BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  51 TTQYIYKALFKEEKNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSD 130
Cdd:cd18305    1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665399606 131 EIEIESADVISVLATATLFHLDGIIDKCAEVMVDN 165
Cdd:cd18305   81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  51 TTQYIYKALFKEEKNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSD 130
Cdd:cd18305    1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665399606 131 EIEIESADVISVLATATLFHLDGIIDKCAEVMVDN 165
Cdd:cd18305   81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606   56 YKALFKEEKNSDVAVMALDKVWHLHKVYLS-QSPYFYTMFNGTwrEAQQNFIQITILDdrITVASLDAVFGSMYSDEIeI 134
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQ--ESESSVSEITLDD--VSPEDFEALLEFMYTGKL-I 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665399606  135 ESADVISVLATATLFHLDGIIDKCAEVMVDNI 166
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  57 KALFKEEKNSDVAV--MALDKVWHLHKVYLSQSP-YFYTMFNGtwreaqqNFIQ--ITILDDritVASLDAVFGSMYSDE 131
Cdd:PHA03098   1 MYSFELQKFCDESIiiVNGGGIIKVHKIILSSSSeYFKKMFKN-------NFKEneINLNID---YDSFNEVIKYIYTGK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606 132 IEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYsKQPNLLrH 211
Cdd:PHA03098  71 INITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIY-NDPDFI-Y 148

                        170       180       190
                 ....*....|....*....|....*....|.
gi 665399606 212 ISIELMSALTASPDLYVMQTEFSLYTLLrTW 242
Cdd:PHA03098 149 LSKNELIKILSDDKLNVSSEDVVLEIII-KW 178

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  51 TTQYIYKALFKEEKNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSD 130
Cdd:cd18305    1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665399606 131 EIEIESADVISVLATATLFHLDGIIDKCAEVMVDN 165
Cdd:cd18305   81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606   56 YKALFKEEKNSDVAVMALDKVWHLHKVYLS-QSPYFYTMFNGTwrEAQQNFIQITILDdrITVASLDAVFGSMYSDEIeI 134
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQ--ESESSVSEITLDD--VSPEDFEALLEFMYTGKL-I 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665399606  135 ESADVISVLATATLFHLDGIIDKCAEVMVDNI 166
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  66 SDVAVMALDKVWHLHKVYLS-QSPYFYTMFNGTWREAQQNFIQITIlddrITVASLDAVFGSMYSDEIEIESADVISVLA 144
Cdd:cd18186    2 CDVTLVVGGREFPAHRAVLAaRSPYFRAMFSSGMKESSSSEIELDD----VSPEAFEALLDYIYTGELELSEENVEELLA 77

                 ....*
gi 665399606 145 TATLF 149
Cdd:cd18186   78 AADKL 82

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB-domain-containing Kelch-like protein. Its function remains unclear. BTBD16 SNPs may be bipolar disorder (BD) genetic susceptibility variants exhibiting genetic background-dependent effects.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606 166 ISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYSKQPNlLRHISIELMSALTASPDLYVMqTEFSLYTLLRTWMFL 245
Cdd:cd18492    1 IKSSTVCKFHRAACKYKQESLATACERWLELNLVPQLSSQIY-LRDLPLELLHKILKSPRLFTF-NEYSLYKTLCYWVFL 78

                 ....
gi 665399606 246 RLHP 249
Cdd:cd18492   79 QLNP 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYL-SQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVfgsmYSDEIEIESADVISVLAT 145
Cdd:cd18235   23 DVILVADGVEIPAHRVVLaSCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYV----YTAEIQVTEENVQVLLPA 98

                         90       100
                 ....*....|....*....|...
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISP 168
Cdd:cd18235   99 ANLLQLTDVRDACCDFLQSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  55 IYKALFKEEKNSDVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQITILDDRItvasLDAVFGSMYSDEIE 133
Cdd:cd18240    7 VFNELRLEGKLCDVVIRVNGVEFPAHRNILCAcSPYFRALFTNGWNETEKKVYKIPGVSPEM----MELIIEYAYTRTVP 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 665399606 134 IESADVISVLATATLFHLDGIIDKCAEVMVDNISPE 169
Cdd:cd18240   83 ITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPE 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYL-SQSPYFYTMFNGTWREAQQNFIQItildDRITVASLDAVFGSMYSDEIEIESADVISVLAT 145
Cdd:cd18255   20 DVTLIADGQRFQAHKVVLaSCSDYFRAMFTGGMRESSQDEIEL----KGVSAKGLKHILDFAYTSELTLDLDCIQDVLGA 95

                         90       100
                 ....*....|....*....|....*
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISPET 170
Cdd:cd18255   96 AVHLQMLPVVELCEEFLKSAMSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQitiLDDrITVASLDAVFGSMYSDEIEIESADVISVLAT 145
Cdd:cd18276   23 DVVLVAEGEKFPCHRLVLAAfSPYFKAMFTCGLMECSQREVV---LHD-ITAESVSIILNYMYSSDLHLTNSNVQGVATA 98

