|
Name |
Accession |
Description |
Interval |
E-value |
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
604-868 |
1.85e-33 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 131.71 E-value: 1.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 604 PHLKYMNLYGTNL--SNDAVERLCSALKfSTCGVEELLLGKCDISSEACGIIAASLINSEVKHLSLVENPLKNKGVMSLC 681
Cdd:cd00116 51 PSLKELCLSLNETgrIPRGLQSLLQGLT-KGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 682 EMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDpNCTLKELWLPGCYLTSE 761
Cdd:cd00116 130 KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 762 CCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALCHPNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWN 841
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....*..
gi 722828676 842 AFDHSGLEMLCKALNHKACNLEVLGLD 868
Cdd:cd00116 289 KFGEEGAQLLAESLLEPGNELESLWVK 315
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
55-214 |
2.67e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 114.71 E-value: 2.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 55 TVVVSGSRGGGKTTFLRKAMLDWASRNLLQNrFQYVFYFSVFSLNNIT-ELSLAELISSTLPESSETVDD----ILSDPK 129
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQG-FDFVFFLPCRELSRSGnARSLADLLFSQWPEPAAPVSEvwavILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 130 RILFILDGFDYLKFDLELRTNLCndwrkklPIQIVLSSLLQKIMLPECSLLLELGNASLSNIIPLLQYPREIIMSGFSEQ 209
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDGPC-------PVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFSES 153
|
....*
gi 722828676 210 TIEIY 214
Cdd:pfam05729 154 DRKQY 158
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
352-467 |
1.14e-25 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 102.76 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 352 HSTLQWYFAVLFYFLQYKDTRHPVIGN---------LAQLLGEIYAHKQNQWFHTRILLFGMATEQVNSLLEPCFGCISS 422
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEffglrkresLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 722828676 423 KEVRQEIIRYIKSLSQQECNeklVVHPQNLFFCILDNQEERFVRQ 467
Cdd:pfam17776 81 SEIKQELLQWIKSLIQKELS---SERFLNLFHCLYELQDESFVKE 122
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
299-342 |
2.04e-06 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
:
Pssm-ID: 465501 Cd Length: 57 Bit Score: 45.63 E-value: 2.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 722828676 299 IRTLCTLAVEGMWKQVYVFDSDDLRRNGISESDKKVWLRMKFLQ 342
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQ 46
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
604-868 |
1.85e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 131.71 E-value: 1.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 604 PHLKYMNLYGTNL--SNDAVERLCSALKfSTCGVEELLLGKCDISSEACGIIAASLINSEVKHLSLVENPLKNKGVMSLC 681
Cdd:cd00116 51 PSLKELCLSLNETgrIPRGLQSLLQGLT-KGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 682 EMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDpNCTLKELWLPGCYLTSE 761
Cdd:cd00116 130 KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 762 CCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALCHPNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWN 841
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....*..
gi 722828676 842 AFDHSGLEMLCKALNHKACNLEVLGLD 868
Cdd:cd00116 289 KFGEEGAQLLAESLLEPGNELESLWVK 315
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
55-214 |
2.67e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 114.71 E-value: 2.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 55 TVVVSGSRGGGKTTFLRKAMLDWASRNLLQNrFQYVFYFSVFSLNNIT-ELSLAELISSTLPESSETVDD----ILSDPK 129
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQG-FDFVFFLPCRELSRSGnARSLADLLFSQWPEPAAPVSEvwavILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 130 RILFILDGFDYLKFDLELRTNLCndwrkklPIQIVLSSLLQKIMLPECSLLLELGNASLSNIIPLLQYPREIIMSGFSEQ 209
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDGPC-------PVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFSES 153
|
....*
gi 722828676 210 TIEIY 214
Cdd:pfam05729 154 DRKQY 158
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
352-467 |
1.14e-25 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 102.76 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 352 HSTLQWYFAVLFYFLQYKDTRHPVIGN---------LAQLLGEIYAHKQNQWFHTRILLFGMATEQVNSLLEPCFGCISS 422
