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Conserved domains on  [gi|698979997|ref|NP_001289305|]
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C-C chemokine receptor-like 2 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606903)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
38-316 8.77e-167

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


:

Pssm-ID: 320299  Cd Length: 279  Bit Score: 466.61  E-value: 8.77e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  38 QQVLQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSS 117
Cdd:cd15171    1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 118 GLYSEVFSNILLLVQGYRVFSQGRLASIFTTV-SCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIE 196
Cdd:cd15171   81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVaPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15171  161 ETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDC 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 277 KSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRkAFMRYL 316
Cdd:cd15171  241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDP-AFRRRL 279
 
Name Accession Description Interval E-value
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
38-316 8.77e-167

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 466.61  E-value: 8.77e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  38 QQVLQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSS 117
Cdd:cd15171    1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 118 GLYSEVFSNILLLVQGYRVFSQGRLASIFTTV-SCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIE 196
Cdd:cd15171   81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVaPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15171  161 ETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDC 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 277 KSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRkAFMRYL 316
Cdd:cd15171  241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDP-AFRRRL 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
55-304 1.66e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 116.63  E-value: 1.66e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997   55 NVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGE--SPGNGTCKVLVGLHSSGLYSEVFSNILLLV 131
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGdwPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  132 QGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGkphFLPIEAPLWKYVLTSKMIIL 211
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCF---IDFPEDLSKPVSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  212 VLAFPLLVFIIC----CRQLRRRQSFRERQYDLHKP------ALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDekssyH 281
Cdd:pfam00001 159 GFLLPLLVILVCytliIRTLRKSASKQKSSERTQRRrkalktLAVVVVVFILCWLPYHIVNLLDSLALDCELSR-----L 233
                         250       260
                  ....*....|....*....|...
gi 698979997  282 LDASVQVTQLVATTHCCVNPLLY 304
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-333 5.13e-24

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 101.01  E-value: 5.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKgLKNLGNIYFLNLALSNLCFLLPLPFW-AHTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:PHA03087  48 STIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTLPFQiYYYILFQWSFGEFACKIVSGLYYIGFYNSM 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQ-KHKCAFGKPhflpiEAPLWKY 202
Cdd:PHA03087 127 NFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHEtLICCMFYNN-----KTMNWKL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIICCRQLR---RRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSS 279
Cdd:PHA03087 202 FINFEINIIGMLIPLTILLYCYSKILitlKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAV 281
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 698979997 280 YHLDASVQVTQLVATTHCCVNPLLYLLLDRKAFMRYLRSLFPRcndipYQSSGG 333
Cdd:PHA03087 282 KYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLM-----FTSSGK 330
 
Name Accession Description Interval E-value
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
38-316 8.77e-167

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 466.61  E-value: 8.77e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  38 QQVLQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSS 117
Cdd:cd15171    1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 118 GLYSEVFSNILLLVQGYRVFSQGRLASIFTTV-SCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIE 196
Cdd:cd15171   81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVaPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15171  161 ETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRDC 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 277 KSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRkAFMRYL 316
Cdd:cd15171  241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDP-AFRRRL 279
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
47-316 1.96e-62

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 200.75  E-value: 1.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15184   10 VFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNAMCKLLTGLYHIGFFSGIFFI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAfgkPHFLPIEAPLWKYVLTS 206
Cdd:cd15184   90 ILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCS---PHFPPSQYQFWKNFQTL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 207 KMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPA---LVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYHLD 283
Cdd:cd15184  167 KMNILGLVLPLLVMIICYSGILKTLLRCRNEKKRHKAVrliFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLD 246
                        250       260       270
                 ....*....|....*....|....*....|...
gi 698979997 284 ASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15184  247 QAMQVTETLGMTHCCINPVIYAFVGEK-FRSYL 278
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
45-316 1.24e-57

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 188.58  E-value: 1.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd14984    8 SLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADGWVFGSFLCKLVSALYTINFYSGIL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgKPHFLPIEAPLWKYVL 204
Cdd:cd14984   88 FLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSIC---SYDYPEDTATTWKTLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFIIC----CRQLRRRQSfRERQYDLhKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE-KSS 279
Cdd:cd14984  165 RLLQNILGFLLPLLVMLFCysriIRTLLRARN-HKKHRAL-RVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISRScELS 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 280 YHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd14984  243 KSLDYALQVTESLAFSHCCLNPVLYAFVGVK-FRKYL 278
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
47-316 1.18e-53

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 178.14  E-value: 1.18e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15183   10 VFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIfGDAMCKFLSGFYYLGLYSEIFF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEaplWKYVLT 205
Cdd:cd15183   90 IILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIR---WKRFQA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SKMIILVLAFPLLVFIIC----CRQLRRRQSfrERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYH 281
Cdd:cd15183  167 LKLNLLGLILPLLVMIICytgiINILLRRPN--EKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCEQSQQ 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 698979997 282 LDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15183  245 LDLALQVTEVIAYTHCCVNPVIYVFVGER-FRKYL 278
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
47-316 9.15e-53

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 175.79  E-value: 9.15e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAH-TAAHGESPGNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15185   10 VFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHyVRWNNWVFGHGMCKLLSGFYYLGLYSEIFF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAfgkPHFLPIEAPLWKYVLT 205
Cdd:cd15185   90 IILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCS---PLYPEDTEDSWKRFHA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SKMIILVLAFPLLVFIIC----CRQLRRRQSfrERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYH 281
Cdd:cd15185  167 LRMNIFGLALPLLIMVICytgiIKTLLRCPS--KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCERSKH 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 698979997 282 LDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15185  245 LDLAMQVTEVIAYTHCCINPVIYAFVGER-FRKYL 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
43-316 6.55e-43

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 150.33  E-value: 6.55e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15187    6 LYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYIGFYSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAfgkpHFLPIEAPLWKY 202
Cdd:cd15187   86 MFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCI----PFYPGQGNSWKV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIIC----CRQLRRRQSfrERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKS 278
Cdd:cd15187  162 FTNFEVNILGLLIPFSILIFCyhniLRNLRRCHN--QNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHIIDGCQN 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 698979997 279 SYHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15187  240 SQRLTLALHLTETISFTHCCLNPVIYAFVGEK-FKKHL 276
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
47-307 5.13e-35

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 129.48  E-value: 5.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVlvglhSSGLYSEVFSN 126
Cdd:cd15176   10 ALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNGWVLGTAMCKI-----TSALYTMNFSC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLL-----VQGYRVFSQGRLASifTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLpieAPLWK 201
Cdd:cd15176   85 GMQFlacisVDRYVAITKATSRQ--FTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSL---VTSAK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTSKMIILVLAFPLLVFIICCRQLRR--RQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQE-HLSLQDEKS 278
Cdd:cd15176  160 ATIQILEVLLGFVLPFLVMVFCYSRVARalSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDViYLLITDCSM 239
                        250       260
                 ....*....|....*....|....*....
gi 698979997 279 SYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15176  240 SKTLDIAIQVTESIALFHSCLNPVLYVFM 268
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-316 8.69e-34

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 125.94  E-value: 8.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15182    6 FYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSGWIFGEILCKAVTSIFYIGFYSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPR-MERQKHKCAFgkphflpiEAPLWK 201
Cdd:cd15182   86 ILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMkSDEDGSLCEY--------SSIKWK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTSKMIILVLaFPLLVFIIC-CRQLRRrqSFRERQYDLHKPA---LVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEK 277
Cdd:cd15182  158 LGYYYQQNLFFL-IPLGIIVYCyVRILQT--LMRTRTMRKHRTVkliFVIVLVFFLSWAPYNIVIFLRSLKDLTIPICEC 234
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 698979997 278 SSyHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15182  235 SK-QLDYAFYICRNIAFSHCCLNPVFYVFVGVK-FRNHL 271
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
47-316 1.25e-33

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 125.67  E-value: 1.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKY-KGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15188   10 VFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWHWVFGSFLCKFVSTLYTINFYSGIFF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEprmERQKHKCAFGKPHFLPIEAPLWKYVLT 205
Cdd:cd15188   90 VSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQ---THHTNNGVWVCHADYGGHHTIWKLVFQ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SKMIILVLAFPLLVFIIC-----CRQLRRRQSFRERQYDLhkpALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSY 280
Cdd:cd15188  167 FQQNLLGFLFPLLAMVFFysriaCVLTRLRPPGQGRALRF---VAALVVVFFVLWFPYNLTLFLHSLQDLHVIGNCERSR 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 281 HLDASVQVTQLVATTHCCVNPLLYLLLdRKAFMRYL 316
Cdd:cd15188  244 HLDYALQVTESLAFVHCCLNPLLYAFV-SKRFRLYL 278
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
46-316 5.33e-33

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 124.03  E-value: 5.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWA-HTAAHGESP-GNGTCKVLVGLHSSGLYSEV 123
Cdd:cd14985    9 AIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWAtYTANQYDWPfGAFLCKVSSYVISVNMFASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRM--ERQKHKCAFGKPHflpieaPLWK 201
Cdd:cd14985   89 FLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAieNLNKTACIMLYPH------EAWH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTSKMIILVLAFPLLVFIIC----CRQLRRRQSF----RERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSL 273
Cdd:cd14985  163 FGLSLELNILGFVLPLLIILTCyfhiARSLRKRYERtgknGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAI 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 698979997 274 QDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd14985  243 RPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRR-FRQKV 284
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
47-304 1.35e-31

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 120.24  E-value: 1.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15174   10 IFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSGWVFGTFLCKVVNSMYKINFYSCMLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTTVSCGI--VACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPhflPIEAPLWKYVL 204
Cdd:cd15174   90 TCISVDRYIAIVQATKAHNSKNKRLLYskLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYP---SNESNRFKVAV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVfIICCRQLRRRQSFRERQYDLHKPALVITGV---FLLMWAPYNTVLFLSAFQ-EHLSLQDEKSSY 280
Cdd:cd15174  167 LALKVTVGFFLPFVV-MVICYTLIIHTLLQAKRFQKHKALKVIIAVvtvFVLSQLPYNSILLIKTINaYNITITDCATSQ 245
                        250       260
                 ....*....|....*....|....
gi 698979997 281 HLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15174  246 NLDIAGQVTQSIAFLHSCLNPFLY 269
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
43-316 3.40e-31

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 119.17  E-value: 3.40e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15186    6 FYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINEWGLHNAMCKLTTAFFFIGFFGG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFyeprMERQKHKCAFGKPHFLpieAPLWKY 202
Cdd:cd15186   86 IFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMF----TKMKENECLGDYPEVL---QEIWPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIIC-CRQLRRRQSFRERQYDLH-KPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSY 280
Cdd:cd15186  159 LRNVELNFLGFLLPLLIMSYCyFRIIQTLFSCKNHKKARAiKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMKK 238
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 281 HLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15186  239 DLRLALSVTETIAFSHCCLNPLIYAFAGEK-FRRYL 273
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
55-304 1.66e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 116.63  E-value: 1.66e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997   55 NVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGE--SPGNGTCKVLVGLHSSGLYSEVFSNILLLV 131
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGdwPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  132 QGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGkphFLPIEAPLWKYVLTSKMIIL 211
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCF---IDFPEDLSKPVSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  212 VLAFPLLVFIIC----CRQLRRRQSFRERQYDLHKP------ALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDekssyH 281
Cdd:pfam00001 159 GFLLPLLVILVCytliIRTLRKSASKQKSSERTQRRrkalktLAVVVVVFILCWLPYHIVNLLDSLALDCELSR-----L 233
                         250       260
                  ....*....|....*....|...
gi 698979997  282 LDASVQVTQLVATTHCCVNPLLY 304
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-310 7.78e-30

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 115.56  E-value: 7.78e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVF- 124
Cdd:cd15180    9 LVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKINFYCGIFl 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 ------SNILLLVQGYRVFSQGRLASIFTTvscgivaCILAWAMATALSLPESVFYEPRMERQKHK--CAfgkpHFLPIE 196
Cdd:cd15180   89 lacisfDRYLSIVHAVQMYSRKKPMLVHLS-------CLIVWLFCLLLSIPDFIFLEATKDPRQNKteCV----HNFPQS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGV---FLLMWAPYNTVLFLSAFQEhLSL 273
Cdd:cd15180  158 DTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGFQKQRAIRVIVAVvvvFFLCWTPYNIALLVDTLID-LSV 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 698979997 274 QDEKSSYH--LDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15180  237 LDRNCGTEsrLDIALSVTSSLGYFHCCLNPLLYAFVGVK 275
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
47-310 6.90e-28

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 110.25  E-value: 6.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15173   10 MFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTINLYSSMLIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTT--VSCGIVACILAWAMATALSLPESVFYEPRMERQKHkCafgkphFLPIEAPLWKYVL 204
Cdd:cd15173   90 TCITVDRFIVIVQATKAHNCHAkkMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKI-C------SMVYPPDAIEVVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFIIcCRQLRRRQSFRERQYDLHKP---ALVITGVFLLMWAPYNTVLFLSAFQEHLSLQdekssYH 281
Cdd:cd15173  163 NIIQMTVGFFLPLLAMII-CYSVIIKTLLHAKGFQKHKSlkiIFVVVAVFILTQLPYNIMKLIRTLHIENTDS-----TN 236
                        250       260
                 ....*....|....*....|....*....
gi 698979997 282 LDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15173  237 FKYAILITEAIAYLHACLNPILYAFVGVK 265
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
47-307 1.19e-26

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 106.78  E-value: 1.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15177   10 VFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQGWIFGNAMCKLIQGLYAINFYSGFLFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFT--TVSCGIVACILAWAMATALSLPESVF--YEPRMERQKHKCAFgkphflPIEAPLWKY 202
Cdd:cd15177   90 TCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIYsrVENRSELSSCRMIF------PEVVSRTVK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKM-IILVLAFPLLVFIIC----CRQLRRRQSFRERQYDLHKPALVITgvFLLMWAPYNTVLFL--SAFQEHLSLQD 275
Cdd:cd15177  164 GATALTqVVLGFAIPLIVMAVCyaaiGRTLLAARGWERHRALRVIAALVVA--FVLFQLPYSVVLLLdtADLLATLELSC 241
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 276 EKSSyHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15177  242 SQSK-RKDIALLVTSGLAYVRCCLNPLLYAFV 272
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
43-307 2.27e-26

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 106.22  E-value: 2.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFWAHTAAHGESP-GNGTCKVLVGLHSSGLY 120
Cdd:cd00637    4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLvIPFSLVSLLLGRWWfGDALCKLLGFLQSVSLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFlpieapLW 200
Cdd:cd00637   84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDL------TL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAFPLLVFIIC----CRQLRRRQSFRERQYDLH-------------KPALVITGVFLLMWAPYNTVLF 263
Cdd:cd00637  158 SKAYTIFLFVLLFLLPLLVIIVCyvriFRKLRRHRRRIRSSSSNSsrrrrrrrerkvtKTLLIVVVVFLLCWLPYFILLL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 698979997 264 LSAFQEHlslqdekSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd00637  238 LDVFGPD-------PSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
43-304 2.74e-26

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 105.82  E-value: 2.74e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15178    6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEANFYSG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VF-------SNILLLVQGYRVFSQGRLASIFttvscgivACILAWAMATALSLP----ESVFYEPRMERQkhKCAfgkPH 191
Cdd:cd15178   86 ILllacisvDRYLAIVHATRALTQKRHLVKF--------VCAGVWLLSLLLSLPallnRDAFKPPNSGRT--VCY---EN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 192 FLPIEAPLWKYVLTSKMIILVLAFPLLVFIIC----CRQLRRRQSFRErqydlHKPALVITGV---FLLMWAPYNTVLFL 264
Cdd:cd15178  153 LGNESADKWRVVLRILRHTLGFLLPLVVMLFCygftIKTLLQTRSFQK-----HRAMRVIFAVvlaFLLCWLPYNVTVLI 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 698979997 265 -SAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15178  228 dTLMRTKLITETCELRNHVDVALYVTQILGFLHSCINPVLY 268
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
43-312 1.01e-25

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 104.30  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYS 121
Cdd:cd14970    6 VYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPfGEVMCKIVLSVDAYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 122 EVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMER-QKHKCAFGkphfLPIEAPLW 200
Cdd:cd14970   86 SIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEgGTISCNLQ----WPDPPDYW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAFPLLVFIIC----CRQLRR-----RQSFRERQYDLHK---PALVITGVFLLMWAPY---NTVLFLS 265
Cdd:cd14970  162 GRVFTIYTFVLGFAVPLLVITVCysliIRRLRSsrnlsTSGAREKRRARRKvtrLVLVVVAVFVVCWLPFhvfQIVRLLI 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 698979997 266 AFQEHLSLQdekSSYHLdasvqvTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd14970  242 DPPETLTVV---GVFLF------CIALSYANSCLNPILYAFLDenfRKSF 282
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
47-304 1.32e-25

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 104.07  E-value: 1.32e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVF-- 124
Cdd:cd15172   10 ICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAHQWIFGNFSCKLLRGIYAINFYSGMLll 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 -----SNILLLVQGYRVFsqgRLASifTTVSCGIVACILAWAMATALSLPESVFYEpRMERQKHKCAFGKPHFLPIEAPL 199
Cdd:cd15172   90 acisvDRYIAIVQATKSF---RLRS--RTLAYSKLICAAVWLLAILISLPTFIFSE-VYDFGLEEQYVCEPKYPKNSTAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 -WKYVLTSKMIILVLAFPLLVFIIC----CRQLRRRQSFRErqydlHKPALVITGV---FLLMWAPYNTVLFLSAFQehL 271
Cdd:cd15172  164 mWKLLVLSLQVSLGFFIPLLVMIFCysfiIKTLLQAQNSQR-----HKAVRVVVAVvlvFLVCQVPYNIVLLIEAIN--L 236
                        250       260       270
                 ....*....|....*....|....*....|....
gi 698979997 272 SLQDEKSSYHLDA-SVQVTQLVATTHCCVNPLLY 304
Cdd:cd15172  237 GEQQSCSSEKAVAyAKTITECLAFFHCCLNPVLY 270
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
47-304 3.82e-25

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 102.92  E-value: 3.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFsn 126
Cdd:cd15175   10 ICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKKWVFGEEMCKAVYCLYKMSFFSGML-- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIF----TTVSCGIVACILAWAMATALSLPESVFyeprmerQKHKCAFGKPHFLPIEAPLWKY 202
Cdd:cd15175   88 LLMCISIDRYFAIVQAASAHrhrsRAVFISKVSSLGVWVLAFILSIPELLY-------SGVNNNDGNGTCSIFTNNKQTL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAF--PLLVFIIC----CRQLRRRQSFrERqYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQ-D 275
Cdd:cd15175  161 SVKIQISQMVLGFlvPLVVMSFCysviIKTLLQARNF-EK-NKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTtD 238
                        250       260
                 ....*....|....*....|....*....
gi 698979997 276 EKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15175  239 CDYSKNLDFALDVTYSLACFRCCLNPFLY 267
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
47-316 4.35e-25

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 102.89  E-value: 4.35e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWA-HTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15192   10 IFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAaYTAMEYHWPfGNFLCKIASALVSFNLYASVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP-----ESVFYEprmERQKHKCAFgkphFLPIEAPL 199
Cdd:cd15192   90 LLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPaiihrDVFFIE---NTNITVCAF----HYPSQNST 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLAFPLLVFIIC-------CRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLS 272
Cdd:cd15192  163 LLVGLGLMKNLLGFLIPFLIILTCytligkaLKKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 698979997 273 LQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15192  243 IQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKN-FRKKF 285
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-333 5.13e-24

