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Conserved domains on  [gi|665408460|ref|NP_001286024|]
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reduced ocelli, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-446 6.45e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 6.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  69 RNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMAS- 147
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLg 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 148 -STFRHLTDLRRLNLADNsivelvqRNFFMLSRLKYLDLSGNPLQDLqPDVFRDVPELKVLKCRNCQLKKINPqmynllp 226
Cdd:COG4886   89 lTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 227 llseldlgrnefkfldkdEFRDVKRLTKVLLDGNQLSVVVDQLFRMqKSLNHLDLSYNRLAKVPnDSFLQLTNLTFLDLS 306
Cdd:COG4886  154 ------------------PLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLP-EPLGNLTNLEELDLS 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 307 YNKLVRLePQSIRSLSNLLTLNISGNVLMDLremretfepliyyffltcsklffqliPQLTHLaiadmgtmpvgllhpfK 386
Cdd:COG4886  214 GNQLTDL-PEPLANLTNLETLDLSNNQLTDL--------------------------PELGNL----------------T 250

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 387 QLRYLNISGNSLnnTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPL 446
Cdd:COG4886  251 NLEELDLSNNQL--TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-446 6.45e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 6.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  69 RNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMAS- 147
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLg 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 148 -STFRHLTDLRRLNLADNsivelvqRNFFMLSRLKYLDLSGNPLQDLqPDVFRDVPELKVLKCRNCQLKKINPqmynllp 226
Cdd:COG4886   89 lTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 227 llseldlgrnefkfldkdEFRDVKRLTKVLLDGNQLSVVVDQLFRMqKSLNHLDLSYNRLAKVPnDSFLQLTNLTFLDLS 306
Cdd:COG4886  154 ------------------PLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLP-EPLGNLTNLEELDLS 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 307 YNKLVRLePQSIRSLSNLLTLNISGNVLMDLremretfepliyyffltcsklffqliPQLTHLaiadmgtmpvgllhpfK 386
Cdd:COG4886  214 GNQLTDL-PEPLANLTNLETLDLSNNQLTDL--------------------------PELGNL----------------T 250

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 387 QLRYLNISGNSLnnTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPL 446
Cdd:COG4886  251 NLEELDLSNNQL--TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-457 2.55e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 2.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 101 SFWGLKYLRILDLSKNNITNIT-ENNFRGQDNLLELDLSKNKVLRMASSTFrhLTDLRRLNLADNSIVELVQRNFFMLSR 179
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 180 LKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLKKINPQmynllpllseldlgrnefkfldkdEFRDVKRLTKVLLDG 259
Cdd:PLN00113 166 LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPR------------------------ELGQMKSLKWIYLGY 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 260 NQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLmdlre 339
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSL----- 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 340 mretfepliyyffltcSKLFFQLIPQLTHLAIADM------GTMPVGlLHPFKQLRYLNISGNSLNNTALEVIDPCRELE 413
Cdd:PLN00113 297 ----------------SGEIPELVIQLQNLEILHLfsnnftGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT 359

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 665408460 414 FLDLSRNQLHGISEDTvlriqgirnvrldnnplICDECHMGKLI 457
Cdd:PLN00113 360 VLDLSTNNLTGEIPEG-----------------LCSSGNLFKLI 386
LRR_8 pfam13855
Leucine rich repeat;
275-334 1.15e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  275 SLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVL 334
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-446 5.00e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 5.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 239 KFLDK-DEFRDVKRLTKVLLDGNQLSVVvDQLFRMQKsLNHLDLSYNRLAKVPNdsFLQLTNLTFLDLSYNKLVRLEpqS 317
Cdd:cd21340   12 KNITKiDNLSLCKNLKVLYLYDNKITKI-ENLEFLTN-LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--G 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 318 IRSLSNLLTLNISGNVLmdLREMRETFEPLiyyffltcsklffqlipqlTHLAIAdmgtmpvgllhpfKQLRYLNISGNS 397
Cdd:cd21340   86 LENLTNLEELHIENQRL--PPGEKLTFDPR-------------------SLAALS-------------NSLRVLNISGNN 131

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665408460 398 LnnTALEVIDPCRELEFLDLSRNQLHGISE--DTVLRIQGIRNVRLDNNPL 446
Cdd:cd21340  132 I--DSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-446 6.45e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 6.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  69 RNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMAS- 147
Cdd:COG4886    9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLg 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 148 -STFRHLTDLRRLNLADNsivelvqRNFFMLSRLKYLDLSGNPLQDLqPDVFRDVPELKVLKCRNCQLKKINPqmynllp 226
Cdd:COG4886   89 lTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 227 llseldlgrnefkfldkdEFRDVKRLTKVLLDGNQLSVVVDQLFRMqKSLNHLDLSYNRLAKVPnDSFLQLTNLTFLDLS 306
Cdd:COG4886  154 ------------------PLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLP-EPLGNLTNLEELDLS 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 307 YNKLVRLePQSIRSLSNLLTLNISGNVLMDLremretfepliyyffltcsklffqliPQLTHLaiadmgtmpvgllhpfK 386
Cdd:COG4886  214 GNQLTDL-PEPLANLTNLETLDLSNNQLTDL--------------------------PELGNL----------------T 250