                         90       100
                 ....*....|....*....|...
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISP 168
Cdd:cd18276   99 AFFLQMEDIFSVCQKYMMDHMDA 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVfgsmYSDEIEIESADVISVLAT 145
Cdd:cd18338   23 DVTIVAEDVEIAAHRVVLAAcSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYV----YTAEIQVTEENVQVLLPA 98

                         90       100
                 ....*....|....*....|...
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISP 168
Cdd:cd18338   99 AGLLQLQDVKKTCCEFLESQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  57 KALFKEEKNSDVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQItildDRITVASLDAVFGSMYSDEIEIE 135
Cdd:cd18298    4 RKAFNDPRTSDLKFRVDGKYIYVHKAILKIrCEYFRSMFQSHWNEDDKNVIEI----DQYSYPVYYAFLRYLYTDQVDLP 79

                         90
                 ....*....|....
gi 665399606 136 SADVISVLATATLF 149
Cdd:cd18298   80 PEDAIGLLDLANSY 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  66 SDVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQITILDDRitvaSLDAVFGSMYSDEIEIESADVISVLA 144
Cdd:cd18234    2 CDVILIAGDRRIPAHRLVLSAvSDYFAAMFTNDVREATEEEIKLKDVDPD----ALWTLVQYCYTGRLELKEDNVESLLA 77

                         90       100
                 ....*....|....*....|....
gi 665399606 145 TATLFHLDGIIDKCAEVMVDNISP 168
Cdd:cd18234   78 TACLLQLSEVVEACCGFLMKQLHP 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQITILDDritvASLDAVFGSMYSDEIEIESADVISVLAT 145
Cdd:cd18257   20 DVVLRVGDVKIHAHKVVLAScSPYFKAMFTGNLSEKENSEVEFQCIDE----TALQAIVEYAYTGTVFISQATVESLLPA 95

                         90       100
                 ....*....|....*....|...
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISP 168
Cdd:cd18257   96 ANLLQIKLVLKECCDFLESQLDP 118

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  57 KALFKEEKNSDVAV--MALDKVWHLHKVYLSQSP-YFYTMFNGtwreaqqNFIQ--ITILDDritVASLDAVFGSMYSDE 131
Cdd:PHA03098   1 MYSFELQKFCDESIiiVNGGGIIKVHKIILSSSSeYFKKMFKN-------NFKEneINLNID---YDSFNEVIKYIYTGK 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606 132 IEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYsKQPNLLrH 211
Cdd:PHA03098  71 INITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIY-NDPDFI-Y 148

                        170       180       190
                 ....*....|....*....|....*....|.
gi 665399606 212 ISIELMSALTASPDLYVMQTEFSLYTLLrTW 242
Cdd:PHA03098 149 LSKNELIKILSDDKLNVSSEDVVLEIII-KW 178

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  66 SDVAVMALDKVWHLHK-VYLSQSPYFYTMFNGTWREAQQNFIQITILDdritVASLDAVFGSMYSDEIEIESADVISVLA 144
Cdd:cd18268   24 TDVILCTGDKEIPCHRnVLASSSPYFRAMFCNNFRESSQAKVDLKGID----SDVLDQIVDYVYTGEILITRDNVLPLME 99

                         90       100
                 ....*....|....*....|....*
gi 665399606 145 TATLFHLDGIIDKCAEVMVDNISPE 169
Cdd:cd18268  100 AASMLQYPKLFEACSLYLQDQLTPE 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  60 FKEEKNSDVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQITILDDRitvaSLDAVFGSMYSDEIEIESAD 138
Cdd:cd18336   14 LQHKQLCDVLLIAGNLKIPAHRLVLSAvSDYFAAMFTNDVREAKQEEIKMEGVDPD----ALKALVHYAYTGVLELKEDT 89

                         90       100       110
                 ....*....|....*....|....*....|....
gi 665399606 139 VISVLATATLFHLDGIIDKCAEVMVDNISPETAI 172
Cdd:cd18336   90 IESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  56 YKALFKEEKNSDVAVMALDKVWHLHKVYL-SQSPYFYTMFNGTWREAQQNFIQITILddriTVASLDAVFGSMYSDEIEI 134
Cdd:cd18244   21 FRALYEEGLLLDVTLVIEDHQFQAHKALLaTQSDYFRIMFTADMRERDQDKIHLKGL----TATGFSHVLQFMYYGTIEL 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 665399606 135 ESADVISVLATATLFHLDGII-------------DKCAEVM 162
Cdd:cd18244   97 SMLTVHEILQAAMYVQLTEVVkfccsfllakiclDNCAEIM 137

