSLMHFLMPHVF 809
Cdd:cd18010 91 VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLF 170
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 747019224 810 QSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd18010 171 GRFHDFGRRYCAAKQGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
2043-2156 |
5.24e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 116.16 E-value: 5.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2043 GKLQTLAVLLRqlKAEGHRVLIFTQMTRMLDvLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFcfILSTRSGG 2122
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDV--LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 747019224 2123 VGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIG 2156
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
646-852 |
2.00e-28 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 116.41 E-value: 2.00e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 646 EKKLNGILADEMGLGKTIQTISLLAHlacekgnwGPHLIIVPTSVMLNWEMELKRWCPS--FKILTYYGAQKERKLKRQG 723
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISLILA--------NFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGERNRDPKLLS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 724 wtkpnAFHVCITSYKLVLQDHQA-----FRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELW 798
Cdd:cd18071 118 -----KYDIVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLG 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 747019224 799 SLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqEYNEGLVKRLHKVLRPFLLRR 852
Cdd:cd18071 193 SLLSFLHLKPFSNPEYWRRLIQRPLT-------MGDPTGLKRLQVLMKQITLRR 239
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
622-802 |
5.72e-28 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 113.74 E-value: 5.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 622 IPLLLRGQLREYQHIGLDWlvtMYEKKLNGILADEMGLGKTIQ-TISLLAHLAceKGNWGPHLIIVPT-SVMLNWEMELK 699
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEA---LLSGLRDVILAAPTGSGKTLAaLLPALEALK--RGKGGRVLVLVPTrELAEQWAEELK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 700 RWCPSF--KILTYYGAQKERKLKRQgWTKpNAFHVCITSYKLVLQD--HQAFRRKNWRYLILDEAQNIKN--FKSQrWQS 773
Cdd:smart00487 76 KLGPSLglKVVGLYGGDSKREQLRK-LES-GKTDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDggFGDQ-LEK 152
|
170 180 190
....*....|....*....|....*....|.
gi 747019224 774 LLNF--NSQRRLLLTGTPLQNSLMELWSLMH 802
Cdd:smart00487 153 LLKLlpKNVQLLLLSATPPEEIENLLELFLN 183
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
630-852 |
2.45e-27 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 113.34 E-value: 2.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTMYEKKLNG-ILADEMGLGKTIQTISLLahLACEKG-------------NWGPH-----------LI 684
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALI--LAQKNTqnrkeeekekaltEWESKkdstlvpsagtLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 685 IVPTSVMLNWEMELKRWCPS--FKILTYYGAQKERK---LKRqgwtkpnaFHVCITSYKLVLQDHQAFR---------RK 750
Cdd:cd18072 79 VCPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIgevLRD--------YDIVITTYSLVAKEIPTYKeesrssplfRI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 751 NWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGS 830
Cdd:cd18072 151 AWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNK----SRKG 226
|
250 260
....*....|....*....|..
gi 747019224 831 QEyneglvkRLHKVLRPFLLRR 852
Cdd:cd18072 227 GE-------RLNILTKSLLLRR 241
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
630-852 |
1.17e-26 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 111.41 E-value: 1.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWL---VT-MYEKKLNG-ILADEMGLGKTIQTISLLAHLACEKGNWGPHL----IIVPTSVMLNWEMELKR 700
Cdd:cd18067 1 LRPHQREGVKFLyrcVTgRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 701 WC-PSFKILTYYGAQKERKL-KRQGW--------TKPnafhVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQR 770
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKEIDrKLVQWasqqgrrvSTP----VLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 771 WQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPL-----TGMIEGSQEYNEGLVKRLHKVL 845
Cdd:cd18067 157 YQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPIlkgrdADASEKERQLGEEKLQELISIV 236
|
....*..
gi 747019224 846 RPFLLRR 852
Cdd:cd18067 237 NRCIIRR 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
630-852 |
1.66e-26 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 110.71 E-value: 1.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLvtmYE----KKLNG----ILADEMGLGKTIQTISLLAHLACEkGNWGPH------LIIVPTSVMLNWE 695
Cdd:cd18066 1 LRPHQREGIEFL---YEcvmgMRVNErfgaILADEMGLGKTLQCISLIWTLLRQ-GPYGGKpvikraLIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 696 MELKRWCPSFKILTYYGAQKErklKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLL 775
Cdd:cd18066 77 KEFQKWLGSERIKVFTVDQDH---KVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 776 NFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGS-----QEYNEGLVKRLHKVLRPFLL 850
Cdd:cd18066 154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTatpeeKKLGEARAAELTRLTGLFIL 233
|
..
gi 747019224 851 RR 852
Cdd:cd18066 234 RR 235
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
652-823 |
2.77e-24 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 104.13 E-value: 2.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 652 ILADEMGLGKTIQTIS----LLAHLACEKGnwgphLIIVPTSVMLNWEMELKRWCPS-----------FKILTYYGAQKE 716
Cdd:cd18069 32 ILAHSMGLGKTLQVISfldvLLRHTGAKTV-----LAIVPVNTLQNWLSEFNKWLPPpealpnvrprpFKVFILNDEHKT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 717 RKLKRQ---GWTKPNAfhvcitsykLVLQDHQAFR-RKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQN 792
Cdd:cd18069 107 TAARAKvieDWVKDGG---------VLLMGYEMFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQN 177
|
170 180 190
....*....|....*....|....*....|.
gi 747019224 793 SLMELWSLMHFLMPHVFQSHREFKEWFSNPL 823
Cdd:cd18069 178 NLIEYWCMVDFVRPDFLGTRQEFSNMFERPI 208
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
651-840 |
4.11e-24 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 104.20 E-value: 4.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 651 GILADEMGLGKTIQTISLLaH--LACEK-GNWGPHLIIVPTSVMLNWEMELKRWCPSFKI--------LTYYGAQKERKL 719
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFL-HtvLLCEKlENFSRVLVVCPLNTVLNWLNEFEKWQEGLKDeekievneLATYKRPQERSY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 720 KRQGWTKPNAfhVCITSYKL---VLQDHQAFRRKNWR-------------YLILDEAQNIKNFKSQRWQSLLNFNSQRRL 783
Cdd:cd18068 110 KLQRWQEEGG--VMIIGYDMyriLAQERNVKSREKLKeifnkalvdpgpdFVVCDEGHILKNEASAVSKAMNSIRTKRRI 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 747019224 784 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLT-GMIEGSQEYNEGLVKR 840
Cdd:cd18068 188 VLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQnGQCADSTLVDVRVMKK 245
|
|
| HSA |
pfam07529 |
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ... |
127-193 |
2.33e-23 |
|
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.
Pssm-ID: 462194 [Multi-domain] Cd Length: 67 Bit Score: 95.72 E-value: 2.33e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 747019224 127 VPEPPR-PKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERaRREEQAKLRR 193
Cdd:pfam07529 1 RDEPERrEKTHHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHKNIEKEEQK-RIEREEKQRL 67
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
2073-2156 |
2.43e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 96.13 E-value: 2.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2073 DVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRifCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRC 2152
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 747019224 2153 HRIG 2156
Cdd:smart00490 79 GRAG 82
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
652-809 |
1.13e-21 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 95.82 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 652 ILADEMGLGKTIQTIsLLAHLACEKGNWGPHLIIVPTSVMLNWEMEL--KRWCPsFKILTYYGAQKERKLKRQGWTkpnA 729
Cdd:cd18011 21 LLADEVGLGKTIEAG-LIIKELLLRGDAKRVLILCPASLVEQWQDELqdKFGLP-FLILDRETAAQLRRLIGNPFE---E 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 730 FHVCITSYKLVLQD---HQAFRRKNWRYLILDEAQNIKN----FKSQRWQ--SLLNFNSQRRLLLTGTPLQNSLMELWSL 800
Cdd:cd18011 96 FPIVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNsgggKETKRYKlgRLLAKRARHVLLLTATPHNGKEEDFRAL 175
|
....*....
gi 747019224 801 MHFLMPHVF 809
Cdd:cd18011 176 LSLLDPGRF 184
|
|
| HSA |
smart00573 |
domain in helicases and associated with SANT domains; |
125-196 |
1.32e-21 |
|
domain in helicases and associated with SANT domains;
Pssm-ID: 214727 [Multi-domain] Cd Length: 73 Bit Score: 90.92 E-value: 1.32e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 125 PKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEER-ARREEQAKLRRIAS 196
Cdd:smart00573 1 QKLEEERRRKQHWDHLLEEMIWHAKDFKEEHKWKIAAAKKMAKAVMDYHQNKEKEEERrEEKNEKRRLRKLAA 73
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1276-1866 |
1.02e-17 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 91.54 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1276 APTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQ-----VPPSMVNntgVVKIVVRQAPRDGLTPVPPLAPAPRPSSSGlP 1350
Cdd:PHA03247 2491 AAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEpvgepVHPRMLT---WIRGLEELASDDAGDPPPPLPPAAPPAAPD-R 2566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1351 AVLTSRPTLTPSrlssptlgttrtpiptptlvrpllklvhSPSPEVSASAPGAAPMtiSSSLHMPSSLPGPASSPmtihn 1430
Cdd:PHA03247 2567 SVPPPRPAPRPS----------------------------EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGP----- 2611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1431 ssplsspvsstvsvpvssslpiSVPTTLPvPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLasagVSPS 1510
Cdd:PHA03247 2612 ----------------------APPSPLP-PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR----VSRP 2664
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1511 MSALALGLATTPAlSPPQTSGHSLLLATTSS-------HVPGLNSAVAPacsPVLVSASAL-TSPFPVSPSSAPAQASLL 1582
Cdd:PHA03247 2665 RRARRLGRAAQAS-SPPQRPRRRAARPTVGSltsladpPPPPPTPEPAP---HALVSATPLpPGPAAARQASPALPAAPA 2740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1583 AAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPlPVLAASQTPLPAMTPPSMSGTPLPSSSlvsAPTSVLAPSSTQTL 1662
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP-AAGPPRRLTRPAVASLSESRESLPSPW---DPADPPAAVLAPAA 2816
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1663 VSTPVSSPLSSLASTQTLTlaPTLAPTLGGLSPSQTHSLGTGSPQGPF----PIQTLSLTPASS-----------LVPTP 1727
Cdd:PHA03247 2817 ALPPAASPAGPLPPPTSAQ--PTAPPPPPGPPPPSLPLGGSVAPGGDVrrrpPSRSPAAKPAAParppvrrlarpAVSRS 2894
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1728 AQTLSLAPGGPVGPTQtlsLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTSvqtltlSPAPVPVPTLDLSATQTL 1807
Cdd:PHA03247 2895 TESFALPPDQPERPPQ---PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT------DPAGAGEPSGAVPQPWLG 2965
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 1808 ALAPALTQAPASQASSlvsasgaaslpvtmvNRLPVPKDEPETLTLRSGPPSPLPTATS 1866
Cdd:PHA03247 2966 ALVPGRVAVPRFRVPQ---------------PAPSREAPASSTPPLTGHSLSRVSSWAS 3009
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
630-804 |
9.52e-17 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 82.01 E-value: 9.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVtmyEKKLNGILADeMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLN-WEMELKRWcPSFKIL 708
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQ-LDDFTRRVLVIAPLRVARStWPDEVEKW-NHLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 709 TYYGA-QKERKLKRQGWTKPNAFHVCITSYK-LVLQDHQAFrrkNWRYLILDEAQNIKNFKSQRWQSL--LNFNSQRRLL 784
Cdd:cd18013 75 TVSVAvGTERQRSKAANTPADLYVINRENLKwLVNKSGDPW---PFDMVVIDELSSFKSPRSKRFKALrkVRPVIKRLIG 151
|
170 180
....*....|....*....|
gi 747019224 785 LTGTPLQNSLMELWSLMHFL 804
Cdd:cd18013 152 LTGTPSPNGLMDLWAQIALL 171
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
630-817 |
1.31e-15 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 79.70 E-value: 1.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLDWLVTmyekkLNGILADEMGLGKTIQTISLLAH------------LACEKGNWGPH-------------LI 684
Cdd:cd18070 1 LLPYQRRAVNWMLV-----PGGILADEMGLGKTVEVLALILLhprpdndldaadDDSDEMVCCPDclvaetpvsskatLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 685 IVPTSVMLNWEMELKRWCP-SFKILTYYGAQKERKLKrqgwtKPNAFHVC-----ITSYKlVLQD-------------HQ 745
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQGVKKDGALA-----SPAPEILAeydivVTTYD-VLRTelhyaeanrsnrrRR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 746 AFRRK----------NWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREF 815
Cdd:cd18070 150 RQKRYeappsplvlvEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWW 229
|
..