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 387 QLRYLNISGNSLnnTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPL 446
Cdd:COG4886  251 NLEELDLSNNQL--TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-431 5.81e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 5.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  83 KLEILRITDSNLPAIGAESFWGLKYLRILDLSknnitniTENNFRGQDNLLELDLSKNKVLRMASStFRHLTDLRRLNLA 162
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 163 DNSIVELvQRNFFMLSRLKYLDLSGNPLQDLqPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGrNEFKFLD 242
Cdd:COG4886  145 NNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSG-NQLTDLP 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 243 kDEFRDVKRLTKVLLDGNQLSVVvDQLFRMqKSLNHLDLSYNRLAKVPndSFLQLTNLTFLDLSYNKLVRLEPQSIRSLS 322
Cdd:COG4886  222 -EPLANLTNLETLDLSNNQLTDL-PELGNL-TNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLL 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 323 NLLTLNISGNVLMDLREMRETFEPLIYYFFLTcsKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYLNISGNSLNNTA 402
Cdd:COG4886  297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLL--LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        330       340
                 ....*....|....*....|....*....
gi 665408460 403 LEVIDPCRELEFLDLSRNQLHGISEDTVL 431
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-446 2.89e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  84 LEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLAD 163
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 164 NSIVELVQRNFFMLSRLKYLDLSGNPLqdlqpdvFRDVPELKVLKCRNCQLKKINpqmynllpllseldlgrnefkfldk 243
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLP------------------------- 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 244 DEFRDVKRLTKVLLDGNQLSVVVDQLFRMqKSLNHLDLSYNRLAKVPnDSFLQLTNLTFLDLSYNKLVRLePQSIRSLSN 323
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTN 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 324 LLTLNISGNvlmdlremretfepliyyffltcsklffqlipQLTHLAIAdmgtmpvglLHPFKQLRYLNISGNSLnnTAL 403
Cdd:COG4886  207 LEELDLSGN--------------------------------QLTDLPEP---------LANLTNLETLDLSNNQL--TDL 243

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 665408460 404 EVIDPCRELEFLDLSRNQLHGISEDtvLRIQGIRNVRLDNNPL 446
Cdd:COG4886  244 PELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-457 2.55e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 2.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 101 SFWGLKYLRILDLSKNNITNIT-ENNFRGQDNLLELDLSKNKVLRMASSTFrhLTDLRRLNLADNSIVELVQRNFFMLSR 179
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 180 LKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLKKINPQmynllpllseldlgrnefkfldkdEFRDVKRLTKVLLDG 259
Cdd:PLN00113 166 LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPR------------------------ELGQMKSLKWIYLGY 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 260 NQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLmdlre 339
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSL----- 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 340 mretfepliyyffltcSKLFFQLIPQLTHLAIADM------GTMPVGlLHPFKQLRYLNISGNSLNNTALEVIDPCRELE 413
Cdd:PLN00113 297 ----------------SGEIPELVIQLQNLEILHLfsnnftGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT 359

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 665408460 414 FLDLSRNQLHGISEDTvlriqgirnvrldnnplICDECHMGKLI 457
Cdd:PLN00113 360 VLDLSTNNLTGEIPEG-----------------LCSSGNLFKLI 386
LRR_8 pfam13855
Leucine rich repeat;
275-334 1.15e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  275 SLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVL 334
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-334 5.55e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 5.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  80 QFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKN-----------------KV 142
Cdd:PLN00113 306 QLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNnltgeipeglcssgnlfKL 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 143 LRMASS-------TFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLK-CRNCQL 214
Cdd:PLN00113 386 ILFSNSlegeipkSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSlARNKFF 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 215 KKInPQMYNLLPLLSELDlGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSF 294
Cdd:PLN00113 466 GGL-PDSFGSKRLENLDL-SRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASF 543

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 665408460 295 LQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVL 334
Cdd:PLN00113 544 SEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
251-310 1.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.27e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  251 RLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKL 310
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-446 5.00e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 5.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 239 KFLDK-DEFRDVKRLTKVLLDGNQLSVVvDQLFRMQKsLNHLDLSYNRLAKVPNdsFLQLTNLTFLDLSYNKLVRLEpqS 317
Cdd:cd21340   12 KNITKiDNLSLCKNLKVLYLYDNKITKI-ENLEFLTN-LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--G 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 318 IRSLSNLLTLNISGNVLmdLREMRETFEPLiyyffltcsklffqlipqlTHLAIAdmgtmpvgllhpfKQLRYLNISGNS 397
Cdd:cd21340   86 LENLTNLEELHIENQRL--PPGEKLTFDPR-------------------SLAALS-------------NSLRVLNISGNN 131

