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Conserved domains on  [gi|665394738|ref|NP_001287460|]
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uncharacterized protein Dmel_CG7084, isoform F [Drosophila melanogaster]

Protein Classification

SLC22 family MFS transporter( domain architecture ID 13022872)

SLC22 (Solute carrier 22) family MFS transporter similar to Caenorhabditis elegans organic cation transporter 1; the SLC22 family includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs)

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
146-542 5.49e-99

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 304.50  E-value: 5.49e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 146 GWSYDKTWYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSsYT 225
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS-YE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 226 WFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSk 305
Cdd:cd17317   80 LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 306 yviesprwliskqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygiaslfagWRLARNTTIMGFSWCVVAV 385
Cdd:cd17317  159 -------------------------------------------------------------WWLPRRTIIVGLIWFVTSL 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 386 SYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYenLMIYLATF 465
Cdd:cd17317  178 VYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENT--LALTLALV 255
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 466 IKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGtTVDIRAPYYILGVLFLLGGIGALFLP 542
Cdd:cd17317  256 GKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLG-KIGPLLPLIIFGVLALLGGLLTLLLP 331
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
146-542 5.49e-99

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 304.50  E-value: 5.49e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 146 GWSYDKTWYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSsYT 225
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS-YE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 226 WFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSk 305
Cdd:cd17317   80 LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 306 yviesprwliskqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygiaslfagWRLARNTTIMGFSWCVVAV 385
Cdd:cd17317  159 -------------------------------------------------------------WWLPRRTIIVGLIWFVTSL 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 386 SYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYenLMIYLATF 465
Cdd:cd17317  178 VYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENT--LALTLALV 255
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 466 IKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGtTVDIRAPYYILGVLFLLGGIGALFLP 542
Cdd:cd17317  256 GKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLG-KIGPLLPLIIFGVLALLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
64-552 4.22e-73

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 242.61  E-value: 4.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738   64 AMIYMNIILALNIPDHWCTVPGreNTNFSLEEWRDITLPKQADNRgrktFSNCEMFQM----NFSEI-TD-WSAWNSNLT 137
Cdd:TIGR00898  22 AFHFVLIVFLGATPEHHCRLPD--AANLSSRCELNLTLPRLPDGR----PESCLRFMVdqwaNPSLLgCEpLKLSDLGLA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  138 KTtEACQNGWSYDKTWYESTIPTDHNWVCAKDLFV---TNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVvfcsLGR 214
Cdd:TIGR00898  96 AT-EPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVdltQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLST----LVT 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  215 LGSIMCTS---SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMW 291
Cdd:TIGR00898 168 AVSGVLTAfspNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  292 LTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLAR 371
Cdd:TIGR00898 248 AVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRK 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  372 NTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSt 451
Cdd:TIGR00898 328 TTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVP- 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  452 dERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGtTVDIRAPYYILGVLF 531
Cdd:TIGR00898 407 -VDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLG-EKWLFLPLVLFGGLA 484
                         490       500
                  ....*....|....*....|.
gi 665394738  532 LLGGIGALFLPETLHKKLPDT 552
Cdd:TIGR00898 485 LLAGILTLFLPETKGVPLPET 505
Sugar_tr pfam00083
Sugar (and other) transporter;
172-549 8.50e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 76.93  E-value: 8.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  172 VTNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSSYTW--FLIMSGIVGL------TVNSLFQ 243
Cdd:pfam00083  51 IVSIFSVGCF---IGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqLIVGRVLVGIgvggasVLAPMYI 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  244 SpqiigmEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRH------WDSFMWLTSIPTAMVLLFSKYVIESPRWLISK 317
Cdd:pfam00083 128 S------EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEK 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  318 QRFREAIVQLQKIAKINGhrfdmTEKELAEIYSRDKQDVTYGIAS--LFAGWRLARNTTIMGFSWCVV-------AVSYF 388
Cdd:pfam00083 202 GRLEEAREVLAKLRGVPD-----VDRELDEIKDSLEAGQEAEKASwkELFSTKTRRQRLLIGVMLQIFqqltginAIFYY 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  389 TLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTnsvsFLISFVTC------LPIIVYSTDERYENLMIYL 462
Cdd:pfam00083 277 STTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPL----LLLGAAGMaicfviLGIVALLGVSKSDWAGIVA 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  463 ATFIKFLNALTFFTVN----LQCLEIYPTCMRQTGVALGTI---LAN-AIGVLAPYLV-YLGTTVdirAPYYILGVLFLL 533
Cdd:pfam00083 353 IVFIALFIAFFAMGWGpvpwVIVSELFPLSVRSKAMALATAanwLANfLIGFLFPIITdAIGLGY---TFFIFAGLLVLF 429
                         410
                  ....*....|....*.
gi 665394738  534 GGIGALFLPETLHKKL 549
Cdd:pfam00083 430 IIFVFFFVPETKGRTL 445
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
171-547 1.59e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.97  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 171 FVTNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVVFCSLGrlgSIMC--TSSYTWFLIMSGIVGLTVNSLFQSPQII 248
Cdd:COG2271   49 LLASAFFLGYA---LGQIPAGLLADRFGRRRVLAIGLLLWGLA---TLLFgfATSFWQLLLLRFLLGLGEAGFFPAALKL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 249 GMEISREEDRSR-IAFFQScGWSIGTTLMPLLYWWLRH---WDSFMWLTSIPTAMVLLFSkyviespRWLIskqrfreAI 324
Cdd:COG2271  123 IAEWFPPKERGRaLGIFNA-GGPLGGALAPPLLGWLLAafgWRAAFLILGLPGLLLALLR-------FWLL-------AL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 325 VQLqkiakinghrfdmtekelaeiysrdkqdVTYGIASLFAGWrlarnttimgfswcvvAVSYFTLVL-FSSRMAGnpFL 403
Cdd:COG2271  188 AYF----------------------------LVYFALYGFLTW----------------LPTYLVEVRgLSLAQAG--LL 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 404 NFLYQsIVEIPAYVVGRYMGDTYGRRFTN--SVSFLISFVTCLPIIVYSTDeryeNLMIYLATFIKFLNALTFFTVNLQC 481
Cdd:COG2271  222 LSLPF-LAGIVGSLLGGWLSDRLGRRRKLvlAIGLLLAALALLLLALLPSP----ALAIALLFLAGFGLGGAFGLLWALA 296
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 482 LEIYPTCMRQTGVALGTILANAIGVLAPYLV-YLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHK 547
Cdd:COG2271  297 AELFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
PRK03893 PRK03893
putative sialic acid transporter; Provisional
186-313 4.37e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 43.15  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 186 GSFILGQMGDSYGRRFVYYISVVFCSlgrLGSIMCTSS--YTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF 263
Cdd:PRK03893  71 GGLLLGAMGDRYGRRLAMVISIVLFS---VGTLACGFApgYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASG 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665394738 264 FQSCGWSIGTTLMPLLYWWLRH---WDSFMWLTSIPTAMVLLFSKYVIESPRW 313
Cdd:PRK03893 148 FLISGFSIGAVVAAQVYSLVVPvwgWRALFFIGILPIIFALWLRKNLPEAEDW 200
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
146-542 5.49e-99

