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Conserved domains on  [gi|665400118|ref|NP_001286296|]
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uncharacterized protein Dmel_CG12325, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11456769)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
306-657 1.06e-57

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.99  E-value: 1.06e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 306 QRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQY 385
Cdd:COG2319   76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 386 IMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVN 465
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 466 RYRNFRTFTSPNPAqFSCVAVDYSGELVVAGGQDvFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDK 545
Cdd:COG2319  235 TGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSP--DGKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 546 TVKIWNcLESNSEHETIDA-VSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRndlsagrleTDIITArkn 624
Cdd:COG2319  311 TVRLWD-LATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH---------TGAVTS--- 377

                        330       340       350
                 ....*....|....*....|....*....|...
gi 665400118 625 aqanyfstIEYSADGECILAAGKSANICIYHVR 657
Cdd:COG2319  378 --------VAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
20-424 1.05e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  20 LVFTPDGNSVISPVG-NRITVYDLKNNKSRTLSLESRYNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTG 98
Cdd:COG2319   84 VAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  99 -VQCICFSPNGAFFAVAVQ-NVVLIFCAPgeiTGEynpfvLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIvaINY 176
Cdd:COG2319  164 aVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGK-----LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL--WDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 177 TKNFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWecslapsDLEDAERPKIAPPQrkkekkavsdnesEDDVEN 256
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-------DLATGELLRTLTGH-------------SGGVNS 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 257 VVekdalkeestkeaedvnhiknedetkshpffykkitrhYLADEprkeqrdvqltaanyntrtKVLVVAFSSGAFYLYE 336
Cdd:COG2319  294 VA--------------------------------------FSPDG-------------------KLLASGSDDGTVRLWD 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 337 LPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSK 416
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD-GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*...
gi 665400118 417 VKLWNTQS 424
Cdd:COG2319  396 VRLWDLAT 403
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 793-895 2.45e-16

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 75.66  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  793 NEPNLIALVLERVPYKDVELVCADLSP-------EFaqrllqQLARQLQSTPHIEFYLQWSCCLLTKHGNQ--DGVFQHT 863
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFsyvlrllKF------LAERLAERSPHLELLLRWLKFLLRTHGGYlvSNPDLRP 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665400118  864 GLLALHEVLSRKYEMLNKICDYNKYTLKVLLD 895
Cdd:pfam04003  75 VLRSLQKLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
306-657 1.06e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.99  E-value: 1.06e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 306 QRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQY 385
Cdd:COG2319   76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 386 IMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVN 465
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 466 RYRNFRTFTSPNPAqFSCVAVDYSGELVVAGGQDvFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDK 545
Cdd:COG2319  235 TGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSP--DGKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 546 TVKIWNcLESNSEHETIDA-VSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRndlsagrleTDIITArkn 624
Cdd:COG2319  311 TVRLWD-LATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH---------TGAVTS--- 377

                        330       340       350
                 ....*....|....*....|....*....|...
gi 665400118 625 aqanyfstIEYSADGECILAAGKSANICIYHVR 657
Cdd:COG2319  378 --------VAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 352-605 6.00e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.30  E-value: 6.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 352 PISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTF 431
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 432 SEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNpAQFSCVAVDYSGELVVAGGQDvFDIFLWSVKTG 511
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSPDGTFVASSSQD-GTIKLWDLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 512 KLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN-----CLESNSEHETIdavsdVTNVTFSPSGEEIAVATLS 586
Cdd:cd00200  168 KCVATLTGHTGEVNSVAFSP--DGEKLLSSSSDGTIKLWDlstgkCLGTLRGHENG-----VNSVAFSPDGYLLASGSED 240