gi 747019224 816 KE 817
Cdd:cd18070 230 AR 231
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1462-1831 |
4.26e-11 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 68.45 E-value: 4.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1462 TSAPLPIPITAPLPVSDLGPallTSVTPALAVVSAASGPPLASAGVSPSMSALALglaTTPALSPPQTSGHSLllaTTSS 1541
Cdd:pfam17823 64 TAAPAPVTLTKGTSAAHLNS---TEVTAEHTPHGTDLSEPATREGAADGAASRAL---AAAASSSPSSAAQSL---PAAI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1542 HVPGLNSAVAPacspvlvSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVL 1621
Cdd:pfam17823 135 AALPSEAFSAP-------RAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLT 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1622 AASqtplPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLAstqtlTLAPTLAPTLGGLSPSQTHSL 1701
Cdd:pfam17823 208 PAR----GISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLA-----AAAGTVASAAGTINMGDPHAR 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1702 gTGSPQGPFPIQTLSLTPASSLVP-TPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPghtltlapAASSASLLV 1780
Cdd:pfam17823 279 -RLSPAKHMPSDTMARNPAAPMGAqAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSV--------ASTNLAVVT 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 747019224 1781 PTSVQTLTLSPAPVPVPtldlsatQTLALAPALTQAPASQASSLVSASGAA 1831
Cdd:pfam17823 350 TTKAQAKEPSASPVPVL-------HTSMIPEVEATSPTTQPSPLLPTQGAA 393
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
628-789 |
4.53e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 68.51 E-value: 4.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 628 GQLREYQHIGLD-WLVTMYEKKLNGILADEMGLGKTIqtisLLAHLACEKGNWGPHLIIVPTSVMLN-WEMELKRWCPSF 705
Cdd:COG1061 79 FELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLGDP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 706 KIltyygaqkerklkrQGWTKPNAFHVCITSY-KLVLQDHQAFRRKNWRYLILDEAQNIKnfkSQRWQSLLN-FNSQRRL 783
Cdd:COG1061 155 LA--------------GGGKKDSDAPITVATYqSLARRAHLDELGDRFGLVIIDEAHHAG---APSYRRILEaFPAAYRL 217
|
....*.
gi 747019224 784 LLTGTP 789
Cdd:COG1061 218 GLTATP 223
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1451-1742 |
7.79e-10 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 64.60 E-value: 7.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1451 PISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSAlalglATTPALSPPQTS 1530
Cdd:pfam17823 123 PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAA-----SSTTAASSAPTT 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1531 GHSLLLATTSSHVPGLNSAVA---PACSPVL-----VSASALTSPFPVSPSSAPAQASLLAAA---------PSTSQALA 1593
Cdd:pfam17823 198 AASSAPATLTPARGISTAATAtghPAAGTALaavgnSSPAAGTVTAAVGTVTPAALATLAAAAgtvasaagtINMGDPHA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1594 TSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPL--------PAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVST 1665
Cdd:pfam17823 278 RRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTdqpvhntaGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKE 357
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 747019224 1666 PVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTlslapGGPVGPT 1742
Cdd:pfam17823 358 PSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAGPGILLAPEQVATEATAGTASAGPTPRSS-----GDPKTLA 429
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1457-1800 |
4.97e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.48 E-value: 4.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1457 TLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALALGL-ATTPALSPPQ-TSGHSL 1534
Cdd:pfam03154 169 TQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiQQTPTLHPQRlPSPHPP 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1535 LLATTSSHVPGLNSAVAPA----------------CSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAP 1598
Cdd:pfam03154 249 LQPMTQPPPPSQVSPQPLPqpslhgqmppmphslqTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1599 MAASQTAILGPSPTPPLAPLPVlaasqtPLPAMTPPSMSGTP-LPSSSLVSAPTSVLAPSSTQ---TLVSTPVSSPLSSL 1674
Cdd:pfam03154 329 PSQSQLQSQQPPREQPLPPAPL------SMPHIKPPPTTPIPqLPNPQSHKHPPHLSGPSPFQmnsNLPPPPALKPLSSL 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1675 ASTQtltlAPTLAPTLGGLSPsQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLP 1754
Cdd:pfam03154 403 STHH----PPSAHPPPLQLMP-QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITP 477
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 747019224 1755 PSSPVGPAPGHTLTLAP---AASSASLLVPTSVQTlTLSPAPVPVPTLD 1800
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPpssASVSSSGPVPAAVSC-PLPPVQIKEEALD 525
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1508-1869 |
3.81e-08 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 59.54 E-value: 3.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1508 SPSMSALALGLATTPALSPPQTSGhslllATTSSHVPglNSAVAPACSPVLVSASALTSPFP---------VSPSSAPAQ 1578
Cdd:pfam05109 424 APESTTTSPTLNTTGFAAPNTTTG-----LPSSTHVP--TNLTAPASTGPTVSTADVTSPTPagttsgaspVTPSPSPRD 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1579 ASLLAAAP--STSQALATSLAPMAASQT-AILGPSP---TPPLAPLPVLAASQTPlpamTPPSMSGTPLPSSSLVSAPTS 1652
Cdd:pfam05109 497 NGTESKAPdmTSPTSAVTTPTPNATSPTpAVTTPTPnatSPTLGKTSPTSAVTTP----TPNATSPTPAVTTPTPNATIP 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1653 VLAPSSTQTLVSTPVSSPLSSLAStQTLTLAPTLAPTLGGLSPSqthSLGTGSPQGPFPIQTlslTPASSLVPTPAQTLS 1732
Cdd:pfam05109 573 TLGKTSPTSAVTTPTPNATSPTVG-ETSPQANTTNHTLGGTSST---PVVTSPPKNATSAVT---TGQHNITSSSTSSMS 645
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1733 LAPGGpVGPTQTLSLAPVPPLPPSSPVGPAP--GHTLTLAPAASSASLLVPTSvqtltlSPAPVPVPTldlsatqtlala 1810
Cdd:pfam05109 646 LRPSS-ISETLSPSTSDNSTSHMPLLTSAHPtgGENITQVTPASTSTHHVSTS------SPAPRPGTT------------ 706
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 1811 paltqapaSQASSLVSASGAASLPVTMVNRLPVPKDePETLTLRSGPPSPLPTATSFSG 1869
Cdd:pfam05109 707 --------SQASGPGNSSTSTKPGEVNVTKGTPPKN-ATSPQAPSGQKTAVPTVTSTGG 756
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1453-1869 |
1.23e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1453 SVPTTLPVPTSAPLPIPITAPLPvSDLGPALLTSVTPALAVvsaasgpplasagvSPSMSALALGL---ATTPALSPPQT 1529
Cdd:PHA03247 2490 FAAGAAPDPGGGGPPDPDAPPAP-SRLAPAILPDEPVGEPV--------------HPRMLTWIRGLeelASDDAGDPPPP 2554
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1530 SGHSLLLATTSSHVPglNSAVAPACSPVLVSASALTSPFPvsPSSAPAQASLLAAAPSTSQALATSLAPMAAsqtailgP 1609
Cdd:PHA03247 2555 LPPAAPPAAPDRSVP--PPRPAPRPSEPAVTSRARRPDAP--PQSARPRAPVDDRGDPRGPAPPSPLPPDTH-------A 2623
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1610 SPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTqTLVSTPVSSPLSslastqtltlaPTLAPT 1689
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRR-----------RAARPT 2691
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1690 LGGLSpsqthSLGTGSPQGPFP-IQTLSLTPASSLVPTPAQTLSLAPGGPVGPTqtlslapvPPLPPSSPVGPAPGHTLT 1768
Cdd:PHA03247 2692 VGSLT-----SLADPPPPPPTPePAPHALVSATPLPPGPAAARQASPALPAAPA--------PPAVPAGPATPGGPARPA 2758
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1769 LAPAASSASLLVPTSVqtltlsPAPVPVPTLDLSATQTLALA-PALTQAPASQASSLVSASGAASLPVTMVNRLPVPKDE 1847
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAA------PAAGPPRRLTRPAVASLSESrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT 2832
|
410 420
....*....|....*....|..
gi 747019224 1848 PETLTLRSGPPSPLPTATSFSG 1869
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLGG 2854
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1041-1655 |
1.81e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 57.64 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1041 GPEVSAQPALgpvppvlpaplmvsaspagtpvvPASRPPGPVLLS-------PLQPNTGPLPQVLPSPVGVMSGTSRPPT 1113
Cdd:PHA03247 2563 APDRSVPPPR-----------------------PAPRPSEPAVTSrarrpdaPPQSARPRAPVDDRGDPRGPAPPSPLPP 2619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1114 PTLSLKPAPPAPvRLSPAPPPGSSSLLKPLTVPPGYTLSPVAATTTSSTIATVTTTAVPAPNSTPQRLILSPemqarlps 1193
Cdd:PHA03247 2620 DTHAPDPPPPSP-SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP-------- 2690
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1194 gevvSIGQLASLAQRPVTSAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQP-RPLQRNVVHLVSAGGqhhlisQPAHVALV 1272
Cdd:PHA03247 2691 ----TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATPG------GPARPARP 2760
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1273 QAVAPTPGPTPVSVLPSTPS-TTPAPTGLSLPLAANQVPPSmvnntgvvkivvrQAPRDGLTPVPPLAPAPRPSSSglPA 1351
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPrRLTRPAVASLSESRESLPSP-------------WDPADPPAAVLAPAAALPPAAS--PA 2825
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1352 VLTSRPTLTPSRLSSPTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSASAPGAAPMTISSSLHMPS------SLPGPASSP 1425
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAvsrsteSFALPPDQP 2905
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1426 MTIHNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLAsa 1505
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA-- 2983
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1506 gvsPSMSalalglatTPALSPPQTSGHSllLATTSSHVPGLNSAVAPACSPVlvsaSALTSPFPVSPSSAPAQASLLAAA 1585
Cdd:PHA03247 2984 ---PSRE--------APASSTPPLTGHS--LSRVSSWASSLALHEETDPPPV----SLKQTLWPPDDTEDSDADSLFDSD 3046
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 747019224 1586 PSTSQalATSLAPMAASQTAilgPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLV-SAPTSVLA 1655
Cdd:PHA03247 3047 SERSD--LEALDPLPPEPHD---PFAHEPDPATPEAGARESPSSQFGPPPLSANAALSRRYVrSTGRSALA 3112
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1510-1739 |
3.01e-07 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 55.67 E-value: 3.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1510 SMSALALglatTPALSPPQTSGHS---LLLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAP 1586
Cdd:COG5651 158 SAAAVAL----TPFTQPPPTITNPgglLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAG 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1587 STSQALATSlAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTP 1666
Cdd:COG5651 234 TGAAAGAAA-AAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGA 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 1667 VSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPV 1739
Cdd:COG5651 313 GGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
2091-2161 |
3.96e-07 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 56.23 E-value: 3.96e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 747019224 2091 GSTRVEQRQALMERFNADKRIfcfILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDV 2161
Cdd:NF038318 469 YGRSVEYKHAIVDYFKNNAKI---LIVTDAGSEGLNLQFCNTVINYDLPWNPQKIEQRIGRCHRYGQKNDV 536
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1290-1682 |
7.50e-07 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 54.97 E-value: 7.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1290 TPSTTPAPTGLSLPLAANQVPPSMVNNTgvvKIVVRQAPRDGLTPVPPLAP-APRPSSSGLPAVLTSRPTLTPSrlSSPT 1368
Cdd:pfam17823 95 TDLSEPATREGAADGAASRALAAAASSS---PSSAAQSLPAAIAALPSEAFsAPRAAACRANASAAPRAAIAAA--SAPH 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1369 LGttrtpiptptlvrpllklvhSPSPEVSASAPGAAPMTISSSlhmPSSLPGPASSPMTIhnssplsSPVSSTVSVPVSS 1448
Cdd:pfam17823 170 AA--------------------SPAPRTAASSTTAASSTTAAS---SAPTTAASSAPATL-------TPARGISTAATAT 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1449 SLPISVPTTLPVPTSAPLPIPITAplPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSP-- 1526
Cdd:pfam17823 220 GHPAAGTALAAVGNSSPAAGTVTA--AVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPaa 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1527 ---PQTSGHSLLLATTSshvPGLNSAVAPACSPVLVSASALTSPFPVSPSSA---PAQASLLAAAPSTSQALATSLAPMA 1600
Cdd:pfam17823 298 pmgAQAQGPIIQVSTDQ---PVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAvvtTTKAQAKEPSASPVPVLHTSMIPEV 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1601 ASQTAILGPSPTPPL----APLPVLAASQTPLPAmTPPSMSGTPLP-SSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLA 1675
Cdd:pfam17823 375 EATSPTTQPSPLLPTqgaaGPGILLAPEQVATEA-TAGTASAGPTPrSSGDPKTLAMASCQLSTQGQYLVVTTDPLTPAL 453
|
....*..