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 101.01  E-value: 5.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKgLKNLGNIYFLNLALSNLCFLLPLPFW-AHTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:PHA03087  48 STIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTLPFQiYYYILFQWSFGEFACKIVSGLYYIGFYNSM 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQ-KHKCAFGKPhflpiEAPLWKY 202
Cdd:PHA03087 127 NFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHEtLICCMFYNN-----KTMNWKL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIICCRQLR---RRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSS 279
Cdd:PHA03087 202 FINFEINIIGMLIPLTILLYCYSKILitlKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAV 281
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 698979997 280 YHLDASVQVTQLVATTHCCVNPLLYLLLDRKAFMRYLRSLFPRcndipYQSSGG 333
Cdd:PHA03087 282 KYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLM-----FTSSGK 330
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
47-304 1.15e-23

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 98.67  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSevfSN 126
Cdd:cd15181   10 VFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGTFLCKLVGAIHKLNFYC---SS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILL----------LVQGYRVFSQGRLASIFTTvscgivaCILAWAMATALSLPESVFYEPRMERQKHK--CAFGKPHFlp 194
Cdd:cd15181   87 LLLacisvdrylaIVHAIHSYRHRRLRSVHLT-------CGSIWLVCFLLSLPNLVFLEVETSTNANRtsCSFHQYGI-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 195 ieaPLWKYVLTSKMIILVLAF--PLLVFIIC----CRQLRRRQSFRERQYDLhKPALVITGVFLLMWAPYNTVLFLSAF- 267
Cdd:cd15181  158 ---HESNWWLTSRFLYHVVGFflPLLIMGYCyatiVVTLCQSSRRLQKQKAI-RVAILVTLVFCLCWLPYNIVIFLDTLd 233
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 268 QEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15181  234 DLKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILY 270
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
43-316 1.16e-21

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 93.13  E-value: 1.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFIlVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGT--CKvlvgLHSSGLY 120
Cdd:cd14974    6 LYALIFLLGLPGNGLVIWV-AGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSvlCK----LNSFVIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVqgyrVFSQGRLASIF--------TTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHF 192
Cdd:cd14974   81 LNMFASVFLLT----AISLDRCLLVLhpvwaqnhRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVED 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIeAPLWKYVLTSkmIILVLAF--PLLVFIIC--CRQLRRRQSFRERQydlHKPALVITGV---FLLMWAPYNTVLFLS 265
Cdd:cd14974  157 YDL-RRSRHKALTV--IRFLCGFllPLLIIAICysVIAVKLRRKRLAKS---SKPLRVLLAVvvaFFLCWLPYHVFALLE 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 698979997 266 AFQEHLSLQdekssyHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd14974  231 LVAAAGLPE------VVLLGLPLATGLAYFNSCLNPILYVFMGQD-FRKRL 274
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
43-310 5.55e-21

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 91.17  E-value: 5.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP--GNGTCKVLVGLHSSGLY 120
Cdd:cd14982    6 VYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWpfGDFLCRLTGLLFYINMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFgkpHFLPIEAPLW 200
Cdd:cd14982   86 GSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCF---EFLSEWLASA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLaFPLLVFIICC----RQLRRRQSFRERQYDLHKPA---LVITGVFLLMWAPYNTVLFLSaFQEHLSL 273
Cdd:cd14982  163 APIVLIALVVGFL-IPLLIILVCYsliiRALRRRSKQSQKSVRKRKALrmiLIVLAVFLVCFLPYHVTRILY-LLVRLSF 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 698979997 274 QDEKSSYH-LDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd14982  241 IADCSARNsLYKAYRITLCLASLNSCLDPLIYYFLSKT 278
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
46-309 8.08e-21

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 90.97  E-value: 8.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE--SPGNGTCKvlvgLHSSGLYSEV 123
Cdd:cd15193    9 IIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGqwLFGEGLCK----LSSFIIAVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLL----VQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFyepRMERQKHKCafgkphflpIEAPL 199
Cdd:cd15193   85 CSSILFLtgmsVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVY---RNLINESVC---------VEDSS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLAF--PLLVFIIC-CRQLRRRQS--------FRERQYDlHKPALVITGVFLLMWAPYNTvlfLSAFq 268
Cdd:cd15193  153 SRFFQGISLATLFLTFvlPLIVILFCyCSILVRLRRhfhgakrtGRRRRNS-LRIVFAIVTAFVLSWLPFNT---LKAV- 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 698979997 269 eHLSLQDEKSSYHLDASVQVTQLVATTHC------CVNPLLYLLLDR 309
Cdd:cd15193  228 -RLLLELGGGVLPCHTTVAIRQGLTITAClafvnsCVNPLIYSLLDR 273
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
40-326 1.28e-20

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 91.12  E-value: 1.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  40 VLQFCCAVFAVGLLDNVLAVFILVkYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGL 119
Cdd:PHA02834  31 VIVFYILLFIFGLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVGF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 120 YSEVFSNILLLVQGY-RVFSQGRLASifTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHflpiEAP 198
Cdd:PHA02834 110 FSNMFFVTLISIDRYiLVVNATKIKN--KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYH----ENF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIILVLAFPLLVFIICCRQL-----RRRQSFRERQYDLHKPALVITGVFllmWAPYNTVLFLSAFQEhLSL 273
Cdd:PHA02834 184 SWSAFFNFEINIFGIVIPLIILIYCYSKIlytlkNCKNKNKTRSIKIILTVVTFTVVF---WVPFNIVLFINSLQS-VGL 259
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 698979997 274 QDeKSSYHLDA---SVQVTQLVATTHCCVNPLLYLLLDrKAFMRYLRSLFPRCNDI 326
Cdd:PHA02834 260 ID-IGCYHFKKivySIDIAELISFVHCCVNPIIYAFVG-KNFKKVFKNMFCRTNNI 313
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
47-310 6.09e-20

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 88.29  E-value: 6.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15179   10 IFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTVNLYSSVLIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYrvfsqgrLASIFTTVSCGI-------VACILAWAMATALSLPESVFYEPRMERQKHKCafgkPHFLPIEA-P 198
Cdd:cd15179   90 AFISLDRY-------LAIVHATNSQRPrkllaekVVYVGVWLPALLLTVPDLVFAKVSELDDRYIC----DRIYPEDTfE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIILVLAFPLLVFIIC----CRQLRRRQSFRERQydLHKPALVITGVFLLMWAPYNTVLFLSAFqehLSLQ 274
Cdd:cd15179  159 LWVVAFRFQHILVGLVLPGLVILTCyciiISKLSHSKGHQKRK--ALKTTVILILAFFACWLPYYIGISIDTF---MLLE 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 275 DEKSSYHLDASVQ----VTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15179  234 IIKQSCEMEQTVHkwisITEALAFFHCCLNPILYAFLGAK 273
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
43-322 7.83e-20

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 90.07  E-value: 7.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVkYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:PHA02638 104 FYIIIFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEFDQWIFGDFMCKVISASYYIGFFSN 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPR---------------------MERQ 181
Cdd:PHA02638 183 MFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASniifsaqdsnetisnyqctliEDNE 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 182 KHKCAFgkphflpieaplWKYVLTSKMIILVLAFPLLVFIICCRQ--LRRRQSFRERQYDLHKPALVITGVFLLMWAPYN 259
Cdd:PHA02638 263 KNNISF------------LGRILQFEINILGMFIPIIIFAFCYIKiiLKLKQLKKSKKTKSIIIVSIIIICSLICWIPLN 330
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 698979997 260 TVLFLS---AFQEHLSLQDEK--SSYHLDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYLRSLFPR 322
Cdd:PHA02638 331 IVILFAtmySFKGFNSIISEHicGFIKLGYAMMLAEAISLTHCCINPLIYTLIGEN-FRMHLLMIFRN 397
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-309 9.31e-20

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 87.91  E-value: 9.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDN--VLAVFILvkYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSG 118
Cdd:cd15189    6 FIFSLCLFGLLGNlfVLLVFLL--HRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNwpFGELLCRVVNGVIKVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 119 LYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRM--ERQKHKCAFGKPHFlpie 196
Cdd:cd15189   84 LYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACVLLYPHE---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 apLWKYVLTSKMIILVLAFPLLVFIICCRQL------RRRQSFRERQYDLHKPALV--ITGVFLLMWAPYNTVLFLSaFQ 268
Cdd:cd15189  160 --AWHFAHIVLLNIVGFLLPLLVITFCNYNIlqalrtREESTRCEDRNDSKATALVlaVTLLFLVCWGPYHFFTFLD-FL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 269 EHLSLQDEKSSYH-LDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15189  237 FDVGVLDECFWEHfIDIGLQLAVFLAFSNSCLNPVLYVFVGR 278
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
43-309 9.45e-20

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 87.99  E-value: 9.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGT--CKVLVGLHSSGLY 120
Cdd:cd15194    6 LYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSflCKGSSYIISVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAfgkphflpiEAPLW 200
Cdd:cd15194   86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCN---------EDAGT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAF--PLLVFIICCRQLRRR-----QSFRERQYDLHKP---ALVITGVFLLMWAPYNTVLFLSAFQeh 270
Cdd:cd15194  157 PSKVIFSLVSLIVAFflPLLSILTCYCTIIWKlchhyQKSGKHQKKLRKSikiVFIVVAAFVFSWMPFNLFKALAIAS-- 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 271 lSLQDEK---SSYHLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15194  235 -GLQVEVtclPYTLAQLGMEVSAPLAFANSCANPFIYYFFDR 275
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
47-308 3.40e-19

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 86.20  E-value: 3.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15090   10 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPfGNILCKIVISIDYYNMFTSIFT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHflpieaPLWKYVLT 205
Cdd:cd15090   90 LCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH------PSWYWENL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SKMIILVLAF--PLLVFIIC-------CRQLRRRQSFRERQYDLH---KPALVITGVFLLMWAPYNTVLFLSAFQEHLSL 273
Cdd:cd15090  164 LKICVFIFAFimPVLIITVCyglmilrLKSVRMLSGSKEKDRNLRritRMVLVVVAVFIVCWTPIHIYVIIKALVTIPET 243
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 698979997 274 QDEKSSYHLDASvqvtqlVATTHCCVNPLLYLLLD 308
Cdd:cd15090  244 TFQTVSWHFCIA------LGYTNSCLNPVLYAFLD 272
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
37-309 6.52e-19

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 85.62  E-value: 6.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  37 PQQVLQFCCavfaVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES-P-GNGTCKVLVGL 114
Cdd:cd15380    4 PTFIIAICF----FGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNwPfGNFLCRVISGV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 115 HSSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRM--ERQKHKCAFGKPHf 192
Cdd:cd15380   80 IKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHvpDLNISACILLFPH- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 lpieaPLWKYVLTSKMIILVLAFPL--LVFIICC--RQLRRRQSFRERQY----DLHKPALVITGV--FLLMWAPYNTVL 262
Cdd:cd15380  159 -----EAWHFARRVELNIVGFLLPLaaIVFFNFHiiASLRERTEESRKRCgglkDTKATRLILTLVlmFLVCWTPYHFFA 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 698979997 263 FLSAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15380  234 FLDFLFQVEVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGK 280
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
43-309 6.73e-18

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 82.50  E-value: 6.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFW-AHTAAHGESP-GNGTCKVLVGLHSSGLY 120
Cdd:cd14987    6 FYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWvVSLVQHNQWPmGEFTCKITHLIFSINLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGY-RVFSQGRLASIFTTVSCGIVaCILAWAMATALSLPESVFYepRMERQKHKCAFGKPHFLPIEApL 199
Cdd:cd14987   86 GSIFFLTCMSVDRYlSVTLFGNTSSRRKKIVRRII-CVLVWLLAFVASLPDTYFL--KTVTSPSNNETYCRSFYPEES-F 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLAF----PLL-VFIICCRQLRRRQSFRERQYDlHKPALVITGVFLLMWAPYNTVLFLS--AFQEHLS 272
Cdd:cd14987  162 KEWLIGMELVSIVLGFvipfPIIaVFYFLLARAISASSDQERKSS-RKIIFSYVVVFLVCWLPYHTVVLLDilSFLHLIP 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 273 LQDEKSSYhLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd14987  241 FSCQLENF-LYAALHVTQCFSLVHCCVNPILYSFINR 276
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
47-309 1.20e-17

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 82.17  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLG--NIYFLNLALSNLCFLLPLPFWAHTAA--HGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd14976   10 VFTVGLLGNLLVLYLLKSNKKLRQQSesNKFVFNLALTDLIFVLTLPFWAVEYAldFVWPFGTAMCKVVRYVTKLNMYSS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGY----RVFSQGRLASIFTTvscgIVACILAWAMATALSLPESVFYEPRMERQKHK-CAFGKPHFLPIEA 197
Cdd:cd14976   90 IFFLTALSVTRYiavaRALKHGWIRKAFGA----FATTIAIWAAAALAAIPEAIFSTDTWSSVNHTlCLLRFPKNSSVTR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 plWKYVL----TSKMI--------ILVLAFPLLVFIICcrqlRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLS 265
Cdd:cd14976  166 --WYNWLgmyqLQKVVlgfflplgIITLSYLLLLRFLQ----RKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 698979997 266 AFQEhLSLQDEKSSYHL--DASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd14976  240 ALIK-FDDVPFSDAFFAfqTYAFPVAICLAHSNSCLNPVLYCLVRR 284
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
47-308 4.34e-17

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 80.38  E-value: 4.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15091   10 VFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPfGDVLCKIVISIDYYNMFTSIFT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVF--YEPRMERQKHKCAFGKPhflpiEAPLWKYV 203
Cdd:cd15091   90 LTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLggTKVREDVDSTECSLQFP-----DDDYSWWD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 LTSKMIILVLAF--PLLVFIIC-------CRQLRRRQSFRERQYDLHKPA---LVITGVFLLMWAPYNTVLFLSAfqehl 271
Cdd:cd15091  165 TFMKICVFIFAFviPVLIIIVCytlmilrLKSVRLLSGSREKDRNLRRITrlvLVVVAVFVVCWTPIHIFILVEA----- 239
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 272 sLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLD 308
Cdd:cd15091  240 -LGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLD 275
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
45-312 4.80e-17

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 80.34  E-value: 4.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL--CfLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYS 121
Cdd:cd15203    8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLllC-LVSLPFTLIYTLTKNWPfGSILCKLVPSLQGVSIFV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 122 EVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVFYEprMERQKHKCAFGKPHFLPIEAPLWK 201
Cdd:cd15203   87 STLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALI--WILSLLLSLPLAIFQE--LSDVPIEILPYCGYFCTESWPSSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTSKMIILVL--AFPLLVFIIC----CRQLRRRQSFR---------------ERQYDLHKPALVITGVFLLMWAPYNT 260
Cdd:cd15203  163 SRLIYTISVLVLqfVIPLLIISFCyfriSLKLRKRVKKKrgkrtlssrrrrselRRKRRTNRLLIAMVVVFAVCWLPLNL 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 698979997 261 VLFLSAFqEHLSLQDEKSSYHLDAsvqVTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd15203  243 FNLLRDF-EPLPQIDGRHFYLIFL---ICHLIAMSSACVNPLLYGWLNdnfRKEF 293
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
46-308 1.22e-16

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 79.22  E-value: 1.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15089    9 VVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPfGELLCKAVLSIDYYNMFTSIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVfyeprMERQKHKCAFGKPHFLPIEAPLWKYVL 204
Cdd:cd15089   89 TLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMV-----MAVTKTPRDGAVVCMLQFPSPSWYWDT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAF--PLLVFIIC-------CRQLRRRQSFRERQYDLH---KPALVITGVFLLMWAPYNTVLFLSAFQEhls 272
Cdd:cd15089  164 VTKICVFIFAFvvPILVITVCyglmilrLRSVRLLSGSKEKDRNLRritRMVLVVVAAFIICWTPIHIFVIVWTLVD--- 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 273 lQDEKSSYHLdASVQVTQLVATTHCCVNPLLYLLLD 308
Cdd:cd15089  241 -IDRRNPLVV-AALHLCIALGYANSSLNPVLYAFLD 274
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
45-304 6.25e-16

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 77.10  E-value: 6.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15191    8 SIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNwlFGSVMCKICGSLLTLNLFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVF-----SQGRLASIFTTVscgivaCILAWAMATALSLPESVFYEPRM--ERQKHKCAFGKPhflPI 195
Cdd:cd15191   88 IFFITCMSVDRYLAVvyplrSQRRRSWQARLV------CLLVWVLACLSSLPTFYFRDTYYieELGVNACIMAFP---NE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 196 EAPLWKYVLTSKMIILVLAFPlLVFIICC-----RQLRRRQSFRERQYDLHKPALVITGV---FLLMWAPYNTVLFLSAF 267
Cdd:cd15191  159 KYAQWSAGLALMKNTLGFLIP-LIVIATCyfgigRHLLKTKGFGKNKQRRDKVLKMVAAVvlaFLICWFPFHVLTFLDAL 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 268 QEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15191  238 ARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLY 274
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
46-308 8.16e-16

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 76.83  E-value: 8.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15092    9 IVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPfGNALCKTVIAIDYYNMFTSTF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGkphfLPIEAPLWKYVL 204
Cdd:cd15092   89 TLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVE----IPTPQDYWDPVF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFIIC-------CRQLRRRQSFRERQYDLHKPA---LVITGVFLLMWAPYNTVLFLSafqehlSLQ 274
Cdd:cd15092  165 GICVFLFSFIIPVLIISVCyslmirrLRGVRLLSGSKEKDRNLRRITrlvLVVVAVFVGCWTPIQIFVLAQ------GLG 238
                        250       260       270
                 ....*....|....*....|....*....|....
gi 698979997 275 DEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLD 308
Cdd:cd15092  239 VQPSSETAVAILRFCTALGYVNSSLNPVLYAFLD 272
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
49-307 1.04e-15

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 76.34  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  49 AVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15088   12 VVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQwyFGEVMCKIITALDANNQFTSTYIL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFyeprMERQKHK-----CAFGkphfLPIEAPLWK 201
Cdd:cd15088   92 TAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVY----SSLIYFPdgttfCYVS----LPSPDDLYW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTSkmIILVLAFPLLVFIICCRQLRRR----------QSFRERQYDLHKPALVITGVFLLMWAPYNTVlflsafqEHL 271
Cdd:cd15088  164 FTIYH--FILGFAVPLVVITVCYILILHRlargvapgnqSHGSSRTKRVTKMVILIVVVFIVCWLPFHVV-------QLV 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 272 SLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15088  235 NLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILV 270
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
40-307 1.65e-15

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 75.66  E-value: 1.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  40 VLQFCCAVFA-VGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSS 117
Cdd:cd15973    2 VIQFIYALVClVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPfGSAMCRTVLSVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 118 GLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRM-ERQKHKCAFGKPHflpie 196
Cdd:cd15973   82 NMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATrKGQAVACNLIWPH----- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 aPLWKYVLTSKMIILVLAFPLLVFIIC-------CRQLRRRQSFRER---QYDLHKPALVITGVFLLMWAPYNTVLFLSA 266
Cdd:cd15973  157 -PAWSAAFVIYTFLLGFLLPVLAIGLCyiliigkMRAVALKAGWQQRrksEKKITRMVLMVVTVFVICWMPFYVVQLLNL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 267 FQehlslqdekssYHLDASV-QVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15973  236 FL-----------PRLDATVnHASLILSYANSCANPILYGFL 266
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-307 2.28e-14