                        250
                 ....*....|....*....
gi 665400118 587 GNITIFDIKSAGQVTTIEG 605
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
20-424 1.05e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  20 LVFTPDGNSVISPVG-NRITVYDLKNNKSRTLSLESRYNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTG 98
Cdd:COG2319   84 VAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  99 -VQCICFSPNGAFFAVAVQ-NVVLIFCAPgeiTGEynpfvLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIvaINY 176
Cdd:COG2319  164 aVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGK-----LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL--WDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 177 TKNFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWecslapsDLEDAERPKIAPPQrkkekkavsdnesEDDVEN 256
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-------DLATGELLRTLTGH-------------SGGVNS 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 257 VVekdalkeestkeaedvnhiknedetkshpffykkitrhYLADEprkeqrdvqltaanyntrtKVLVVAFSSGAFYLYE 336
Cdd:COG2319  294 VA--------------------------------------FSPDG-------------------KLLASGSDDGTVRLWD 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 337 LPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSK 416
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD-GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*...
gi 665400118 417 VKLWNTQS 424
Cdd:COG2319  396 VRLWDLAT 403
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 793-895 2.45e-16

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 75.66  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  793 NEPNLIALVLERVPYKDVELVCADLSP-------EFaqrllqQLARQLQSTPHIEFYLQWSCCLLTKHGNQ--DGVFQHT 863
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFsyvlrllKF------LAERLAERSPHLELLLRWLKFLLRTHGGYlvSNPDLRP 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665400118  864 GLLALHEVLSRKYEMLNKICDYNKYTLKVLLD 895
Cdd:pfam04003  75 VLRSLQKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-421 4.01e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 4.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  22 FTPDGNSVISPVGNR-ITVYDLKNNK-SRTLSLESRyNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHK-FQTG 98
Cdd:cd00200   17 FSPDGKLLATGSGDGtIKVWDLETGElLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTgHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  99 VQCICFSPNGAFFAVA-VQNVVLIFCAPgeitgeynPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYT 177
Cdd:cd00200   96 VSSVAFSPDGRILSSSsRDKTIKVWDVE--------TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 178 KnfRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWEcslapsdledaerpkiappqrkkekkavsdneseddvenv 257
Cdd:cd00200  168 K--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---------------------------------------- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 258 vekdalkeestkeaedvnhiknedetkshpffykkitrhyladeprkeqrdvqltaanyntrtkvlvvaFSSGAFylyel 337
Cdd:cd00200  206 ---------------------------------------------------------------------LSTGKC----- 211

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 338 pdvnmIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKV 417
Cdd:cd00200  212 -----LGTLRGHENGVNSVAFSPDGYLLASGSED-GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                 ....
gi 665400118 418 KLWN 421
Cdd:cd00200  286 RIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 510-551 2.47e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665400118   510 TGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN 551
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
511-551 1.66e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 1.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 665400118  511 GKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN 551
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 408-653 2.43e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 2.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 408 IATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSR-NKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPnpAQFSCVAV 486
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK--ANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 487 DYSGELVVAGGQDVFDIFLWSVKTGKL-LEIISGHEGPVVSIAFspvATSSTLVSGSWDKTVKIWNCLESNS--EHETID 563
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF---VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLH 702

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 564 AVSDVTN----VTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDiitarknAQANYFSTIEYSADG 639
Cdd:PLN00181 703 SFMGHTNvknfVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEVD-------DASQFISSVCWRGQS 775

                        250
                 ....*....|....
gi 665400118 640 ECILAAGKSANICI 653
Cdd:PLN00181 776 STLVAANSTGNIKI 789
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
306-657 1.06e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.99  E-value: 1.06e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 306 QRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQY 385
Cdd:COG2319   76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 386 IMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVN 465
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 466 RYRNFRTFTSPNPAqFSCVAVDYSGELVVAGGQDvFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDK 545
Cdd:COG2319  235 TGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSP--DGKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 546 TVKIWNcLESNSEHETIDA-VSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRndlsagrleTDIITArkn 624
Cdd:COG2319  311 TVRLWD-LATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH---------TGAVTS--- 377

                        330       340       350
                 ....*....|....*....|....*....|...
gi 665400118 625 aqanyfstIEYSADGECILAAGKSANICIYHVR 657
Cdd:COG2319  378 --------VAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
321-596 2.22e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 2.22e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 321 KVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIA 400
Cdd:COG2319  133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 401 YSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQ 480
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 481 FScVAVDYSGELVVAGGQDvFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWNcLESNSEHE 560
Cdd:COG2319  292 NS-VAFSPDGKLLASGSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGTVRLWD-LATGELLR 366