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEffglrkresLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 722828676 423 KEVRQEIIRYIKSLSQQECNeklVVHPQNLFFCILDNQEERFVRQ 467
Cdd:pfam17776 81 SEIKQELLQWIKSLIQKELS---SERFLNLFHCLYELQDESFVKE 122
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
600-855 |
4.68e-22 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 100.25 E-value: 4.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 600 FLHLPHLKYMNLYGTNLSNDAVERLCSALKFSTcGVEELLLGKCDISSEACGIIAASLI-NSEVKHLSLVENPLKNKGVM 678
Cdd:COG5238 176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKgNKSLTTLDLSNNQIGDEGVI 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 679 SLCEMLKDPSCVlESLMLSyccLTFIACGH---LYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDpNCTLKELWLPG 755
Cdd:COG5238 255 ALAEALKNNTTV-ETLYLS---GNQIGAEGaiaLAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAY 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 756 CYLTSECCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALchpNCEMQCLGLDMCD--FTSDCCEDLALVLTTcNTL 833
Cdd:COG5238 330 NGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL---EGNTTLRELNLGKnnIGKQGAEALIDALQT-NRL 405
|
250 260
....*....|....*....|....*
gi 722828676 834 KSLNLDWN---AFDHSGLEMLCKAL 855
Cdd:COG5238 406 HTLILDGNligAEAQQRLEQLLERI 430
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
299-342 |
2.04e-06 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 45.63 E-value: 2.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 722828676 299 IRTLCTLAVEGMWKQVYVFDSDDLRRNGISESDKKVWLRMKFLQ 342
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQ 46
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
773-798 |
8.58e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 34.69 E-value: 8.58e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
604-868 |
1.85e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 131.71 E-value: 1.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 604 PHLKYMNLYGTNL--SNDAVERLCSALKfSTCGVEELLLGKCDISSEACGIIAASLINSEVKHLSLVENPLKNKGVMSLC 681
Cdd:cd00116 51 PSLKELCLSLNETgrIPRGLQSLLQGLT-KGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 682 EMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDpNCTLKELWLPGCYLTSE 761
Cdd:cd00116 130 KGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 762 CCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALCHPNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWN 841
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....*..
gi 722828676 842 AFDHSGLEMLCKALNHKACNLEVLGLD 868
Cdd:cd00116 289 KFGEEGAQLLAESLLEPGNELESLWVK 315
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
55-214 |
2.67e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 114.71 E-value: 2.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 55 TVVVSGSRGGGKTTFLRKAMLDWASRNLLQNrFQYVFYFSVFSLNNIT-ELSLAELISSTLPESSETVDD----ILSDPK 129
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQG-FDFVFFLPCRELSRSGnARSLADLLFSQWPEPAAPVSEvwavILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 130 RILFILDGFDYLKFDLELRTNLCndwrkklPIQIVLSSLLQKIMLPECSLLLELGNASLSNIIPLLQYPREIIMSGFSEQ 209
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDGPC-------PVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFSES 153
|
....*
gi 722828676 210 TIEIY 214
Cdd:pfam05729 154 DRKQY 158
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
352-467 |
1.14e-25 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 102.76 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 352 HSTLQWYFAVLFYFLQYKDTRHPVIGN---------LAQLLGEIYAHKQNQWFHTRILLFGMATEQVNSLLEPCFGCISS 422
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEffglrkresLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 722828676 423 KEVRQEIIRYIKSLSQQECNeklVVHPQNLFFCILDNQEERFVRQ 467
Cdd:pfam17776 81 SEIKQELLQWIKSLIQKELS---SERFLNLFHCLYELQDESFVKE 122
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
528-815 |
4.14e-24 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 103.97 E-value: 4.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 528 QKLLAKHWTTLCTFLCNLHVLDLDSCHFNEKAIEVLCNCL---PLTSLVPLTGFK-------LHRLLCSFTTN------- 590
