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Conserved domains on  [gi|665408177|ref|NP_001285960|]
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uncharacterized protein Dmel_CG18480, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-230 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  66 ISANIEIP--TTVELLDLSYNDITTIDDdSFKTTIHLLNLTLAHNAIHTLyGDAFVELTRLRYLDLSYNRLEQIDEHILE 143
Cdd:COG4886  103 LSGNEELSnlTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGN 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 144 SNNqLIHLNLEGNKLSTLGKgPILRSPSLRSLNLRNSQVNQLGTQlLSALPQLRQLDLAQNLLLTLSpgDFHAPRNLASL 223
Cdd:COG4886  181 LTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEEL 255


                 ....*..
gi 665408177 224 NVEENPF 230
Cdd:COG4886  256 DLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-230 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  66 ISANIEIP--TTVELLDLSYNDITTIDDdSFKTTIHLLNLTLAHNAIHTLyGDAFVELTRLRYLDLSYNRLEQIDEHILE 143
Cdd:COG4886  103 LSGNEELSnlTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGN 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 144 SNNqLIHLNLEGNKLSTLGKgPILRSPSLRSLNLRNSQVNQLGTQlLSALPQLRQLDLAQNLLLTLSpgDFHAPRNLASL 223
Cdd:COG4886  181 LTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEEL 255


                 ....*..
gi 665408177 224 NVEENPF 230
Cdd:COG4886  256 DLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
74-134 6.44e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 6.44e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665408177   74 TTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRL 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-231 1.02e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  50 DLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDdsfKTTIHLLNLTLAHNAIHTLyGDAFVEltRLRYLDL 129
Cdd:PRK15370 217 NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCL-PENLPE--ELRYLSV 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 130 SYNRLEQIDEHILESnnqLIHLNLEGNKLS----TLGKG--------------PILRSPSLRSLNLRNSQVNQLGTQLls 191
Cdd:PRK15370 291 YDNSIRTLPAHLPSG---ITHLNVQSNSLTalpeTLPPGlktleagenaltslPASLPPELQVLDVSKNQITVLPETL-- 365

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 665408177 192 aLPQLRQLDLAQNLLLTLspgdfhaPRNL-ASLNVEENPFN 231
Cdd:PRK15370 366 -PPTITTLDVSRNALTNL-------PENLpAALQIMQASRN 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-204 2.35e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  79 LDLSYNDITTIDDDSfkttiHLLNLT---LAHNAIhtlygdAFVE----LTRLRYLDLSYNRLEQ-----IDEHILES-N 145
Cdd:cd21340   51 LYLQNNQIEKIENLE-----NLVNLKklyLGGNRI------SVVEglenLTNLEELHIENQRLPPgekltFDPRSLAAlS 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665408177 146 NQLIHLNLEGNKLSTLGKGPILRSpsLRSLNLRNSQVNQLG--TQLLSALPQLRQLDLAQN 204
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRN--LEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 200-250 1.84e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.22  E-value: 1.84e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 665408177   200 DLAQNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALAKVATGLRQRGVAI 250
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKV 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-230 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  66 ISANIEIP--TTVELLDLSYNDITTIDDdSFKTTIHLLNLTLAHNAIHTLyGDAFVELTRLRYLDLSYNRLEQIDEHILE 143
Cdd:COG4886  103 LSGNEELSnlTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGN 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 144 SNNqLIHLNLEGNKLSTLGKgPILRSPSLRSLNLRNSQVNQLGTQlLSALPQLRQLDLAQNLLLTLSpgDFHAPRNLASL 223
Cdd:COG4886  181 LTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEEL 255


                 ....*..
gi 665408177 224 NVEENPF 230
Cdd:COG4886  256 DLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
74-134 6.44e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 6.44e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665408177   74 TTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRL 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-231 5.65e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 5.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  61 SAKRLISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYL------------- 127
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELdlsgneelsnltn 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 128 ----DLSYNRLEQIDEHIlESNNQLIHLNLEGNKLSTLGKgPILRSPSLRSLNLRNSQVNQLGTQlLSALPQLRQLDLAQ 203
Cdd:COG4886  115 leslDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                        170       180
                 ....*....|....*....|....*...
gi 665408177 204 NLLLTLsPGDFHAPRNLASLNVEENPFN 231
Cdd:COG4886  192 NQITDL-PEPLGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-231 4.75e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  66 ISANIEIPTTVELLDLSYNDITTIDDdSFKTTIHLLNLTLAHNAIHTLygDAFVELTRLRYLDLSYNRLEQIDEhiLESN 145
Cdd:COG4886  197 LPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANL 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 146 NQLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLsaLPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNV 225
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL--LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349