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 665400118 561 TIDAVSD-VTNVTFSPSGEEIAVATLSGNITIFDIKS 596
Cdd:COG2319  367 TLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
355-747 9.86e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.34  E-value: 9.86e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 355 AALFNCTGDWVALASREIGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEH 434
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 435 TSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAqFSCVAVDYSGELVVAGGQDvFDIFLWSVKTGKLL 514
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-VTSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 515 EIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWNcLESNSEHETIDAVSD-VTNVTFSPSGEEIAVATLSGNITIFD 593
Cdd:COG2319  198 RTLTGHTGAVRSVAFSP--DGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGsVRSVAFSPDGRLLASGSADGTVRLWD 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 594 IKSAGQVTTIEGrndlsagrlETDIITArknaqanyfstIEYSADGECILAAGKSANICIYHVREAILLkkfeitqnHSL 673
Cdd:COG2319  275 LATGELLRTLTG---------HSGGVNS-----------VAFSPDGKLLASGSDDGTVRLWDLATGKLL--------RTL 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 674 DGLNDFISRKHLSEFGNMalveereeleggrVA-------IRLPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTE 746
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKT-------------LAsgsddgtVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                 .
gi 665400118 747 G 747
Cdd:COG2319  394 G 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 352-605 6.00e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.30  E-value: 6.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 352 PISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTF 431
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 432 SEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNpAQFSCVAVDYSGELVVAGGQDvFDIFLWSVKTG 511
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSPDGTFVASSSQD-GTIKLWDLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 512 KLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN-----CLESNSEHETIdavsdVTNVTFSPSGEEIAVATLS 586
Cdd:cd00200  168 KCVATLTGHTGEVNSVAFSP--DGEKLLSSSSDGTIKLWDlstgkCLGTLRGHENG-----VNSVAFSPDGYLLASGSED 240

                        250
                 ....*....|....*....
gi 665400118 587 GNITIFDIKSAGQVTTIEG 605
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 390-666 1.14e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.75  E-value: 1.14e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 390 QGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRN 469
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 470 FRTFTSpNPAQFSCVAVDYSGELVVAGGQDvFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKI 549
Cdd:cd00200   86 VRTLTG-HTSYVSSVAFSPDGRILSSSSRD-KTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 550 WN-----CLESNSEHEtidavSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRNdlsagrletdiitarkn 624
Cdd:cd00200  162 WDlrtgkCVATLTGHT-----GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE----------------- 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 665400118 625 aqaNYFSTIEYSADGECILAAGKSANICIYHVREAILLKKFE 666
Cdd:cd00200  220 ---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-593 1.28e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.97  E-value: 1.28e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 312 TAANYNTRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASrEIGQLLVWEWQSEQYIMKQQG 391
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGS-SDKTIRLWDLETGECVRTLTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 392 HSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFR 471
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 472 TFTSPNpAQFSCVAVDYSGELVVAGGQDVfDIFLWSVKTGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN 551
Cdd:cd00200  172 TLTGHT-GEVNSVAFSPDGEKLLSSSSDG-TIKLWDLSTGKCLGTLRGHENGVNSVAFSP--DGYLLASGSEDGTIRVWD 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 665400118 552 cLESNSEHETIDAVSD-VTNVTFSPSGEEIAVATLSGNITIFD 593
Cdd:cd00200  248 -LRTGECVQTLSGHTNsVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 430-663 1.63e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 1.63e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 430 TFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYsGELVVAGGQDvFDIFLWSVK 509
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSD-KTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 510 TGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVATLSGNI 589
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665400118 590 TIFDIKSAGQVTTIEGRNDlsagrletdiitarknaqanYFSTIEYSADGECILAAGKSANICIYHVREAILLK 663
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTG--------------------EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213
WD40 COG2319
WD40 repeat [General function prediction only];
20-424 1.05e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  20 LVFTPDGNSVISPVG-NRITVYDLKNNKSRTLSLESRYNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTG 98
Cdd:COG2319   84 VAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  99 -VQCICFSPNGAFFAVAVQ-NVVLIFCAPgeiTGEynpfvLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIvaINY 176
Cdd:COG2319  164 aVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGK-----LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL--WDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 177 TKNFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWecslapsDLEDAERPKIAPPQrkkekkavsdnesEDDVEN 256
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-------DLATGELLRTLTGH-------------SGGVNS 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 257 VVekdalkeestkeaedvnhiknedetkshpffykkitrhYLADEprkeqrdvqltaanyntrtKVLVVAFSSGAFYLYE 336
Cdd:COG2319  294 VA--------------------------------------FSPDG-------------------KLLASGSDDGTVRLWD 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 337 LPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSK 416
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD-GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*...
gi 665400118 417 VKLWNTQS 424
Cdd:COG2319  396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-463 4.10e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 4.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  98 GVQCICFSPNGAFFAVAVQ-NVVLIFcapgeitgEYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVaiNY 176
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGdGTIKVW--------DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--DL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 177 TKNFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWecslapsdledaerpkiappqrkkekkavsdnesedDVEN 256
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW------------------------------------DVET 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 257 VVEKDALKEEStkeaEDVNHIKnedetkshpffykkitrhyladeprkeqrdvqltaanYNTRTKVLVVAFSSGAFYLYE 336
Cdd:cd00200  125 GKCLTTLRGHT----DWVNSVA-------------------------------------FSPDGTFVASSSQDGTIKLWD 163