gi 747019224 1676 STQTLTL 1682
Cdd:pfam17823 454 VDKMFLL 460
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1523-1741 |
1.67e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 54.11 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1523 ALSPPQTSGHSL----LLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAP 1598
Cdd:PRK12323 344 ALAPDEYAGFTMtllrMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1599 MAAS----------QTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTlvsTPVS 1668
Cdd:PRK12323 424 ARRSpapealaaarQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP---PPWE 500
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 1669 SPLSSLASTQTLTLAPTLAPTLGGLSPSQthslGTGSPQGPFPiqtlSLTPASSLVPTPAQTLSLAPGGPVGP 1741
Cdd:PRK12323 501 ELPPEFASPAPAQPDAAPAGWVAESIPDP----ATADPDDAFE----TLAPAPAAAPAPRAAAATEPVVAPRP 565
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1497-1695 |
1.80e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 53.73 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1497 ASGPPLASAGVSPSMSALALGLATTPALSPPQ-TSGHSLLLATTSSHVPGLNSAVAPACSPVLVS------ASALTSPFP 1569
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPaAPAAAPAAAAAARAVAAAPARRSPAPEALAAArqasarGPGGAPAPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1570 VSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSP--TPPLAPLPVLAASQTPL---PAMTPPSMSGTPLPSS 1644
Cdd:PRK12323 452 PAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddPPPWEELPPEFASPAPAqpdAAPAGWVAESIPDPAT 531
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 747019224 1645 SLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSP 1695
Cdd:PRK12323 532 ADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWP 582
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1469-1688 |
1.96e-06 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 52.97 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1469 PITAPLPVSdLGPALLTSvTPALAVVSAASGPPLASAGVSpSMSALALGLATTPALSPPQTSGHSLLLATTSSHVPGLNS 1548
Cdd:COG5651 166 PFTQPPPTI-TNPGGLLG-AQNAGSGNTSSNPGFANLGLT-GLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAA 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1549 AVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPT--PPLAPLPVLAASQT 1626
Cdd:COG5651 243 AAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATglGLGAGGAAGAAGAT 322
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 747019224 1627 PLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAP 1688
Cdd:COG5651 323 GAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1451-1651 |
3.21e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 52.96 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1451 PISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSPPQTS 1530
Cdd:PRK12323 393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPV 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1531 GHSLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQAsllAAAPSTSQALATSLAPMAAsqtailgPS 1610
Cdd:PRK12323 473 AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGW---VAESIPDPATADPDDAFET-------LA 542
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 747019224 1611 PTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPT 1651
Cdd:PRK12323 543 PAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPA 583
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1526-1865 |
3.78e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 52.85 E-value: 3.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1526 PPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPfpvsPSSAPAQASLLAAAPSTSQALATSLAPMAAsqta 1605
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSP----ATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---- 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1606 ilgPSPTPPLAPLPVLAA-SQTPLPAMTPPSMSGT--PLPSSsLVSAPTSVLAPSSTQTLVSTPVSSplSSLASTQTLTL 1682
Cdd:pfam03154 243 ---PSPHPPLQPMTQPPPpSQVSPQPLPQPSLHGQmpPMPHS-LQTGPSHMQHPVPPQPFPLTPQSS--QSQVPPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1683 APTLAPTLGGLSPSQThslgtgSPQGPFPIQTLSLTPAsslvPTPAQTLSLAPGGPVGPTQTLSLAPVpplppsspvgpa 1762
Cdd:pfam03154 317 APGQSQQRIHTPPSQS------QLQSQQPPREQPLPPA----PLSMPHIKPPPTTPIPQLPNPQSHKH------------ 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1763 PGHTLTLAPAASSASLLVPTSVQTLTL-----SPAPVPVPTLDLSATQTLALAPAltQAPASQASSLVSASGAASLPVTM 1837
Cdd:pfam03154 375 PPHLSGPSPFQMNSNLPPPPALKPLSSlsthhPPSAHPPPLQLMPQSQQLPPPPA--QPPVLTQSQSLPPPAASHPPTSG 452
|
330 340
....*....|....*....|....*...
gi 747019224 1838 VNRLPVPKDEPETLTLRSGPPSPLPTAT 1865
Cdd:pfam03154 453 LHQVPSQSPFPQHPFVPGGPPPITPPSG 480
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
1548-1768 |
4.43e-06 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 52.45 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1548 SAVAPACSPVLVSASALTSPFPVSPSSAPAQASLlAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPlpvlAASQTP 1627
Cdd:COG3469 1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTL-TAATATTVVSTTGSVVVAASGSAGSGTGTTAASST----AATSST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1628 LPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQ 1707
Cdd:COG3469 76 TSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSG 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 747019224 1708 GPF----PIQTLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGpaPGHTLT 1768
Cdd:COG3469 156 TETatggTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGL--PKHVLV 218
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
650-788 |
4.87e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 48.94 E-value: 4.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 650 NGILADEMGLGKTIQTISLLAHLACEKGnwGPHLIIVPT-SVMLNWEMELKRW-CPSFKILTYYGAqkERKLKRQGWTKP 727
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTkALALQTAERLRELfGPGIRVAVLVGG--SSAEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 728 NAfHVCITSYKLV---LQDHQAFRRKNWRYLILDEAQNI-KNFKSQRWQSLLNFNSQ----RRLLLTGT 788
Cdd:cd00046 79 DA-DIIIATPDMLlnlLLREDRLFLKDLKLIIVDEAHALlIDSRGALILDLAVRKAGlknaQVILLSAT 146
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1459-1645 |
8.85e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.77 E-value: 8.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1459 PVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALAlglATTPALSPPQTSGHSlllAT 1538
Cdd:PRK07003 367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA---EAPPAAPAPPATADR---GD 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1539 TSSHVPglnsAVAPACSPVLVSASALTSPFPVSPSSAPAQASllAAAPSTSQALATSLAPMAASQTAILGPSPTPPlAPL 1618
Cdd:PRK07003 441 DAADGD----APVPAKANARASADSRCDERDAQPPADSGSAS--APASDAPPDAAFEPAPRAAAPSAATPAAVPDA-RAP 513
|
170 180
....*....|....*....|....*..
gi 747019224 1619 PVLAASQTPLPAMTPPSMSGTPLPSSS 1645
Cdd:PRK07003 514 AAASREDAPAAAAPPAPEARPPTPAAA 540
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1522-1866 |
2.66e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1522 PALSPPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLV----SASALTSPfPVSPSSAPAQASLlaAAPSTSQALATSLA 1597
Cdd:pfam17823 35 NGAGKQNASGDAVPRADNKSSEQ*NFCAATAAPAPVTLtkgtSAAHLNST-EVTAEHTPHGTDL--SEPATREGAADGAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1598 PMAasqtailgpsPTPPLAPLPVLAASQTPLPAMTPPSMSGTPlPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLAST 1677
Cdd:pfam17823 112 SRA----------LAAAASSSPSSAAQSLPAAIAALPSEAFSA-PRAAACRANASAAPRAAIAAASAPHAASPAPRTAAS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1678 QTLTLAPTLAPTLGglspsqthslgtgspqgpfPIQTLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSS 1757
Cdd:pfam17823 181 STTAASSTTAASSA-------------------PTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1758 PVGPAPGHTLTLAPAASSASLLVPTSVQTLTLSPAPVPVPTLDLSATQTLALAPALTQAPASQASSLvsasgAASLPVTM 1837
Cdd:pfam17823 242 TAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPII-----QVSTDQPV 316
|
330 340
....*....|....*....|....*....
gi 747019224 1838 VNRLPVPKDEPETLTLRSGPPSPLPTATS 1866
Cdd:pfam17823 317 HNTAGEPTPSPSNTTLEPNTPKSVASTNL 345
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1559-1784 |
2.75e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 49.51 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1559 VSASALTSPfpvsPSSAPAQASLLAAAPSTSQALATSlAPMAASQTAILGPSPTPPLApLPVLAASQTPLPAMTPPSM-- 1636
Cdd:COG5651 157 ASAAAVALT----PFTQPPPTITNPGGLLGAQNAGSG-NTSSNPGFANLGLTGLNQVG-IGGLNSGSGPIGLNSGPGNtg 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1637 ---SGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQ 1713
Cdd:COG5651 231 fagTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGL 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 747019224 1714 TL-SLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTSV 1784
Cdd:COG5651 311 GAgGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGG 382
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
630-789 |
3.19e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 46.53 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 630 LREYQHIGLD-WLVTMYEKKlnGILADEMGLGKTIQTISLLAHLACEKgnwgpHLIIVPTSVMLN-WEMELKRWCPSFKI 707
Cdd:cd17926 1 LRPYQEEALEaWLAHKNNRR--GILVLPTGSGKTLTALALIAYLKELR-----TLIVVPTDALLDqWKERFEDFLGDSSI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 708 ltyyGAQKERKLKrqgwTKPNAFHVCITSYKLVLQDHQAFRRKN-WRYLILDEAQNI--KNFKsqrwQSLLNFNSQRRLL 784
Cdd:cd17926 74 ----GLIGGGKKK----DFDDANVVVATYQSLSNLAEEEKDLFDqFGLLIVDEAHHLpaKTFS----EILKELNAKYRLG 141
|
....*
gi 747019224 785 LTGTP 789
Cdd:cd17926 142 LTATP 146
|
|
| PRK04654 |
PRK04654 |
sec-independent translocase; Provisional |
1573-1685 |
3.35e-05 |
|
sec-independent translocase; Provisional
Pssm-ID: 135173 [Multi-domain] Cd Length: 214 Bit Score: 47.88 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1573 SSAPAQASLLAAAPSTSQALATSLAPMAASQTAilGPSPTPPLAPLPVLAASQTPLPAmtpPSMSGTPLPSSSLVSAPTS 1652
Cdd:PRK04654 103 TSATPVATPLELAHADLSASAQVDAAAGAEPGA--GQAHTPVPAPAPVIAQAQPIAPA---PHQTLVPAPHDTIVPAPHA 177
|
90 100 110
....*....|....*....|....*....|...