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 304.50  E-value: 5.49e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 146 GWSYDKTWYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSsYT 225
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS-YE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 226 WFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSk 305
Cdd:cd17317   80 LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 306 yviesprwliskqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygiaslfagWRLARNTTIMGFSWCVVAV 385
Cdd:cd17317  159 -------------------------------------------------------------WWLPRRTIIVGLIWFVTSL 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 386 SYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYenLMIYLATF 465
Cdd:cd17317  178 VYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENT--LALTLALV 255
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 466 IKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGtTVDIRAPYYILGVLFLLGGIGALFLP 542
Cdd:cd17317  256 GKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLG-KIGPLLPLIIFGVLALLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
64-552 4.22e-73

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 242.61  E-value: 4.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738   64 AMIYMNIILALNIPDHWCTVPGreNTNFSLEEWRDITLPKQADNRgrktFSNCEMFQM----NFSEI-TD-WSAWNSNLT 137
Cdd:TIGR00898  22 AFHFVLIVFLGATPEHHCRLPD--AANLSSRCELNLTLPRLPDGR----PESCLRFMVdqwaNPSLLgCEpLKLSDLGLA 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  138 KTtEACQNGWSYDKTWYESTIPTDHNWVCAKDLFV---TNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVvfcsLGR 214
Cdd:TIGR00898  96 AT-EPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVdltQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLST----LVT 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  215 LGSIMCTS---SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMW 291
Cdd:TIGR00898 168 AVSGVLTAfspNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  292 LTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLAR 371
Cdd:TIGR00898 248 AVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRK 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  372 NTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSt 451
Cdd:TIGR00898 328 TTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVP- 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  452 dERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGtTVDIRAPYYILGVLF 531
Cdd:TIGR00898 407 -VDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLG-EKWLFLPLVLFGGLA 484
                         490       500
                  ....*....|....*....|.
gi 665394738  532 LLGGIGALFLPETLHKKLPDT 552
Cdd:TIGR00898 485 LLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
140-542 1.79e-32

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 127.97  E-value: 1.79e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 140 TEACQNGWSYDKTWYESTIPTDHNWVCAKDLFV---TNVFVVGRVTevaGSFILGQMGDSYGRRFVYYISVVFCSLGRLG 216
Cdd:cd17376    5 QEPCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVpltTSLFFVGVLL---GSFISGQLSDRFGRKKVLFATMAVQTGFSFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 217 SIMCTSsYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSC-GWSIGTTLMPLLYWWLRHWDSFMWLTSI 295
Cdd:cd17376   82 QIFSPS-WEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCiFYAIGYMLLPLFAYFIRDWRMLLLALTL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 296 PTamvllfskyVIESPRWliskqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygiaslfagWRLARNTTI 375
Cdd:cd17376  161 PG---------VLCVPLW-----------------------------------------------------WFIPITTIM 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 376 MGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDerY 455
Cdd:cd17376  179 SLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTD--L 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 456 ENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGtTVDIRAPYYILGVLFLLGG 535
Cdd:cd17376  257 QVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLG-AYDRYLPYILMGSLTVLIG 335

                 ....*..
gi 665394738 536 IGALFLP 542
Cdd:cd17376  336 ILTLFLP 342
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
139-542 2.23e-30

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 122.01  E-value: 2.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 139 TTEACQNGWSYDKTWYESTIPTDHNWVC--------AKDLFVTNVFVvgrvtevaGSFILGQMGDSYGRRFVYYISVVFC 210
Cdd:cd17374    4 DTEPCVDGWVYDRSKFTSTIVTEWDLVCesqslksvAQSIFMAGLLV--------GALIFGHLSDRFGRKFILLLSLLQL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 211 SLGRLGSIMCTSSYTW----FLIMSGIVGLTVNSLfqspqIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHW 286
Cdd:cd17374   76 AIFGTCAAFAPTFPVYcvlrFLAGFAVSGISINTL-----ILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDW 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 287 dsfMWLTSIPTAMVLLFSkyviesprwliskqrfreaivqlqkiakinghrfdmtekelaeIYSrdkqdvtygiaslfag 366
Cdd:cd17374  151 ---RLLQLVVSVPFFLFF-------------------------------------------LYS---------------- 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 367 WRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPI 446
Cdd:cd17374  169 WWLPKRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILAN 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 447 IVYSTDerYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPyLVYLGTTVDIRAPYYI 526
Cdd:cd17374  249 IFVPQE--MQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAP-LIMLLGVYSPLLPMII 325
                        410
                 ....*....|....*.
gi 665394738 527 LGVLFLLGGIGALFLP 542
Cdd:cd17374  326 YGVLPILAGLLALLLP 341
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
142-542 9.99e-28

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 114.37  E-value: 9.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 142 ACQNGWSYDKtwYESTIPTDHNWVCAK----DLFVTNV---FVVGrvtevagSFILGQMGDSYGRRFVYYISVVFcsLGR 214
Cdd:cd17379    7 PCQDGWVYNT--PRSSIVTEFNLVCEDawklDLFQSSLnlgFLIG-------SIVIGYLADRFGRKVCFLISILG--NGV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 215 LGSIMCTS-SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLT 293
Cdd:cd17379   76 SGVLMAFSpNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 294 SIPTAMVLLFskyviespRWLISKqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygiaslfagwrlarNT 373
Cdd:cd17379  156 TLPNFLFLLY--------YWFIPK------------------------------------------------------HT 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 374 TIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDE 453
Cdd:cd17379  174 FILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDL 253
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 454 RYenLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLL 533
Cdd:cd17379  254 HW--LKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYRLAEIWLELPLIVFGVLALV 331

                 ....*....
gi 665394738 534 GGIGALFLP 542
Cdd:cd17379  332 AGGLVLLLP 340
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
140-542 1.55e-24