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 72.49  E-value: 2.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15093   10 VCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPfGSVLCRLVLSVDGINMFTSIFC 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPR-MERQKHKCAFGKPHflpiEAPLWKYVL 204
Cdd:cd15093   90 LTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTReNQDGSSACNMQWPE----PAAAWSAGF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFIIC-------CRQLRRRQSFRERQYDLHKPA---LVITGVFLLMWAPYNTVLFLSAFQEHLSLQ 274
Cdd:cd15093  166 IIYTFVLGFLLPLLIICLCyllivikVKSAGLRAGWQQRKRSERKVTrmvVMVVVVFVICWLPFYVLQLVNVFVQLPETP 245
                        250       260       270
                 ....*....|....*....|....*....|...
gi 698979997 275 DEKSSYHLdasvqvTQLVATTHCCVNPLLYLLL 307
Cdd:cd15093  246 ALVGVYHF------VVILSYANSCANPILYGFL 272
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
44-309 2.95e-14

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 71.72  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  44 CCAVFAVGLLDNVLAVFIL-VKYKglKNLGNIYFLNLALSNLCFLLPLPF-WAHTAAHGESP-GNGTCKVLvglhSSGLY 120
Cdd:cd15115    7 LSLTFLLGVPGNGLVIWVAgLKMK--RTVNTIWFLNLAVADLLCCLSLPFsIAHLLLNGHWPyGRFLCKLL----PSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVqgyrVFSQGRLASIFTTVSC--------GIVACILAWAMATALSLPESVFYEPRMERQKHKCAFgkphf 192
Cdd:cd15115   81 LNMFASVFTLT----AISLDRFLLVIKPVWAqnhrsvllACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGY----- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 lpieaplwKYVLTSKMIILVLAF--PLLVFIICCRQLRRR---QSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSaf 267
Cdd:cd15115  152 --------DFLVAITITRAVFGFllPLLIIAACYSFIAFRmqrGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILS-- 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 268 qehlSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15115  222 ----LYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGK 259
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
49-307 3.34e-14

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 72.15  E-value: 3.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  49 AVGLLDNVLAVFILVKYKGlKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15339   12 STGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEwvFGSPLCTIITSLDTCNQFACSAIM 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPesVFYEPRMERQK---HKCAFGkphflpIEAPLWKYV 203
Cdd:cd15339   91 TAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLP--VWVYAKVIKFRdglESCAFN------LTSPDDVLW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 LTSKMIILVLAFPLLVFIIC-----------CRQLRRRQSF-----RERQYDLHKPALVITGVFLLMWAPYNTVlflsaf 267
Cdd:cd15339  163 YTLYQTITTFFFPLPLILICyililcytwemYRKNKKAGRYntsipRQRVMRLTKMVLVLVGVFLVSAAPYHVI------ 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 268 qEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15339  237 -QLVNLSVSQPTLAFYVSYYLSICLSYASSSINPFLYILL 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
47-310 3.75e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 71.85  E-value: 3.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLPFWAHtAAHGESPGNGTCKV---LVGLhsSGLY 120
Cdd:cd14969   10 IGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLlmsVVGYPLSFYSN-LSGRWSFGDPGCVIygfAVTF--LGLV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SeVFSNILLLVQGYRVFSQGRLASIFTTvSCGIVACILAWAMATALSLPESVF---YEPrmERQKHKCAfgkPHFLPIEA 197
Cdd:cd14969   87 S-ISTLAALAFERYLVIVRPLKAFRLSK-RRALILIAFIWLYGLFWALPPLFGwssYVP--EGGGTSCS---VDWYSKDP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 PLWKYVLTskMIILVLAFPLLVFIICC-------RQLRRRQSFRERQYDLHKP----------ALVITGVFLLMWAPYNT 260
Cdd:cd14969  160 NSLSYIVS--LFVFCFFLPLAIIIFCYykiyrtlRKMSKRAARRKNSAITKRTkkaekkvakmVLVMIVAFLIAWTPYAV 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 698979997 261 VLFLSAFQEhlslqDEKSSYHLdasVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd14969  238 VSLYVSFGG-----ESTIPPLL---ATIPALFAKSSTIYNPIIYVFMNKQ 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
47-306 2.75e-13

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 69.41  E-value: 2.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHG-ESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15381   10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPfGEFLCKSVNAVIYMNLYSSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGY----RVFSQGRLasifTTVSCGIVACILAWAMATALSLPESVF----YEPrmERQKHKCAFGKPhflpie 196
Cdd:cd15381   90 FLMMVSIDRYlalvKTMSSGRM----RRPACAKLNCLIIWMFGLLMSTPMIVFrtvmYFP--EYNITACVLDYP------ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKyvLTSKMIILVLAF--PLLVFIICCRQL------RRRQSFRERQYDLHKPALVITG--VFLLMWAPYNTVLFLSA 266
Cdd:cd15381  158 SEGWH--VALNILLNVVGFliPLSIITFCSTQIiqvlrnNKMQKFKEIQTERKATVLVLAVllMFFICWLPFHIFTFLDT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 267 FQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLL 306
Cdd:cd15381  236 LHKLGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVI 275
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
46-310 3.16e-13

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 68.97  E-value: 3.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFilVKYKGLKN-LGNIYFLNLALSNLCFLLPLPFWA-HTAAHGESP-GNGTCKVLvglhSSGLYSE 122
Cdd:cd15114    9 VVFLVGVPGNALVAW--VTGFEAKRsVNAVWFLNLAVADLLCCLSLPILAvPIAQDGHWPfGAAACKLL----PSLILLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVqgyrVFSQGRLASIFTTVSCG--------IVACILAWAMATALSLPESVFYEPRMER--QKHKCAFGKPHF 192
Cdd:cd15114   83 MYASVLLLT----AISADRCLLVLRPVWCQnhrrarlaWIACGAAWLLALLLTVPSFIYRRIHQEHfpEKTVCVVDYGGS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIEaplwkyvLTSKMIILVLAF--PLLVFIICCRQLRRRQSFRERQYDlHKPALVITGV---FLLMWAPYNTVLFLSAF 267
Cdd:cd15114  159 TGVE-------WAVAIIRFLLGFlgPLVVIASCHGVLLVRTWSRRRQKS-RRTLKVVTAVvvgFFLCWTPYHVVGLIIAA 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 698979997 268 QEHLSLQDEKssyhLDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15114  231 SAPNSRLLAN----ALKADPLTVSLAYINSCLNPIIYVVAGRG 269
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
47-310 5.91e-13

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 68.39  E-value: 5.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLPFWAHTAAhGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd14993   10 VFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLlvsLFCMPLTLLENVYR-PWVFGEVLCKAVPYLQGVSVSASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCgIVACILA-WAMATALSLPESVFYepRMERQKHKCAFGKPHFLPIE---APL 199
Cdd:cd14993   89 LTLVAISIDRYLAICYPLKARRVSTKRR-ARIIIVAiWVIAIIIMLPLLVVY--ELEEIISSEPGTITIYICTEdwpSPE 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLAFPLLVFIICC----RQLRRRQSFRERQYDLHKPA--------------LVITGVFLLMWAPYNTV 261
Cdd:cd14993  166 LRKAYNVALFVVLYVLPLLIISVAYsligRRLWRRKPPGDRGSANSTSSrrilrskkkvarmlIVVVVLFALSWLPYYVL 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997 262 LFLSAFQehlSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd14993  246 SILLDFG---PLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKK 291
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
47-312 1.05e-12

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 67.50  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15094   10 ICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPfGAAMCKIYMVLTSINQFTSSFT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAplWKyVLT 205
Cdd:cd15094   90 LTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNG--QK-AFT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SKMIILVLAFPLLV----FIICCRQLRR------RQSFRERQYDLHKPALVITGVFLLMWAPYntvlflSAFQEHLSLQD 275
Cdd:cd15094  167 LYTFLLGFAIPLLLisvfYTLVILRLRTvgpknkSKEKRRSHRKVTRLVLTVISVYIICWLPY------WAFQVHLIFLP 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 698979997 276 EK---SSYHLDASvQVTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd15094  241 PGtdmPKWEILMF-LLLTVLSYANSMVNPLLYAFLSenfRKSF 282
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
47-316 1.67e-12

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 67.21  E-value: 1.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNvLAVFILVKYKGLKNLG--NIYFLNLALSNLCFLLPLPFWAHTAAHGES-P-GNGTCKVLVGLHSSGLYSE 122
Cdd:cd15925   10 VCAIGLLGN-LAVMYLLRNCARRAPPpiDVFVFNLALADFGFALTLPFWAVESALDFHwPfGGAMCKMVLTATVLNVYAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKY 202
Cdd:cd15925   89 VFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNYWLGAYHLQR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMI-ILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYH 281
Cdd:cd15925  169 VVVAFVVpLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFRAVPWNSTFYF 248
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 282 LDASV-QVTQLVATTHCCVNPLLYLLLdRKAFMRYL 316
Cdd:cd15925  249 IHTYVfPVTTCLAHSNSCLNPVLYCLM-RREFRQAL 283
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
47-304 2.46e-12

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 66.71  E-value: 2.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15154   10 LFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPfGNFLCQFSGSIFQMNMYGSCLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGY---------RVFSQGRLASIfttvscgivACILAWAMATALSLPESvfyepRMERQKHKCAFGKPHFLPIE 196
Cdd:cd15154   90 LMCINVDRYlaivhplrfRHLRRPKVARL---------LCLAVWALILGGSVPAA-----IVHSSSDCLLHGEKVYRCFE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 A---PLWKYVLTSKMIILVLAF--PLLVFIICCRQL-----RRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSA 266
Cdd:cd15154  156 SfsdNDWKGLLPLVVLAEILGFllPLAAVLYCSCRIfvelcRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYG 235
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 698979997 267 FQEHLSLQDEKSSY-HLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15154  236 LLRANLVEDTWNIKdTLRKVLSVTVLLASTNCALDPLVY 274
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
47-312 4.00e-12

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 65.94  E-value: 4.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFIlVKYKGLKNLGNIYFLNLALSNLCFLLPLPF-WAHTAAHGESP-GNGTCKvlvgLHSSGLYSEVF 124
Cdd:cd15116   10 VFVLGVLGNGLVIFI-TGFKMKKTVNTVWFLNLAVADFLFTFFLPFsIAYTAMDFHWPfGRFMCK----LNSFLLFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVqgyrVFSQGRLASIF--------TTVSCGIVACILAWAMATALSLPESVFYE--PRMERQKHKC----AFGKP 190
Cdd:cd15116   85 TSVFLLT----VISIDRCISVVfpvwsqnhRSVRLASLVSLAVWVVAFFLSSPSFIFRDtaPSQNNNKIICfnnfSLSGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 191 HFLPIEAPLwKYVLTSKMIILVLAFPLLV---FIICCR-----QLRRRQSFRERqydlhKPALVITGV---FLLMWAPYN 259
Cdd:cd15116  161 NSSPEVNQL-RNMRHQVMTITRFLLGFLIpftIIICCYaaivlKLKRNRLAKSS-----KPFKIIAAVivtFFLCWAPYH 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 698979997 260 TVLFLSAFQEHLslqdekSSYHLDASVQVTQLVATTHCCVNPLLYLLL--DRKAF 312
Cdd:cd15116  235 ILNLLEMEATRS------PASVFKIGLPITSSLAFINSCLNPILYVFMgqDFKKF 283
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
47-304 5.88e-12

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 65.33  E-value: 5.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKV-----LVGLHSSGLY 120
Cdd:cd15155   10 VFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPfGDSLCKIsgtafLTNIYGSMLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQgrlaSIFTTVSCGIVaCILAWAMATALSLPESVFYEPRMERQKHKCafgkphFLPIEAPLW 200
Cdd:cd15155   90 LTCISVDRFLAIVYPFRSR----TIRTRRNSAIV-CAGVWILVLSGGISASLFSTTNVSNTSTTC------FEGFSKSIW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMI-ILVLAF--PLLVFIICC----RQLRRRQSFRE---RQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEH 270
Cdd:cd15155  159 KTYLSKITIfIEVVGFiiPLLLNLTCSslvlRTLRKPATLSQigtNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRS 238
                        250       260       270
                 ....*....|....*....|....*....|....
gi 698979997 271 LSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15155  239 QAIANCGVERFARTMYPITLCLATLNCCFDPFVY 272
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
47-304 6.77e-12

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 65.15  E-value: 6.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKvlvgLHSSGLYSEVF 124
Cdd:cd15158   10 ITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQwlFGDFLCR----ISSYALYVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVqgyrVFSQGR-LASIF-------TTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgkphFLPIE 196
Cdd:cd15158   86 CSIYFMT----AMSFTRfLAIVFpvqnlnlVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC------FEPPQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWK-YVLTSKMIILVLAF--PLLVFIIC----CRQLRRRQSFRERQYDLHKPAL----VITGVFLLMWAPYN---TVL 262
Cdd:cd15158  156 SNQQLtKLLVLNYISLVVGFiiPFLVILICyamiIRTLLKNTMKARKQQSSRKKAIrmiiIVLLAFLVSFMPYHiqrTIH 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 263 FLSAFQEHLSLQDeksSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15158  236 LHFLSRKDSTCEE---VLYMQKSVVITLCLAAANCCFDPLLY 274
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
47-310 7.08e-12

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 65.30  E-value: 7.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLG-NIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15926   10 VCALGLVGNLLVLYLMKSKQGWKKSSiNLFVTSLAVTDFQFVLTLPFWAVENALDFTwlFGKAMCKIVSYVTAMNMYASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGrLASIFTTVSCGIVA-CILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPiEAPLWKY 202
Cdd:cd15926   90 FFLTAMSVARYHSVASA-LKSKRRRGCCSAKWlCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRG-NAQFWLG 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIICCRQLRRRQSFR-------ERQYDLHKPALVITGVFLLMWAPyNTVLFLSAFQEHLSLQD 275
Cdd:cd15926  168 LYHAQKVLLGFLIPLGIISLCYLLLVRFITDKnitgsstKRRSKVTKSVTIVVLSFFLCWLP-NQALTTWGILIKLNVVH 246
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 276 EKSSYHLDAS--VQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15926  247 FSYEYFTTQVyiFPITVCLAHSNSCLNPILYCLMRRE 283
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
45-309 1.13e-11

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 64.76  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVkYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES-P-GNGTCKVLVGLHSSGLYSE 122
Cdd:cd15117    8 SSAFVLGTLGNGLVIWVTG-FRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHwPfGWFLCKLYSTLVVFNLFAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFsnILLLVQGYRVFSQGR--LASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKC--AFGKPHFLPIEAP 198
Cdd:cd15117   87 VF--LLTLISLDRCVSVLWpvWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCylNFDPWNETAEDPV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIIL-----VLAFPLLVFIIC-CRQLRRRQSFRERQYDLHKPALVITGV---FLLMWAPYNTVLFLsafqE 269
Cdd:cd15117  165 LWLETVVQRLSAQvitrfVLGFLVPLVIIGgCYGLIAARLWREGWVHSSRPFRVLTAVvaaFFLCWFPFHLVSLL----E 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 270 HLSLQDEKSSYH--LDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15117  241 LVVILNQKEDLNplLILLLPLSSSLACVNSCLNPLLYVFVGR 282
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
47-313 1.16e-11

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 64.22  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLPFWAHTAAHGeSPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15001    9 TFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLlllVFCVPLKTAEYFSPTW-SLGAFLCKAVAYLQLLSFICSV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP-----ESVFYEPRMERQKHKCafgkphFLPIEAP 198
Cdd:cd15001   88 LTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPvlfgqGLVRYESENGVTVYHC------QKAWPST 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQsfrerqydLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLqDEKS 278
Cdd:cd15001  162 LYSRLYVVYLAIVIFFIPLIVMTFAYARDTRKQ--------VIKMLISVVVLFAVCWGPLLIDNLLVSFDVISTL-HTQA 232
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 698979997 279 SYHLDasvQVTQLVATTHCCVNPLLYllldrkAFM 313
Cdd:cd15001  233 LKYMR---IAFHLLSYANSCINPIIY------AFM 258
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
47-304 1.99e-11

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 63.67  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15921   10 IFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHwpFGDIACRIILYVLYVNMYSSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgkphflpIEAPLW--KY 202
Cdd:cd15921   90 FLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRC---------LELAHDavDK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAF--PLLVFIIC----CRQLRRRQSFRERQYDLHKPAL----VITGVFLLMWAPYNTVLFLSAFQEHLS 272
Cdd:cd15921  161 LLLINYVTLPVGFvvPFMTVIFCyifiIKNLLKPSPALGRTRPSRRKACaliiISLGIFLVCFLPYHIVRTIHLITERQI 240
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 273 LQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15921  241 KESCGYILRVRKAAVITLCLAASNSCFDPLLY 272
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
45-316 2.12e-11

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 63.98  E-value: 2.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL-PLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSE 122
Cdd:cd14977    8 LVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLlCVPLNAYNLLTKDWLfGDVMCKLVPFIQVTSLGVT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQgrlasifTTVSCGIVAC-------ILAWAMATALSLPESVFYEPRMERQKHkcafGKPHFLPI 195
Cdd:cd14977   88 VFSLCALSIDRYRAAVN-------SMPMQTIGAClstcvklAVIWVGSVLLAVPEAVLSTVARESSLD----NSSLTVCI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 196 EAPLWKYVLTSKMIILVLAF------PLLVFIIC----CRQLRRRQSFRERQYDLH--------KPALVITGVFLLMWAP 257
Cdd:cd14977  157 MKPSTPFAETYPKARSWWLFgcyfclPLAFTAVCyllmARTLIRAAKEYTRGTKKHmkqrrqlaKTVLCLVLVFAFCWLP 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 698979997 258 YNTVLFLSAFQEHlSLQDEKSSYHLDASVqVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd14977  237 EHISNILRATLYN-EVLIDTRSTLDILDL-IGQFLSFFNSCVNPIALYLLSEP-FRRAF 292
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
46-309 5.73e-11

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 62.40  E-value: 5.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE--SPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15160    9 FVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHnwTFGPLSCKVVGFFFYTNIYASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKphflpieAPLWKYV 203
Cdd:cd15160   89 GFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCYEK-------YPMEGWQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 LTSKMIILVLAFPL-LVFIICC-----RQLRRRQSF-RERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15160  162 ASYNYARFLVGFLIpLSLILFFyrrvlRAVRQSPSLeREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGLC 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 698979997 277 KSSYHLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15160  242 GFEKRVFTAYQISLCLTSLNCVADPILYIFVTE 274
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
45-320 6.26e-11

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 62.42  E-value: 6.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPF---WAHTAAHgeSPGNGTCKVLVGLHSSGLY 120
Cdd:cd15195    8 WVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMdavWNYTVEW--LAGDLMCRVMMFLKQFGMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNIlllvqgyrVFSQGRLASIFTTVSCG------IVACILAWAMATALSLPESVFYE--PRMERQK--HKCAfgKP 190
Cdd:cd15195   86 LSSFMLV--------VIALDRVFAILSPLSANqarkrvKIMLTVAWVLSALCSIPQSFIFSvlRKMPEQPgfHQCV--DF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 191 HFLPIEAPLWKYVLTS-------KMIILVLAFPLLVFIICCRQLRRRQSF-------------RERQYDLhKPALVITGV 250
Cdd:cd15195  156 GSAPTKKQERLYYFFTmilsfviPLIITVTCYLLILFEISKMAKRARDTPisnrrrsrtnsleRARMRTL-RMTALIVLT 234
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 251 FLLMWAPYNTVLFLSAFQEHLSLQDEKSSYHldasvqVTQLVATTHCCVNPLLYllldrKAFMRYLRSLF 320
Cdd:cd15195  235 FIVCWGPYYVLGLWYWFDKESIKNLPPALSH------IMFLLGYLNPCLHPIIY-----GVFMKEIRNWI 293
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
46-310 7.58e-11