gi 747019224 1653 VLAPSSTQTLVSTpvsSPLSSLASTQTLTLAPT 1685
Cdd:PRK04654 178 AHLPSAPATPVSV---APVDAGTSASPTPSEPT 207
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1394-1656 |
3.57e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 49.85 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1394 PEVSASAPGAAPMTISSSLHMPSSLPGPASSPMTIHNSSPLSSPVSSTVSVPVSSSLPiSVPTTLPVPTSAPLPIPITAP 1473
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAA-AAATRAEAPPAAPAPPATADR 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1474 LPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSPPQTSGhsllLATTSSHVPGLNSAVAPA 1553
Cdd:PRK07003 439 GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRA----AAPSAATPAAVPDARAPA 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1554 CSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALAT------------SLAPMAASQTAILGPSPTPPLAPLPVL 1621
Cdd:PRK07003 515 AASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVlrnagmrvssdrGARAAAAAKPAAAPAAAPKPAAPRVAV 594
|
250 260 270
....*....|....*....|....*....|....*
gi 747019224 1622 aasQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAP 1656
Cdd:PRK07003 595 ---QVPTPRARAATGDAPPNGAARAEQAAESRGAP 626
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1387-1735 |
4.27e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.53 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1387 KLVHSPSPEVSASAPG------AAPMT---ISSSLHMPSSLPGPASSPMTIHNSSPLSSPVSSTVSVPVS---------- 1447
Cdd:pfam05109 418 KVIFSKAPESTTTSPTlnttgfAAPNTttgLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPvtpspsprdn 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1448 --------SSLPISVPTTlPVPTSAPLPIPITAPLPvSDLGPAL---------------LTSVTPAlaVVSAASGPPLAS 1504
Cdd:pfam05109 498 gteskapdMTSPTSAVTT-PTPNATSPTPAVTTPTP-NATSPTLgktsptsavttptpnATSPTPA--VTTPTPNATIPT 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1505 AGVSPSMSALAlglATTPALSPPqTSGHSLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAA 1584
Cdd:pfam05109 574 LGKTSPTSAVT---TPTPNATSP-TVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPS 649
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1585 ------APSTSQAlATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAptsvlAPSS 1658
Cdd:pfam05109 650 sisetlSPSTSDN-STSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTST-----KPGE 723
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1659 TQTLVSTPVSSPLSSLASTQTLTLAPTLAPTlGGLSPSQT---HSLGTGSPQGPFPIQTL---SLTP-----ASSLVPtP 1727
Cdd:pfam05109 724 VNVTKGTPPKNATSPQAPSGQKTAVPTVTST-GGKANSTTggkHTTGHGARTSTEPTTDYggdSTTPrtrynATTYLP-P 801
|
....*...
gi 747019224 1728 AQTLSLAP 1735
Cdd:pfam05109 802 STSSKLRP 809
|
|
| PspA |
COG1842 |
Phage shock protein A [Transcription, Signal transduction mechanisms]; |
2240-2358 |
4.36e-05 |
|
Phage shock protein A [Transcription, Signal transduction mechanisms];
Pssm-ID: 441447 [Multi-domain] Cd Length: 217 Bit Score: 47.51 E-value: 4.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2240 ILEQALcraED-EEDIRAATQAKAEQVAELAefnendgfpagegeeanrpgpgaedeemsRAEQEIAALVEQLTPIERYA 2318
Cdd:COG1842 27 MLDQAI---RDmEEDLVEARQALAQVIANQK-----------------------------RLERQLEELEAEAEKWEEKA 74
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 747019224 2319 MKFLEASLEEVSRE---ELKQAEEQVEAARKDLDQAKEEVFRL 2358
Cdd:COG1842 75 RLALEKGREDLAREaleRKAELEAQAEALEAQLAQLEEQVEKL 117
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2253-2371 |
4.93e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 49.57 E-value: 4.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2253 DIRAATQAKAEQVAELAEFNENDGFPAGEG-EEANRPGPGAEDEEMSRAEQEIAALVEQLTPIERyAMKFLEASLEEVSR 2331
Cdd:PRK04863 1024 SLKSSYDAKRQMLQELKQELQDLGVPADSGaEERARARRDELHARLSANRSRRNQLEKQLTFCEA-EMDNLTKKLRKLER 1102
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 747019224 2332 eELKQAEEQVEAARKD----LDQAKE-EVFRLPHEEEEGPGAGDE 2371
Cdd:PRK04863 1103 -DYHEMREQVVNAKAGwcavLRLVKDnGVERRLHRRELAYLSADE 1146
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
1471-1825 |
5.40e-05 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 48.77 E-value: 5.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1471 TAPLPVSDLGPALLT---SVTPALAVVSAAS---GPPLASAGVSPSMSA--LALGLA-TTPALSPPQTSGHSLLLATTSS 1541
Cdd:cd22540 4 AAVSPSEYLQPAASTtqdSQPSPLALLAATCskiGPPAVEAAVTPPAPPqpTPRKLVpIKPAPLPLGPGKNSIGFLSAKG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1542 HV----PGLNSAVAPAC-------SPVLVSASALTSP---------FPVSPSSAPAQASLLAAAPSTSQALATSL----A 1597
Cdd:cd22540 84 NIiqlqGSQLSSSAPGGqqvfaiqNPTMIIKGSQTRSstnqqyqisPQIQAAGQINNSGQIQIIPGTNQAIITPVqvlqQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1598 PMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSA-----PTSVLAPSSTQTLVSTPVSSPLS 1672
Cdd:cd22540 164 PQQAHKPVPIKPAPLQTSNTNSASLQVPGNVIKLQSGGNVALTLPVNNLVGTqdgatQLQLAAAPSKPSKKIRKKSAQAA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1673 SLASTQ----TLTLAPTLAPTLG--GLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLApggpvgptqtls 1746
Cdd:cd22540 244 QPAVTVaeqvETVLIETTADNIIqaGNNLLIVQSPGTGQPAVLQQVQVLQPKQEQQVVQIPQQALRVV------------ 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1747 lapvpplppsspvgPAPGHTLTLAPAASSASLLVPTS---------------VQTLTLSPAPVPVPTLDLSATQTLALAP 1811
Cdd:cd22540 312 --------------QAASATLPTVPQKPLQNIQIQNSeptptqvyiktpsgeVQTVLLQEAPAATATPSSSTSTVQQQVT 377
|
410
....*....|....
gi 747019224 1812 ALTQAPASQASSLV 1825
Cdd:cd22540 378 ANNGTGTSKPNYNV 391
|
|
| Nucleoporin_FG2 |
pfam15967 |
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
1497-1737 |
5.91e-05 |
|
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.
Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 48.90 E-value: 5.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1497 ASGPPLASAGVSPSMSALALGLATTPAlSPPQTSGHSlllattsshvpGLNSAVAPACSPVLVSASALTspfpvspssap 1576
Cdd:pfam15967 1 MSGFSFGGGPGSTATAGGGFSFGAAAA-SNPGSTGGF-----------SFGTLGAAPAATATTTTATLG----------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1577 AQASLLAAAPSTSQALATslapmAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTP--LPSS-------SLV 1647
Cdd:pfam15967 58 LGGGLFGQKPATGFTFGT-----PASSTAATGPTGLTLGTPAATTAASTGFSLGFNKPAASATPfsLPASstsggglSLG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1648 SAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLaPTLGGLSPSQTHSLGTGSpqgpfpiQTLSLTP-ASSLVPT 1726
Cdd:pfam15967 133 SVLTSTAAQQGATGFTLNLGGTPATTTAVSTGLSLGSTL-TSLGGSLFQNTNSTGLGQ-------TTLGLTLlATSTAPV 204
|
250
....*....|.
gi 747019224 1727 PAQTLSLAPGG 1737
Cdd:pfam15967 205 SAPAASEGLGG 215
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
999-1505 |
6.12e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 999 PkpvkmkvnrmlQPVPKQEGRTVVVVNSPRPPLGPVPVRPPPGPEVSAQPALGPVPPVLPAPLMVSASPAGTPVVPASRP 1078
Cdd:PHA03247 2633 P-----------AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADP 2701
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1079 PGPvllsPLQPNTGPLPQVLPSPVGVMSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSSLLKPLTVPPGYTLSPV--AA 1156
Cdd:PHA03247 2702 PPP----PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapAA 2777
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1157 TTTSSTIATVTTTAVPAPNSTPQRLILSPEMQARLPSGEVVSIGQL-ASLAQRPVTSAGGSKPLTFQIQGNKLTLTGAqv 1235
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS-- 2855
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1236 rqLAVGQP---RPLQRNVVHLVSAGGQhhlisQPAHVALVQAVAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPS 1312
Cdd:PHA03247 2856 --VAPGGDvrrRPPSRSPAAKPAAPAR-----PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1313 MvnntgvvkivvRQAPRDGLTPVPPLAPAPRPSSSGLPAVLTSRP---TLTPSRLSSPTLGTTRTPIPTPTLVRPLLKLV 1389
Cdd:PHA03247 2929 P-----------QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1390 HSPSPEVSASAPgaapmtiSSSLHMPSSlPGPASSPMTIHNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIP 1469
Cdd:PHA03247 2998 GHSLSRVSSWAS-------SLALHEETD-PPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHE 3069
|
490 500 510
....*....|....*....|....*....|....*.
gi 747019224 1470 ITAPLPVSDlgpalltsvtpALAVVSAASGPPLASA 1505
Cdd:PHA03247 3070 PDPATPEAG-----------ARESPSSQFGPPPLSA 3094
|
|
| PLN02217 |
PLN02217 |
probable pectinesterase/pectinesterase inhibitor |
1569-1679 |
6.43e-05 |
|
probable pectinesterase/pectinesterase inhibitor
Pssm-ID: 215130 [Multi-domain] Cd Length: 670 Bit Score: 48.93 E-value: 6.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1569 PVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGpspTPPLAPLPVLAASQTPlpamtppsmsgtplPSSSLVS 1648
Cdd:PLN02217 566 PGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTSPPAGHLG---SPPATPSKIVSPSTSP--------------PASHLGS 628
|
90 100 110
....*....|....*....|....*....|...