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 105.20  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 140 TEACQNGWSYDKTWYESTIPTDHNWVCAK---DLFVTNVFVVGrVTevAGSFILGQMGDSYGRRFVYYISVVfCSLGRLG 216
Cdd:cd17447    5 VVPCQNGWVYDHSTFSSTIATEWDLVCDRkglNQATATFFFAG-VT--MGAVAFGYLSDRFGRKRMLLVAYV-LSLVFGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 217 SIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWdsfmwltsip 296
Cdd:cd17447   81 ASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDW---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 297 tamvllfskyviespRWLIskqrfreaivqlqkiakinghrfdmtekeLAeiysrdkqdVTYGIA-SLFAGWRLARNTTI 375
Cdd:cd17447  151 ---------------RWLI-----------------------------LA---------VTLPCApGIITWWWVPKISLC 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 376 MGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDerY 455
Cdd:cd17447  178 TGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSE--F 255
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 456 ENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPyLVYLGTTVDIRAPYYILGVLFLLGG 535
Cdd:cd17447  256 TVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAP-LVILLDDVWLSLPQVIFCGVALLAG 334

                 ....*..
gi 665394738 536 IGALFLP 542
Cdd:cd17447  335 GVAFLLP 341
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
138-542 3.75e-24

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 104.06  E-value: 3.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 138 KTTEACQNGWSYDKTWYESTIPTDHNWVCAKDLF---VTNVFVVGRVTevaGSFILGQMGDSYGRR----------FVYY 204
Cdd:cd17375    3 KTRFSCSDGFVYDQSKWESSIVTDWDLVCDREWLaklIQPIFMLGVLL---GAVIFGDIADRIGRRpvlwftstgqFVFG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 205 ISVVFcslgrlgsimcTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLR 284
Cdd:cd17375   80 IAVAF-----------TFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVR 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 285 HWdsfmWLTSIPTAMVLlfskyviesprwliskqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygIASLF 364
Cdd:cd17375  149 TW----WIYQIILSLVT----------------------------------------------------------IPFIL 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 365 AGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCL 444
Cdd:cd17375  167 CCWMLPKRTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACM 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 445 PIIVYSTDerYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLgTTVDIRAPY 524
Cdd:cd17375  247 LIMVIPQD--YEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYL-SDVWIFLPQ 323
                        410
                 ....*....|....*...
gi 665394738 525 YILGVLFLLGGIGALFLP 542
Cdd:cd17375  324 LLVGIMAFLSGILTLMLP 341
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
186-539 1.45e-19

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 90.35  E-value: 1.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 186 GSFILGQMGDSYGRRFVYYISVVFCSLGRLGsIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQ 265
Cdd:cd17316   52 GALLFGYLGDRIGRKKALILTLLLFGLATLL-IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 266 SCGWSIGTTLMPLLYWWLRH-------WDSFMWLTSIPTAMVLLFSKYVIesprwliskqrfreaivqlqkiakinghrf 338
Cdd:cd17316  131 QSGWALGALLAALVASLLIPllsgdwgWRILFLIGALPALLALLLRRRTL------------------------------ 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 339 dmtekelaeiysrdkqdvtygiaslfagwrlarntTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNF-------LYQSIV 411
Cdd:cd17316  181 -----------------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPatsslylLLISLG 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 412 EIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYeNLMIYLATFIkFLNALTFFTVNLQCLEIYPTCMRQ 491
Cdd:cd17316  226 ALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT-LLLLLLFILS-FFVGGVWGALYAYLAELFPTEVRA 303
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 665394738 492 TGVALGTILANAIGVLAPYLV--YLGTTVDIRAPYYILGVLFLLGGIGAL 539
Cdd:cd17316  304 TGVGLSYNLGRLGGGGAPPLIalLLASTGGTGVPALILALLAIVALIVAL 353
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
184-544 3.93e-16

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 80.42  E-value: 3.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 184 VAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMcTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF 263
Cdd:cd17371   48 AIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF-AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALG 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 264 FQSCGWSIGTTLMPLLYWWL-------RHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRfreaivqlqkiakingH 336
Cdd:cd17371  127 YVQSGWAVGWLLATLLAALLfpllppeIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAA----------------R 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 337 RFDMTEKELAEIYSRDKQDVTYgIASLFAGWRLARNTTIMGFswcvvAVSYFTLVLFSS--RMAGnpFLNFLYqsIVEIP 414
Cdd:cd17371  191 RHFADRPSLRELFSPPLLRTTL-LASLLATGALGGYYGITTW-----LPSYLTGERGLSfeGSAG--YLVVTI--LGGFL 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 415 AYVVGRYMGDTYGRRFTNSVSFLISFVtCLPIIVYSTDErYENLMIYLATFIKFLNA-----LTFFTvnlqclEIYPTCM 489
Cdd:cd17371  261 GYLAGGFLADRIGRRNNFALFALGSAI-SILLYFFLPLS-PTLILILGFPLGFFASGpfsgmGAYLT------ELFPTAV 332
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 490 RQTGVALGTILANAIGVLAPYLV-YLGTTVDIRAPYYILG-VLFLLGGIGALFLPET 544
Cdd:cd17371  333 RATAQGFCYNVGRIIGALFPFLVgFLATSGSLGTAIAVFAaVYYIAGLVLALLLPET 389
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
140-542 1.34e-15