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 62.04  E-value: 7.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILV--KYKGLKNLGNIYFLNLALSNLCFLL-PLPFwaHTAAHGESP---GNGTCKVLVGLHSSGL 119
Cdd:cd15002    8 VICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLfSVPF--RAAAYSKGSwplGWFVCKTADWFGHACM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 120 YSEVFSNILLLVQGYR-VFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVFYEPRMERQKHKCAFgkphflpieap 198
Cdd:cd15002   86 AAKSFTIAVLAKACYMyVVNPTKQVTIKQRRITAVVASI--WVPACLLPLPQWLFRTVKQSEGVYLCIL----------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIILVLAFPLLVFII-----------CCRQLRRR----QSFRE--RQYDLHKPALVITGVFLLMWAPyNTV 261
Cdd:cd15002  153 CIPPLAHEFMSAFVKLYPLFVFCLpltfalfyfwrAYGQCQRRgtktQNLRNqiRSRKLTHMLLSVVLAFTILWLP-EWV 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997 262 LFLSafqehLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15002  232 AWLW-----LIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEE 275
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
47-307 2.56e-10

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 60.59  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15974   10 VCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPfGSFLCRLVMTVDGVNQFTSIFC 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEprMERQKHKCAFGKPHflPIEapLWKYVLT 205
Cdd:cd15974   90 LTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSD--VQPDLNTCNISWPE--PVS--VWSTAFI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SKMIILVLAFPLLVFIICCRQL--------------RRRQSFRErqydLHKPALVITGVFLLMWAPYNTvlfLSAFQEHL 271
Cdd:cd15974  164 IYTAVLGFFGPLLVICLCYLLIvikvkssglrvgstKRRKSERK----VTRMVVIIVVVFVFCWLPFYM---LNIVNLIV 236
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 272 SLQDEKSSYHLDASVQVtqlVATTHCCVNPLLYLLL 307
Cdd:cd15974  237 ILPEEPAFVGVYFFVVV---LSYANSCANPILYGFL 269
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-310 2.89e-10

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 60.53  E-value: 2.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHT-AAHGESPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd14999    8 LMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTyFLKKWYFGDVGCRLLFSLDFLTMHASIF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQgRLASIFTTVSCGIVACILAWAMATALSLPESVFYepRMERQKHKCAFGKPHFLPIEAPLWKYVL 204
Cdd:cd14999   88 TLTVMSTERYLAVVK-PLDTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMI--RLVTVEDKSGGSKRICLPTWSEESYKVY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFIIC--------CRQLRRRQSFRERQYDLHKPALVITGVFLLMWA---PYNTVLFLSAFQEHLSL 273
Cdd:cd14999  165 LTLLFSTSIVIPGLVIGYLyirlarkyWLSQAAASNSSRKRLPKQKVLKMIFTIVLVFWAcflPFWIWQLLYLYSPSLSL 244
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 698979997 274 QDEKSSYhldasVQ-VTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd14999  245 SPRTTTY-----VNyLLTCLTYSNSCINPFLYTLLTKN 277
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
45-306 4.61e-10

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 59.70  E-value: 4.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF----LLPLPFWAHTAAHgeSPGNGTCKVLVGLHSSGLY 120
Cdd:cd14986    8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVafftVLTQIIWEATGEW--VAGDVLCRIVKYLQVVGLF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRV------FSQGRLASIFTTVScgivacilAWAMATALSLPES-VFYEPRMERQKHKCafgKPHFl 193
Cdd:cd14986   86 ASTYILVSMSLDRYQAivkpmsSLKPRKRARLMIVV--------AWVLSFLFSIPQLvIFVERELGDGVHQC---WSSF- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 194 pIEAPLWKYVLTSkMIILVLAFPLLVFIIC-----------CRQLRRRQSFRE---------RQYDLH----------KP 243
Cdd:cd14986  154 -YTPWQRKVYITW-LATYVFVIPLIILSYCygrilrtiwirSRQKTDRPIAPTamscrsvscVSSRVSlisrakiktiKM 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 698979997 244 ALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDekssyhlDASVqVTQLVATTHCCVNPLLYLL 306
Cdd:cd14986  232 TLVIILAFILCWTPYFIVQLLDVYAGMQQLEN-------DAYV-VSETLASLNSALNPLIYGF 286
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
40-312 7.58e-10

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 59.02  E-value: 7.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  40 VLQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL----------PLPFWAHtaahgespGNGTCK 109
Cdd:cd14971    3 VPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfcvpftatiyPLPGWVF--------GDFMCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 110 VLVGLHSSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHK--CAF 187
Cdd:cd14971   75 FVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRtvCSE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 188 GKPhflpiEAPLWKYVLTSKMIILVLaFPLLVFIIC----CRQLRR--------RQSFRERQyDLHKPALVITGVFLLMW 255
Cdd:cd14971  155 AWP-----SRAHRRAFALCTFLFGYL-LPLLLICVCyaamLRHLWRvavrpvlsEGSRRAKR-KVTRLVLVVVVLFAACW 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 698979997 256 APYNTVLFLSAF-QEHLslqdeksSYHLDASVQVTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd14971  228 GPIHAILLLVALgPFPL-------TYATYALRIWAHCLAYSNSAVNPVLYAFLSehfRKAF 281
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
46-307 1.95e-09

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 57.86  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFW--AHTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd14988    9 VIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWmlEVMLDYTWLWGSFLCKFTHYFYFANMYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGY------RVFSQGRLASIFTTVSCGIvacilaWAMATALSLPESVFYEpRMERQKHKCAFGKPHFLPIEA 197
Cdd:cd14988   89 FFLTCLSVDRYltltssSPFWQQHQHRIRRALCAGI------WVLSAIIPLPEVVHMQ-LLDGVEPMCLFLAPFETYDEW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 PLWKYVLTSKMIILVLAFPLLVF-IICCRQLRRRQSFRERQYDLHKPALVItgVFLLMWAPYNTVLFLsafqehLSLQDE 276
Cdd:cd14988  162 ALAVSLLTLIIGFLIPFSIIAVFnVLTARYIRTAGRPESRRHCLLIYAYIL--VFVVCWLPYHVTLLL------LTLHGS 233
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 277 KSSYH------LDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd14988  234 HISLHcnlvhfLYFFYDVIDCFSLLHCVANPILYNFL 270
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
50-306 2.02e-09

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 57.89  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVFIlVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKvlvgLHSSGLYSEVFSNI 127
Cdd:cd15118   13 LGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTweLGTTFCR----IHSSIFFLNMFVSG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 128 LLL----VQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPrMERQKHK--CAFGKPHFLPIEAPL-- 199
Cdd:cd15118   88 FLLaaisLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDV-IERKDGRklCYYNFALFSPSPDNNhp 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 ----WKYVLTSKMIILVLAFPLLVFIICCRQ--LRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAfqehlsl 273
Cdd:cd15118  167 ickqRQEGLAISKLLLAFLIPLVIIAVSYAVvsLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEV------- 239
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 274 qDEKSSYHLDASVQVTQLVATT----HCCVNPLLYLL 306
Cdd:cd15118  240 -MAHNQHSLRPLVIQGLPFATTlaflNSVLNPVLYVF 275
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
45-304 3.41e-09

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 57.32  E-value: 3.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLG-NIYFLNLALSNLC---FLLPLPF-WAHTAA-HGespGNGTCKVLVGLHSSG 118
Cdd:cd15382    8 SVLFLIAAVGNLTVLLILLRNRRRKRSRvNILLMHLAIADLLvtfIMMPLEIgWAATVAwLA---GDFLCRLMLFFRAFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 119 LYseVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEprmeRQKHKCA--------FGkp 190
Cdd:cd15382   85 LY--LSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFH----VESHPCVtwfsqcvtFN-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 191 hFLPIEAPLWKYVLTSkmIILVLAFPLLVFIIC-----------------------CRQLRRRQSF----RERQYDLhKP 243
Cdd:cd15382  157 -FFPSHDHELAYNIFN--MITMYALPLIIIVFCyslilceisrkskekkedvseksSSVRLRRSSVglleRARSRTL-KM 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 698979997 244 ALVITGVFLLMWAPYNTVLFLSAFqehlslqDEKSSYHLDASVQ-VTQLVATTHCCVNPLLY 304
Cdd:cd15382  233 TIVIVLVFIICWTPYFIMSLWYWF-------DRESASKVDPRIQkGLFLFAVSNSCMNPIVY 287
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-312 4.03e-09

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 57.04  E-value: 4.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLG--NIYFLNLALSNLCFLL-PLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSE 122
Cdd:cd15098   10 IFCLGVLGNSLVITVLARVKPGKRRSttNVFILNLSIADLFFLLfCVPFQATIYSLPEWVfGAFMCKFVHYFFTVSMLVS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFlpiEAPLWKY 202
Cdd:cd15098   90 IFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQTFCWENW---PEKQQKP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIIC--------CRQLRRRQSFRERQYD-LHKPALVITGVFLLMWAPYNTVLFLSAFqehlsl 273
Cdd:cd15098  167 VYVVCTFVFGYLLPLLLITFCyakvlnhlHKKLKNMSKKSERSKKkTAQTVLVVVVVFGISWLPHHIIHLWVEF------ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 698979997 274 qdekSSYHLDASVQVTQLVAttHC------CVNPLLYLLLD---RKAF 312
Cdd:cd15098  241 ----GDFPLTQASFVLRITA--HClayansCVNPIIYAFLSenfRKAY 282
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
43-312 4.78e-09

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 56.42  E-value: 4.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP-GNGTCKVLVGLHssglY 120
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPfGPVLCRFWIALD----V 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVqgyrVFSQGRLASI----------FTTVSCGIVACIlaWAMATALSLPESVFY--EPRMERQKHKCAFg 188
Cdd:cd14967   81 LCCTASILNLC----AISLDRYLAItrplryrqlmTKKRALIMIAAV--WVYSLLISLPPLVGWrdETQPSVVDCECEF- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 189 kphflpieAPLWKYVLTSKMIILVLafPLLVFIIC-CRQLRRRQsfRERqydlhKPAL---VITGVFLLMWAPYNTVLFL 264
Cdd:cd14967  154 --------TPNKIYVLVSSVISFFI--PLLIMIVLyARIFRVAR--REL-----KAAKtlaIIVGAFLLCWLPFFIIYLV 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 698979997 265 SAFQEHLSLQDEKSSyhldasvqVTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd14967  217 SAFCPPDCVPPILYA--------VFFWLGYLNSALNPIIYALFNrdfRRAF 259
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
47-312 5.02e-09

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 56.54  E-value: 5.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL-PLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15096   10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVfCVPFTATDYVLPTWPfGDVWCKIVQYLVYVTAYASVY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP----ESVFYEPRMERQKHKCAFGKPHFLPIEAPLW 200
Cdd:cd15096   90 TLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPvlflHGVVSYGFSSEAYSYCTFLTEVGTAAQTFFT 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAFPLLVFIICCRQL-------RRRQSFRERQydlHKPALVIT--GVFLLMWAPYNTVLFLSAFqehl 271
Cdd:cd15096  170 SFFLFSYLIPLTLICVLYMLMLRRLRRqkspggrRSAESQRGKR---RVTRLVVVvvVVFAICWLPIHIILLLKYY---- 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 698979997 272 slqDEKSSYHLDASVQVT-QLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd15096  243 ---GVLPETVLYVVIQILsNCLAYGNSCVNPILYAFLSqnfRKAF 284
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
50-307 5.68e-09

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 56.46  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFSNIL 128
Cdd:cd15970   13 VGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPfGSLLCRLVLSVDAINMFTSIYCLTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 129 LLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKH-KCAFgkphFLPIEAPLWKYVLTSK 207
Cdd:cd15970   93 LSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSvACNM----QMPEPSQRWLAVFVVY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 208 MIILVLAFPLLVFIIC-------CRQLRRRQSFRERQYDLHKPALVIT---GVFLLMWAPYNTVLFLSAFQEhlslQDek 277
Cdd:cd15970  169 TFLMGFLLPVIAICLCyiliivkMRVVALKAGWQQRKRSERKITLMVMmvvTVFVICWMPFYVVQLVSVFVG----QH-- 242
                        250       260       270
                 ....*....|....*....|....*....|.
gi 698979997 278 ssyhlDASV-QVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15970  243 -----DATVsQLSVILGYANSCANPILYGFL 268
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
46-309 9.71e-09

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 55.99  E-value: 9.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSN-LCFLLPLPFWA-HTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15396    9 VVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDvLVCVMCIPFTAvYTLMDHWIFGETMCKLTSFVQSVSVSVSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSC-GIVaciLAWAMATALSLPESVFYEPRMERQKH---KCAFGKPHFLPIEApl 199
Cdd:cd15396   89 FSLVLIAIERYQLIVNPRGWKPSASHAYwGIV---LIWLFSLMISIPFLIFHQLTDEPFRNlssHSDFYKDKVVCIEA-- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 W-----KYVLTSKMIILVLAFPLLVFIICCRQ----LRRRQSFRERQYD----------LHKPALVITGVFLLMWAPYNT 260
Cdd:cd15396  164 WpseteRLIFTTSLLVFQYFVPLGFIFICYLKifvcLKKRNSKIDRMREnesrlsenkrINTMLISIVVTFAACWLPLNI 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 698979997 261 vlFLSAFQ-EHLSLQdeksSYHLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15396  244 --FNVVFDwNHEVLM----SCHHNLVFTLCHLVAMVSTCINPIFYGFLNK 287
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
45-310 1.59e-08

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 55.13  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFIlVKYKGLKNLGNIYFLNLALSNLCFLLPLPFW-AHTAAHGESP-GNGTCKVLVGLHSSGLYSE 122
Cdd:cd15119    8 IVAFVLGVPGNAIVIWV-TGFKWKKTVNTLWFLNLAIADFVFVLFLPLHiTYVALDFHWPfGVWLCKINSFVAVLNMFAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPieaplwKY 202
Cdd:cd15119   87 VLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKHD------GD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLA-------FPLLVFIIC--CRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHlsl 273
Cdd:cd15119  161 LIVMRHTILVWVrfffgflFPLLTMVVCysLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHH--- 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 274 qDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15119  238 -SSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKK 273
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
45-304 1.99e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 54.75  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLavFILVKYKGLKNLGNIY--FLNLALSNL---CFLLP-LPFWAHTAAHgeSPGNGTCKVLVGLHSSG 118
Cdd:cd15384    8 AVMFVISFIGNLL--TIIQIYRLRRSRRTIYslLLHLAIADLlvtFFCIPsEAIWAYTVAW--LAGNTMCKLVKYLQVFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 119 LYSEVFsnILLLVQGYRVFS---------QGRLASIFTTVscgivacilAWAMATALSLPESV-FYEPRMERQK--HKC- 185
Cdd:cd15384   84 LYLSTY--ITVLISLDRCVAilypmkrnqAPERVRRMVTV---------AWILSPIFSIPQAViFHVERGPFVEdfHQCv 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 186 AFGkphflpIEAPLWKYVLTSkMIILVLAF--PLLVFIIC-----------------------CRQLRRRQSFRERQYDL 240
Cdd:cd15384  153 TYG------FYTAEWQEQLYN-MLSLVFMFpiPLVIMVTCyvlifitlskssrdfqgleiytrNRGPNRQRLFHKAKVKS 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 698979997 241 HKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYHLdasvqvtqLVATTHCCVNPLLY 304
Cdd:cd15384  226 LRMSAVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIF--------FFGMSNSCVNPLIY 281
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
47-304 2.68e-08

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 54.47  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLhssgLYSEVFS 125
Cdd:cd15156   10 VFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPfGDLLCKISVTL----FYTNMYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVqgyrVFSQGR-LASIFTTVSCGI-------VACILAWAMATALSLPESVFYEP--RMERQKHKCafgkphFLPI 195
Cdd:cd15156   86 SILFLT----CISVDRfLAIVYPFRSKTLrtkrnakIVCAAVWLTVLAGSLPASFFQSTnnQLNNNSETC------FENF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 196 EAPLWKYVLtSKMIILV----LAFPLLVFIICC----RQLRRRQSFRERQYDLHKPALVIT---GVFLLMWAPYNTVLFL 264
Cdd:cd15156  156 SSKTWKTYL-SKIVIFIeivgFFIPLILNVTCStmvlKTLRRPNTLSRSKLNKKKVLKMIFvhlFIFCFCFIPYNVNLVL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 265 SAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15156  235 YSLVRTQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVY 274
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
47-316 2.82e-08

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 54.54  E-value: 2.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFWA-HTAAHGESPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15123   10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDAtRYIADTWLFGRIGCKLLSFIQLTSVGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYR--VFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVFYEPRMERQKHK-CAFGKPHFLPIEAPLWK 201
Cdd:cd15123   90 TLTVLSADRYRaiVKPLELQTSDAVLKTCCKAGCV--WIVSMLFAIPEAVFSDLYSFRDPEKnTTFEACAPYPVSEKILQ 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTSKMIILVLAFPLLV----FIICCRQLRR--------RQSFRERQYD----LHKPALVITGVFLLMWAPYNTVLFLS 265
Cdd:cd15123  168 EIHSLLCFLVFYIIPLSIisvyYFLIARTLYKstfnmpaeEHSHARKQIEsrkrVAKTVLVLVALFAFCWLPNHILYLYR 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 698979997 266 AFQEHLSLqdEKSSYHLDASVqVTQLVATTHCCVNPL-LYLLldRKAFMRYL 316
Cdd:cd15123  248 SFTYHTSV--DSSAFHLIATI-FSRVLAFSNSCVNPFaLYWL--SKSFRQHF 294
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
44-309 2.93e-08

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 54.19  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  44 CCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLP---FWAHTAAHGEspgnGTCKVLVGLHSS 117
Cdd:cd15210    7 GIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLlfcAFNLPLAastFLHQAWIHGE----TLCRVFPLLRYG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 118 GLYSEVFSNILLLVQGY-RVFSQGRLASIFTTVSCGIVAcILAWAMATALSLPESVFYEPRMERQK--HKCAFGKphflP 194
Cdd:cd15210   83 LVAVSLLTLVLITLNRYiLIAHPSLYPRIYTRRGLALMI-AGTWIFSFGSFLPLWLGIWGRFGLDPkvCSCSILR----D 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 195 IEAPLWKYVLtskmIILVLAFPLLVFIIC--CRQLRRrqsfrerqydLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLS 272
Cdd:cd15210  158 KKGRSPKTFL----FVFGFVLPCLVIIICyaRREDRR----------LTRMMLVIFLCFLVCYLPITLVNVFDDEVAPPV 223
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 273 LqdekssyHLDASVqVTQLVAtthcCVNPLLYLLLDR 309
Cdd:cd15210  224 L-------HIIAYV-LIWLSS----CINPIIYVAMNR 248
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
33-304 3.03e-08

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 54.32  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  33 EFLSPQQVLQFCCAVfavglLDNVLAVFILV-KYKGLKNLGNIYFLNLALSNLCFLLPLPFwahTAAHGESP-----GNG 106
Cdd:cd15376    1 DFLWPILGVEFLVAV-----LGNGLALWLFVtRERRPWHTGVVFSFNLAVSDLLYALSLPL---LAAYYYPPknwrfGEA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 107 TCKVLVGLHSSGLYSEVFSNILLLVQGYRV-----FSQGRLASIFTTVSCGIVacilaWAMATALSLPesVFYEPRMERQ 181
Cdd:cd15376   73 ACKLERFLFTCNLYGSIFFITCISLNRYLGivhpfFTRSHVRPKHAKLVSLAV-----WLLVAALSAP--VLSFSHLEVE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 182 KHKCA--FGKPHFLPIEAPLwKYVLTskMIILVLAFPLLVFIICC----RQLRRRQSFrERQYDLHKPALVITGVFL--L 253
Cdd:cd15376  146 RHNKTecLGTAVDSRLPTYL-PYSLF--LAVVGCGLPFLLTLASYlaivWAVLRSPGI-TTLEKRKVAALVAVVVALyaV 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 698979997 254 MWAPYNtvlFLSAFQEHLSLQDEKSSYHLDA--SVQVTQLVATTHCCVNPLLY 304
Cdd:cd15376  222 SFVPYH---ILRNLNLYRRLQWLKAAASLRIyfAYQVTKGLVTLNMCIHPLLY 271
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
46-307 3.58e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 54.25  E-value: 3.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15168    9 VVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHwiFGDFMCKLVRFLFYFNLYGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 F-------SNILLLVQGYRVFSQGRLasifttvSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgkpHFLPIE 196
Cdd:cd15168   89 LfltcisvHRYLGICHPLRSLGKLKK-------RHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTC-----YDTTSP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSkMIILVLAF--PLLVFIIC--------CRQLRRRQSFRERQYDLhKPALVITGVFLLMWAPYNT--VLFL 264
Cdd:cd15168  157 EELNDYVIYS-MVLTGLGFllPLLIILACyglivralIRKLGEGVTSALRRKSI-RLVIIVLALFAVCFLPFHVtrTINL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 698979997 265 sAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15168  235 -AARLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLA 276
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
47-304 4.00e-08