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  66 SDVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQItildDRITVASLDAVFGSMYSDEIEIESADVISVLA 144
Cdd:cd18253   19 TDVIICVEGREFPCHRAILSAcSSYFRAMFCNDHRESREMLVEI----NGILAEAMDCFLQYVYTGKVKITTENVQYLFE 94

                         90       100
                 ....*....|....*....|....
gi 665399606 145 TATLFHLDGIIDKCAEVMVDNISP 168
Cdd:cd18253   95 TSSLFQISPLRDACAKFLEEQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYLS-QSPYFYTMFNGTWREAQQNFIQITilddRITVASLDAVFGSMYSDEIEIESADVISVLAT 145
Cdd:cd18266   27 DVVLVADEQRVPAHRNLLAvCSDYFNSMFTIGMREAHQKEVELV----GASYIGLKAVIDFLYSSELPLDGGNIDYVLET 102

                         90       100       110
                 ....*....|....*....|....*....|...
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISPETAIQYYEAA 178
Cdd:cd18266  103 AHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  49 LTTTQYIYKAlFKEEKNSDVAVMALDKVWHLHKVYLS-QSPYFYTMFNGTWREAQQNFIQItildDRITVASLDAVFGSM 127
Cdd:cd18353    5 LTVAESLKKE-FDSPETSDLKFRVDGKYIHVHKAVLKiRCEHFRTMFQSHWNEDMKEVIEI----DQFSYPVYRAFLEYL 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665399606 128 YSDEIEIESADVISVLATATLFHLDGIIDKCAEVM 162
Cdd:cd18353   80 YTDSVDLPPEDAIGLLDLATSYCENRLKKLCQHII 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYLSQ-SPYFYTMFNG--TWREAQQNFIQITILD-DRITVASLDAVFGSMYSDEIEIESADVISV 142
Cdd:cd18228   21 DVTIRVQDKIFRAHKVVLAAcSDFFRSKLVGqaSPRLVLVSPAGKCVLDlHHVTVTGFAPLLEYAYTSTLSINTENIIDV 100

                         90       100
                 ....*....|....*....|....
gi 665399606 143 LATATLFHLDGIIDKCAEVMVDNI 166
Cdd:cd18228  101 LAAASYMQMFNVANTCSEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  67 DVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQITILDDRitvaSLDAVFGSMYSDEIEIESADVISVLAT 145
Cdd:cd18337   25 DVVLVAGDRRIPAHRLVLSSvSDYFAAMFTNDVREAKQEEIKMEGVEPN----ALWALVQYAYTGRLELKEDNIECLLST 100

                         90       100
                 ....*....|....*....|....*..
gi 665399606 146 ATLFHLDGIIDKCAEVMVDNISPETAI 172
Cdd:cd18337  101 ACLLQLSQVVEACCKFLMKQLHPSNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  80 HKVYLS-QSPYFYTMFNGTWREAQQnfiQITILDdrITVASLDAVFGSMYSDEIEIESADVISVLATATLFHLDGIIDKC 158
Cdd:cd18281   41 HKFVLSiGSAVFDAMFNGGMATTSA---EIELPD--VEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESAC 115

                         90
                 ....*....|.
gi 665399606 159 AEVMVDNISPE 169
Cdd:cd18281  116 VEFLKKNLSSD 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665399606  87 SPYFYTMFNGTWREAQQNfiQITILDdrITVASLDAVFGSMYSDEIEIESADVISVLATATLFHLDGIIDKCAEVM 162
Cdd:cd18273   57 SPYFKSMFTGGLYESKQE--TVTIHD--VDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFL 128

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  60 FKEEKNSDVAVMALDKVWHLHKVYL-SQSPYFYTMFNGTWREAQQNFIQITILDDritvASLDAVFGSMYSDEIEIESAD 138
Cdd:cd18314    1 YNDSEFSDVVLCVGDRKFFAHRIVLcARSPVFRSMLTGSMIESNLKEVTLEDVEP----EIFETVLKYMYTGQVTLSEEN 76

                         90       100
                 ....*....|....*....|
gi 665399606 139 VISVLATATLFHLDGIIDKC 158
Cdd:cd18314   77 VLDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399606  66 SDVAVMALDKVWHLHKVYLSQ-SPYFYTMFNGTWREAQQNFIQitiLDDRITVASLDAVFGSMYSDEIEIESADVISVLA 144
Cdd:cd18254   23 TDVTLWAGNRSFPCHRAVLAAcSRYFEAMFSNGLRESLDSTVN---FHDSLHPEVLELLLDFAYSSRIIINEENAESLLE 99

                         90       100
                 ....*....|....*....|....*...
gi 665399606 145 TATLFHLDGIIDKCAEVMVDNISPETAI 172
Cdd:cd18254  100 AGDMLQFHDVRDAAAEFLEKNLYPSNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.