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 78.23  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 140 TEACQNGWSYDKTWYESTIPTDHNWVC--------AKDLFVTNVFVvgrvtevaGSFILGQMGDSYGRRFVYYISVVFCS 211
Cdd:cd17446    3 TEPCTDGWVYDKSEFPSTIITEWDLVCnhralrqlAQSIYMAGVLV--------GAIVFGGLSDRFGRRPLLIWSYLQMA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 212 LGRLGSIMcTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMW 291
Cdd:cd17446   75 VSGTCAAF-SPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 292 LTSIPTAMVLLFSkyviesprwliskqrfreaivqlqkiakinghrfdmtekelaeiysrdkqdvtygiaslfagWRLAR 371
Cdd:cd17446  154 AVSLPFFIFFLYS--------------------------------------------------------------WWFPR 171
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 372 NTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYST 451
Cdd:cd17446  172 ITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQ 251
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 452 DerYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIrAPYYILGVLF 531
Cdd:cd17446  252 D--LQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPF-LPLIIYGAAP 328
                        410
                 ....*....|.
gi 665394738 532 LLGGIGALFLP 542
Cdd:cd17446  329 ILSGIAACFLP 339
Sugar_tr pfam00083
Sugar (and other) transporter;
172-549 8.50e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 76.93  E-value: 8.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  172 VTNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSSYTW--FLIMSGIVGL------TVNSLFQ 243
Cdd:pfam00083  51 IVSIFSVGCF---IGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqLIVGRVLVGIgvggasVLAPMYI 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  244 SpqiigmEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRH------WDSFMWLTSIPTAMVLLFSKYVIESPRWLISK 317
Cdd:pfam00083 128 S------EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEK 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  318 QRFREAIVQLQKIAKINGhrfdmTEKELAEIYSRDKQDVTYGIAS--LFAGWRLARNTTIMGFSWCVV-------AVSYF 388
Cdd:pfam00083 202 GRLEEAREVLAKLRGVPD-----VDRELDEIKDSLEAGQEAEKASwkELFSTKTRRQRLLIGVMLQIFqqltginAIFYY 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  389 TLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTnsvsFLISFVTC------LPIIVYSTDERYENLMIYL 462
Cdd:pfam00083 277 STTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPL----LLLGAAGMaicfviLGIVALLGVSKSDWAGIVA 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  463 ATFIKFLNALTFFTVN----LQCLEIYPTCMRQTGVALGTI---LAN-AIGVLAPYLV-YLGTTVdirAPYYILGVLFLL 533
Cdd:pfam00083 353 IVFIALFIAFFAMGWGpvpwVIVSELFPLSVRSKAMALATAanwLANfLIGFLFPIITdAIGLGY---TFFIFAGLLVLF 429
                         410
                  ....*....|....*.
gi 665394738  534 GGIGALFLPETLHKKL 549
Cdd:pfam00083 430 IIFVFFFVPETKGRTL 445
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
369-542 3.84e-14

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 73.93  E-value: 3.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 369 LARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIV 448
Cdd:cd17378  171 FARRLLAVMVIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFV 250
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 449 YSTDERYEnLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIrAPYYILG 528
Cdd:cd17378  251 LSIGGTTS-LQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAA-LSFGVFG 328
                        170
                 ....*....|....
gi 665394738 529 VLFLLGGIGALFLP 542
Cdd:cd17378  329 VAILLLGLFALGLP 342
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
172-539 6.68e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.53  E-value: 6.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 172 VTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGrlGSIMCTS-SYTWFLIMSGIVGLTVNSLFQSPQIIGM 250
Cdd:cd06174   33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG--ALLFAFApSFWLLLLGRFLLGLGSGLIDPAVLALIA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 251 EISREEDRSRIAFFQSCGWSIGTTLMPLL-----YWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIV 325
Cdd:cd06174  111 DLFPERERGRALGLLQAFGSVGGILGPLLggilaSSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 326 QLQKIAKinghrfdmtekelaeIYSRDKQDVTYGIASLFAgwrlarNTTIMGFSwcvvavSYFTLVLFSSRMAGNPFLNF 405
Cdd:cd06174  191 SVLKLLK---------------RVLKNPGLWLLLLAIFLV------NLAYYSFS------TLLPLFLLDLGGLSVAVAGL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 406 LY--QSIVEIPAYVVGRYMGDtygRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKFLNALTFFTVNLQCLE 483
Cdd:cd06174  244 LLslFGLAGALGSLLLGLLSD---RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665394738 484 IYPTCMRQTGVALGTILANAIGVLAPYLV--YLGTTVDIRAPYYILGVLFLLGGIGAL 539
Cdd:cd06174  321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAgfLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
184-555 7.43e-13

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 70.68  E-value: 7.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 184 VAGSFILGQMGDSYGRRFVYYISVVFCSLGRLgSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF 263
Cdd:cd17358   55 LIGALLSGKLADRIGRKRTLLISAIPCILGWL-LIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGS 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 264 FQSCGWSIGTTLMPLLYWWLrHWDSFMWLTSIPT--AMVLLFskYVIESPRWLISKQRFREAIVQLQkiaKINGHRFDmT 341
Cdd:cd17358  134 LNQLLVNIGILLGYVLGSFL-PWRTLALIGAIPPvvFLILLF--FIPESPRWLAKKGREEEAEKSLQ---FLRGKDAD-I 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 342 EKELAEI-YSRDKQDVTY---GIASLFAgwRLARNTTIMGFS------WC-VVAVSYFTLVLFSSRMAG-NPFLNFLYQS 409
Cdd:cd17358  207 SKEAAEIqEELAELEKEAkesSFSDLFQ--RKYLKPLVIGLGlmlfqqLSgINAVIFYASSIFDEAGSGlDPNTATIIIG 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 410 IVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLA--TFIKFLNALTFFTVNLQCL----- 482
Cdd:cd17358  285 VVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEHGALLSSVSwlPLVGLVIYIISFSIGLGPLpwvim 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 483 -EIYPTCMRQTGVALGTI---------------LANAIGVLAPYLVYLGTTVdirapyyiLGVLFLLggigaLFLPETLH 546
Cdd:cd17358  365 sEIFPAKIKGLAGSLVTLvnwlfafivtktfpfLTLAWGASGTFWIFAGICG--------LALVFVL-----LFVPETKG 431

                 ....*....
gi 665394738 547 KklpdTMEE 555
Cdd:cd17358  432 K----SLEE 436
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
360-542 2.16e-12