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 337 LPDVNMIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSK 416
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 665400118 417 VKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFD 463
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 793-895 2.45e-16

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 75.66  E-value: 2.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  793 NEPNLIALVLERVPYKDVELVCADLSP-------EFaqrllqQLARQLQSTPHIEFYLQWSCCLLTKHGNQ--DGVFQHT 863
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFsyvlrllKF------LAERLAERSPHLELLLRWLKFLLRTHGGYlvSNPDLRP 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665400118  864 GLLALHEVLSRKYEMLNKICDYNKYTLKVLLD 895
Cdd:pfam04003  75 VLRSLQKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-756 6.63e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 6.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 513 LLEIISGHEGPVVSIAFSPVatSSTLVSGSWDKTVKIWN-----CLESNSEHEtidavSDVTNVTFSPSGEEIAVATLSG 587
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD--GKLLATGSGDGTIKVWDletgeLLRTLKGHT-----GPVRDVAASADGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 588 NITIFDIKSAGQVTTIEGRNDlsagrletdiitarknaqanYFSTIEYSADGECILAAGKSANICIYHVREAillkkfei 667
Cdd:cd00200   74 TIRLWDLETGECVRTLTGHTS--------------------YVSSVAFSPDGRILSSSSRDKTIKVWDVETG-------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 668 TQNHSLDGLNDFISRKHLSEFGNMALVEEREELeggrvaIRLpgvqrGDMSSRRFQQ-----EVRVFSVKFSPTGQAFAA 742
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT------IKL-----WDLRTGKCVAtltghTGEVNSVAFSPDGEKLLS 194

                        250
                 ....*....|....*
gi 665400118 743 AGTEGLC-IYALDKG 756
Cdd:cd00200  195 SSSDGTIkLWDLSTG 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-421 4.01e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 4.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  22 FTPDGNSVISPVGNR-ITVYDLKNNK-SRTLSLESRyNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHK-FQTG 98
Cdd:cd00200   17 FSPDGKLLATGSGDGtIKVWDLETGElLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTgHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  99 VQCICFSPNGAFFAVA-VQNVVLIFCAPgeitgeynPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYT 177
Cdd:cd00200   96 VSSVAFSPDGRILSSSsRDKTIKVWDVE--------TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 178 KnfRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWEcslapsdledaerpkiappqrkkekkavsdneseddvenv 257
Cdd:cd00200  168 K--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---------------------------------------- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 258 vekdalkeestkeaedvnhiknedetkshpffykkitrhyladeprkeqrdvqltaanyntrtkvlvvaFSSGAFylyel 337
Cdd:cd00200  206 ---------------------------------------------------------------------LSTGKC----- 211