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 53.95  E-value: 4.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLvglhSSGLYSEVF 124
Cdd:cd15157   10 IFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHwvFGDIACRIM----SYSLYVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVqgyrVFSQGRLASI--------FTTVSCGIVACILAWAMATALSLPeSVFYEPRMERQKHKCafgkphfLPIE 196
Cdd:cd15157   86 CSIYFLT----VLSIVRFLAIvhpfklwkVTSIKYARILCAVIWIFVMAASSP-LLSKGTSKYNSQTKC-------LDLH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSKMIILVLAF--PLLVFIIC----CRQLRRRQSFRERQYDLHKPALV----ITGVFLLMWAPYNTVLFLsa 266
Cdd:cd15157  154 PSKIDKLLILNYIVLVVGFilPFCTLSICyiliIKALLKPRVPQSKLRVSHKKALLtiiiTLILFLLCFLPYHILRTV-- 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 698979997 267 fqeHL-SLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15157  232 ---HLmQWSEGQCNLRLHKAVVITLCLAAANSCLDPLLY 267
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
47-304 5.73e-08

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 53.60  E-value: 5.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLhssgLYSEVF 124
Cdd:cd15162   10 VFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNwiFGEALCRLVTVA----FYGNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLL----VQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP----ESVFYEPRMERQKHKCAfgkpHFLPIE 196
Cdd:cd15162   86 CSILLLtcisIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPlylvKQTIFLPALDITTCHDV----LPEQLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLWKYVLTSKMIILVLaFPLLVFIIC----CRQLRRRQSFRERQYDLH--KPALVITGVFLLMWAPYNTVLFLsafqeH 270
Cdd:cd15162  162 VGDWFYYFLSLAIVGFL-IPFILTASCyvatIRTLAALEDENSEKKKKRaiKLAATVLAIFIICFAPSNLLLLA-----H 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 698979997 271 LSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15162  236 YSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIY 269
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
48-312 5.83e-08

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 53.26  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  48 FAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE-SPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd14975   11 FAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTwDFGLAACKGCVYVCAVSMYASVFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPhflpieAPLWKYVLTS 206
Cdd:cd14975   91 TLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHY------SDGQLVFHLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 207 KMIILVLAFPLLVFIIC----CRQLRRRqSFRERQYDLHKPALVITgVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYH- 281
Cdd:cd14975  165 LETVVGFAVPFTAVVLCysclLRRLRRR-RFRRRRRTGRLIASVVV-AFAACWLPYHVGNLLEVVSELIGGSKMAGTLGk 242
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 282 -LDASVQVTQLVATTHCCVNPLLYLLLDRKAF 312
Cdd:cd14975  243 vAEAGRPIAGALAFLSSSINPLLYAFAARGLF 274
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 1.06e-07

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 52.48  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILvKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGT--CKVLVGLHSSGLYSEV 123
Cdd:cd15120    9 VTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTvlCKVLNSTLSVGMFTSV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYR-----VFSQG----RLASIfttvscgIVACIlaWAMATALSLPESVFYEPRM-ERQKHKCAFG---KP 190
Cdd:cd15120   88 FLLTAISLDRYLltlhpVWSRQhrtnRWASA-------IVLGV--WISAILLSIPYLAFRETRLdEKGKTICQNNyalST 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 191 HFLPIEAPLWKYVLTSKMII--LVLAF--PLLVFIIC----CRQLRRRQSFRERqydlhKPALVI-TGV--FLLMWAPYN 259
Cdd:cd15120  159 NWESAEVQASRQWIHVAMFVfrFLLGFllPFLIITFCyvrmALKMKERGLARSS-----KPFKVMfTAVvsFFVCWLPYH 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 698979997 260 tvlflsaFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLL 306
Cdd:cd15120  234 -------LHSGLVLTRGRPPSLTDITLLLTVGTTCFNTCFTPVLYLF 273
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-308 1.13e-07

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 52.84  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKN-LGNIYFLNLALSNLCFLLPLPFWAHTAAHG-ESP-GNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15190   20 VFVLGLSGNGLVLWTVFRSKRKRRrSADTFIANLALADLTFVVTLPLWAVYTALGyHWPfGSFLCKLSSYLVFVNMYASV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAP---LW 200
Cdd:cd15190  100 FCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICDMDYSGVVSNEsewAW 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAFPLLVFIICC-----------RQLRRRQSFRERQydLHKPALVITGVFLLMWAPYNTVLFLSAFQE 269
Cdd:cd15190  180 IAGLGLSSTVLGFLLPFLIMLTCYffigrtvarhfSKLRRKEDKKKRR--LLKIIITLVVTFALCWLPFHLVKTLYALMY 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 698979997 270 hLSLQDEKSSYH--LDASVQVTQLVATTHCCVNPLLYLLLD 308
Cdd:cd15190  258 -LGILPFSCGFDlfLMNAHPYATCLAYVNSCLNPFLYAFFD 297
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
49-312 1.59e-07

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 52.05  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  49 AVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPF-WAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSNI 127
Cdd:cd15087   12 AVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPInIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 128 LLLVQGYRVFsqgrLASI------FTTVSCGIVACILAWAMATALSLPESVFYEPRM-ERQKHKCAFGKPHflpIEAPLW 200
Cdd:cd15087   92 VMSVDRYLVV----LATVrsrrmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSnELGRKSCVLSFPS---PESLWF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KyvlTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPAL------------VITGVFLLMWAPYN--TVLFLSA 266
Cdd:cd15087  165 K---ASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALdkakkkvtlmvlVVLAVCLFCWTPFHlsTVVALTT 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997 267 FQEHLSLQdekssyhLDASVQVTQLvATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd15087  242 DLPQTPLV-------IGISYFITSL-SYANSCLNPFLYAFLDdsfRKSF 282
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-310 1.61e-07

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 52.24  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLPFWahTAAHGE-SPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd16003   10 VVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAsmaAFNTLINFI--YALHSEwYFGEAYCRFHNFFPITSVFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVFYEPRMERQKHKCAFGKPhflpiEAPLWKY 202
Cdd:cd16003   88 IYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSI--WILAFLLAFPQCLYSKTKVMPGRTLCFVAWP-----GGPDQHF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFPLLVFIICC---------------------RQLRRRQSfrerqydLHKPALVITGVFLLMWAPYNTV 261
Cdd:cd16003  161 TYHIIVIVLVYCLPLLVMGITYtivgitlwggeipgdtsdkyhEQLRAKRK-------VVKMMIIVVLTFAICWLPYHIY 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997 262 LFLSAFQEHLSLQDEKSSYHLdasvqVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd16003  234 FIVTGLYQQLNRWKYIQQVYL-----ASFWLAMSSTMYNPIIYCCLNKR 277
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
43-244 1.77e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 51.91  E-value: 1.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL---P---LPFWAHtaahgeSP---GNGTCKVLVG 113
Cdd:cd14997    6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvcmPvalVETWAR------EPwllGEFMCKLVPF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 114 LHSSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP-----ESVFYEPRMERQKHKCAfg 188
Cdd:cd14997   80 VELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPvlfitEFKEEDFNDGTPVAVCR-- 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 189 kphfLPIEAPlWK--YVLTSKMIILVLAFPLLV--FIICCRQLRRRQSFRERQYDLHKPA 244
Cdd:cd14997  158 ----TPADTF-WKvaYILSTIVVFFVVPLAILSglYSVICRRLVGHPALESRRADAANRH 212
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
46-310 2.85e-07

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 51.21  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15392    9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDIlmaVFCVPFSFIALLILQYWPFGEFMCPVVNYLQAVSVFVS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFS---QGRLASIFTTVscgIVACILAWAMATALSLP-ESVFYEPRMER-QKHKCAFGKPHFLpiea 197
Cdd:cd15392   89 AFTLVAISIDRYVAIMwplRPRMTKRQALL---LIAVIWIFALATALPIAiTSRLFEDSNAScGQYICTESWPSDT---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 plWKYVLTSKMIILVLAFPLLVFIIC---------CR------QLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVL 262
Cdd:cd15392  162 --NRYIYSLVLMILQYFVPLAVLVFTytrigivvwAKrtpgeaENNRDQRMAESKRKLVKMMITVVAIFALCWLPLNILN 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 698979997 263 flsafqehLSLQDEKSSYHLDASVQV---TQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15392  240 --------LVGDHDESIYSWPYIPYLwlaAHWLAMSHCCYNPFIYCWMNAK 282
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
46-308 3.15e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 51.23  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFI-LVKYKGLKNlGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLvglhSSGLYSE 122
Cdd:cd15375    9 IIFIVGFPGNIIAIFVyLFKMRPWKS-STIIMLNLALTDLLYVTSLPFLIYYYINGESwiFGEFMCKFI----RFIFHFN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVqgyrVFSQGRLASIFTTVSC--------GIVACILAWAMATALSLPESVFYEPRMERQKHKCA-FGKPHfl 193
Cdd:cd15375   84 LYGSILFLT----CFSIFRYVVIVHPLRAfqvqkrrwAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLdFTSSD-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 194 PIEAPLW-KYVLTskmiilVLAF--PLLVFIIC----CRQLRR----RQSFRERQYDLhkpALVITGVFLLMWAPYNTVL 262
Cdd:cd15375  158 NLNTIWWyNWILT------VLGFllPLVIVTLCytriIYTLAKgphtGSASKQKARRL---IILILLVFYVCFLPFHILR 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 698979997 263 FLsafqeHLSLQDEKSSYHLDASVQ----VTQLVATTHCCVNPLLYLLLD 308
Cdd:cd15375  229 VV-----RIETRLPPVSCCLKHQVHaiyiITRPLAALNTFGNLLLYVVSG 273
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
34-307 3.33e-07

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 51.25  E-value: 3.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  34 FLSPQQVLQFCcavfaVGLLDNVLAVF-ILVKYKGLKNlGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVL 111
Cdd:cd15378    2 YLPTMYSIEFV-----LGFIGNTIVILgYIFCLKNWKS-SNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLfGDFLCKSN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 112 VGLHSSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKC----AF 187
Cdd:cd15378   76 RYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCkdyaSS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 188 GKPhflpieaplwKYVLTSKMIILVLAFPLLVFIICC------RQLRRRQSFRERQYDLHKP-ALVITGV--FLLMWAPY 258
Cdd:cd15378  156 GDA----------TNSLIYSLFLTVTGFLIPLCVMCFfyykiaLFLKNRNRQLANATSFEKPlTLVILAVviFSVLFTPY 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 698979997 259 NTVLFLS-AFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15378  226 HVMRNVRiASRLDSIGVSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLM 275
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
47-124 3.81e-07

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 51.00  E-value: 3.81e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15971   10 VCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPfGKAICRVVMTVDGINQFTSIF 88
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
44-310 3.98e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 50.82  E-value: 3.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  44 CCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL---PLPFWAHTAAHGESPGNGTCKVLVGLHSSGLY 120
Cdd:cd14979    7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLvglPVELYNFWWQYPWAFGDGGCKLYYFLFEACTY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESV--------FYEPRMERQKHKCAfgkphf 192
Cdd:cd14979   87 ATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFlmgiqylnGPLPGPVPDSAVCT------ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIEAPLWKYVLTSKmIILVLAFPLLVFII----CCRQLRRR---------QSFRERQYDLHKPAL--------VITGVF 251
Cdd:cd14979  161 LVVDRSTFKYVFQVS-TFIFFVLPMFVISIlyfrIGVKLRSMrnikkgtraQGTRNVELSLSQQARrqvvkmlgAVVIAF 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 698979997 252 LLMWAPYNT--VLFLSAFQEHLSLQDekSSYHLDASVQVTQLVATThccVNPLLYLLLDRK 310
Cdd:cd14979  240 FVCWLPFHAqrLMFSYASKEDTFLFD--FYQYLYPISGILFYLSSA---INPILYNLMSSR 295
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
47-310 4.10e-07

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 50.96  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15972   10 VCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPfGSFMCRLVMTVDAINQFTSIFC 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVF------SQGRLASIFTTVSCGIvacilaWAMATALSLPESVFYEprMERQKHKCAFGKPHflpiEAPL 199
Cdd:cd15972   90 LTVMSVDRYLAVvhpirsSKWRKPPVAKTVNATV------WALSFLVVLPVVIFSG--VPGGMGTCHIAWPE----PAQV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLAFPLLVFIIC----------------CRQLRRRQSFRErqydLHKPALVITGVFLLMWAPYntvLF 263
Cdd:cd15972  158 WRAGFIIYTATLGFFCPLLVICLCyllivvkvrssgrrvrATSTKRRGSERK----VTRMVVIVVAAFVLCWLPF---YA 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 698979997 264 LSAFQEHLSLQDEKSSYHLDASVQVtqlVATTHCCVNPLLYLLLDRK 310
Cdd:cd15972  231 LNIVNLVCPLPEEPSLFGLYFFVVV---LSYANSCANPIIYGFLSDN 274
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
45-308 4.22e-07

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 50.89  E-value: 4.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSN-LCFLLPLPFW-AHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15397    8 SLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDiLVCLVCLPFTvVYTLMDYWIFGEVLCKMTPFIQCMSVTVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFsqgrlasIFTT-----VSCGIVACILAWAMATALSLPESVFY----EPrMERQKHKCAFGKPHFL 193
Cdd:cd15397   88 ILSLVLIALERHQLI-------INPTgwkpsVSQAYLAVVVIWMLACFISLPFLAFHiltdEP-YKNLSHFFAPLADKAV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 194 PIEA-PLWKYVLTSKMIILVLAFPL-LVFIICC-----RQLRRRQSFRERQYDLHKPA----------LVITGVFLLMWA 256
Cdd:cd15397  160 CTESwPSEHHKLAYTTWLLLFQYCLpLLFILVCylriyLRLRRRKDMLERRGEYNRRAghskrinvmlVSLVAAFALCWL 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 698979997 257 PYNTvlFLSAFQEHLSLQdekSSYHLDASVQVTQLVATTHCCVNPLLYLLLD 308
Cdd:cd15397  240 PLNV--FNAIADWNHEAI---PHCQHNLIFSLCHLAAMASTCVNPIIYGFLN 286
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
47-312 5.19e-07

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 50.70  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLPFWAHTaAHGESPGNGTCKVlvglhssglysev 123
Cdd:cd15207   10 IFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLlvgVFCMPFTLVDNI-LTGWPFGDVMCKL------------- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 fsniLLLVQGYRVfsqgrLASIFTTV----------------------SCGIVACIlaWAMATALSLPESVF--YEPRME 179
Cdd:cd15207   76 ----SPLVQGVSV-----AASVFTLVaiavdryravvhptepkltnrqAFVIIVAI--WVLALAIMIPQALVleVKEYQF 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 180 RQKHKCAFGKPHFlpiEAPLWKYVLTSKMIILVLAFPLLVFI---------ICCRQLRRRQSfRERQYDLHKPA------ 244
Cdd:cd15207  145 FRGQTVHICVEFW---PSDEYRKAYTTSLFVLCYVAPLLIIAvlyvrigyrLWFKPVPGGGS-ASREAQAAVSKkkvrvi 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 698979997 245 ---LVITGVFLLMWAPYNTVLFLSAFQeHLSLQDEKSSYHLdaSVQVTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd15207  221 kmlIVVVVLFALSWLPLHTVTMLDDFG-NLSPNQREVLYVY--IYPIAHWLAYFNSCVNPIVYGYFNrnfRKGF 291
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
47-304 6.20e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 50.41  E-value: 6.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSN--LCFL-LPLPFWAhTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15083   10 IGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDflMCILnCPLMVIS-SFSGRWIFGKTGCDMYGFSGGLFGIMSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEP-RMERQKHKCAFGKPHFLPieAPLWKY 202
Cdd:cd15083   89 NTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRyVLEGLLTSCSFDYLSRDD--ANRSYV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLtskMIILVLAFPLLVfIICC------------RQLRR------------RQSFRERQYDLHKPALVITGVFLLMWAPY 258
Cdd:cd15083  167 IC---LLIFGFVLPLLI-IIYCysfifravrrheKAMKEmakrfskselssPKARRQAEVKTAKIALLLVLLFCLAWTPY 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 698979997 259 NTVLFLSAF--QEHLSlqdekssyhlDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15083  243 AVVALIGQFgyLEVLT----------PLATAIPAAFAKTSAIYNPVIY 280
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
47-308 8.22e-07

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 49.81  E-value: 8.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15202   10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNTWIfGLFMCHFSNFAQYCSVHVSAY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFS---QGRLASIFTTVscgIVACIlaWAMATALSLPESvfYEPRMERQKHKCAFGKPHFLPI---EAP 198
Cdd:cd15202   90 TLTAIAVDRYQAIMhplKPRISKTKAKF---IIAVI--WTLALAFALPHA--ICSKLETFKYSEDIVRSLCLEDwpeRAD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIILVLAFPLLVFIIC----------CR-----QLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNtVLF 263
Cdd:cd15202  163 LFWKYYDLALFILQYFLPLLVISFAyarvgiklwaSNmpgdaTTERYFALRRKKKKVIKMLMVVVVLFALCWLPFN-IYV 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 698979997 264 LsafqehlsLQDEKSSYHLDASVQV---TQLVATTHCCVNPLLYLLLD 308
Cdd:cd15202  242 L--------LLSSKPDYLIKTINAVyfaFHWLAMSSTCYNPFIYCWLN 281
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
47-314 9.28e-07

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 49.69  E-value: 9.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVF-ILVKYKGLKNLgNIYFLNLALSNLCFLLPLPF-WAHTAAHGESP-GNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15967   10 VFVVGLVGNVWGLKsLLANWKKLGNI-NVFVLNLGLADLLYLLTLPFlVVYYLKGRKWIfGQVFCKITRFCFNLNLYGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 fsNILLLVQGYRVFS-------QGRLasiftTVSCGIVACILAWAMATALSLPESVFyePRMERQKHKCaFGKPHFLPIE 196
Cdd:cd15967   89 --GFLTCISVYRYLAivhpmrvMGRI-----TTTHSVVISALVWLLVVIQSLPDLFF--SKTNSNGTKC-FDTTFNDYLE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 197 APLwKYVLTSKMIILVLafPLLVFIIC--------CRQLRRRQSFRERQYDLhkpALVITGVFLLMWAPYNTVLFLSAFQ 268
Cdd:cd15967  159 SYL-TYSLGWTVTGFVI--PLLIILGCyghvvvvlCRNNNVDKGLKQRCLKL---VIILIVLFSVCYIPYHVFRNLNLLS 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 698979997 269 EHLSLQD--EKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRKAFMR 314
Cdd:cd15967  233 RILQKQGscTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDILSR 280
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
50-310 1.04e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 49.58  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLC---FLLPLPFwAHTAAHGESPGNGTCKV--LVGLhssgLYSEVF 124
Cdd:cd15074   13 LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGisvFGYPLAI-ISAFAHRWLFGDIGCVFygFCGF----LFGCCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYR--VFSQGRLASIFT-TVSCGIVACIlaWAMATALSLPESV---FYEPRMERQKHKCAFGKPHFLPIEAp 198
Cdd:cd15074   88 INTLTAISIYRylKICHPPYGPKLSrRHVCIVIVAI--WLYALFWAVAPLVgwgSYGPEPFGTSCSIDWTGASASVGGM- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 lwkyVLTSKMIILVLAFPLLVFIIC---------------CRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLF 263
Cdd:cd15074  165 ----SYIISIFIFCYLLPVLIIVFSyvkiirkvkssrkrvAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 698979997 264 LSAFQEHLSLQDEKSSyhldasvqVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15074  241 WSAFGSPDSVPILASI--------LPALFAKSSCMYNPIIYLLFSSK 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
47-304 1.81e-06