gi 747019224 1649 APTSVLAPSSTQTLVSTPVSSPLSSL--ASTQT 1679
Cdd:PLN02217 629 PSTTPSSPESSIKVASTETASPESSIkvASTES 661
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1264-1503 |
7.27e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 48.72 E-value: 7.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1264 SQPAHVALVQAVAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPR 1343
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1344 PSSSGLPAVLTSRPTLTPSRLSSPTlgttrtpiptptlvrpllklVHSPSPEVSASAPGAAPMTISSSLHMPSSLPGPAS 1423
Cdd:PRK12323 452 PAPAAAPAAAARPAAAGPRPVAAAA--------------------AAAPARAAPAAAPAPADDDPPPWEELPPEFASPAP 511
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1424 SPMtihnSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSvtPALAVVSAASGPPLA 1503
Cdd:PRK12323 512 AQP----DAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASA--SGLPDMFDGDWPALA 585
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2232-2364 |
7.92e-05 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 47.97 E-value: 7.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2232 AVASKQthiLEQALCRAED-EEDIRAATQAKAEQVAELAEFNEndgfpagegeeanrpgpgaedeEMSRAEQEIAALVEQ 2310
Cdd:COG4372 27 AALSEQ---LRKALFELDKlQEELEQLREELEQAREELEQLEE----------------------ELEQARSELEQLEEE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 747019224 2311 LTPIEryamKFLEASLEEV--SREELKQAEEQVEAARKDLDQAKEEVFRLPHEEEE 2364
Cdd:COG4372 82 LEELN----EQLQAAQAELaqAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ 133
|
|
| COG4233 |
COG4233 |
Thiol-disulfide interchange protein, contains DsbC and DsbD domains [Posttranslational ... |
1470-1839 |
1.10e-04 |
|
Thiol-disulfide interchange protein, contains DsbC and DsbD domains [Posttranslational modification, protein turnover, chaperones, Energy production and conversion];
Pssm-ID: 443377 [Multi-domain] Cd Length: 681 Bit Score: 47.97 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1470 ITAPLPVSDLGPAL------LTSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSPpqtsghSLLLATTSSHV 1543
Cdd:COG4233 238 LTLTLPLSGGPKAApgsplrLTVLDGGRAVEISLCAAAAAAAALAAAALAGLLALALALLLLL------LLLLLALLLLL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1544 PGLnsAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPtPPLAPLPVLAA 1623
Cdd:COG4233 312 LLL--LLLALLLLLLLSLLLLLAAGALLAALLLALAAGLALGGAALGGLLLGLLALGLLAAALFALLL-LGLLLLLLALL 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1624 SQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSstqTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGT 1703
Cdd:COG4233 389 LGLLLLLLLLGLLGGLALGGGFAGGLAALAGAAA---GAAAAAAAALAAAAAAAAAAAAAAGALLAALLALAALLLLALL 465
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1704 GSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTS 1783
Cdd:COG4233 466 LLALLLLLLALLLLLLPLLLAPLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLLLLLALLALLLLLLLVGLLLLLAGLAA 545
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 747019224 1784 VQTLTLSPAPVPVPTLDLSATQTLALAPALTQAPASQASSLVSASGAASLPVTMVN 1839
Cdd:COG4233 546 LLAAAAAAAALALALLLAALVLAAAAAAAAALAASAAALAVAAAAAAAAAAVAAVV 601
|
|
| PHA03255 |
PHA03255 |
BDLF3; Provisional |
1560-1724 |
1.20e-04 |
|
BDLF3; Provisional
Pssm-ID: 165513 [Multi-domain] Cd Length: 234 Bit Score: 46.44 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1560 SASALTSPFPVSPSSAPAQASLLAAAPSTSQA--LATSLAPMaaSQTAILGPSPTpplaplpVLAASQTPLPAMtPPSMS 1637
Cdd:PHA03255 27 SGSSTASAGNVTGTTAVTTPSPSASGPSTNQSttLTTTSAPI--TTTAILSTNTT-------TVTSTGTTVTPV-PTTSN 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1638 GTPLPSSSLVSAPTSvlAPSSTQTLVSTPVSSPLSSLASTQT-----LTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPI 1712
Cdd:PHA03255 97 ASTINVTTKVTAQNI--TATEAGTGTSTGVTSNVTTRSSSTTsattrITNATTLAPTLSSKGTSNATKTTAELPTVPDER 174
|
170
....*....|....
gi 747019224 1713 QTLSLT--PASSLV 1724
Cdd:PHA03255 175 QPSLSYglPLWTLV 188
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
2040-2158 |
1.34e-04 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 44.42 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2040 YDCGKLQTLAVLLRQLKAEGH--RVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKrifCFIL- 2116
Cdd:cd18787 6 VVVEEEEKKLLLLLLLLEKLKpgKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGK---VRVLv 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 747019224 2117 ST----RsggvGVNLTGADTVVFYDsdwnptMDAQAQDRCHRIGQT 2158
Cdd:cd18787 83 ATdvaaR----GLDIPGVDHVINYD------LPRDAEDYVHRIGRT 118
|
|
| PRK13335 |
PRK13335 |
superantigen-like protein SSL3; Reviewed; |
1512-1660 |
1.48e-04 |
|
superantigen-like protein SSL3; Reviewed;
Pssm-ID: 139494 [Multi-domain] Cd Length: 356 Bit Score: 47.04 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1512 SALALGLATTPALS-PPQTSGHSLLLATTSSHVPGLNsavAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQ 1590
Cdd:PRK13335 9 TSLALGLLTTGAITvTTQSVKAEKIQSTKVDKVPTLK---AERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEE 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 747019224 1591 ALATSLA-----PMAASQTAILGPSPTPPLAPLP-VLAASQTPLPAMTPPSMSGTPLPSSSLVS-APTSvlaPSSTQ 1660
Cdd:PRK13335 86 KTSASKIekisqPKQEEQKSLNISATPAPKQEQSqTTTESTTPKTKVTTPPSTNTPQPMQSTKSdTPQS---PTIKQ 159
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1560-1680 |
2.60e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 46.63 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1560 SASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGT 1639
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 747019224 1640 PLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTL 1680
Cdd:PRK14951 447 LAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1462-1861 |
3.20e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.70 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1462 TSAPLPIPITAPLPVSDLGPALLTSVTPALAVvsaasgPPLASAGVSPsmsalalglaTTPALSPPQTSGHSLLLATTSS 1541
Cdd:PHA03307 22 PRPPATPGDAADDLLSGSQGQLVSDSAELAAV------TVVAGAAACD----------RFEPPTGPPPGPGTEAPANESR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1542 HVPGLNSAVAPACSPVlvSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVL 1621
Cdd:PHA03307 86 STPTWSLSTLAPASPA--REGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1622 AASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSL 1701
Cdd:PHA03307 164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1702 GTGSPQGPfpiqtLSLTPASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPGH----TLTLAPAASSAS 1777
Cdd:PHA03307 244 SSGCGWGP-----ENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSpgsgPAPSSPRASSSS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1778 LLVPTSVQTLTLS---------------PAPVPVPTLDLSATQTLALAPALTQAPASQASSLVSASGAASLPVTMVNRLP 1842
Cdd:PHA03307 319 SSSRESSSSSTSSssessrgaavspgpsPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRA 398
|
410
....*....|....*....
gi 747019224 1843 VPKDEPETLTLRSGPPSPL 1861
Cdd:PHA03307 399 RRRDATGRFPAGRPRPSPL 417
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
1453-1614 |
3.56e-04 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 46.28 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1453 SVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSPPQTSGH 1532
Cdd:COG3469 59 SGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1533 SLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAasqtailGPSPT 1612
Cdd:COG3469 139 SATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTG-------PPTPG 211
|
..
gi 747019224 1613 PP 1614
Cdd:COG3469 212 LP 213
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
1266-1722 |
3.85e-04 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 46.35 E-value: 3.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1266 PAHVALVQAVAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPV------PPLA 1339
Cdd:COG4935 75 GAAAGAVDAAPAAATVVGAALGVVAVAGAGLAATASGAAAGAVAAAANGNTGAGPGSGGTGGGSGGAGAAaaaaalSAAG 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1340 PAPRPSSSGLPAVLTSRPTLTPSRLSSPTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSASAPGAAPMTISSSLHMPSSLP 1419
Cdd:COG4935 155 AAVGVAAVAGAAGGGGGVGVAAAVGVVLGAGLVADGGNGGGGAVAGGAAGGGGGGGGGGGLGGAAGGGGAGLAAAGGGGG 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1420 GPASSPMTIHNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLP-----IPITAPLPVSDLGPALLTSVTPALAVV 1494
Cdd:COG4935 235 GAAAAAAAGVGGLGAAATAAAADGGGGGGAGAAGAGGSAGAAAGGAGAgvvgaAAGGGDAALGGAVGAAGTGNAAAAAAA 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1495 SAASGPPLASAGVSPSMSALALGLATTPALSPPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLVSASAlTSPFPVSPSS 1574
Cdd:COG4935 315 SAGSGGGGGSAAAAGAAAAAAAAAAGAAAGVSGAASVVAGASGGGAGTAAAAGGGAAAAAAGGAAAAGA-AAGAAAGAAA 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1575 APAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVL 1654
Cdd:COG4935 394 GAAAAGGVASAAGAVGAGTAAGASATAAVSTGAASGSSTTSSTGTTATATGLGGGADAGSTSTGTGSAAGAAGGTTTATS 473
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 747019224 1655 APSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGT------GSPQGPFPIQTLSLTPASS 1722
Cdd:COG4935 474 GLASSTTAAAAAAAAGLATTAAVAAGAAGAAAAAATAASVGGATGAAGTtnstatFSNTTDVAIPDNGPAGVTS 547
|
|
| PRK10118 |
PRK10118 |
flagellar hook length control protein FliK; |
1472-1686 |
4.42e-04 |
|
flagellar hook length control protein FliK;
Pssm-ID: 236652 [Multi-domain] Cd Length: 408 Bit Score: 45.63 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1472 APLPVSDLGPAlltsVTPALAVVSAASGPPLASAGVSPSMSALALGLA----TTPALSPPQTSGHSLLLATTSSHVPGLN 1547
Cdd:PRK10118 48 APLTLADLQAA----GGKLSKGLLTTKGEPLVSDKLADLLAQQANLLIpvdeTLPVITDEQSLSSPLTPALKTSALAALS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1548 SAV-----APACS-PVLVSASALTSPFP----VSPSSAPAQASLLAAAPST-SQALATSLAPMAASQT---AILGPSPTP 1613
Cdd:PRK10118 124 KNAqkdekADDLSdEDLASLSALFAMLPgqdnTTPVADAPSTVLPAEKPTLlTKDMPSAPQDETHTLSsdeHEKGLTSAQ 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1614 PLAPLPVLAASqTPLPAMTPPSMSGTPLPSSSLVSAPTSVLA-----PSSTQTL--VSTPV-SSPLSSLASTQTLTLAPT 1685
Cdd:PRK10118 204 LTTAQPDDAPG-TPAQPLTPLAAEAQAKAEVISTPSPVTAAAsptitPHQTQPLptAAAPVlSAPLGSHEWQQSLSQHIT 282
|
.
gi 747019224 1686 L 1686
Cdd:PRK10118 283 L 283
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
1260-1852 |
5.37e-04 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 45.58 E-value: 5.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1260 HHLISQPAHVALVQAVAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPVPPLA 1339
Cdd:COG4935 5 GAGSTTGLAAAVLAAAAGTGSAATAEGGAASTATSAAVAGASAAAAAATAVGAGASSLAASAAAAAAAASGAAAGAVDAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1340 PAPRPSSSGLPAVLTSRPTLTPSRLSSPTLGTTRTPIPtptlvrpllklvhspspevSASAPGAAPMTISSSLHMPSSLP 1419
Cdd:COG4935 85 PAAATVVGAALGVVAVAGAGLAATASGAAAGAVAAAAN-------------------GNTGAGPGSGGTGGGSGGAGAAA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1420 GPASSPMTIHNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASG 1499
Cdd:COG4935 146 AAAALSAAGAAVGVAAVAGAAGGGGGVGVAAAVGVVLGAGLVADGGNGGGGAVAGGAAGGGGGGGGGGGLGGAAGGGGAG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1500 PPLASAGVSPSMSALALGLATTPALSPPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQA 1579
Cdd:COG4935 226 LAAAGGGGGGAAAAAAAGVGGLGAAATAAAADGGGGGGAGAAGAGGSAGAAAGGAGAGVVGAAAGGGDAALGGAVGAAGT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1580 SLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSmSGTPLPSSSLVSAPTSVLAPSST 1659
Cdd:COG4935 306 GNAAAAAAASAGSGGGGGSAAAAGAAAAAAAAAAGAAAGVSGAASVVAGASGGGAG-TAAAAGGGAAAAAAGGAAAAGAA 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1660 QTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPV 1739
Cdd:COG4935 385 AGAAAGAAAGAAAAGGVASAAGAVGAGTAAGASATAAVSTGAASGSSTTSSTGTTATATGLGGGADAGSTSTGTGSAAGA 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1740 GPTQTlslapvpplppsspvgpapghtltlAPAASSASLLVPTSVQTLTLSPAPVPVPTLDLSATQTLALAPALTQAPAS 1819
Cdd:COG4935 465 AGGTT-------------------------TATSGLASSTTAAAAAAAAGLATTAAVAAGAAGAAAAAATAASVGGATGA 519
|
570 580 590
....*....|....*....|....*....|...
