C-C motif chemokine 28 isoform b [Homo sapiens]
Protein Classification
CC/CxC family chemokine( domain architecture ID 10441213)
CC/CxC family chemokine similar to human C-X-C motif chemokine 14, which is preferentially expressed in normal vs malignant tissue and as a chemokine is involved in the regulation of leukocyte infiltration into inflamed tissue and may affect disease processes
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
2-39 | 2.44e-05 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. : Pssm-ID: 459650 Cd Length: 60 Bit Score: 38.02 E-value: 2.44e-05
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| Name | Accession | Description | Interval | E-value | ||
| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
2-39 | 2.44e-05 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 38.02 E-value: 2.44e-05
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| Chemokine_CC_DCCL | cd01119 | Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ... |
3-39 | 2.93e-03 | ||
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238539 Cd Length: 61 Bit Score: 32.76 E-value: 2.93e-03
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| Name | Accession | Description | Interval | E-value | ||
| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
2-39 | 2.44e-05 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 38.02 E-value: 2.44e-05
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| Chemokine_CC_DCCL | cd01119 | Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ... |
3-39 | 2.93e-03 | ||
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238539 Cd Length: 61 Bit Score: 32.76 E-value: 2.93e-03
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