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 68.65  E-value: 2.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 360 IASLFAGWRlarnTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDT--YGRRFTNSVSFL 437
Cdd:cd17377  170 LLSLFIPGR----TLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQkwSGRRRTLAGFLF 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 438 ISFVTCLPIIVYSTDERYENLMIYLATFIKFLNALT----FFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVY 513
Cdd:cd17377  246 LGGIACLLVMFVPEKKDSGVFAVVNSTSLSLLGKLTisaaFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPS 325
                        170       180
                 ....*....|....*....|....*....
gi 665394738 514 LgTTVDIRAPYYILGVLFLLGGIGALFLP 542
Cdd:cd17377  326 L-KSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_1 pfam07690
Major Facilitator Superfamily;
184-509 2.73e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.21  E-value: 2.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  184 VAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSSYtWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSR--- 260
Cdd:pfam07690  46 ALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW-LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRalg 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  261 -IAFFQSCGWSIGTTLMPLLYWWLrHWDSFMWLTSIPTAMVLLFSKYVIESPRwlISKQRFREAIVQLQKIAkinghrfd 339
Cdd:pfam07690 125 lVSAGFGLGAALGPLLGGLLASLF-GWRAAFLILAILSLLAAVLLLLPRPPPE--SKRPKPAEEARLSLIVA-------- 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  340 mtekelaeiysrdkqdvtygIASLFAGWRLARNTTIMGFSWCVVAVSYFtLVLFSSRMAGNPFLNFLYQSIVEI---PAY 416
Cdd:pfam07690 194 --------------------WKALLRDPVLWLLLALLLFGFAFFGLLTY-LPLYQEVLGLSALLAGLLLGLGGLlgaIGR 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  417 VVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYeNLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVAL 496
Cdd:pfam07690 253 LLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS-LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
                         330
                  ....*....|...
gi 665394738  497 GTILANAIGVLAP 509
Cdd:pfam07690 332 YNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
171-547 1.59e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.97  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 171 FVTNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVVFCSLGrlgSIMC--TSSYTWFLIMSGIVGLTVNSLFQSPQII 248
Cdd:COG2271   49 LLASAFFLGYA---LGQIPAGLLADRFGRRRVLAIGLLLWGLA---TLLFgfATSFWQLLLLRFLLGLGEAGFFPAALKL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 249 GMEISREEDRSR-IAFFQScGWSIGTTLMPLLYWWLRH---WDSFMWLTSIPTAMVLLFSkyviespRWLIskqrfreAI 324
Cdd:COG2271  123 IAEWFPPKERGRaLGIFNA-GGPLGGALAPPLLGWLLAafgWRAAFLILGLPGLLLALLR-------FWLL-------AL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 325 VQLqkiakinghrfdmtekelaeiysrdkqdVTYGIASLFAGWrlarnttimgfswcvvAVSYFTLVL-FSSRMAGnpFL 403
Cdd:COG2271  188 AYF----------------------------LVYFALYGFLTW----------------LPTYLVEVRgLSLAQAG--LL 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 404 NFLYQsIVEIPAYVVGRYMGDTYGRRFTN--SVSFLISFVTCLPIIVYSTDeryeNLMIYLATFIKFLNALTFFTVNLQC 481
Cdd:COG2271  222 LSLPF-LAGIVGSLLGGWLSDRLGRRRKLvlAIGLLLAALALLLLALLPSP----ALAIALLFLAGFGLGGAFGLLWALA 296
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 482 LEIYPTCMRQTGVALGTILANAIGVLAPYLV-YLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHK 547
Cdd:COG2271  297 AELFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
181-508 1.84e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.68  E-value: 1.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 181 VTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMcTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSR 260
Cdd:COG2814   56 LGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGR 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 261 -IAFFQScGWSIGTTLMPLLYWWLRH---WDSFMWLTSIPTAMVLLFSKYVIESPRwLISKQRFREAIVQLQkiakingh 336
Cdd:COG2814  135 aLGLLGA-GLGLGPALGPLLGGLLADlfgWRWVFLVNAVLALLALLLLLRLLPESR-PAARARLRGSLRELL-------- 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 337 rfdmtekelaeiysRDKQDVTYGIASLFAGwrlarnttIMGFSWCVVAVSYFTLVL-FSSRMAGnpfLNFLYQSIVEIPA 415
Cdd:COG2814  205 --------------RRPRLLLLLLLAFLLG--------FGFFALFTYLPLYLQEVLgLSASAAG---LLLALFGLGGVLG 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 416 YVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTderyeNLMIYLATFI-KFLNALTFFTVNLQCLEIYPTCMRQTGV 494
Cdd:COG2814  260 ALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS-----LWLLLLALFLlGFGFGLLFPLLQALVAELAPPEARGRAS 334
                        330
                 ....*....|....
gi 665394738 495 ALGTILANAIGVLA 508
Cdd:COG2814  335 GLYNSAFFLGGPLA 348
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
171-544 2.21e-10

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 63.05  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 171 FVTNVFVVGrvtEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSSYTWFLIMSG--IVGLTVNSLFQSPQII 248
Cdd:cd17357   53 LIVSIFFIG---GAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGrfLVGIACGLSTGFVPMY 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 249 GMEISREEDRSRIAFFQSCGWSIGTTL-----MPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFR-E 322
Cdd:cd17357  130 LQEISPSELRGALGSLTQIGVTLGILLgqvfgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEeE 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 323 AIVQLQKIAKINghrfDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARN----TTIMGFSWC-----VVAVSYFTLVLF 393
Cdd:cd17357  210 AEKSLKFLRGIE----DDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLrlplLLVLVVSASqqfsgINAIFFYSTFIF 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 394 SS---RMAGNPFLNFLyQSIVEIPAYVVGRYMGDTYGRRfTNSVSFLISFVTCLPIIVYSTDERYEN----------LMI 460
Cdd:cd17357  286 ENagfSPQLAEWANLG-IGIVNVLSTIVGPFLIEKVGRR-PLLLISLSVCAVALLLMSVFLFLSEQNswmsygcivaIFL 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 461 YLATFIKFLNALTFFTVNlqclEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVdIRAPYYILGVLFLLGGIGALF 540
Cdd:cd17357  364 FIFFFAIGLGPIPWFIGA----ELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSI-GGGFVFIIFAIPCALFLLYLY 438

                 ....*.
gi 665394738 541 --LPET 544
Cdd:cd17357  439 ryLPET 444
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
184-512 1.54e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 60.06  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  184 VAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSImCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF 263
Cdd:TIGR00895  66 AFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCA-LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVG 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  264 FQSCGWSIGTTLMPLLYWWL---RHWDSFMWL-TSIPTAMVLLFSKYVIESPRWLISKqRFREAIVQLQKIAKINGHRFD 339
Cdd:TIGR00895 145 LMFCGYPIGAAVGGFLAGWLipvFGWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSK-RPETVRRIVNAIAPQMQAEAQ 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  340 mteKELAEIySRDKQDVTYGIASLFAGwRLARNTTIMGFSWCVVAVSYFTL-----VL-----FSSRMAGnpFLNFLYQS 409
Cdd:TIGR00895 224 ---SALPEQ-KSTQGTKRSVFKALFQG-KTARITVLLWLLYFMLLVGVYFLtnwlpKLmvelgFSLSLAA--TGGALFNF 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  410 IVEIPAYVVGRYMgDTYGRRFTNSVSFLISFvtcLPIIVYSTdERYENLMIYLATFIKFLnALTFFTVNLQCL-EIYPTC 488
Cdd:TIGR00895 297 GGVIGSIIFGWLA-DRLGPRVTALLLLLGAV---FAVLVGST-LFSPTLLLLLGAIAGFF-VNGGQSGLYALMaLFYPTA 370
                         330       340
                  ....*....|....*....|....
gi 665394738  489 MRQTGVALGTILANAIGVLAPYLV 512
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGPILA 394
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
171-549 2.41e-09

