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Conserved domains on  [gi|683523937|ref|NP_001288640|]
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mannose-P-dolichol utilization defect 1 protein isoform 3 [Mus musculus]

Protein Classification

cystinosin/MPDU1 family protein( domain architecture ID 707892)

cystinosin/MPDU1 family protein similar to homo sapiens mannose-P-dolichol utilization defect 1, a cystinosin homolog that required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors

Gene Ontology:  GO:0006810|GO:0016020
PubMed:  22363504
TCDB:  2.A.43

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A43 super family cl28663
Lysosomal Cystine Transporter; [Transport and binding proteins, Amino acids, peptides and ...
 1-115 3.89e-42

Lysosomal Cystine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00951:

Pssm-ID: 130026 [Multi-domain]  Cd Length: 220  Bit Score: 138.45  E-value: 3.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 683523937    1 MHYRGETVKG-------------VAFLACYAMVLLALLSPLTPLAVVTLLQASNVPAVVVGKLLQAATNYRNGHTGQLSA 67
Cdd:TIGR00951  93 LHQCGDYERGwqrvsnpwilrilVALLACFATLLVALLSPITPLAFVTMLSYIKVAVTLVKYFPQAATNYHNKSTGQLSI 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 683523937   68 ITVFMLFGGSLARIFTSVQETGDPLMAGVFVVSSLCNGLIAAQVLFYW 115
Cdd:TIGR00951 173 ITVFLDFTGLLQRIFQSVNETGDPLKAGLFVVSSLFNGLFAAQVFFYW 220
 
Name Accession Description Interval E-value
2A43 TIGR00951
Lysosomal Cystine Transporter; [Transport and binding proteins, Amino acids, peptides and ...
 1-115 3.89e-42

Lysosomal Cystine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130026 [Multi-domain]  Cd Length: 220  Bit Score: 138.45  E-value: 3.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 683523937    1 MHYRGETVKG-------------VAFLACYAMVLLALLSPLTPLAVVTLLQASNVPAVVVGKLLQAATNYRNGHTGQLSA 67
Cdd:TIGR00951  93 LHQCGDYERGwqrvsnpwilrilVALLACFATLLVALLSPITPLAFVTMLSYIKVAVTLVKYFPQAATNYHNKSTGQLSI 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 683523937   68 ITVFMLFGGSLARIFTSVQETGDPLMAGVFVVSSLCNGLIAAQVLFYW 115
Cdd:TIGR00951 173 ITVFLDFTGLLQRIFQSVNETGDPLKAGLFVVSSLFNGLFAAQVFFYW 220
CTNS smart00679
Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, ...
 47-78 1.04e-05

Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins; Function unknown, but likely to be associated with the glycosylation machinery.


Pssm-ID: 128923 [Multi-domain]  Cd Length: 32  Bit Score: 39.74  E-value: 1.04e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 683523937    47 VGKLLQAATNYRNGHTGQLSAITVFMLFGGSL 78
Cdd:smart00679   1 VSLLPQIIKNYRRKSTEGLSILFVLLWLLGDI 32
 
Name Accession Description Interval E-value
2A43 TIGR00951
Lysosomal Cystine Transporter; [Transport and binding proteins, Amino acids, peptides and ...
 1-115 3.89e-42

Lysosomal Cystine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130026 [Multi-domain]  Cd Length: 220  Bit Score: 138.45  E-value: 3.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 683523937    1 MHYRGETVKG-------------VAFLACYAMVLLALLSPLTPLAVVTLLQASNVPAVVVGKLLQAATNYRNGHTGQLSA 67
Cdd:TIGR00951  93 LHQCGDYERGwqrvsnpwilrilVALLACFATLLVALLSPITPLAFVTMLSYIKVAVTLVKYFPQAATNYHNKSTGQLSI 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 683523937   68 ITVFMLFGGSLARIFTSVQETGDPLMAGVFVVSSLCNGLIAAQVLFYW 115
Cdd:TIGR00951 173 ITVFLDFTGLLQRIFQSVNETGDPLKAGLFVVSSLFNGLFAAQVFFYW 220
CTNS smart00679
Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, ...
 47-78 1.04e-05

Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins; Function unknown, but likely to be associated with the glycosylation machinery.


Pssm-ID: 128923 [Multi-domain]  Cd Length: 32  Bit Score: 39.74  E-value: 1.04e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 683523937    47 VGKLLQAATNYRNGHTGQLSAITVFMLFGGSL 78
Cdd:smart00679   1 VSLLPQIIKNYRRKSTEGLSILFVLLWLLGDI 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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