gi 747019224 1820 QASSLVSASGAASLPVTmvnrlpVPKDEPETLT 1852
Cdd:COG4935 520 AGTTNSTATFSNTTDVA------IPDNGPAGVT 546
|
|
| half-pint |
TIGR01645 |
poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
1510-1697 |
5.67e-04 |
|
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 45.83 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1510 SMSALALG---LATTPALSPPQtsghSLLLATTSSHVPglnSAVAPACSPVLVSASALTSpfpVSPSSAPAQASLLAAAP 1586
Cdd:TIGR01645 265 SMNLFDLGgqyLRVGKCVTPPD----ALLQPATVSAIP---AAAAVAAAAATAKIMAAEA---VAGAAVLGPRAQSPATP 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1587 STSqaLATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSslvSAPTSVLAPSSTQTLVstp 1666
Cdd:TIGR01645 335 SSS--LPTDIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSL---VAPPGLVAPTEINPSF--- 406
|
170 180 190
....*....|....*....|....*....|.
gi 747019224 1667 VSSPLSSLASTQTLTLAPTLAPTLGGLSPSQ 1697
Cdd:TIGR01645 407 LASPRKKMKREKLPVTFGALDDTLAWKEPSK 437
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2227-2364 |
6.79e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 45.70 E-value: 6.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2227 EDEEEAVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFnENDGFPAGEGEEANRpgpgaedEEMSRAEQEIAA 2306
Cdd:COG1196 256 EELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL-EQDIARLEERRRELE-------ERLEELEEELAE 327
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 747019224 2307 LVEQLtpieryamKFLEASLEEVsREELKQAEEQVEAARKDLDQAKEEVFRLPHEEEE 2364
Cdd:COG1196 328 LEEEL--------EELEEELEEL-EEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
1569-1688 |
6.81e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 45.24 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1569 PVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPsmsgTPLPSSSLVS 1648
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAAR----QQLQRAQGAT 436
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 747019224 1649 APTSvlaPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAP 1688
Cdd:PRK07994 437 KAKK---SEPAAASRARPVNSALERLASVRPAPSALEKAP 473
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2178-2358 |
7.28e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 45.68 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2178 KKANQKRMLGDMAIEGGNF------TTAyFKQ-QTIRELF-DMPLEEPPgssvssVPEDEEEAVASKQTHI-LEQALCRA 2248
Cdd:COG4913 175 FSAYLARLRRRLGIGSEKAlrllhkTQS-FKPiGDLDDFVrEYMLEEPD------TFEAADALVEHFDDLErAHEALEDA 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2249 EDE----EDIRAATQAKAEQVAELAEFNE-NDGFPAGEGEEANRpgpgAEDEEMSRAEQEIAALVEQLTPIERyAMKFLE 2323
Cdd:COG4913 248 REQiellEPIRELAERYAAARERLAELEYlRAALRLWFAQRRLE----LLEAELEELRAELARLEAELERLEA-RLDALR 322
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 747019224 2324 ASLEEVSR-------EELKQAEEQVEAARKDLDQAKEEVFRL 2358
Cdd:COG4913 323 EELDELEAqirgnggDRLEQLEREIERLERELEERERRRARL 364
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
1573-1797 |
7.30e-04 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 45.13 E-value: 7.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1573 SSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSmSGTPLPSSSLVSAPTS 1652
Cdd:COG3469 8 ASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTA-ATSSTTSTTATATAAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1653 VLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTlGGLSPSQTHSLGTGSPqgpfpiqTLSLTPASSLVPTPAQTLS 1732
Cdd:COG3469 87 AAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVT-STTSSTAGSTTTSGAS-------ATSSAGSTTTTTTVSGTET 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 747019224 1733 LAPGGPVGPTQTLSLAPVPplppsspvgpAPGHTLTLAPAASSASLLVPTSVQTLTLSPAPVPVP 1797
Cdd:COG3469 159 ATGGTTTTSTTTTTTSAST----------TPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
2168-2352 |
7.68e-04 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 45.33 E-value: 7.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2168 SERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRElfdmpleEPPGSSVSSVPEDEEEAV-ASKQTHILEQALC 2246
Cdd:COG5185 227 EIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRL-------EKLGENAESSKRLNENANnLIKQFENTKEKIA 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2247 RAEDEEDIRAATQAKAEQVAELAEFNENdgfpagegEEANRPGPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASL 2326
Cdd:COG5185 300 EYTKSIDIKKATESLEEQLAAAEAEQEL--------EESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVE 371
|
170 180
....*....|....*....|....*.
gi 747019224 2327 EEVSREELKQAEEQVEAARKDLDQAK 2352
Cdd:COG5185 372 LSKSSEELDSFKDTIESTKESLDEIP 397
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1455-1783 |
8.72e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.16 E-value: 8.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1455 PTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGP----PLASAGVSPSMSALALGLATTPALSPPQTS 1530
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtppgPSSPDPPPPTPPPASPPPSPAPDLSEMLRP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1531 GHSLLLATTSSHVPGLNSAVAPACSPvlVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILG-P 1609
Cdd:PHA03307 141 VGSPGPPPAASPPAAGASPAAVASDA--ASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASaS 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1610 SPTPPLAPLPVLAASQTPLPAMTPPSM-------SGTPLPSSSLVSAPTSVLAPSStqTLVSTPVSSPLSSLASTQTLTL 1682
Cdd:PHA03307 219 SPAPAPGRSAADDAGASSSDSSSSESSgcgwgpeNECPLPRPAPITLPTRIWEASG--WNGPSSRPGPASSSSSPRERSP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1683 APTLAPTLGGLSPSQTHSLGTGSPQGPfpiqtlSLTPASSLVPTPAQTLSLAPGGPVGPTQTlSLAPVPPLPPSSPVGPA 1762
Cdd:PHA03307 297 SPSPSSPGSGPAPSSPRASSSSSSSRE------SSSSSTSSSSESSRGAAVSPGPSPSRSPS-PSRPPPPADPSSPRKRP 369
|
330 340
....*....|....*....|.
gi 747019224 1763 PGHTLTLAPAASSASLLVPTS 1783
Cdd:PHA03307 370 RPSRAPSSPAASAGRPTRRRA 390
|
|
| PHA02732 |
PHA02732 |
hypothetical protein; Provisional |
1468-1684 |
1.21e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 165099 [Multi-domain] Cd Length: 1467 Bit Score: 44.74 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1468 IPITAPLPVSDLGPALLTSVTPALAVVS--AASGPPLASAGVSPS--------MSALALGLATTPALSPPQTSGHSLLLA 1537
Cdd:PHA02732 1032 INVNTPFPWSEIGYVAIRVDTDNIFYVSyfAASQGPSPFTFVSPSyiflnswaSSYVAPGFLGSPYALPYFMNQTSALVG 1111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1538 TTSshVP-GLNSAVAPACSPVLVSASALtspFPVSPSSAPAQASLLAAAPSTS-QALATSLAPMAASQTAILGPSPTPPL 1615
Cdd:PHA02732 1112 NTA--LPkGLNVFSGYMFGAGTVASAFL---YMNSTPQSPVLALLLAPYISYKfNALSLGFSITADAAIFSLFGIPAPQL 1186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 747019224 1616 APLPVLAAS---QTPLPAMTPP---SMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSplSSLASTQTLTLAP 1684
Cdd:PHA02732 1187 LSSYIPTGSvlyQDPIFTYIPPgiiGMSGTNTFTFKAAQLQLSAASSPPAATTPTPPPSS--SSSSSAQSISTSP 1259
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
1536-1739 |
1.33e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 44.21 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1536 LATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAApstsqALATsLAPMAASQTAILgPSPTPpl 1615
Cdd:PRK12727 55 LETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASA-----AEDM-IAAMALRQPVSV-PRQAP-- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1616 APLPVLAASQ-TPLPAMTPPSMSGTPLPSsslvsaPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLS 1694
Cdd:PRK12727 126 AAAPVRAASIpSPAAQALAHAAAVRTAPR------QEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAAL 199
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 747019224 1695 PSQTHSLGTGSPQGPFPIQTLSLTPASSLVPTPAQTLSLAPGGPV 1739
Cdd:PRK12727 200 AAHAAYAQDDDEQLDDDGFDLDDALPQILPPAALPPIVVAPAAPA 244
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1472-1660 |
1.54e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1472 APLPVSDLGPALLTSVTPALAVVSAASGPPlASAGVSPSMSALALGLATTPALSPPqtsghslllatTSSHVPGLNSAVA 1551
Cdd:PRK07003 359 EPAVTGGGAPGGGVPARVAGAVPAPGARAA-AAVGASAVPAVTAVTGAAGAALAPK-----------AAAAAAATRAEAP 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1552 PACSPVLVSASALTSPfpvSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAM 1631
Cdd:PRK07003 427 PAAPAPPATADRGDDA---ADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAAT 503
|
170 180 190
....*....|....*....|....*....|.