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 48.87  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15389   10 IIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILItLLNTPFTLVRFVNSTWVfGKIMCHLSRFAQYCSVYVSTL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIftTVSCGIVACILAWAMATALSLPESVF-----YEPRMERQKHKCafgKPHFLPIEAPL 199
Cdd:cd15389   90 TLTAIALDRHRVILHPLKPRI--TPCQGVVVIAIIWIMASCLSLPHAIYqklveFEYSNERTRSRC---LPSFPEPSDLF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYvLTSKMIILVLAFPLLVFIIC----CRQLRRRQSF---RERQYDLHKPA--------LVITGVFLLMWAPYNTVLFL 264
Cdd:cd15389  165 WKY-LDLATFILQYVLPLLIIGVAytrvAKKLWLRNAIgdvTTEQYVAQRRKkkktikmlMLVVLLFAICWLPLNCYHVL 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 265 SAFQehlslqdekSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15389  244 LSSH---------PIRSNSALFFAFHWLAMSSTCYNPFIY 274
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
43-304 1.94e-06

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 48.89  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES-P-GNGTCKVLVGLHSSGLY 120
Cdd:cd15159    6 FYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDwPfGDWLCRLTALLFYINTY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPesVFYEPRMERQKHKCAFgkphflpIEAPLW 200
Cdd:cd15159   86 AGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLP--LLFMPMTKEMGGRITC-------MEYPNF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIIL---VLAF--PLLVFIICCRQ--LRRRQSFRERQY----DLHKPA----LVITGVFLLMWAPY--NTVLF 263
Cdd:cd15159  157 EKIKRLPLILLgacVIGFgvPVGIILFCYSQitLKLCRTAKENPLteksGHHKKAcnviLLVLLVFVVCFSPYhlNIIQF 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 698979997 264 LSAFQEHLSLQDEKSSYHLdaSVQVTQLVATTHCCVNPLLY 304
Cdd:cd15159  237 MIRKLLYQPSCSELKAFKI--SLQITVCLMNLNCCLDPFIY 275
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
47-316 2.90e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 48.21  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNI--YFLNLALSNLCFLLPLPFWA---HTAAHGESPgNGTCKVLVGLHSSGLYS 121
Cdd:cd15147   10 IFVLGLIANCYVLWVFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWIvyyHNEGNWILP-KFLCNVAGCLFFINTYC 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 122 EVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP----ESVFYEPRMERQKHKCafgkphFLPIEA 197
Cdd:cd15147   89 SVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYflfmDSTNTVKIDSGNFTRC------FEGYEK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 PLWKYVLTSKMIILVLAFPLLVFIICC-----RQLRRRQSFRERQYDLHKPAL----VITGVFLLMWAPYNTVLFLSAFQ 268
Cdd:cd15147  163 DNSKPVLIIHFIIIGLFFLVFLLILVCnlviaRTLLSQPVQGQRNAGVKRRALwmvcTVLAVFVICFVPHHVVQGPWTLA 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 698979997 269 EHLSLQDEKSSYH--LDASVQVTQLVATTHCCVNPLLYLLLDRKaFMRYL 316
Cdd:cd15147  243 VLQQWRYWDCQFRqaLNDAHQITLCLMSTNCVLDPVIYCFLTKK-FRKHL 291
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
50-304 3.29e-06

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 48.26  E-value: 3.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVF-ILVKYKG-LKNLGNIYFLNLALSNLCFLLPLPFW-AHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15122   13 LGLPGNGFIIWsILWKMKArGRSVTCILILNLAVADGAVLLLTPFFiTFLTRKTWPFGQAVCKAVYYLCCLSMYASIFII 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPeSVFYEPRMERQKHKCAFGKP-HFLPIEApLWKYVLT 205
Cdd:cd15122   93 GLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALP-AFVYRHVWKDEGMNDRICEPcHASRGHA-IFHYTFE 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 SkMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQehlSLQDEKSSYHLDAS 285
Cdd:cd15122  171 T-LVAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVA---NLAPGEVLEKLGGA 246
                        250       260
                 ....*....|....*....|...
gi 698979997 286 VQVTQLVATT----HCCVNPLLY 304
Cdd:cd15122  247 AKAARAGATAlaffSSSVNPLLY 269
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
47-315 6.04e-06

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 47.26  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL-PLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15927   10 IFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLtCVPFTSTIYTLDSWPfGEFLCKLSEFLKDTSIGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYR--VFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVFYeprmerqkHKCAFGKPHFLPIEA----- 197
Cdd:cd15927   90 TLTALSADRYFaiVNPMRKHRSQATRRTLVTAASI--WIVSILLAIPEAIFS--------HVVTFTLTDNQTIQIcypyp 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 PLWKYVLTSKMII---LVL-AFPLLV----FIICCRQLRRRQSFRERQYDLH------------KPALVITGVFLLMWAP 257
Cdd:cd15927  160 QELGPNYPKIMVLlrfLVYyLIPLLIigvfYVLMARHLIRSTRNIGSGQNQAaqrqiearkkvaKTVLAFVVLFAVCWLP 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 698979997 258 YNtvLFLSAFQEHLSLQDEKSSYHLDASVqVTQLVATTHCCVNPL-LYLLldRKAFMRY 315
Cdd:cd15927  240 RH--VFMLWFHFAPNGLVDYNAFWHVLKI-VGFCLSFINSCVNPVaLYLL--SGSFRRH 293
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
47-169 7.19e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 47.45  E-value: 7.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLC---FLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15005   10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLrslACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSA 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP 169
Cdd:cd15005   90 FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
41-308 9.73e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 46.70  E-value: 9.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  41 LQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLC---FLLPLPFWAHTAAHGESpGNGTCKVLVGLHSS 117
Cdd:cd15205    4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLitfFCIPFTLLQNISSNWLG-GAFMCKMVPFVQST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 118 GLYSEVFSNILLLVQGYrvfsQG-----RLASIFTTVSCGIVACILaWAMATALSLPesVFYEPRMErQKHKCAFGKPHF 192
Cdd:cd15205   83 AVVTSILTMTCIAVERH----QGivhplKMKWQYTNRRAFTMLGLV-WIVSVIVGSP--MLFVQQLE-VKYDFLYEKRHV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIEA---PLWKYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDLH---------------------KPALVIT 248
Cdd:cd15205  155 CCLERwysPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRVGDASvlqtihgiemskisrkkkravKMMVTVV 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 249 GVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYHLDASVqvtQLVATTHCCVNPLLYLLLD 308
Cdd:cd15205  235 LLFAVCWAPFHVVHMMIEYSNLENKYDGVTIKLIFAIV---QLIGFSNSFNNPIVYAFMN 291
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
45-315 1.07e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 46.66  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSE 122
Cdd:cd14992    8 VVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMaLFCTPFNFTYVVSLSWEyGHFLCKIVNYLRTVSVYAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPeSVFYEpRMERQKHKCAFGKPHFLPIEAPLWKY 202
Cdd:cd14992   88 SLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIP-QLYYA-TTEVLFSVKNQEKIFCCQIPPVDNKT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMI-ILVLAF--PLLVFIICCRQLRRRQSFRER-------QYDLH--------KPALVITGVFLLMWAPYNTVLFL 264
Cdd:cd14992  166 YEKVYFLlIFVVIFvlPLIVMTLAYARISRELWFRKVpgfsikeVERKRlkckrrviKMLVCVVVLFVICWLPFHLFFLL 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 698979997 265 SAFQEHLSLqdEKSSYHLDASVqvtQLVATTHCCVNPLLYLLLDRKaFMRY 315
Cdd:cd14992  246 RDFFPLIMK--EKHTLQVYYFL---HWIAMSNSMYNPIIYVTLNNN-FRKN 290
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
46-316 1.08e-05

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 46.51  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFwahTAAHGESP----GNGTCKVlvglhssgly 120
Cdd:cd15095    9 IIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCcVPF---TAALYATPswvfGDFMCKF---------- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 seVFSNILLLVQG----YRVFSQGR-------LASI-FTTVSCGIVACILAWAMATALSLPESVFYeprmerQKHKCAFG 188
Cdd:cd15095   76 --VNYMMQVTVQAtcltLTALSVDRyyaivhpIRSLrFRTPRVAVVVSACIWIVSFLLSIPVAIYY------RLEEGYWY 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 189 KPHFLPIEAPLWKYVLTSKMIILVLA---FPLLVFIICC----RQLRRRQSFRERQYD-LHKPA-----------LVITG 249
Cdd:cd15095  148 GPQTYCREVWPSKAFQKAYMIYTVLLtyvIPLAIIAVCYglilRRLWRRSVDGNNQSEqLSERAlrqkrkvtrmvIVVVV 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 698979997 250 VFLLMWAPyNTVLFLsafqehlsLQDEKSSYHLDASVQVTQLVAttHC------CVNPLLYLLLDRKaFMRYL 316
Cdd:cd15095  228 LFAICWLP-NHVLNL--------WQRFDPNFPETYATYALKIAA--LClsyansAVNPFVYAFMGEN-FRKYF 288
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
55-316 1.09e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 46.50  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  55 NVLAVFILVKYKGLKNLGNIYFLNLALSN-LCFLLPLPF-----------WAHtaahgespGNGTCKVLVGLHSSGLYse 122
Cdd:cd15204   18 NLLLIAVLARYKKLRTLTNLLIANLALSDfLVAVFCLPFemdyyvvrqrsWTH--------GDVLCAVVNYLRTVSLY-- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLL--VQGYRVFSQGRLASIFTTVSCGIVAciLAWAMATALSLPESVFYEPRMERQKHKCAFGKphFLPI-EAPL 199
Cdd:cd15204   88 VSTNALLViaIDRYLVIVHPLKPRMKRRTACVVIA--LVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQ--IWPVdQQAY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WK-YVLTskMIILVLAFPLLVFIICC-----------------RQLRRRQSFRERQYDLhkpALVITGVFLLMWAPYNTV 261
Cdd:cd15204  164 YKaYYLF--LFVLEFVLPVLIMTLCYlrivrkvwfrrvpgqqtEQIRRRLRRRRRKVRL---LVVILTAFVLCWAPYYGY 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 698979997 262 LFLSAFQEHLSLqdeKSSYHLDAsVQVTQLVATTHCCVNPLLYLLLdRKAFMRYL 316
Cdd:cd15204  239 AIVRDFFPTLLS---KEKLNTTI-FYIVEALAMSNSMINTVVYVAF-NNNIRKYL 288
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
41-175 1.48e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 45.97  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  41 LQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLhsSGL 119
Cdd:cd15166    4 LVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPfGDYFCRILGAL--TVF 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 698979997 120 YSEVFSNILLLVQG--YRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYE 175
Cdd:cd15166   82 YPSIALWLLAFISAdrYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYE 139
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
47-304 2.47e-05

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 45.51  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVkYKGLKNLGNIYFLNLALSNLCFLLPLPF--WAHTAAHGESPGNGTCKVLvglhSSGLYSEVF 124
Cdd:cd15372   10 VFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPFkiSYHFLGNNWPFGEGLCRVV----TAFFYGNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLL----VQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYE--PRMERQKHKCAFGkphfLPIEAP 198
Cdd:cd15372   85 CSVLLLmcisLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQsyPLERLNITLCHDV----LPLDEQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LwKYVLTSKMIILVLAF--PLLVFIIC-CRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQD 275
Cdd:cd15372  161 D-TYLFYYFACLAVLGFllPLVVILFCyGSVLHTLLRSGQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLHYSDPTLDDGG 239
                        250       260
                 ....*....|....*....|....*....
gi 698979997 276 EkssyhLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15372  240 N-----LYIVYMVSLAISTLNSCVDPFIY 263
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
47-304 2.56e-05

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 45.14  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15923   10 TFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRESAGLQKLCNFVLSLYYINMYVSIFTI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLAS-IFTTVSCGIVACILaWAMATALSLPESVFYEprmERQKHKCafgkphFLPIEAPLWKYVLt 205
Cdd:cd15923   90 TAISVDRYVAIRYPLRAReLRSPRKAAVVCAVI-WVLVVTISIPYFLLDS---SNEKTMC------FQRTKQTESLKVF- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 206 skMIILVLAF--PLLVFIICC----RQLRRRQSFRERQYDLHKPALVITG---VFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15923  159 --LLLEIFGFllPLIIMTFCSarviHTLQKRLDDVGSRSETKQCIRVIMAnliVFIVCFLPVHVGFFVKFIVGKSYSCDS 236
                        250       260
                 ....*....|....*....|....*...
gi 698979997 277 KSSYHLdaSVQVTQLVATTHCCVNPLLY 304
Cdd:cd15923  237 KLIIHF--FLQSAFCLSDMNCCLDAFCY 262
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
41-304 3.83e-05

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 44.63  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  41 LQFCCAV--FAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSG 118
Cdd:cd15165    2 LQLVVYIptFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLGRTLCSFLESLYFVN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 119 LYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMErqKHKC-------AFGKPH 191
Cdd:cd15165   82 MYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPTN--NTRCfhgfsnkTWSKKV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 192 FLPIEaplwKYVLTSKMIILVlaFPLLVFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHL 271
Cdd:cd15165  160 IVVVE----EFGFLIPMAVMV--FCSVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKND 233
                        250       260       270
                 ....*....|....*....|....*....|...
gi 698979997 272 SLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15165  234 IINDCSTKQSIRLFVQVSMCLANVNCCLDAICY 266
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
45-308 3.96e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 44.73  E-value: 3.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESPGNGT--CKVLVGLHSSGLYSE 122
Cdd:cd14964    6 SLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQalCYLIYLLWYGANLAS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVF--YEPRMERQKHKCAFGKphflpieaplW 200
Cdd:cd14964   86 IWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGkgAIPRYNTLTGSCYLIC----------T 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAFPLLVFIICCRQLRRRQSFRERQYDL------------HKPALVITGVFLLMWAPYNTVLFLsafq 268
Cdd:cd14964  156 TIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSaaslntdknlkaTKSLLILVITFLLCWLPFSIVFIL---- 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 698979997 269 eHLSLQDeksSYHLDASVQVTQLVATTHCCVNPLLYLLLD 308
Cdd:cd14964  232 -HALVAA---GQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
47-307 4.05e-05

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 44.78  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15153   10 IFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPfGRFLCLLCFYLKYLNMYASICF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGRLASIFTT-VSCGIVACIlaWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKYVL 204
Cdd:cd15153   90 LTCISIQRCFFLLHPFKARDWKRrYDVGISAAV--WIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAIAMMT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLafPLLVFIICcrQLRRRQSFRERQYDLH---------KPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQD 275
Cdd:cd15153  168 VAELFGFVI--PLFIIAWC--TWKTENSLRQRNKQQQstsekqkalRMVRMCAAVFFICFAPYHINFLFYLMVSESIITN 243
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 276 EKSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15153  244 CEVSQVILQFHPISLCLASLNCCLDPILYYFM 275
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
48-304 4.07e-05

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 44.74  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  48 FAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKV---LVGLHSSGlySE 122
Cdd:cd14991   11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHwiFGEAWCRVnlfMLSVNRSA--SI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILaWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKY 202
Cdd:cd14991   89 AFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLL-WALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIRWHN 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTskMIILVLAFPLLVF----IICcrQLRRRQSFrERQYDLHKPA---LVITGVFLLMWAPynTVLFLSAFQEHLSLQD 275
Cdd:cd14991  168 ALF--LLEFFLPLGLIVFcsvrIAC--NLRIRQSL-GKQARVQRAIrlvFLVVIVFVLCFLP--SIIAGLLALVFKNLGS 240
                        250       260
                 ....*....|....*....|....*....
gi 698979997 276 EKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd14991  241 CRCLNSVAQLFHISLAFTYLNSALDPVIY 269
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
44-310 4.11e-05

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 44.88  E-value: 4.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  44 CCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLP-----FWAHTAAHGespGNGTCKVLVGLHSSG 118
Cdd:cd15131    7 CVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPldlyrLWQYRPWNF---GDLLCKLFQFVSESC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 119 LYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPesVFYEPRMERQKHKCAFGKPHFLPIEAP 198
Cdd:cd15131   84 TYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGP--IFVLVGVEHENGTNPIDTNECKATEYA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMIILVLAFPLLVFIICC------RQLRRRQ--------SFRERQY-DLHKPALVITGVFLLMWAPYNTVLF 263
Cdd:cd15131  162 VRSGLLTIMVWVSSVFFFLPVFCLTVlysligRKLWRRRrenigpnaSHRDKNNrQTVKMLAVVVFAFVLCWLPFHVGRY 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 698979997 264 LsafqehLSLQDEKSSYHLDASVQVTQLVATT----HCCVNPLLYLLLDRK 310
Cdd:cd15131  242 L------FSKSFEAGSLEIALISQYCNLVSFVlfylSAAINPILYNIMSKK 286
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
47-304 5.42e-05

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 44.39  E-value: 5.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE--SPGNGTCKVLVGLHSSGLYSEV- 123
Cdd:cd15365   10 VIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDnwTLSGFVCIFSAFLLYTNFYTSTa 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 ------FSNILLLVQGYRvFSQGRLASIFTTVScgivacILAWAMATALSLPESVFYEPRMERQKHKCAFgkpHFLPIEa 197
Cdd:cd15365   90 lltciaLDRYLAVVHPLK-FMHLRTIRTALSVS------VAIWLLEICFNAVILTWEDSFHESSSHTLCY---DKFPLE- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 pLWKYVLTSKMIILVLAFPLLVFIICCRQL----RRRQSFRERQYD-LHKPALVITGVFLLMWAPYNTVLFLSAFQEHLS 272
Cdd:cd15365  159 -DWQARLNLFRICLGYLLPLLIILFCYWKIyqavRSNQATEDQEKKkIFKLLLLITVTFVICFTPYHVVLLIRSIVEPCD 237
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 273 LQDEKSSYHLDasvQVTQLVATTHCCVNPLLY 304
Cdd:cd15365  238 CRNAKWLYTLY---KITVALTSLNCIADPFLY 266
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 6.84e-05

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 44.02  E-value: 6.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLP-FWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15374    9 LVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtLIYYYADHNHWPfGVVACKIVRFLFYANLYCSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgkpHFLPIEAPLWKYV 203
Cdd:cd15374   89 LFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLC-----HDTTRPEEFDHYV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 -LTSKMIILVLAFPLLVFIIC----CRQLRRRQ--SFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15374  164 hYSSAVMVLLFGIPCLVIVVCyglmARRLCKPRvgSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLK 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 698979997 277 KSSYHLDA---SVQVTQLVATTHCCVNPLLYLL 306
Cdd:cd15374  244 ADCDTLNIinvTYKVTRPLASANSCLDPILYFL 276
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
47-304 9.31e-05