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 60.05  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  171 FVTNVFVVGRVTevaGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIM-CTSSYTWFLIMSGIV---GLTVNSLFqSPQ 246
Cdd:TIGR00879  75 LVVSIFLVGGFI---GALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLaAFALSVEMLIVGRVLlgiGVGIASAL-VPM 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  247 IIGmEISREEDRSRIAFFQSCGWSIG------TTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRF 320
Cdd:TIGR00879 151 YLS-EIAPKALRGALTSLYQLAITFGilvaygFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRV 229
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  321 REAIVQLQKIAKINGhrfdmTEKELAEIYSRDKQDVTYGIASLFAGW------------RLARNTTIMGFSW--CVVAVS 386
Cdd:TIGR00879 230 EEARKSLARLRGTSG-----EDKELLDELELIDIKRSIEKRSVQPSWgslfsstrrirrRLFLGVVLQWFQQftGINAIM 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  387 YFTLVLFSSRMAGN--PFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTnsvsFLISFVTC------LPIIVYSTDERYENL 458
Cdd:TIGR00879 305 YYSPTIFENAGVSTdhAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPL----LLIGAAGMaiclfvLGILGASFVTGSSKS 380
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  459 MIYLATFikFLNALTFF-------TVNLQCLEIYPTCMRQTGVALGTILANA----IGVLAPYLV-YLGTTVdiraPYYI 526
Cdd:TIGR00879 381 SGNVAIV--FILLFIAFfamgwgpVPWVIVSEIFPLSLRPKGISIAVAANWLanfiVGFLFPTMLeSIGVGG----VFIF 454
                         410       420
                  ....*....|....*....|....
gi 665394738  527 LGVLFLLGGIGALF-LPETLHKKL 549
Cdd:TIGR00879 455 FGGLNVLGLIFVYFfLPETKGRTL 478
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
172-541 4.62e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 58.70  E-value: 4.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 172 VTNVFVVGRVTevaGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMcTSSYTWFLIMSGIVGLTVNSLFQSpQIIGME 251
Cdd:cd17372   39 ITSVVFAGMMI---GSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAF-APNYMWLIILRCLVGLGLGGGPQL-ASWYLE 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 252 ISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWL---TSIPTAMVLLFSKYViesPRwliskqrfreAIVQLQ 328
Cdd:cd17372  114 FLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLlafSSVPSSLLLVFYRWT---PK----------TTLLLW 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 329 KIAKINGHRFDMTEKELAEIYSRDkqDVTYgiaslfagwrlARNTTIMGFSWCVVAVSYFtlvlfssrmAGNPFLNFLYQ 408
Cdd:cd17372  181 VIWFGNAFAYYGVVLLTTELNNSH--NVCG-----------SKSDSDSGESPTEKQCRNS---------NDVDYRDVFIA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 409 SIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTderyENLMIYLATFIKFLNALTFFTVNLQCLEIYPTC 488
Cdd:cd17372  239 TFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQS----PFILTVLLFGGRACISAAFTVVYIYTPEVYPTA 314
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665394738 489 MRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLLGGIGALFL 541
Cdd:cd17372  315 VRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
171-327 1.14e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 56.74  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 171 FVTNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGsIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGM 250
Cdd:COG0477   53 WIVSAYLLGRA---IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL-CGLAPSPELLIAARALQGIGAGGLMPGALALIA 128
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665394738 251 EISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSF--MWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQL 327
Cdd:COG0477  129 ELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWrwIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALL 207
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
186-548 1.77e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.81  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 186 GSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTsSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQ 265
Cdd:COG2223   56 LRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV-SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLA 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 266 SCGWSIGTTLMPLLYWWLRH---WDSFMWLTSIPTA-MVLLFSKYVIESPRWLISKQRFreaivqlqkiakinghrfdmT 341
Cdd:COG2223  135 AGGGNLGAAVAAFLAPLLIAafgWRNAFLILGILLLvVAVLAWLFLRDPPAGAAAAAKA--------------------S 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 342 EKELAEIYsRDKQdvTYGIASLFAGwrlarnTTIMGFSWCVVAVSYFTLVL-FSSRMAGnpFLNFLYqSIVEIPAYVVGR 420
Cdd:COG2223  195 LRDQLEAL-RDPR--FWLLSLLYFG------TFGSFIGFSSWLPPYLVDQFgLSAATAG--LLAALF-ALLGALGRPLGG 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 421 YMGDTYGRRFTNSVSFLISFVTCLPIIVYSTderyeNLMIYLATFI------KFLNALTFFTVnlqcLEIYPTcmRQTGV 494
Cdd:COG2223  263 WLSDRIGGRRVLLIVFALMALGLLLLALALG-----SLWLFLVLFLllglalGGGNGAVFALV----PDIFPT--KNAGA 331
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665394738 495 ALGTILA--NAIGVLAPYLV--YLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKK 548
Cdd:COG2223  332 VYGLVGAagGLGGFLGPLLFgaLLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
172-542 1.97e-08

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 56.74  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 172 VTNVFVVGRVtevAGSFILGQMGDSYGRRFVYYISVVF-CSLGRLGSImcTSSYTWFLIMSGIVGLTVNSLFQSPQIIGm 250
Cdd:cd17441   39 LTSVVFIGMM---LSSSLWGNISDQYGRKTGLKISVLWtLYYGILSAF--APIYSWILVLRGLVGFGIGGVPQSVTLYA- 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 251 EISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSkyvIESPrWLISKQRFREAIVqLQKI 330
Cdd:cd17441  113 EFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFA---VLCF-WLPESARYWTTIL-LWFI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 331 AKINGHRFdmtekelaeiysrdkqdvtYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSrmagNPFLNFLYQSI 410
Cdd:cd17441  188 WFSNAFSY-------------------YGLVLLTTELFQAGDVCSGSSGKKVEGKCSLECEYLTT----SDYMDLLWTTL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 411 VEIPAYVVGRYMGDTYGRRFTNSVSFLIsFVTCLpIIVYSTDERYeNLMIYLatFIkflnALTFFTVNLQCL-----EIY 485
Cdd:cd17441  245 SEFPGLLVTLWIIDRFGRKKTMALCFFV-FSFCT-LLLFSCVGRF-SLTVLL--FI----ARAFISGGFQAAyvytpEVY 315
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665394738 486 PTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLP 542
Cdd:cd17441  316 PTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
140-303 3.57e-07

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 52.47  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 140 TEACQNGWSYDK-TWYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLgrLGSI 218
Cdd:cd17443    5 AVLCTGGWPFSAaAGLGSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATL--LGVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 219 MC-TSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPT 297
Cdd:cd17443   83 VAlSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPL 162