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 338 pdvnmIHSLSISDYPISAALFNCTGDWVALASREiGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKV 417
Cdd:cd00200  212 -----LGTLRGHENGVNSVAFSPDGYLLASGSED-GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                 ....
gi 665400118 418 KLWN 421
Cdd:cd00200  286 RIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 510-551 2.47e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665400118   510 TGKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN 551
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
511-551 1.66e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 1.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 665400118  511 GKLLEIISGHEGPVVSIAFSPvaTSSTLVSGSWDKTVKIWN 551
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 382-421 8.13e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 8.13e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 665400118   382 SEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWN 421
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
384-421 1.81e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665400118  384 QYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWN 421
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 408-653 2.43e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 2.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 408 IATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSR-NKKFLVSSSLDGTVRAFDVNRYRNFRTFTSPnpAQFSCVAV 486
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK--ANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 487 DYSGELVVAGGQDVFDIFLWSVKTGKL-LEIISGHEGPVVSIAFspvATSSTLVSGSWDKTVKIWNCLESNS--EHETID 563
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF---VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLH 702

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 564 AVSDVTN----VTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDiitarknAQANYFSTIEYSADG 639
Cdd:PLN00181 703 SFMGHTNvknfVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEVD-------DASQFISSVCWRGQS 775

                        250
                 ....*....|....
gi 665400118 640 ECILAAGKSANICI 653
Cdd:PLN00181 776 STLVAANSTGNIKI 789
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-216 9.13e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 9.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  18 GNLVFTPDGNSVISpVG--NRITVYDLKNNKS-RTLSLESRYNYTnIALSPDGSLLIAVNEKGEA---QLISMMSCTVIH 91
Cdd:cd00200   55 RDVAASADGTYLAS-GSsdKTIRLWDLETGECvRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIkvwDVETGKCLTTLR 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  92 RHkfQTGVQCICFSPNGAFFAVAVQN-VVLIFcapgeitgEYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTK 170
Cdd:cd00200  133 GH--TDWVNSVAFSPDGTFVASSSQDgTIKLW--------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 665400118 171 IVAINYTKNFRTynLSGHTDAIVACFFEANSLHLNTISRNGQLCLW 216
Cdd:cd00200  203 LWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
446-596 2.52e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.69  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 446 NKKFLVSSSLDGTVRAFDVNRYRNFRTFTS-PNPAQfscVAVDYSGELVVAGGQDVFDIFLWSVKTGKLLEIISGHEGPV 524
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLATGKVVATIPVgGGPRG---LAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPH 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118 525 vSIAFSPvATSSTLVSGSWDKT----VKIWNcLESNSEHETIDAVSDVTNVTFSPSGEEIAVA--------TLSGNITIF 592
Cdd:COG3391  156 -GIAVDP-DGKRLYVANSGSNTvsviVSVID-TATGKVVATIPVGGGPVGVAVSPDGRRLYVAnrgsntsnGGSNTVSVI 232


                 ....
gi 665400118 593 DIKS 596
Cdd:COG3391  233 DLAT 236
WD40 pfam00400
WD domain, G-beta repeat;
427-463 2.90e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.90e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 665400118  427 CFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFD 463
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 427-463 3.54e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 3.54e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 665400118   427 CFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFD 463
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-171 1.61e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  20 LVFTPDGNSVISPVGNR-ITVYDLKNNKS-RTLSLESRyNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHKFQT 97
Cdd:cd00200  141 VAFSPDGTFVASSSQDGtIKLWDLRTGKCvATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665400118  98 -GVQCICFSPNGAFFAVAVQ-NVVLIFcapgeitgEYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKI 171
Cdd:cd00200  220 nGVNSVAFSPDGYLLASGSEdGTIRVW--------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 363-446 8.27e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400118  363 DWVALASrEIGQLLV----WE--WQseqyiMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTS 436
Cdd:pfam12894   8 DLIALAT-EDGELLLhrlnWQrvWT-----LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81

                          90
                  ....*....|
gi 665400118  437 GVTGIQFSRN 446
Cdd:pfam12894  82 LITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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