gi 747019224 1632 TPPSMSGTPLPSSSLVS--APTSVLAPSSTQ 1660
Cdd:PRK07003 504 PAAVPDARAPAAASREDapAAAAPPAPEARP 534
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
2109-2158 |
1.68e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.61 E-value: 1.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 747019224 2109 KRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQT 2158
Cdd:cd18785 20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1548-1675 |
1.78e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.93 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1548 SAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSlAPMAASQTAILGPSPTPPLAPLPVLAASQT- 1626
Cdd:PRK14951 389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAA-APAAAPAAVALAPAPPAQAAPETVAIPVRVa 467
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 747019224 1627 --PLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLA 1675
Cdd:PRK14951 468 pePAVASAAPAPAAAPAAARLTPTEEGDVWHATVQQLAAAEAITALARELA 518
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
1565-1709 |
1.92e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 43.76 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1565 TSPFPVSPSSAPAQASLL--AAAPSTSQalaTSLAPMAASQTAILGPSPTP-----PLAPLPVLAASQTP-LPAMTPPSM 1636
Cdd:PLN03209 384 TSPIPTPPSSSPASSKSVdaVAKPAEPD---VVPSPGSASNVPEVEPAQVEakktrPLSPYARYEDLKPPtSPSPTAPTG 460
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 747019224 1637 SGTPLPSSSLVSAP--TSVLAPSSTQTLVSTPVSSPLSSLASTQTLT--LAPTLAPTLGGLSPSQTHSLGTGSPQGP 1709
Cdd:PLN03209 461 VSPSVSSTSSVPAVpdTAPATAATDAAAPPPANMRPLSPYAVYDDLKppTSPSPAAPVGKVAPSSTNEVVKVGNSAP 537
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1549-1866 |
1.96e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.01 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1549 AVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTP-PLAPLPvlaasqTP 1627
Cdd:PHA03307 57 AGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPpPASPPP------SP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1628 LPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTQtlvSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGTGSPQ 1707
Cdd:PHA03307 131 APDLSEMLRPVGSPGPPPAASPPAAGASPAAVA---SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1708 GPFPIqtlSLTPASSLVPTPAQTLSLAPGG------PVGPTQTLSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVP 1781
Cdd:PHA03307 208 RRSSP---ISASASSPAPAPGRSAADDAGAsssdssSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1782 TSVQTLTLSPAPVPVPT------LDLSATQTLALAPALTQAPASQASSLVSASGAASLPVTMVNRLPVPKDEPETL---- 1851
Cdd:PHA03307 285 ASSSSSPRERSPSPSPSspgsgpAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPAdpss 364
|
330 340
....*....|....*....|
gi 747019224 1852 -----TLRSGPPSPLPTATS 1866
Cdd:PHA03307 365 prkrpRPSRAPSSPAASAGR 384
|
|
| TolA |
COG3064 |
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
2225-2412 |
2.28e-03 |
|
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 43.49 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2225 VPEDEEEAVASKQThilEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAGEgEEANRpgpgAEDEEMSRAEQEI 2304
Cdd:COG3064 1 AQEALEEKAAEAAA---QERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAE-EEARE----AKAEAEQRAAELA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2305 AALVEQLTPIERyAMKFLEASLEEVSREELKQAEEQ-------VEAARKDLDQAKEEVfrlpheEEEGPGAGDEMSCGSS 2377
Cdd:COG3064 73 AEAAKKLAEAEK-AAAEAEKKAAAEKAKAAKEAEAAaaaekaaAAAEKEKAEEAKRKA------EEEAKRKAEEERKAAE 145
|
170 180 190
....*....|....*....|....*....|....*
gi 747019224 2378 GASHRRSKKIRAPERLGTRVSERLRGARAETQGAN 2412
Cdd:COG3064 146 AEAAAKAEAEAARAAAAAAAAAAAAAARAAAGAAA 180
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1455-1597 |
2.56e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.55 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1455 PTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPAL--AVVSAASGPPLASAGVSPSMSALAlGLATTPALSPPQTSGH 1532
Cdd:PRK14951 381 PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPpaAAPPAPVAAPAAAAPAAAPAAAPA-AVALAPAPPAQAAPET 459
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 747019224 1533 SLLLATTSSHVPGLNSAVAPACSPvlvsASALTSPFPVSPSSAPAQASLLAAAPSTsqALATSLA 1597
Cdd:PRK14951 460 VAIPVRVAPEPAVASAAPAPAAAP----AAARLTPTEEGDVWHATVQQLAAAEAIT--ALARELA 518
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1600-1823 |
2.58e-03 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 42.96 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1600 AASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVS-APTSVLAPSSTQTLVSTPVSSPLSSLASTQ 1678
Cdd:COG5651 156 AASAAAVALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGlNQVGIGGLNSGSGPIGLNSGPGNTGFAGTG 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1679 TLTLAPTLAPTLGGLSPSQTHSLGTGSPQGPFPIQTLSLT-----PASSLVPTPAQTLSLAPGGPVGPTQTLSLAPVPPL 1753
Cdd:COG5651 236 AAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAataasSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGA 315
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1754 PPSSPVGPAPGHTLTLAPAASSASLLVPTSVQTLTLSPAPVPVPTLDLSATQTLALAPALTQAPASQASS 1823
Cdd:COG5651 316 AGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
|
|
| PRK02292 |
PRK02292 |
V-type ATP synthase subunit E; Provisional |
2240-2354 |
2.63e-03 |
|
V-type ATP synthase subunit E; Provisional
Pssm-ID: 235026 [Multi-domain] Cd Length: 188 Bit Score: 41.52 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2240 ILEQALCRAEDeedIRAATQAKAEQVAELAEfnendgfpagegEEANRPGPGAEDEemsrAEQEIAALVEQ-LTPIErya 2318
Cdd:PRK02292 10 IRDEARARASE---IRAEADEEAEEIIAEAE------------ADAEEILEDREAE----AEREIEQLREQeLSSAK--- 67
|
90 100 110
....*....|....*....|....*....|....*...
gi 747019224 2319 mkfLEASLE--EVSREELKQAEEQVEAARKDLDQAKEE 2354
Cdd:PRK02292 68 ---LEAKRErlNARKEVLEDVRNQVEDEIASLDGDKRE 102
|
|
| Not5 |
COG5665 |
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; |
1492-1844 |
3.00e-03 |
|
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
Pssm-ID: 444384 [Multi-domain] Cd Length: 874 Bit Score: 43.50 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1492 AVVSAASGPPLASAGVSPSMSALALG-----LATTPALSPPQTSGhSLLLATTSSHVPGLNSAVAPACSPVLVS---ASA 1563
Cdd:COG5665 163 DGASNPVAVVVTTMIAVPSAPAAPPNavdysVLVPIAAQDPAASV-STPQAFNASATSGRSQHIVQAAKRVGVEwwgDPS 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1564 LTSPFPVSPSSAPAQASllaAAPSTSQALATSLAPMAASQ-TAILGPSPTpplaplpvlAASQTPLPAMTPPSMSGTPLP 1642
Cdd:COG5665 242 LLATPPATPATEEKSSQ---QPKSQPTSPSGGTTPPSTNQlTTSNTPTST---------AKAQPQPPTKKQPAKEPPSDT 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1643 SSSLVSAPTSVLAPSSTQTLVSTPVSSPlsSLASTQTLTLAPTLAPTlggLSPSQTHSLGTGSPQGPFPIQTL---SLTP 1719
Cdd:COG5665 310 ASGNPSAPSVLINSDSPTSEDPATASVP--TTEETTAFTTPSSVPST---PAEKDTPATDLATPVSPTPPETSvdkKVSP 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1720 ASSLVPTPAQTLSLAPGGPVGPTQT--------------LSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTSvQ 1785
Cdd:COG5665 385 DSATSSTKSEKEGGTASSPMPPNIAigakddvdatdpsqEAKEYTKNAPMTPEADSAPESSVRTEASPSAGSDLEPEN-T 463
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 747019224 1786 TLT-----LSPAPVPVPTL--DLSATQTLALAPALTQAPASQASSLVSASGAASLPVTMVNRLPVP 1844
Cdd:COG5665 464 TLRdpapnAIPPPEDPSTIgrLSSGDKLANETGPPVIRRDSTPSSTADQSIVGVLAFGLDQRTQAE 529
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1545-1660 |
3.35e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.44 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1545 GLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVLAAS 1624
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPS 463
|
90 100 110
....*....|....*....|....*....|....*.
gi 747019224 1625 QTPLPAMTPPsMSGTPLPSSSLVSAPTSVLAPSSTQ 1660
Cdd:PRK07764 464 AQPAPAPAAA-PEPTAAPAPAPPAAPAPAAAPAAPA 498
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2227-2357 |
3.93e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.00 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2227 EDEEEAVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEANRPGPGAED--EEMSRAEQEI 2304
Cdd:COG1196 697 EALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEEleRELERLEREI 776
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 747019224 2305 AAL--V--------EQLTpiERYamKFLEaslEEvsREELKQAEEQVEAARKDLDQAKEEVFR 2357
Cdd:COG1196 777 EALgpVnllaieeyEELE--ERY--DFLS---EQ--REDLEEARETLEEAIEEIDRETRERFL 830
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1323-1706 |
4.28e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.85 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1323 VVRQAPRDGLTPVPPLAPAPR-------PSSSGLPAVLTSRPTLTPSRLSSPTLGTTRTPIPTPTLVRPLLKlvhSPSPE 1395
Cdd:PHA03307 44 VSDSAELAAVTVVAGAAACDRfepptgpPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPD---PPPPT 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1396 VSASAPGAAPMTISSSLHMPSSLPGPASSPMTIHNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIPITAPLP 1475
Cdd:PHA03307 121 PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1476 VSDLGPALLTSVTPALAVVSAASGPPLASAGVSPSMSALAL---------GLATTPALSPPQTSGHSLLLATTSSHVPGL 1546
Cdd:PHA03307 201 AASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSsessgcgwgPENECPLPRPAPITLPTRIWEASGWNGPSS 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1547 NSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAilGPSPTPPLAPLPVLAASQT 1626
Cdd:PHA03307 281 RPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGA--AVSPGPSPSRSPSPSRPPP 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1627 PLPAmTPPSMSGTPLPSSSLVSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQTHSLGT--G 1704
Cdd:PHA03307 359 PADP-SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTpsG 437
|
..