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 43.63  E-value: 9.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFL--LPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15370   10 VFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFViwFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYCSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVF-----SQGRLASIFTTVSCGIvaCILAWAMATALSLPESVFYEPRMerQKHKCAFGKPHFLPIEAPl 199
Cdd:cd15370   90 FMTCLSVQRYWVIvnpmsHSRKKANIAIGISLAI--WLLILLVTIPLYLVKQTVFIPAL--DITTCHDVLPEQLLVGDM- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTskMIILVLAFPLLVFIICCRQLRRR-------QSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLsafqeHLS 272
Cdd:cd15370  165 FNYFLS--LAIGVFLFPAFLTAVAYVLMIRAlkssindESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVV-----HYF 237
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 273 LQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15370  238 LLKNQGQSSVYAFYITALCLSTLNSCIDPFVY 269
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-312 9.48e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 43.57  E-value: 9.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  41 LQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF----LLPLPFWAHTAAHgeSPGNGTCKVLVGLHS 116
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVglinVLTDIIWRITVEW--RAGDFACKVIRYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 117 SGLYSEVFSNILLLVQGY-------RVFSQGRLASIFTTVscgivacilAWAMATALSLPESVFYEPRMERQKH-KCafg 188
Cdd:cd15197   82 VVTYASTYVLVALSIDRYdaichpmNFSQSGRQARVLICV---------AWILSALFSIPMLIIFEKTGLSNGEvQC--- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 189 kphFLPIEAPLWKYVLTSKMIILVLAFPLLVFIIC--------------CRQLRRRQSFRERQYDLH------------- 241
Cdd:cd15197  150 ---WILWPEPWYWKVYMTIVAFLVFFIPATIISICyiiivrtiwkkskiQVTINKAGLHDGSSRRSSsrgiiprakikti 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 698979997 242 KPALVITGVFLLMWAPYNTVLFLSAFqEHLSLQDEKSSYHLdasvqVTQLVATTHCCVNPLLYLLLDRKAF 312
Cdd:cd15197  227 KMTFVIVTVFIICWSPYFVFDLLDVF-GLLPRSKTKIAAAT-----FIQSLAPLNSAINPLIYCLFSTHLC 291
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-316 1.45e-04

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 43.02  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15125   10 IITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMfGTVGCKLIPVIQLTSVGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKYVL 204
Cdd:cd15125   90 TLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQTDEMHPKIH 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFII----CCRQL---------------RRRQSFRERqydLHKPALVITGVFLLMWAPyNTVLFLs 265
Cdd:cd15125  170 SVLIFLVYFLIPLAIISIyyyhIAKTLiksahnipgeysehsKRQMETRKR---LAKIVLVFVGLFAFCWFP-NHVLYM- 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 698979997 266 aFQEHLSLQDEKSSYHLDASVqVTQLVATTHCCVNPL-LYLLldRKAFMRYL 316
Cdd:cd15125  245 -YRSFNYNEIDSSLGHMIVTL-VARVLSFCNSCVNPFaLYLL--SESFRRHF 292
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-92 1.46e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 43.25  E-value: 1.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997  44 CCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPF 92
Cdd:cd15132    7 CLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPF 55
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
48-306 1.47e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 42.86  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  48 FAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE--SPGNGTCKVLVGLHS-SGLYSEVF 124
Cdd:cd15199   11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNrwSLGGGTCKALLFMLSlSRGVSIAF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACiLAWAMATALSLPESVFYEPRMERQKHKcafgkphFLPIEAPLWKYVL 204
Cdd:cd15199   91 LTAVALDRYFRVVHPRGKKNSLSLQAAPYISF-LVWLLLVGLTIPTLLASQPKNFTECNS-------FSPKDDEDFSDTW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 205 TSKMIILVLAFPLLVFIIC----CRQLRRRQSFRERQYDLHKPALVITGVFLLMwapynTVLFLSAFQEH---LSLQDEK 277
Cdd:cd15199  163 QEAVFFLQFLLPFGLIVFCtvriIRRLKKRLRDVGKQPKLQRAMALVTSVVVVF-----GFCFLPCFLARvlmLIFQNKE 237
                        250       260       270
                 ....*....|....*....|....*....|..
gi 698979997 278 SSYHLDASVQ---VTQLVATTHCCVNPLLYLL 306
Cdd:cd15199  238 SCNALNIAVHtydVTMCLTYLNSVLDPIVYCF 269
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
46-310 1.71e-04

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 42.84  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15968    9 FVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRwlFGDFMCRLVRFLFYFNLYGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgkpHFLPIEAPLWKYV 203
Cdd:cd15968   89 LFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVC-----YDLAPPALFPHYV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 LTSkMIILVLAF--PLLVFIIC--------CRQL---------RRRQSFRErqydlhkpALVITGVFLLMWAPYNTVLFL 264
Cdd:cd15968  164 PYG-MALTVSGFllPFSIILWCyclvvrtlCRTLgpaeppaqaRRRKSIRT--------IVTVTLLFALCFLPFHITRTI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 698979997 265 SAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15968  235 YLAVRVTPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKK 280
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
50-307 1.81e-04

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 42.88  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVFILVKYKGLK---NLGNIYFLNLALSNLCFLLPLPFWAHTAAhgespGNGT-------CKVLVGLHSSGL 119
Cdd:cd15338   13 LGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLL-----GNGVwhfgetmCTLITALDTNSQ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 120 YSEVFSNILLLVQGYRV------FSQGRLASIFTTVSC-----GIVACILAWAMATALSLPESVFyeprmerqkhKCAFG 188
Cdd:cd15338   88 ITSTYILTVMTLDRYLAtvhpirSTKIRTPRVAVAVIClvwilSLLSITPVWMYAGLMPLPDGSV----------GCALL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 189 KPHflPIEAPLWkyvLTSKMIILVLAFPLLVFIICCRQLRRR----------QSFRERQYDLHKPALVITGVFLLMWAPY 258
Cdd:cd15338  158 LPN--PETDTYW---FTLYQFFLAFALPLVVICVVYFKILQNmastvaplpqRSLRVRTKKVTRMAVAICLAFFICWAPF 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997 259 nTVLFLSafqeHLSLQDEKSSYHLDASVQVTQLVATThcCVNPLLYLLL 307
Cdd:cd15338  233 -YILQLA----HLSIDRPSLAFLYAYNVAISMGYANS--CINPFLYIML 274
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
47-311 2.04e-04

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 42.47  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLVGLHSSGLY-SEV 123
Cdd:cd15366   10 VIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNwiHGPESCKLFGFIFYTNIYiSIA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIfTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKphfLPIEAplWKYV 203
Cdd:cd15366   90 FLCCISVDRYLAVAHPLRFAKV-RRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTFCFEK---YPMED--WVAW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 LTSKMIILVLAFPLLVFIICCRQLRRR-----QSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKS 278
Cdd:cd15366  164 MNLYRVFVGFLFPWVLMLFSYRGILRAvrgnvSTEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYLGKPCDCGF 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 698979997 279 SYHLDASVQVTQLVATTHCCVNPLLYLLLDRKA 311
Cdd:cd15366  244 EERVFTAYHVSLALTSLNCVADPILYCLVNEGA 276
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
74-310 2.20e-04

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 42.48  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  74 IYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLvglhSSGLYSEVFSNILLLVqgyrVFSQGRLASI---FTT 148
Cdd:cd15371   36 IFYANLAISDLLFCITLPFKIVYHLNGNNwvFGETMCRII----TITFYGNMYCSILLLT----CISINRYLAIvhpFIY 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 149 VSC-----GIVACILAWAMATALSLPESVFYEPRMERQ---------KHKCAFGKPHFLpieaplwkYVLTSkMIILVLA 214
Cdd:cd15371  108 RSLpkktyAVLICALVWTIVFLYMLPFFILKQTYYLKElnittchdvLPECEQNSNFQF--------YYFIS-MAVFGFL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 215 FPLLVFIIC-CRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKSSYHLdasvqVTQLVA 293
Cdd:cd15371  179 IPLVITIFCyISIIRTLNAYEHKWFWYVKITALVLIIFTICFAPSNVILIIHHFNYYYFNNDNLYSIYL-----IALCLG 253
                        250
                 ....*....|....*..
gi 698979997 294 TTHCCVNPLLYLLLDRK 310
Cdd:cd15371  254 SLNSCLDPFLYFLMSKW 270
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
50-310 2.61e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 42.42  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP-GNGTCKV------LVGLHSSGLYS 121
Cdd:cd15073   13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVsIIGYPFSAASDLHGSWKfGYAGCQWyaflniFFGMASIGLLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 122 evfsniLLLVQGYRVFSQGRLASIFTTVSCGIVAcILAW--AMATAlSLPESVFYEPRMERQKHKCAFGKPHFlpiEAPL 199
Cdd:cd15073   93 ------VVAVDRYLTICRPDLGRKMTTNTYTVMI-LLAWtnAFFWA-AMPLVGWASYALDPTGATCTINWRKN---DSSF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTskMIILVLAFPLLVFIICCRQLRRRQSFR-------------ERQYDLHKPALVITGVFLLMWAPYNTVLFLSA 266
Cdd:cd15073  162 VSYTMS--VIVVNFIVPLAVMFYCYYNVSRFVKKVlasdclesvnidwTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWAS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 698979997 267 FQEHlslQDEKSSYHLdasvqVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15073  240 FGEP---KKIPPWMAI-----IPPLFAKSSTFYNPCIYVIANKK 275
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-172 2.98e-04

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 42.12  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  43 FCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP------GNGTCKVLVGLH 115
Cdd:cd15128    6 VSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYiVIDLPINVYKLLAMDWPfgdqpfGQFLCKLVPFIQ 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 698979997 116 SSGLYSEVFSNILLLVQGYR-VFSQGRLASIFTTVSCgIVACILAWAMATALSLPESV 172
Cdd:cd15128   86 KASVGITVLNLCALSVDRYRaVASWSRIQGIGIPMWT-AVEIVMIWMLSAVLAVPEAI 142
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
46-306 3.79e-04

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 41.69  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAA--HGESPGNGTCKVLVGLhssgLYSEV 123
Cdd:cd15364    9 VVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSnnHKWPWGSLACKITGYI----FFCNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLL----------VQgYRVFSQG----RLASIFTTVSCGIVACIlawaMATALSLPESvfyeprMERQKHKCAfgk 189
Cdd:cd15364   85 YISILLLccisidrfvaVV-YALESRGrrrqRIAAFISFLIFIVVGLV----HSPVFIMREG------QTEGSHTCF--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 190 pHFLPIEAPLWKYVLTSKMIILVLAFPLLVFIICC--RQLRRRQSFRERQYDLHK-PALVITGVFLLMWAPYNTVLFLSA 266
Cdd:cd15364  151 -ETLQMDTQVAGFYYARFCIGFAIPLAILIFTNYRifRSIQTSTSLTPHQKAKVKyLAIAVIVIFLICFAPYHLVLLVRA 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 698979997 267 FQEHLSLQD----EKSSYHLDAsvqVTQLVATTHCCVNPLLYLL 306
Cdd:cd15364  230 IAFSLYPNGmcgfEERIYTPSV---IFLCLSTVNSVADPIIYVL 270
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
55-258 4.31e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 41.52  E-value: 4.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  55 NVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVFSNILLLVQ 132
Cdd:cd15048   18 NLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGKWPfGKVFCKAWLVVDYTLCTASALTIVLISLD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 133 GYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFlpieAPLWKYVLTSKMIILV 212
Cdd:cd15048   98 RYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIVPTGDCEVEF----FDHFYFTFITSVLEFF 173
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 698979997 213 LAFPLLVFI---ICCRQLRRRQSFRERQYDLHKPAL-------------------------VITGVFLLMWAPY 258
Cdd:cd15048  174 IPFISVSFFnllIYLNIRKRSRRRPLRSVPILPASQnpsrarsqreqvklrrdrkaakslaILVLVFLICWAPY 247
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
47-304 4.33e-04

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 41.68  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES--PGNGTCKVLvglhSSGLYSEVF 124
Cdd:cd15369   10 VFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDwlFGEAMCRVV----TAAFYCNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVqgyrVFSQGRLASI--------FTTVSCGIVACILAWAMATALSLP----ESVFYEPRMERQkhKCAfgkpHF 192
Cdd:cd15369   86 CSILLMT----CISVDRFLAVvypmqslsWRTLRRASFTCAAIWLLSIAGVVPlllsEQTIQIPDLGIT--TCH----DV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIEAPLWKYVLTSKMIILVLAF-PLLVFIICCRQLRR---------RQSFRERQYDLhkpALVITGVFLLMWAPYNTVL 262
Cdd:cd15369  156 LNEQLLMGYYVYYFSIFSCLFFFvPLIITTVCYVSIIRclssssdvaNSSKKTRALFM---AVAVFCVFVICFGPTNVLL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 263 FLSAFQEHLSLQDEkSSYhldASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15369  233 LAHYVRFAYTSTND-ASY---FAYLLCVCVGSISCCLDPLIY 270
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
47-169 5.23e-04

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 41.22  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWA--HTAAHGESPGNGTCKVLVGLhssgLYSEVF 124
Cdd:cd15148   10 IFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRIlyHVNNNQWTLGPLLCKVVGNL----FYMNMY 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 698979997 125 SNILLL----VQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLP 169
Cdd:cd15148   86 ISIILLgfisLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVP 134
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
47-304 6.02e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 41.02  E-value: 6.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAH-GESPGNGTCKVLVGLHSSGLYSEVFS 125
Cdd:cd15079   10 LGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYeGWALGPLGCQIYAFLGSLSGIGSIWT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 126 NILLLVQGYRVFSQGrLASIFTTVSCGIVACILAWAMATALSLPESVF----YEPrmERQKHKCAFgkpHFLPIEAPLWK 201
Cdd:cd15079   90 NAAIAYDRYNVIVKP-LNGNPLTRGKALLLILFIWLYALPWALLPLLFgwgrYVP--EGFLTSCSF---DYLTRDWNTRS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 202 YVLTskMIILVLAFPLLvFIICC-----------RQLRRRQ-------SFRERQYD--------LHKPALVITGVFLLMW 255
Cdd:cd15079  164 FVAT--IFVFAYVIPLI-IIIYCysfivkavfahEKALREQakkmnvvSLRSNADAnkqsaeirIAKVALTNVFLWFIAW 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 698979997 256 APYNTVLFLSAF--QEHLSlqdekssyhlDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15079  241 TPYAVVALIGAFgnQSLLT----------PLVSMIPALFAKTAACYNPIVY 281
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
46-316 6.35e-04

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 40.95  E-value: 6.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPF-WAHTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15395    9 AVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFtFVYTLMDHWVFGEAMCKLNSMVQCISITVSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVFY----EPRMERQKHKCAFGKPHFLPIEAPL 199
Cdd:cd15395   89 FSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVI--WVLAVLTSLPFLIFQvltdEPFKNVNVSLDAYKGKYVCLDQFPS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLA-FPLLVFIICCR-----QLRRRQSFRERQYD----------LHKPALVITGVFLLMWAPYNtvLF 263
Cdd:cd15395  167 DTIRLSYTTCLLVLQyFGPLCFIFICYlkiyiRLKRRNNMMDKMRDnkyrssetkrINIMLISIVVAFAVCWLPLN--IF 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 698979997 264 LSAFQEHlslQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDrKAFMRYL 316
Cdd:cd15395  245 NAVFDWN---HEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLN-KNFQRDL 293
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-310 6.72e-04

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 41.00  E-value: 6.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL---PLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15357   10 IFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLfgmPLEVYEMWSNYPFLFGPVGCYFKTALFETVCFASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKY- 202
Cdd:cd15357   90 LSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFPNGTLIPDSATCTVVKPLWIYn 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 --VLTSKMIILVLAFPLLVFIICCRQLRRRQSF------------RERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQ 268
Cdd:cd15357  170 liIQITSLLFYVLPMGVISVLYYLMGLKLRGDKsleademnvniqRPSRKSVTKMLFVLVLVFAICWAPFHVDRLFFSFV 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 698979997 269 EHLSLQdekssyhLDASVQVTQLVATT----HCCVNPLLYLLLDRK 310
Cdd:cd15357  250 VEWTEP-------LANVFNLIHVVSGVffylSSAVNPIIYNLLSRR 288
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
47-306 8.40e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 40.66  E-value: 8.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPF--WAHTAAHGESPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15377   10 VFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPAliFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYR-----VFSQGRLASifttvSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHflpiEAPL 199
Cdd:cd15377   90 FLTCISVHRYTgvvhpLKSLGRLKK-----KNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTS----DEYL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSkMIILVLAF--PLLVFIICCRQLRRRQSFRERQYDLHKPA----------LVITGVFLLMWAPYNTVLFLSaF 267
Cdd:cd15377  161 RSYFIYS-MCTTVAMFcvPFILILGCYGLIVRALIYKDMKYTEENNAplrrksiylvIIVLTVFAVSYLPFHVMKTLN-L 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 268 QEHLSLQDEKSSYHLD---ASVQVTQLVATTHCCVNPLLYLL 306
Cdd:cd15377  239 RARLDFQTPAMCAFNDrvyATYQVTRGLASLNSCVDPILYFL 280
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
47-304 8.58e-04

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 40.52  E-value: 8.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE--SPGNGTCKVLVGLhssgLYSEVF 124
Cdd:cd15367   10 VLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDnwTYSELLCKICGIL----LYENIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLL----VQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFgkpHFLPIEAplW 200
Cdd:cd15367   86 ISIGFLccisVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCF---EHYPIKA--W 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 201 KYVLTSKMIILVLAFP--LLVFIICC--RQLRRRQSFRERQYD-LHKPALVITGVFLLMWAPYNTVLFL-SAFQEHLSLQ 274
Cdd:cd15367  161 EHNINYYRFYAGFLFPifLLSFSYCRilRAVRKSHGTQKSQKIqIKRLVLSTVVIFLVCFGPYHILLLVrSVFERDCNFA 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 698979997 275 DEKSSYHldasvQVTQLVATTHCCVNPLLY 304
Cdd:cd15367  241 EGIFNYY-----HFSLLLTSFNCVADPVLY 265
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
45-310 8.65e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 40.68  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILvkYKGLKNLGNIYF--LNLALSNL--CFLLPLPFWAHTAAHGESPGNGTCKVLVGLHSSGLY 120
Cdd:cd15196    8 ATILVLALFGNSCVLLVL--YRRRRKLSRMHLfiLHLSVADLlvALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACIlAWAMATALSLPESVFYEPRMERQKHK-CafgKPHFlpieAPL 199
Cdd:cd15196   86 ASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSIPQLFIFSYQEVGSGVYdC---WATF----EPP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMIILVLAF-PLLVFIIC----CRQLRRR--QSFrerqydlhKPALVITGVFLLMWAPYNTVLFLSAFqehls 272
Cdd:cd15196  158 WGLRAYITWFTVAVFVvPLIILAFCygriCYVVWRAkiKTV--------KLTLVVVACYIVCWTPFFVVQMWAAW----- 224
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 698979997 273 lqDEKSSYHLDASVqVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15196  225 --DPTAPIEGPAFV-IIMLLASLNSCTNPWIYLAFSGN 259
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
47-306 1.03e-03