                 ....*.
gi 665394738 298 AMVLLF 303
Cdd:cd17443  163 LLLLLY 168
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
189-536 2.52e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.86  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 189 ILGQMGDSYGRRFVYYISVVFCSLGrLGSIMCTSSYTWFLIMSGIVGLTVnSLFQsPQiiGMEISREEDRSRIAFFQS-- 266
Cdd:cd17478   50 LFGYLADRKPRRYLLPLGPLLTGLG-LSLLGFAPNYWLLLLLVALAGIGS-AAFH-PE--GARLASQAAGGRRGLAMSif 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 267 -CGWSIGTTLMPLLYWWL-RHWD--SFMWLTSIPTAMVLLFskyviesprWLISKQRFREAIVQLQKIAKInghrfdmte 342
Cdd:cd17478  125 sVGGNLGFALGPLIAAALvALFGglGLLILLIIPGLAVALL---------LLRLRPLKKPEAKKAAAKSSA--------- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 343 kelaeiysrdkqdvtygIASLFAGWRLARNTTIMGF--SWCVVAVSYFTLVLFSSRMAGNPFLNFLyQSIVEIPAYV--- 417
Cdd:cd17478  187 -----------------RSTLKGVWRALLLLLIIVFlrSWVLSSLTTFLPFYLVQRGYSLVFAGLL-LSLFLFAGAIgtl 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 418 VGRYMGDTYGRRFTNSVSFLISFVtCLPIIVYSTDeryenLMIYLATFIKFLNALTFFTVNL-QCLEIYPtcmRQTGVAL 496
Cdd:cd17478  249 IGGPLSDRFGRRRVIIASLLLAAP-FLLLFLLTPG-----IWSYILLVLAGFLLFASFPVTVvLAQELLP---GNVGLAS 319
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 665394738 497 GTI--LANAIG-VLAPYLVYLGTTVDIRAPYYILGVLFLLGGI 536
Cdd:cd17478  320 GLMmgLSFGLGgIGAPVLGALADAFGLESVLLILALLPLLGAL 362
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
184-541 3.18e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.85  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 184 VAGSFILGQMGDSYGRRFVYYISVVFCSLGrLGSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF 263
Cdd:COG0738   57 LLASLPAGRLIDRFGYKRGLLLGLLLMALG-LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNL 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 264 FQSCgWSIGTTLMPLLYWWL------RHWDSFMWLTSIPTAMVLLfskyviesprwLISKQRFREaivqlqkiAKINGHR 337
Cdd:COG0738  136 LHAF-FSLGALLGPLLGGLLillglsLSWHLPYLILAVLLLLLAL-----------LFLRSKLPE--------IEEEEEE 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 338 FDMTEKELAEIYsRDKQDVTYGIASLF-AGwrlarnTTIMGFSWcvvAVSYFTLVL-FSSRMAGNPFLNFLYqsiveipA 415
Cdd:COG0738  196 AAGSAASLKSLL-KNPRLLLGGLAIFLyVG------AEGAIGDW---LPLYLKDVLgLSEATAALGLSLFWG-------G 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 416 YVVGRYMGDTYGRRFTNS----VSFLISFVTCLpIIVYSTDeryENLMIYLATFIKFLNALtfftvnlqcleIYPTCM-- 489
Cdd:COG0738  259 MTIGRFLGGFLLKRFGPVrllrLSALLAAVGLL-LALLAPG---PWLALIGLALVGLGLSL-----------MFPTIFsl 323
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665394738 490 ------RQTGVALGTILANAI--GVLAPYLV-YLGTTVDIRAPYYILGVLFLLGGIGALFL 541
Cdd:COG0738  324 aldglgKRTAAAVSAVLIMGIvgGAIGPPLIgFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
185-314 1.08e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 48.02  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 185 AGSFILGQMGDSYGRRFVYYISVVFCSLGRLgsIMCTSSYTWFLIMSG--IVGLTVNSLFQSPQIIGMEISREEDRSRIA 262
Cdd:cd17356   60 FGALISSFLSDRIGRKKSIQIGCVIYIIGAI--IQVAAIGKWYQLIVGriIAGLGVGFASVLVPVYQSEVAPKHIRGTLV 137
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665394738 263 FFQSCGWSIGTTLMPLLYWWLRHWDSFMW------LTSIPTAMVLLFSKYVIESPRWL 314
Cdd:cd17356  138 SLYQLAITIGILVAYCINYGTHKLDGSAQwriplgLQIVWGLLLLIGMFFLPESPRWL 195
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
170-315 1.41e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.57  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 170 LFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLgsIMCTSSYTWFLIMS-GIVGLTVNSLFQSPQII 248
Cdd:cd17330   34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV--LLGLSRNLWLLFLArFLDGLTGGNVSVAQAYI 111
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665394738 249 GmEISREEDRSR-IAFFQSCgWSIGTTLMPLLYWWLRHWDSF---MWLTSIPTAMVLLFSKYVIESPRWLI 315
Cdd:cd17330  112 A-DITDEEERAKaFGIISAA-FGLGFILGPALGGFLSTPYGYalpFLVAAALALLNLVLVLFFLPPLRRLL 180
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
168-319 3.05e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 46.41  E-value: 3.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 168 KDLFVTNVFVVGRVTEVA------GSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSSyTWFLIMSGIVGLTVN-S 240
Cdd:cd17359   28 QTDFNLTPFLEGLVVSSAllgaaiGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF-TIFIIARIIGGLAVGgA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 241 LFQSPQIIGmEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTS-----------IPtAMVLLFSKYVI- 308
Cdd:cd17359  107 SALVPMYIA-EVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAegwrwmlgleaIP-AILFLLGMLFIp 184
                        170
                 ....*....|.
gi 665394738 309 ESPRWLISKQR 319
Cdd:cd17359  185 ESPRWLVSKGK 195
MFS_1 pfam07690
Major Facilitator Superfamily;
409-560 1.76e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  409 SIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDEryenLMIYLATFIKFLNALTFFTVNLQCLEIYPTC 488
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW----LLLVLRVLQGLGAGALFPAALALIADWFPPE 117
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665394738  489 MRQTGVALGTILANAIGVLAPYLV-YLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHFG 560
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGgLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
181-279 2.58e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 43.32  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 181 VTEVAGSFILGQMGDSYGRRFVYYISVV-FCslgrLGSIMC--TSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREED 257
Cdd:cd17502   41 LTSTAFQPIYGKLSDLFGRKWVLLIAIViFE----LGSLLCglAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
                         90       100
                 ....*....|....*....|..
gi 665394738 258 RSRIAFFQSCGWSIGTTLMPLL 279
Cdd:cd17502  117 RGKYQGYIGAVFGIASVAGPLI 138
PRK03893 PRK03893
putative sialic acid transporter; Provisional
186-313 4.37e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 43.15  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 186 GSFILGQMGDSYGRRFVYYISVVFCSlgrLGSIMCTSS--YTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF 263
Cdd:PRK03893  71 GGLLLGAMGDRYGRRLAMVISIVLFS---VGTLACGFApgYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASG 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665394738 264 FQSCGWSIGTTLMPLLYWWLRH---WDSFMWLTSIPTAMVLLFSKYVIESPRW 313
Cdd:PRK03893 148 FLISGFSIGAVVAAQVYSLVVPvwgWRALFFIGILPIIFALWLRKNLPEAEDW 200
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
175-275 1.18e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 175 VFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGrLGSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISR 254
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG-LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
                         90       100
                 ....*....|....*....|.
gi 665394738 255 EEDRSRIAFFQSCGWSIGTTL 275
Cdd:COG2814  327 PEARGRASGLYNSAFFLGGPL 347
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
189-302 1.21e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 189 ILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTsSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCG 268
Cdd:cd17489   50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT-SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA 128
                         90       100       110
                 ....*....|....*....|....*....|....
gi 665394738 269 WSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLL 302
Cdd:cd17489  129 TTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
402-544 1.40e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 41.50  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  402 FLNFLyQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLpIIVYSTDEryeNLMIYLATFIKFLNALTFFTVNLQC 481
Cdd:TIGR01299 599 FVNFL-GTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCF-FLSFGNSE---SAMIALLCLFGGLSIAAWNALDVLT 673
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665394738  482 LEIYPTCMRQTGVALGTILANAIGVLApyLVYLGTTVDIR--APYYILGVLFLLGGIGALFLPET 544
Cdd:TIGR01299 674 VELYPSDKRATAFGFLNALCKAAAVLG--ILIFGSFVGITkaAPILFASAALACGGLLALKLPDT 736
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
184-393 1.42e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 41.45  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 184 VAGSFILGQMGDSYGRRFVYYISV-VFCSLGRLGSIMctSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIA 262
Cdd:cd17438   48 MAGAFIWGGLADKLGRKRCLIISLaINASFAFLSSFV--QGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 263 FFQSCGWSIGTTLMPLLYW-------W---------LRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQ 326
Cdd:cd17438  126 SWLCMFWMIGGLYASAMAWsiiphygWgfsmgtnyhFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMI 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665394738 327 LQKIakingHRFDMTEKELAEIysrdkqdvtygiasLFAGWRLAR-NTTIMGFSWCVVAVSYFTLVLF 393
Cdd:cd17438  206 LKNI-----HDTNMRAKGTPEK--------------VFTVSNIKRkNTLFLAVVWFTMAFSYYGLTVW 254
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
187-308 4.27e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 39.57  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 187 SFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSSYT----WFLIMSGIV-GLTVNS--LFQSPQIIGMEISREEDRS 259
Cdd:cd17386   47 SLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTTvpsvWWFYLSAIPlALFGGFtaFLSASFAYISDISSEKKRT 126
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 665394738 260 -RIAFFQSCgWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVI 308
Cdd:cd17386  127 yRMAILEVA-LGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYIL 175
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
175-541 7.02e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 7.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 175 VFVVGRVTEVAGSFILGQMGDS----YGRR--FVYYISVVFCslgrLGSIMC--------TSSYTWFLIMSGIVGLtVNS 240
Cdd:COG2211   51 ILLVARLWDAITDPLIGALSDRtrtrWGRRrpWILIGAIPLA----LSFVLLftapdlspTGKLIYALVTYLLLGL-AYT 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 241 LFQSPQI-IGMEISRE-EDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDS---------FMWLTSIP-TAMVLLFSKYVI 308
Cdd:COG2211  126 LVNIPYSaLGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgyrlTALIFAVLgLLAFLLTFFGTK 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 309 ESPRWLISKQRFREAIVQLqkiakinghrfdmtekelaeiySRDKQDVTYGIASLFagwrlarNTTIMGFSWcVVAVSYF 388
Cdd:COG2211  206 ERPVPEEEKVSLKESLKAL----------------------LKNRPFLLLLLAYLL-------FFLALALVA-ALLLYYF 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 389 TLVL-FSSRMAGnpFLNFLYqSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYenlMIYLATFIK 467
Cdd:COG2211  256 KYVLgLSAALVG--LLLALY-FLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW---LLLVLAALA 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 468 FLnALTFFTVNLQCL-------EIYPTCMRQTGVALGTI-----LANAIG--VLAPYLVYLGTTVDIR-APYYILGVLFL 532
Cdd:COG2211  330 GI-GLGAILVLPWAMladvvdyDEWKTGRRREGLYFGIFtfaikLGQALAgaLAGLLLALFGYVAGAAqSPSALTGIRLL 408