gi 747019224 1705 SP 1706
Cdd:PHA03307 438 EP 439
|
|
| motB |
PRK12799 |
flagellar motor protein MotB; Reviewed |
1520-1659 |
5.03e-03 |
|
flagellar motor protein MotB; Reviewed
Pssm-ID: 183756 [Multi-domain] Cd Length: 421 Bit Score: 42.40 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1520 TTPALSPPQTSghslllATTSSHVPGLNSAVAPacSPVLVSASALTSPfpVSPSSAPAqasllAAAPSTSQALATSLAPM 1599
Cdd:PRK12799 298 TVPVAAVTPSS------AVTQSSAITPSSAAIP--SPAVIPSSVTTQS--ATTTQASA-----VALSSAGVLPSDVTLPG 362
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1600 AASQTAILGPSPTPPLAPLPVLAASQTPlpamtpPSMSGTPLPSSSLVSAPTSVLAPSST 1659
Cdd:PRK12799 363 TVALPAAEPVNMQPQPMSTTETQQSSTG------NITSTANGPTTSLPAAPASNIPVSPT 416
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2229-2358 |
5.51e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 42.59 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2229 EEEAVASKQTHI--LEQALCRAEDE-EDIRAATQAKAEQVAELAEFNEndgfpagEGEEANRPGpGAEDEEMSRAEQEIA 2305
Cdd:COG4913 659 DEIDVASAEREIaeLEAELERLDASsDDLAALEEQLEELEAELEELEE-------ELDELKGEI-GRLEKELEQAEEELD 730
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 747019224 2306 ALVEQLTPIERYAMKFLEASLEEVSREEL---------KQAEEQVEAARKDLDQAKEEVFRL 2358
Cdd:COG4913 731 ELQDRLEAAEDLARLELRALLEERFAAALgdaverelrENLEERIDALRARLNRAEEELERA 792
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
1467-1743 |
6.10e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 42.35 E-value: 6.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1467 PIPITAPLPVSDL------GPALLTSVTPalaVVSAASGPPLASAGVSPSMSALAlglatTPALSPPQTSGHSLllatts 1540
Cdd:PHA03379 419 PVEKPRPEVPQSLetatshGSAQVPEPPP---VHDLEPGPLHDQHSMAPCPVAQL-----PPGPLQDLEPGDQL------ 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1541 shvPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQasllAAAPSTSQALATSLAPMAASqtailgpSPTPPLAPLPV 1620
Cdd:PHA03379 485 ---PGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGV----AFAPVMPQPMPVEPVPVPTV-------ALERPVCPAPP 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1621 LAASQtplpamTPPSMSGTPLPSSSLVSAPtsvLAPSSTQTLVSTPVSSPLSSLASTQ------------TLTLAPTLAP 1688
Cdd:PHA03379 551 LIAMQ------GPGETSGIVRVRERWRPAP---WTPNPPRSPSQMSVRDRLARLRAEAqpyqasvevqppQLTQVSPQQP 621
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 747019224 1689 TLGGLSPSQTHSLGTGSPQGPFPIQ------------TLSLT-PASSLVPTPAQTLSLAPGGPVGPTQ 1743
Cdd:PHA03379 622 MEYPLEPEQQMFPGSPFSQVADVMRaggvpamqpqyfDLPLQqPISQGAPLAPLRASMGPVPPVPATQ 689
|
|
| PRK10118 |
PRK10118 |
flagellar hook length control protein FliK; |
1470-1643 |
6.21e-03 |
|
flagellar hook length control protein FliK;
Pssm-ID: 236652 [Multi-domain] Cd Length: 408 Bit Score: 42.16 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1470 ITAPLPVSDLGPA--LLTSVTPALAVVSAASGPPLASAGVS---------PSMSALALGLATTPALSPPQTSGHSLLLAT 1538
Cdd:PRK10118 91 IPVDETLPVITDEqsLSSPLTPALKTSALAALSKNAQKDEKaddlsdedlASLSALFAMLPGQDNTTPVADAPSTVLPAE 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1539 TSSHVPGlNSAVAPACSPVLVSASALTSPfPVSPSSAPAQASLLAAAPSTSqaLATSLAPMAASQTAILGPSPTPPLAPL 1618
Cdd:PRK10118 171 KPTLLTK-DMPSAPQDETHTLSSDEHEKG-LTSAQLTTAQPDDAPGTPAQP--LTPLAAEAQAKAEVISTPSPVTAAASP 246
|
170 180
....*....|....*....|....*
gi 747019224 1619 PVLAASQTPLPAMTPPSMSgTPLPS 1643
Cdd:PRK10118 247 TITPHQTQPLPTAAAPVLS-APLGS 270
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1650-1869 |
6.24e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 42.36 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1650 PTSVLAPSSTQTLVStPVSSPLSSLASTQTLTLAPTLAPTLGGLSPS-QTHSLGTGSP-QGPFPIQTLSLTPASslvptp 1727
Cdd:PHA03378 565 PAPGLGPLQIQPLTS-PTTSQLASSAPSYAQTPWPVPHPSQTPEPPTtQSHIPETSAPrQWPMPLRPIPMRPLR------ 637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1728 AQTLSLAPGGPVGPTQTLSLAPVPPLPPSSPVGPAPGHTLTLAPAASSASLLVPTSVQTLTLSPAPVPVPTLDLSATQTL 1807
Cdd:PHA03378 638 MQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRP 717
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 747019224 1808 ALAPALTQAPAsqasslvSASGAASLPVTMVNRLPVPKDEPETLTLRSGPPSPLPTATSFSG 1869
Cdd:PHA03378 718 AAATGRARPPA-------AAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG 772
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2225-2361 |
6.30e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2225 VPEDEEEAVASKQTHILEQA--LCRAEDEEDIRAATQAKAEQVAELAEFnendgfpAGEGEEANRPGPGAEDEEMSRAEQ 2302
Cdd:COG4717 330 LPPDLSPEELLELLDRIEELqeLLREAEELEEELQLEELEQEIAALLAE-------AGVEDEEELRAALEQAEEYQELKE 402
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 747019224 2303 EIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPHE 2361
Cdd:COG4717 403 ELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAE 461
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2227-2364 |
6.36e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2227 EDEEEAVASKQTHiLEQALCRAEDEEDIRAATQAKAEQVAELAEFNEN-DGFPAGEGEEANRpgpgaeDEEMSRAEQEIA 2305
Cdd:COG4717 101 EEELEELEAELEE-LREELEKLEKLLQLLPLYQELEALEAELAELPERlEELEERLEELREL------EEELEELEAELA 173
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 747019224 2306 ALVEQLtpiERYAMKFLEASLEEVSR--EELKQAEEQVEAARKDLDQAKEEVFRLPHEEEE 2364
Cdd:COG4717 174 ELQEEL---EELLEQLSLATEEELQDlaEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2234-2358 |
6.68e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 42.21 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2234 ASKQTHILEQALCRAEDE-----------EDIRAATQAKAEQVAELAEFNEndgfpagegeeanrpgpgaEDEEMSRAEQ 2302
Cdd:COG4913 608 NRAKLAALEAELAELEEElaeaeerlealEAELDALQERREALQRLAEYSW-------------------DEIDVASAER 668
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 747019224 2303 EIAALVEQLtpiERyamkfLEASLEEVS--REELKQAEEQVEAARKDLDQAKEEVFRL 2358
Cdd:COG4913 669 EIAELEAEL---ER-----LDASSDDLAalEEQLEELEAELEELEEELDELKGEIGRL 718
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
1566-1697 |
7.36e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 41.39 E-value: 7.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1566 SPFPVSPSSAPAQASLLAAAPSTSQALATSLAPMAASQTAILGPSPTPPLAPLPVlaasqTPLPAMTPPSMSGTPLPsss 1645
Cdd:PHA02682 80 SPLAPSPACAAPAPACPACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPA-----RPAPACPPSTRQCPPAP--- 151
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 747019224 1646 lvSAPTSVLAPSSTQTLVSTPVSSPLSSLASTQTLTLAPTLAPTLGGLSPSQ 1697
Cdd:PHA02682 152 --PLPTPKPAPAAKPIFLHNQLPPPDYPAASCPTIETAPAASPVLEPRIPDK 201
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
2227-2422 |
7.86e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 42.25 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2227 EDEEEAVASKQTHI--LEQALCRAEDEE-DIRAATQAKAEQVAELAEFNENDGFPAGEGEEANRPGPGAEDEEMSRAEQE 2303
Cdd:COG3096 832 PDPEAELAALRQRRseLERELAQHRAQEqQLRQQLDQLKEQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAF 911
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 2304 IAALVEQLTPIERYAmkfleASLEE--VSREELKQAEEQVEAARKDLDQ---AKEEVF-RLPH---EEEEGpgagdeMSC 2374
Cdd:COG3096 912 IQQHGKALAQLEPLV-----AVLQSdpEQFEQLQADYLQAKEQQRRLKQqifALSEVVqRRPHfsyEDAVG------LLG 980
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 747019224 2375 GSSGASHRRSKKIRAPERLGTRVSERLRGARAETQGANH--TPVTSSHHT 2422
Cdd:COG3096 981 ENSDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQvlASLKSSRDA 1030
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1353-1582 |
8.02e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 8.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1353 LTSRPTLTPSRLSSPTLGTTRTPIPTPTLVRPLLklvhSPSPEVSASAPGAAPMTISSSLHMPSSLPGPASSPMtihnsS 1432
Cdd:PRK12323 361 LAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAA----AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAP-----E 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1433 PLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPlpiPITAPLPVSDLGPALLTSVTPALAVVSAASGPP--------LAS 1504
Cdd:PRK12323 432 ALAAARQASARGPGGAPAPAPAPAAAPAAAARP---AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpweelppeFAS 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1505 AGVSPSMSALA---LGLATTPALSPPQTSGHSLLLATTSSHVPGLNSAVAPACSPVLVSASALTSPfPVSPSSAPAQASL 1581
Cdd:PRK12323 509 PAPAQPDAAPAgwvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLP-DMFDGDWPALAAR 587
|
.
gi 747019224 1582 L 1582
Cdd:PRK12323 588 L 588
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
1193-1672 |
8.04e-03 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 41.73 E-value: 8.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1193 SGEVVSIGQLASLAQRPVTSAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRP--LQRNVVHLVSAGGQHHLISQPAHVA 1270
Cdd:COG4935 78 AGAVDAAPAAATVVGAALGVVAVAGAGLAATASGAAAGAVAAAANGNTGAGPGsgGTGGGSGGAGAAAAAAALSAAGAAV 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1271 LVQAVAPTPGPTPVSVLPSTPSTTPAPTGLSLPLAANQVPPSMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPSSSGLP 1350
Cdd:COG4935 158 GVAAVAGAAGGGGGVGVAAAVGVVLGAGLVADGGNGGGGAVAGGAAGGGGGGGGGGGLGGAAGGGGAGLAAAGGGGGGAA 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1351 AVLTSRPTLTPSRLSS--PTLGTTRTPIPTPTLVRPLLKLVHSPSPEVSASAPGAAPMTISSSLHMPSSLPGPASSPMTI 1428
Cdd:COG4935 238 AAAAAGVGGLGAAATAaaADGGGGGGAGAAGAGGSAGAAAGGAGAGVVGAAAGGGDAALGGAVGAAGTGNAAAAAAASAG 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1429 HNSSPLSSPVSSTVSVPVSSSLPISVPTTLPVPTSAPLPIPITAPLPVSDLGPALLTSVTPALAVVSAASGPPLASAGVS 1508
Cdd:COG4935 318 SGGGGGSAAAAGAAAAAAAAAAGAAAGVSGAASVVAGASGGGAGTAAAAGGGAAAAAAGGAAAAGAAAGAAAGAAAGAAA 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1509 PSMSALALGLATTPALSPPQTsghslllATTSSHVPGLNSAVAPACSPVLVSASALTSPFPVSPSSAPAQASLLAAAPST 1588
Cdd:COG4935 398 AGGVASAAGAVGAGTAAGASA-------TAAVSTGAASGSSTTSSTGTTATATGLGGGADAGSTSTGTGSAAGAAGGTTT 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1589 SQALATSLAPMAASQTAILGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSSSLVSAPTSVLAPSSTqtlvSTPVS 1668
Cdd:COG4935 471 ATSGLASSTTAAAAAAAAGLATTAAVAAGAAGAAAAAATAASVGGATGAAGTTNSTATFSNTTDVAIPDNG----PAGVT 546
|
....
gi 747019224 1669 SPLS 1672
Cdd:COG4935 547 STIT 550
|
|
| SOG2 |
pfam10428 |
RAM signalling pathway protein; SOG2 proteins in Saccharomyces cerevisiae are involved in cell ... |
1485-1687 |
8.84e-03 |
|
RAM signalling pathway protein; SOG2 proteins in Saccharomyces cerevisiae are involved in cell separation and cytokinesis.
Pssm-ID: 431280 Cd Length: 476 Bit Score: 41.63 E-value: 8.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1485 TSVTPALAVVSAASGPPLASAGVSPSMSALALGLATTPALSPPQTSGHSLLLATTSSHVPGLNSAVAPacspvlvSASAL 1564
Cdd:pfam10428 150 ASLGPLLEAVRPPSPKKRAGRTKQPSPSITSGGSPSSPAESSTRPSSSSVTPTRRRRHAGSFSSKLPP-------LRSDT 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 1565 TSPFPVSPSSAPAQAsllAAAPSTSQALATSLAPMaasqtailGPSPTPPLAPLPVLAASQTPLPAMTPPSMSGTPLPSS 1644
Cdd:pfam10428 223 TIPHPGGNLSSPAPN---GAQTPTPPRSATSPGVP--------SSAPTLGTGSTGAISRSNHSTSGSQSSLTSSSRSRSS 291
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 747019224 1645 SLVSAPTSVLAPSStqtLVSTPVSSPLSSLASTQTLTLAPTLA 1687
Cdd:pfam10428 292 SRSNTLLSTSGPSS---LATTPRPSSGESFAPTSTGSRINPLT 331
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
87-228 |
9.08e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 41.68 E-value: 9.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 747019224 87 QKWEKSHAEIAEQAKHEAEIETRIAELRKEGFW---SLKRLPKVPEPPRPKGHWDYLCEEMQWLsadfaqERRWKRGVAR 163
Cdd:COG4717 81 KEAEEKEEEYAELQEELEELEEELEELEAELEElreELEKLEKLLQLLPLYQELEALEAELAEL------PERLEELEER 154
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 747019224 164 -KVVRMVIRHHEEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKA 228
Cdd:COG4717 155 lEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQE 220
|
|
| |