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 40.27  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15124   10 IILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLfGRVGCKLIPFIQLTSVGVSVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVF------YEPRMERQKHKCAFG------KPHF 192
Cdd:cd15124   90 TLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFsdlhpfYDKSTNKTFVSCAPYphsnelHPKI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIEAPLWKYVLTSKMIILVLAFPLLVFIICCRQL--------RRRQSFRERqydLHKPALVITGVFLLMWAPYNTVLFL 264
Cdd:cd15124  170 HSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNLpvegnvhvRRQIESRKR---LAKTVLVFVGLFAFCWLPNHIIYLY 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 698979997 265 SAFqeHLSLQDeKSSYHLDASVqVTQLVATTHCCVNPL-LYLL 306
Cdd:cd15124  247 RSY--HYSEVD-TSMLHFVSSI-CARILAFTNSCVNPFaLYLL 285
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
45-312 1.30e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 40.07  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPF-WAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15206    8 SVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFtLVGQLLRNFIFGEVMCKLIPYFQAVSVSVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVF--YEPRMERQKHKCAFgkphFLPIE-APL 199
Cdd:cd15206   88 TFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFsnLIPMSRPGGHKCRE----VWPNEiAEQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLtskMIILVLAFPLLV----FIICCRQLrrrqsfRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFqehlslqD 275
Cdd:cd15206  164 AWYVF---LDLMLLVIPGLVmsvaYGLISWTL------LEAKKRVIRMLFVIVVEFFICWTPLYVINTWKAF-------D 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 276 EKSSYH--LDASVQVTQLVATTHCCVNPLLYLLLD---RKAF 312
Cdd:cd15206  228 PPSAARyvSSTTISLIQLLAYISSCVNPITYCFMNkrfRQAF 269
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
49-309 1.73e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 39.84  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  49 AVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAH-GESPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15400   12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVaLYPYPLVLVAIFHnGWALGEMHCKVSGFVMGLSVIGSIFNI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGY----RVFSQGRLASIFTTvscgIVACILAWAMATALSLPE----SVFYEPRMerqkHKCAFgkphflpIEAP 198
Cdd:cd15400   92 TGIAINRYcyicHSFAYDKLYSRWNT----LLYVCLIWALTVVAIVPNffvgSLEYDPRI----YSCTF-------VQTA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 199 LWKYVLTSKMI-----ILVLAFPLLVFIICCRQLRRR----QSFRERQYDLHK--PALVITGVFLLMWAPYNTVLFLSAF 267
Cdd:cd15400  157 SSSYTIAVVVIhfivpITVVSFCYLRIWVLVIQVRRKvkseSKPRLKPSDFRNflTMFVVFVIFAICWAPLNLIGLAVAI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 698979997 268 QEhlslqDEKSSYHLDASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15400  237 NP-----QEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQ 273
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
45-120 1.88e-03

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 39.72  E-value: 1.88e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGN-IYFLNLALSNLCFLLPLPFWA-HTAAHGESPGNGTCKVLVGLHSSGLY 120
Cdd:cd14983    8 VLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIKIvEALSSAWTLPAVLCPLYNLAHFSTLY 85
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
47-310 2.16e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 39.41  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLP---LPFWAHTAAHGESpgngTCKVLVGLHSSGLY 120
Cdd:cd15979   10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlaVFCMPftlIPNLMGTFIFGEV----ICKAVAYLMGVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 121 SEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRM-----ERQKHKCAFGKPHFLPI 195
Cdd:cd15979   86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPvpvgdRPRGHQCRHAWPSAQVR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 196 EAplWkYVLtskMIILVLAFPLLVFIIC----CRQLRRRQSFRERqydLHKPALVITGVFLLMWAPYNTVLFLSAFQEhL 271
Cdd:cd15979  166 QA--W-YVL---LLLILFFIPGVVMIVAygliSRELYRGLLAKKR---VIRMLVVIVAMFFLCWLPIFSANTWRAFDP-L 235
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 698979997 272 SLQDEKSSyhldASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15979  236 SAHRALSG----APISFIHLLSYTSACVNPLVYCFMNRR 270
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
48-261 2.36e-03

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 39.41  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  48 FAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE-SPGNGTCKVLVGLHSSGLYSEVFSN 126
Cdd:cd15121   11 FILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGwEFGSVVCKLCHYVCGVSMYASIFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFTT--VSCGIVACIlaWAMATALSLPESVFYEPRMERQKHKCAFgkPHFlPIEAPLWKYVL 204
Cdd:cd15121   91 TLMSMDRCLAVAKPFLSQKMRTkrSVRALLLAI--WIVAFLLSLPMPFYRTVLKKNINMKLCI--PYH-PSVGHEAFQYL 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 698979997 205 TSKMIILVLAFPLLVFIIC--CRQLRRRQSFRERQYDlhKPALVITGVFLLMWAPYNTV 261
Cdd:cd15121  166 FETITGFLLPFTAIVTCYStiGRRLRSARFRRKRRTN--RLVVLIIATFALFWLPYHVV 222
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-175 2.90e-03

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 39.12  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPFWAHTAAHGESPGNG-TCKV--LVGLHSSGLY 120
Cdd:cd15977    8 CVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYiLIAIPINVIKLIAEDWPFGVhVCKLypFIQKASVGIT 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 698979997 121 seVFSNILLLVQGYR-VFSQGRLASIFTTVScGIVACILAWAMATALSLPESVFYE 175
Cdd:cd15977   88 --VLSLCALSIDRYRaVASWSRIRGIGIPVW-KAVEVTLIWAVAIIVAVPEAIAFD 140
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
144-317 3.00e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.12  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 144 SIFTTVSCGIVACILAWAMATALSLPESVFYEPRMER--QKHKCAFGKPHFLPIEAPLWKYVltsKMIILVLAFPLLVFI 221
Cdd:cd15305  110 SRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKvfVNGTCVLNDENFVLIGSFVAFFI---PLIIMVITYCLTIQV 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 222 iccrqLRRRQSFR-ERQYDlhKPALVITGVFLLMWAPYNTVLFLSAFQEHlSLQDEKSSYHLDASVQVTQLVATthccVN 300
Cdd:cd15305  187 -----LQRQQAINnERRAS--KVLGIVFFLFLIMWCPFFITNILSVLCKE-ACDQKLMEELLNVFVWVGYVSSG----IN 254
                        170       180
                 ....*....|....*....|
gi 698979997 301 PLLYLLLD---RKAFMRYLR 317
Cdd:cd15305  255 PLVYTLFNktyRRAFSNYIR 274
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
47-306 3.10e-03

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 38.97  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES-P-GNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15373   10 VFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDwPfSEALCKIVRFLFYTNLYCSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 snILLLVQGYRVFSQGR-LASI-FTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCafgkpHFLPIEAPLWKY 202
Cdd:cd15373   90 --FLLCISVHRFLGVCYpVRSLrWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITC-----HDTSSPELFDQF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSkMIILVLAF--PLLVFIICCRQLRRR---------QSFRERQYDLhKPALVITGVFLLMWAPY--NTVLFLSAFQE 269
Cdd:cd15373  163 VVYS-SVMLVLLFcvPFVVILVCYALMVRKllkpsagtsTNSRSKKKSV-KMIIIVLAVFILCFLPFhvTRTLYYSFRSM 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 270 HLSLQDEKSSyhlDASVQVTQLVATTHCCVNPLLYLL 306
Cdd:cd15373  241 DLSCGTLNAI---NLAYKVTRPLASANSCLDPILYFL 274
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
154-322 4.52e-03

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 38.39  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 154 VACILAWAMATALSLPESVFYEPRMERqkhKCAFGKPHFLPIEApLWKYVLTSKMIILVLAfpLLVFIICCRQLRRRQSF 233
Cdd:cd14973  117 VVCALLWALSLLLSVLESYFCGFLFWK---FNESACRTFNFLSA-LLFLLLFLVMCVSSLT--LLIRVQCSSQRRPPTRL 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 234 rerqydlhkPALVITGVFLLmwapyntVLFLSAFQEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLYLL---LDRK 310
Cdd:cd14973  191 ---------YVVILLTVLVF-------LLCGLPLGIYWFLLLWFSNYLFHTFHPISDLLSCVNSSANPIIYFFvgsLRGR 254
                        170
                 ....*....|..
gi 698979997 311 AFMRYLRSLFPR 322
Cdd:cd14973  255 RLREPLRVVLQR 266
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
40-316 4.54e-03

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 38.27  E-value: 4.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  40 VLQFCCAVFA-VGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNL---CFLLPLpFWAHTAAHGESPGNGTCKVLVGLH 115
Cdd:cd15295    2 VLLFLMSLLAlVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFfvgAISIPL-YIPYTLTNRWDFGRGLCVFWLVID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 116 SSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILA-WAMATALSLPESVFYEpRMERQKHKCA---FGKPH 191
Cdd:cd15295   81 YLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTATLRIVTQMVAvWVLAFLVHGPAILVSD-SWKTEDGECEpefFSNWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 192 FLPIEAPLWKYVLTskmiILVLAFPLLVFiiccRQLRRRqsFRERQydLHKPALVITGVFLLMWAPYNTVLFLSAFQEhl 271
Cdd:cd15295  160 ILAITSVLEFLVPV----ILVAYFNTQIY----WSLWKR--LRDRK--LAKSLAIILGTFAICWAPYSLFTIIRAACE-- 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 698979997 272 slQDEKSSYHldasvQVTQLVATTHCCVNPLLYLLLD---RKAFMRYL 316
Cdd:cd15295  226 --KHRGSPWY-----NFAFWLQWFNSFINPFLYPLCHkrfRKAFLKIF 266
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
209-309 4.62e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 38.38  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 209 IILVLAFPLLVFIICCRQLRRRQ----SFRERQYDLH--KPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKssyhl 282
Cdd:cd15069  188 LLIMLVIYIKIFLVACRQLQRTElmdhSRTTLQREIHaaKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPK----- 262
                         90       100
                 ....*....|....*....|....*..
gi 698979997 283 dASVQVTQLVATTHCCVNPLLYLLLDR 309
Cdd:cd15069  263 -WAMNVAILLSHANSVVNPIVYAYRNR 288
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
46-316 4.81e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 38.18  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFwahTAAHGESP-----GNGTCKVLVGLHSSGL 119
Cdd:cd15394    9 LVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPL---TLAYAFEPrgwvfGRFMCYFVFLMQPVTV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 120 YSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACIlaWAMATALSLPESVfyeprmerQKHKCAFgKPHFLPIEAPL 199
Cdd:cd15394   86 YVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAI--WLLSCGLALPAAA--------HTYYVEF-KGLDFSICEEF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 200 WKYVLTSKMI------ILVLAFPLLVFIIC-CR---QLRRR-------QSFRE----RQYDLHKPALVITGVFLLMWAPY 258
Cdd:cd15394  155 WFGQEKQRLAyacstlLITYVLPLLAISLSyLRisvKLRNRvvpgsmtQSQAEwdraRRRKTFRLLVVVVVAFAICWLPL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 698979997 259 NTVLFLSAFQEHLSlqdEKSSYHLdasVQVT-QLVATTHCCVNPLLYLLLdRKAFMRYL 316
Cdd:cd15394  235 HIFNVIRDIDIDLI---DKQYFNL---IQLLcHWLAMSSACYNPFLYAWL-HDSFRGEL 286
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
40-310 5.76e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 38.24  E-value: 5.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  40 VLQFCCAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPF-----WAHTA-AHGESPGNG------T 107
Cdd:cd15928    3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLdlyrlWRYRPwRFGDLLCRLmyffseT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 108 CKVLVGLHSSGLYSEVFSNILLLVQGYRVFSQGRLASifttvscgIVACIlaWAMATALSLPESVFY-----EPRMERQK 182
Cdd:cd15928   83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKL--------LIAVI--WAVAIVSAGPALVLVgvehiQGQQTPRG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 183 HKCAFGKPHFLPIEAPLWkyVLTSKMIILVLAFPLLVFIICCRQLRRRQSFR----ERQYDLHKPA----LVITGVFLLM 254
Cdd:cd15928  153 FECTVVNVSSGLLSVMLW--VSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRtagaSRRDNNHRQTvrmlAVIVLAFVLC 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 698979997 255 WAPYNT--VLFLSAFQEHLSLQDEKSSYHLdASVQVTQLVATthccVNPLLYLLLDRK 310
Cdd:cd15928  231 WLPFHVgrVIFNHSRASTKHLHYVSQYFNL-VSFVLFYLSAA----INPILYNLMSKR 283
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
46-304 6.14e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 37.95  E-value: 6.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  46 AVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP-LPFWAHTAAHGE-SPGNGTCKVLVGLHSSGLYSEV 123
Cdd:cd15326    9 AFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGYwVFGRIFCDIWAAVDVLCCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 124 FSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKYV 203
Cdd:cd15326   89 LSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEITEEPFYALFSSLGSFY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 204 LTskmIILVLAFPLLVFIICCRQLRRRQSfrerqydlHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQdekssyhlD 283
Cdd:cd15326  169 IP---LIVILVMYCRVYIVALKFSREKKA--------AKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPP--------E 229
                        250       260
                 ....*....|....*....|.
gi 698979997 284 ASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15326  230 TLFKIIFWLGYFNSCLNPIIY 250
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
47-312 6.24e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.18  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLL--PLPFWAHTAAHGESPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd15000    9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLvcPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 SniLLLVqgyrvfSQGRLASI-------FTTVSCGIVACIlAWAMATALSLPESVFYEPRmERQ-----KHKCAfGKPHF 192
Cdd:cd15000   89 A--LCAV------SYDRLTAIvlpsearLTKRGAKIVIVI-TWIVGLLLALPLAIYRSYR-ERQwknflETYCA-ENTQV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 193 LPIeapLWkYVLtskmIILVLAFPLLVFIIC-----CRQLRRRQSFRERQYDLH--------KPALVITGVFLLMWAPYN 259
Cdd:cd15000  158 LPI---YW-HVI----ITVLVWLPLGIMLICysaifWKLDKYERRVLRREHPSVvrykkkaaKTLFIVLITFVVCRIPFT 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 260 TVLFLsafqEHLSLQDEKSSYHLDASVQVTQLVAT----THCCVNPLLYLLLD---RKAF 312
Cdd:cd15000  230 ALIFY----RYKLVPNDNTQNSVSGSFHILWFASKylmfLNAAVNPLIYGFTNenfRKAF 285
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
157-312 6.37e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 37.71  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 157 ILAWAMATALSLPESVFYEPRMERQKHKCAFGKPHFlpieaplwkyVLTSKMIILVLAFP--LLVFIICCRQLRRrqsfr 234
Cdd:cd15053  123 AIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPDF----------IIYSSISSFYIPCIvmLLLYYRIFRALRR----- 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 235 ERQYDlhKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQdekssyhlDASVQVTQLVATT-----HCCVNPLLYLLLD- 308
Cdd:cd15053  188 EKKAT--KTLAIVLGVFLFCWLPFFTLNILNAICPKLQNQ--------SCHVGPALFSLTTwlgyvNSFLNPIIYTIFNi 257

                 ....*.
gi 698979997 309 --RKAF 312
Cdd:cd15053  258 efRKAF 263
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
242-306 6.70e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 37.88  E-value: 6.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 698979997 242 KPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDEKssyhlDASVQVTQLVATTHCCVNPLLYLL 306
Cdd:cd15385  233 KMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDESE-----NTAVTITALLASLNSCCNPWIYMF 292
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
51-304 6.75e-03

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 37.78  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  51 GLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGESP-GNGTCKVLVGLHSSGLYSEVF----- 124
Cdd:cd15152   14 GLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPfGKFLCMFCFYLKYVNMYASIYflvci 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 125 --SNILLLVQGYRVFSQGRLASIFTTVSCGIVACIlawamaTALSLPESVFYEPRmerqKHKCAFgkphflpIEAPLWKY 202
Cdd:cd15152   94 svRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCV------GCLPFPLLRQSQDT----NPTCCF-------ADLPLRNV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLA------FPLLVFIICcrQLRRRQSFRERQYDLH---------KPALVITGVFLLMWAPYNTVLFLSAF 267
Cdd:cd15152  157 GLTTSVIMLTIAeltgfvTPLLIVLYC--SWKTVMSLREKTPVLQdlgekkkalKMILTCAVVFLICFAPYHISFPLDFL 234
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 698979997 268 QEHLSLQDEKSSYHLDASVQVTQLVATTHCCVNPLLY 304
Cdd:cd15152  235 VKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIY 271
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-310 7.42e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 37.69  E-value: 7.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  50 VGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLP--LPFWAHTAAHGESP-GNGTCKvLVGLhSSGLYSEVFSN 126
Cdd:cd15337   13 LGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVngFPLKTISSFNKKWIwGKVACE-LYGF-AGGIFGFMSIT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLV--QGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPeSVFYEPR--MERQKHKCAFgkpHFLPIEAPLWKY 202
Cdd:cd15337   91 TLAAIsiDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP-PFFGWGRyvPEGFQTSCTF---DYLSRDLNNRLF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTskMIILVLAFPLLVfIICC-----RQLRRR-------------------QSFRERQYDLHKPALVITGVFLLMWAPY 258
Cdd:cd15337  167 ILG--LFIFGFLCPLLI-IIFCyvniiRAVRNHekemtqtaksgmgkdteknDARKKAEIRIAKVAIILISLFLLSWTPY 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 698979997 259 NTVLFLSAFqehlslqdeKSSYHLDASV-QVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15337  244 AVVALLGQF---------GPAYWITPYVsELPVMFAKASAIYNPIIYALSHPK 287
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
47-307 7.85e-03

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 37.47  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFwaHTAAHGESPGNGTCKVLVGLHSSGLYSEVFsn 126
Cdd:cd15920   10 ICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPF--RVAYQNTAGPLSFCKIVGAFFYLNMYASIL-- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 127 ILLLVQGYRVFSQGRLASIFT--TVSCGIVACILAWAMATALSLPesVFYEprmERQKHKCAFGKPHFLP--IEAPLWKY 202
Cdd:cd15920   86 FLSLISLDRYLKIIKPLQQFKihTVPWSSAASGGVWLLLLACMIP--FLFE---SRNEGPCDNKCFHFRSkgLTAGGINL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 203 VLTSKMIILVLAFpLLVFIICCRQLRRRQSFRERQYDLHKPALVIT------GVFLLMWAPYNTVLFLSAFQEHLSLQDE 276
Cdd:cd15920  161 TAVVIFYILSLLF-LYFYAKISHKLYKVSLGNAQQQIKKASKRAIIktfivlAIFIVCFVPYHIVRVPYVLAQIDVISSL 239
                        250       260       270
                 ....*....|....*....|....*....|.
gi 698979997 277 KSSYHLDASVQVTQLVATTHCCVNPLLYLLL 307
Cdd:cd15920  240 PWKQTLHIANELVLCLSALNSCLDPIIYFFL 270
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
45-310 8.85e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 37.54  E-value: 8.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  45 CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCF-LLPLPF-WAHTAAHGESPGNGTCKVLVGLHSSGLYSE 122
Cdd:cd15978    8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLcLFCMPFtLIPNLLKDFIFGSAVCKTATYFMGISVSVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 123 VFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAWAMATALSLPESVF-----YEPRMERQKHKCAFGKPHFLPIEA 197
Cdd:cd15978   88 TFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYsnlvpFTRINNSTGNMCRLLWPNDVTQQS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997 198 plWkYVLTSKMIILVLAFPLLV-FIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFqehlslqDE 276
Cdd:cd15978  168 --W-YIFLLLILFLIPGIVMMTaYGLISLELYRGIKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRAF-------DT 237
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 698979997 277 KSSYHL--DASVQVTQLVATTHCCVNPLLYLLLDRK 310
Cdd:cd15978  238 RSADRLlsGAPISFIHLLSYTSACVNPIIYCFMNKR 273
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
47-130 9.03e-03

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 37.47  E-value: 9.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 698979997  47 VFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGE--SPGNGTCKVLVGLHSSGLYSEVF 124
Cdd:cd14996   10 LFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFywKYQSTQCRIANFFGTLVIHVSMC 89

                 ....*.
gi 698979997 125 SNILLL 130
Cdd:cd14996   90 VSILIL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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