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665408460 398 LnnTALEVIDPCRELEFLDLSRNQLHGISE--DTVLRIQGIRNVRLDNNPL 446
Cdd:cd21340  132 I--DSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
131-190 2.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.94e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  131 NLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPL 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.37e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 665408460  156 LRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQL 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 250-343 2.66e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 250 KRLTKVLLDGNQLSVV----------------------------VDQLFRMQKSLNHLDLSYNRLAKVpnDSFLQLTNLT 301
Cdd:cd21340   68 VNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLE 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 665408460 302 FLDLSYNKLVRLEP--QSIRSLSNLLTLNISGNVLMDLREMRET 343
Cdd:cd21340  146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRDK 189
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-424 3.04e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 131 NLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDlqpdvfrDVPELkVLKCR 210
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG-------EIPEL-VIQLQ 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 211 NCQLKKINPqmynllpllseldlgrNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLA-KV 289
Cdd:PLN00113 309 NLEILHLFS----------------NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEI 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 290 PnDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQL------I 363
Cdd:PLN00113 373 P-EGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRInsrkwdM 451

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 364 PQLTHLAIA--------------------DM------GTMPVGLLHpFKQLRYLNISGNSLNNTALEVIDPCRELEFLDL 417
Cdd:PLN00113 452 PSLQMLSLArnkffgglpdsfgskrlenlDLsrnqfsGAVPRKLGS-LSELMQLKLSENKLSGEIPDELSSCKKLVSLDL 530


                 ....*..
gi 665408460 418 SRNQLHG 424
Cdd:PLN00113 531 SHNQLSG 537
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-313 3.58e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  69 RNSIT-IGPALRQFMKLEILRITDSNLPAIGaESFWGLKYLRILDLSKNNITNITENnFRGQDNLLELDLSKNKVLRMAS 147
Cdd:COG4886  168 NNQLTdLPEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 148 stFRHLTDLRRLNLADNSIVELvqRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPL 227
Cdd:COG4886  246 --LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 228 LSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSY 307
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401


                 ....*.
gi 665408460 308 NKLVRL 313
Cdd:COG4886  402 LLTLAL 407
PLN03150 PLN03150
hypothetical protein; Provisional
 274-334 1.04e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 1.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665408460 274 KSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVL 334
Cdd:PLN03150 442 RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-446 3.65e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 3.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  45 GGLNSLlspNELDVDVKVIIirGPrnsitIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITEN 124
Cdd:PLN00113 233 GGLTSL---NHLDLVYNNLT--GP-----IPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 125 NFRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPEL 204
Cdd:PLN00113 303 LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNL 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 205 KVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYN 284
Cdd:PLN00113 383 FKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARN 462

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 285 RLAKVPNDSFlQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMdlremretfepliyyffltcsklffqlip 364
Cdd:PLN00113 463 KFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS----------------------------- 512

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 365 qlthlaiadmGTMPvGLLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNN 444
Cdd:PLN00113 513 ----------GEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581


                 ..
gi 665408460 445 PL 446
Cdd:PLN00113 582 HL 583
LRR_8 pfam13855
Leucine rich repeat;
178-262 3.97e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 3.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460  178 SRLKYLDLSGNPLQDLQPDVFRDVPELKVLKcrncqlkkinpqmynllpllseldLGRNEFKFLDKDEFRDVKRLTKVLL 257
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLD------------------------LSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 665408460  258 DGNQL 262
Cdd:pfam13855  57 SGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 128-212 1.69e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 128 GQDNLLELDLSKNKVLRMASSTFR------HLTDLRRLNLADNSIVELvqRNFFMLSRLKYLDLSGNPLQDLQP--DVFR 199
Cdd:cd21340   88 NLTNLEELHIENQRLPPGEKLTFDprslaaLSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLS 165

                         90
                 ....*....|...
gi 665408460 200 DVPELKVLKCRNC 212
Cdd:cd21340  166 SWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
298-334 1.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 665408460  298 TNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVL 334
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 151-422 7.51e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 151 RHLTDLRRLNLADN------SIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDV---PELKVLKCRNCQLKKinpqm 221
Cdd:cd00116   48 RPQPSLKELCLSLNetgripRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGD----- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 222 ynllpllseldlgrnefkfldkdefRDVKRLTKVLLDgnqlsvvvdqlfrMQKSLNHLDLSYNRLAKVPNDS----FLQL 297
Cdd:cd00116  123 -------------------------RGLRLLAKGLKD-------------LPPALEKLVLGRNRLEGASCEAlakaLRAN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408460 298 TNLTFLDLSYNKL----VRLEPQSIRSLSNLLTLNISGNVLMDL--REMRETFEPLiyyffltcsklffqliPQLTHLAI 371
Cdd:cd00116  165 RDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEgaSALAETLASL----------------KSLEVLNL 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665408460 372 -------ADMGTMPVGLLHPFKQLRYLNISGNSLNN----TALEVIDPCRELEFLDLSRNQL 422
Cdd:cd00116  229 gdnnltdAGAAALASALLSPNISLLTLSLSCNDITDdgakDLAEVLAEKESLLELDLRGNKF 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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