                 ....*....
gi 665394738 533 LGGIGALFL 541
Cdd:COG2211  409 FFLLPAVLL 417
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
175-303 8.06e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 8.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 175 VFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGrLGSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISR 254
Cdd:cd17325  240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA-LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665394738 255 EEDRSR-IAFFQSCgWSIGTTLMPLLYWWLRHWDSF---MWLTSIPTAMVLLF 303
Cdd:cd17325  319 PEGRGTaMGLFNTA-FSLGMVLGPLLGGFLYDAFGFatpFLAAAALLLLAAVL 370
MFS_1 pfam07690
Major Facilitator Superfamily;
175-277 8.54e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738  175 VFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMC--TSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEI 252
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLslTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
                          90       100
                  ....*....|....*....|....*
gi 665394738  253 SREEDRSRIAFFQSCGWSIGTTLMP 277
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
186-302 9.28e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.75  E-value: 9.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394738 186 GSFILGQMGDSYGRRFVYYISVVFCSLGR--LGsimCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGmEISREEDRSRI-- 261
Cdd:cd17390   47 SSPLVGSWSDVVGRRPVLLICLLLTALGYvlLG---FSTSLALLFLSRIPLGIFKHTQSLCKAYLS-DLVSEQERSRVlg 122
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 665394738 262 ---AFFqscgwSIGTTLMPLLYWWLRHWDS-FMWLTSIPTAMVLL 302
Cdd:cd17390  123 rfnAAS-----SLGFILGPVVGGHLAETDGgFYYVALLCSAIFIL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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