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Conserved domains on  [gi|725503321|ref|NP_001289753|]
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appetite-regulating hormone isoform 1 preproprotein [Homo sapiens]

Protein Classification

Motilin_ghrelin and Motilin_assoc domain-containing protein( domain architecture ID 10519229)

Motilin_ghrelin and Motilin_assoc domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Motilin_assoc pfam04643
Motilin/ghrelin-associated peptide; This family represents a peptide sequence that lies ...
 57-115 5.30e-32

Motilin/ghrelin-associated peptide; This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.


:

Pssm-ID: 368034  Cd Length: 59  Bit Score: 107.16  E-value: 5.30e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 725503321   57 LRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPA 115
Cdd:pfam04643   1 FRPEDGSQAEGAEDELEIRFNAPFDIGIKLSGAQYQQHGQALGKFLQDILWEEAKETPA 59
Motilin_ghrelin pfam04644
Motilin/ghrelin; Motilin is a gastrointestinal regulatory polypeptide produced by motilin ...
 24-51 5.43e-11

Motilin/ghrelin; Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas. This family also includes ghrelin, a growth hormone secretagogue synthesized by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system.


:

Pssm-ID: 461377  Cd Length: 28  Bit Score: 53.05  E-value: 5.43e-11
                          10        20
                  ....*....|....*....|....*...
gi 725503321   24 GSSFLSPEHQRVQQRKESKKPPAKLQPR 51
Cdd:pfam04644   1 GSSFLSPEYQRMQQRKRNKKPKASLHVR 28
 
Name Accession Description Interval E-value
Motilin_assoc pfam04643
Motilin/ghrelin-associated peptide; This family represents a peptide sequence that lies ...
 57-115 5.30e-32

Motilin/ghrelin-associated peptide; This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.


Pssm-ID: 368034  Cd Length: 59  Bit Score: 107.16  E-value: 5.30e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 725503321   57 LRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPA 115
Cdd:pfam04643   1 FRPEDGSQAEGAEDELEIRFNAPFDIGIKLSGAQYQQHGQALGKFLQDILWEEAKETPA 59
Motilin_ghrelin pfam04644
Motilin/ghrelin; Motilin is a gastrointestinal regulatory polypeptide produced by motilin ...
 24-51 5.43e-11

Motilin/ghrelin; Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas. This family also includes ghrelin, a growth hormone secretagogue synthesized by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system.


Pssm-ID: 461377  Cd Length: 28  Bit Score: 53.05  E-value: 5.43e-11
                          10        20
                  ....*....|....*....|....*...
gi 725503321   24 GSSFLSPEHQRVQQRKESKKPPAKLQPR 51
Cdd:pfam04644   1 GSSFLSPEYQRMQQRKRNKKPKASLHVR 28
 
Name Accession Description Interval E-value
Motilin_assoc pfam04643
Motilin/ghrelin-associated peptide; This family represents a peptide sequence that lies ...
 57-115 5.30e-32

Motilin/ghrelin-associated peptide; This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.


Pssm-ID: 368034  Cd Length: 59  Bit Score: 107.16  E-value: 5.30e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 725503321   57 LRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPA 115
Cdd:pfam04643   1 FRPEDGSQAEGAEDELEIRFNAPFDIGIKLSGAQYQQHGQALGKFLQDILWEEAKETPA 59
Motilin_ghrelin pfam04644
Motilin/ghrelin; Motilin is a gastrointestinal regulatory polypeptide produced by motilin ...
 24-51 5.43e-11

Motilin/ghrelin; Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas. This family also includes ghrelin, a growth hormone secretagogue synthesized by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system.


Pssm-ID: 461377  Cd Length: 28  Bit Score: 53.05  E-value: 5.43e-11
                          10        20
                  ....*....|....*....|....*...
gi 725503321   24 GSSFLSPEHQRVQQRKESKKPPAKLQPR 51
Cdd:pfam04644   1 GSSFLSPEYQRMQQRKRNKKPKASLHVR 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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