Cdd:cd00116 8 ELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALrpqPSLKELCLSLNEtgriprgLQSLLQGLTKGcglqeld 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 591 -----FGDGL--LFCTFLHLPHLKYMNLYGTNLSNDAVERLCSALKFSTCGVEELLLGKCDISSEACGIIAASLI-NSEV 662
Cdd:cd00116 88 lsdnaLGPDGcgVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRaNRDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 663 KHLSLVENPLKNKGVMSLCEMLKDpSCVLESLMLSYCCLTFIACGHLYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALK 742
Cdd:cd00116 168 KELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALL 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 722828676 743 DPNCTLKELWLPGCYLTSECCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALCHPNCEMQCLGLDMCDF 815
Cdd:cd00116 247 SPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDDSF 319
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
691-895 |
3.15e-23 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 101.66 E-value: 3.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 691 LESLMLSYCCLTFIACGHLYEALLSNEHLSLLDLGSNFLE--DTGVNLLCEALKDpNCTLKELWLPGCYLTSECCEEISA 768
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK-GCGLQELDLSDNALGPDGCGVLES 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 769 VLTcNTNLKTLKLGNNNIQDTGVKRLCEALCHPNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWNAFDHSGL 848
Cdd:cd00116 104 LLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGI 182
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 722828676 849 EMLCKALNHKaCNLEVLGLDKSLFSEESQTLLQAVEKKNKNLKVLHF 895
Cdd:cd00116 183 RALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL 228
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
600-855 |
4.68e-22 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 100.25 E-value: 4.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 600 FLHLPHLKYMNLYGTNLSNDAVERLCSALKFSTcGVEELLLGKCDISSEACGIIAASLI-NSEVKHLSLVENPLKNKGVM 678
Cdd:COG5238 176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKgNKSLTTLDLSNNQIGDEGVI 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 679 SLCEMLKDPSCVlESLMLSyccLTFIACGH---LYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDpNCTLKELWLPG 755
Cdd:COG5238 255 ALAEALKNNTTV-ETLYLS---GNQIGAEGaiaLAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAY 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 756 CYLTSECCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALchpNCEMQCLGLDMCD--FTSDCCEDLALVLTTcNTL 833
Cdd:COG5238 330 NGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL---EGNTTLRELNLGKnnIGKQGAEALIDALQT-NRL 405
|
250 260
....*....|....*....|....*
gi 722828676 834 KSLNLDWN---AFDHSGLEMLCKAL 855
Cdd:COG5238 406 HTLILDGNligAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
628-856 |
8.15e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 90.23 E-value: 8.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 628 LKFSTCGVEELLLG-KCDISSEACGIIAASLINSEVKHLSLVENPLKNKGVMSLCEMLKDPSCVlESLMLSYCCLTFIAC 706
Cdd:COG5238 147 LKDPLGGNAVHLLGlAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTV-TTLWLKRNPIGDEGA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 707 GHLYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDpNCTLKELWLPGCYLTSECCEEISAVLTCNTNLKTLKLGNNNI 786
Cdd:COG5238 226 EILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 787 QDTGVKRLCEALCHpNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWNAFDHSGLEMLCKALN 856
Cdd:COG5238 305 GDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
707-894 |
9.04e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 83.69 E-value: 9.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 707 GHLYEALLSNEHLSLLDLGSNFLEDTGVNLLCEALKDPNcTLKELWLPGCYLTSECCEEISAVLTCNTNLKTLKLGNNNI 786
Cdd:COG5238 170 AISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 787 QDTGVKRLCEALCHpNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWNAFDHSGLEMLCKALNHKAcNLEVLG 866
Cdd:COG5238 249 GDEGVIALAEALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLN 326
|
170 180
....*....|....*....|....*...
gi 722828676 867 LDKSLFSEESQTLLQAVEKKNKNLKVLH 894
Cdd:COG5238 327 LAYNGIGAQGAIALAKALQENTTLHSLD 354
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
56-407 |
1.05e-15 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 82.16 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 56 VVVSGSRGGGKTTFLRKAMLDWASRNLLQNRfQYVFYFSvfsLNNI-TELSLAELISSTL----PESSETVDDILSDpKR 130
Cdd:COG5635 183 LLILGEPGSGKTTLLRYLALELAERYLDAED-PIPILIE---LRDLaEEASLEDLLAEALekrgGEPEDALERLLRN-GR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 131 ILFILDGFDYLkFDLELRTNLCN---DWRKKLP-IQIVLSSLLQkimlpecslllELGNASLSNIipllqypREIIMSGF 206
Cdd:COG5635 258 LLLLLDGLDEV-PDEADRDEVLNqlrRFLERYPkARVIITSRPE-----------GYDSSELEGF-------EVLELAPL 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 207 SEQTIEIYCVSFF--NTQTGVEIFKNLKSIKPLFNLCRCPHLCWMICSTIKWQyerrevaSRFGRTLGLLYTIFMVSAF- 283
Cdd:COG5635 319 SDEQIEEFLKKWFeaTERKAERLLEALEENPELRELARNPLLLTLLALLLRER-------GELPDTRAELYEQFVELLLe 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 284 ------KSTYARNPSKQNRARIrtLCTLAVEgMWKQ-VYVFDSDDLRRN----GISESDKKVWL-----RMKFLQNQGSN 347
Cdd:COG5635 392 rwdeqrGLTIYRELSREELREL--LSELALA-MQENgRTEFAREELEEIlreyLGRRKDAEALLdelllRTGLLVERGEG 468
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 722828676 348 IV-FYHSTLQWYFAVLFYFlqykdtRHPVIGNLAQLLGEIyahKQNQWFHTRILLFGMATE 407
Cdd:COG5635 469 RYsFAHRSFQEYLAARALV------EELDEELLELLAEHL---EDPRWREVLLLLAGLLDD 520
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
721-894 |
2.48e-12 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.82 E-value: 2.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 721 LLDLGSNFLEDTGVNLLCEALKDPNCTLkeLWLPGCYLTSECCEEISAVLTCNTNLKTLKLGNNNIQDTGVKRLCEALCH 800
Cdd:COG5238 157 HLLGLAARLGLLAAISMAKALQNNSVET--VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 801 pNCEMQCLGLDMCDFTSDCCEDLALVLTTCNTLKSLNLDWNAFDHSGLEMLCKALNhKACNLEVLGLDKSLFSEESQTLL 880
Cdd:COG5238 235 -NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ-GNTTLTSLDLSVNRIGDEGAIAL 312
|
170
....*....|....
gi 722828676 881 QAVEKKNKNLKVLH 894
Cdd:COG5238 313 AEGLQGNKTLHTLN 326
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
748-896 |
2.27e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.98 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 748 LKELWLPGCYLTSECCEEISAVLTCNTNLKTLKLGNNNIQ--DTGVKRLCEALcHPNCEMQCLGLDMCDFTSDCCEDLAL 825
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGL-TKGCGLQELDLSDNALGPDGCGVLES 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 722828676 826 VLTTcNTLKSLNLDWNAFDHSGLEMLCKALNHKACNLEVLGLDKSLFSEESQTLLQAVEKKNKNLKVLHFP 896
Cdd:cd00116 104 LLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLA 173
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
299-342 |
2.04e-06 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 45.63 E-value: 2.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 722828676 299 IRTLCTLAVEGMWKQVYVFDSDDLRRNGISESDKKVWLRMKFLQ 342
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQ 46
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
691-843 |
1.02e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.61 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 691 LESLMLSYCCLTfiacgHLYEALLSNEHLSLLDLGSNFLEDtgvnlLCEALKdpNCT-LKELWLPGCYLTSecceeISAV 769
Cdd:COG4886 115 LESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLG--NLTnLKSLDLSNNQLTD-----LPEE 177
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 722828676 770 LTCNTNLKTLKLGNNNIQDtgvkrLCEALCHPNcEMQCLGLDMCDFTsdcceDLALVLTTCNTLKSLNLDWNAF 843
Cdd:COG4886 178 LGNLTNLKELDLSNNQITD-----LPEPLGNLT-NLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQL 240
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
773-798 |
8.58e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 34.69 E-value: 8.58e-03
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
602-794 |
9.26e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 39.53 E-value: 9.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 602 HLPHLKYMNLYGTNLSNdaverLCSALKFSTcGVEELLLGKCDISSeacgiIAASLIN-SEVKHLSLVENPLKNKGvMSL 680
Cdd:COG4886 134 NLTNLKELDLSNNQLTD-----LPEPLGNLT-NLKSLDLSNNQLTD-----LPEELGNlTNLKELDLSNNQITDLP-EPL 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 722828676 681 CEMLKdpscvLESLMLSYCCLTfiacgHLYEALLSNEHLSLLDLGSNFLEDtgvnlLCEALKDPNctLKELWLPGCYLTS 760
Cdd:COG4886 202 GNLTN-----LEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLTD-----LPELGNLTN--LEELDLSNNQLTD 264
|
170 180 190
....*....|....*....|....*....|....
gi 722828676 761 ecceeISAvLTCNTNLKTLKLGNNNIQDTGVKRL 794
Cdd:COG4886 265 -----LPP-LANLTNLKTLDLSNNQLTDLKLKEL 292
|
|
| |