                 ....*.
gi 665408177 226 EENPFN 231
Cdd:COG4886  350 LTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-231 1.02e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  50 DLHAQRNRAVCSAKRLISANIEIPTTVELLDLSYNDITTIDDdsfKTTIHLLNLTLAHNAIHTLyGDAFVEltRLRYLDL 129
Cdd:PRK15370 217 NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCL-PENLPE--ELRYLSV 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 130 SYNRLEQIDEHILESnnqLIHLNLEGNKLS----TLGKG--------------PILRSPSLRSLNLRNSQVNQLGTQLls 191
Cdd:PRK15370 291 YDNSIRTLPAHLPSG---ITHLNVQSNSLTalpeTLPPGlktleagenaltslPASLPPELQVLDVSKNQITVLPETL-- 365

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 665408177 192 aLPQLRQLDLAQNLLLTLspgdfhaPRNL-ASLNVEENPFN 231
Cdd:PRK15370 366 -PPTITTLDVSRNALTNL-------PENLpAALQIMQASRN 398
LRR_8 pfam13855
Leucine rich repeat;
99-158 1.29e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.29e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177   99 HLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKL 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
122-185 5.61e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.61e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665408177  122 TRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNsqvNQL 185
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG---NRL 61
LRR_8 pfam13855
Leucine rich repeat;
170-230 1.61e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665408177  170 PSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPF 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-204 2.35e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  79 LDLSYNDITTIDDDSfkttiHLLNLT---LAHNAIhtlygdAFVE----LTRLRYLDLSYNRLEQ-----IDEHILES-N 145
Cdd:cd21340   51 LYLQNNQIEKIENLE-----NLVNLKklyLGGNRI------SVVEglenLTNLEELHIENQRLPPgekltFDPRSLAAlS 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665408177 146 NQLIHLNLEGNKLSTLGKGPILRSpsLRSLNLRNSQVNQLG--TQLLSALPQLRQLDLAQN 204
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRN--LEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 76-230 2.98e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.36  E-value: 2.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  76 VELLDLSYNDITTIDDD------SFKTTIHLLNLT---LAHNAIHTLyGDAFVELTRLRYLDLSYNRLE----QIDEHIL 142
Cdd:cd00116  139 LEKLVLGRNRLEGASCEalakalRANRDLKELNLAnngIGDAGIRAL-AEGLKANCNLEVLDLNNNGLTdegaSALAETL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 143 ESNNQLIHLNLEGNKL-----STLGKGPILRSPSLRSLNLRNSQVNQLGT----QLLSALPQLRQLDLAQNLLL----TL 209
Cdd:cd00116  218 ASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGNKFGeegaQL 297

                        170       180
                 ....*....|....*....|..
gi 665408177 210 SPGDFHAPRN-LASLNVEENPF 230
Cdd:cd00116  298 LAESLLEPGNeLESLWVKDDSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 44-204 1.32e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  44 PTVCHCDLHaqRNRAVCSAKRLISANIEIPTTVELLDLSYNDITtidddsfKTTIHLLNLTLAHNaihtlygdafvelTR 123
Cdd:COG5238  236 KSLTTLDLS--NNQIGDEGVIALAEALKNNTTVETLYLSGNQIG-------AEGAIALAKALQGN-------------TT 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 124 LRYLDLSYNRL-----EQIDEHiLESNNQLIHLNLEGNKLSTLGKGPILRS----PSLRSLNLrnsQVNQLG-------T 187
Cdd:COG5238  294 LTSLDLSVNRIgdegaIALAEG-LQGNKTLHTLNLAYNGIGAQGAIALAKAlqenTTLHSLDL---SDNQIGdegaialA 369

                        170
                 ....*....|....*..
gi 665408177 188 QLLSALPQLRQLDLAQN 204
Cdd:COG5238  370 KYLEGNTTLRELNLGKN 386
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-231 2.20e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  57 RAVCSAKRL-------------ISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAI------------- 110
Cdd:PLN00113 326 VALTSLPRLqvlqlwsnkfsgeIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLegeipkslgacrs 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 111 --------HTLYGDAFVELTRLR---YLDLSYNRLE-QIDEHILESNnQLIHLNLEGNKLStlGKGP-ILRSPSLRSLNL 177
Cdd:PLN00113 406 lrrvrlqdNSFSGELPSEFTKLPlvyFLDISNNNLQgRINSRKWDMP-SLQMLSLARNKFF--GGLPdSFGSKRLENLDL 482

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 665408177 178 RNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFN 231
Cdd:PLN00113 483 SRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-231 2.68e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  76 VELLDLSYNDIT-TIDDDSFKTTiHLLNLTLAHNAIHTLYGDAFVElTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLE 154
Cdd:PLN00113 430 VYFLDISNNNLQgRINSRKWDMP-SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665408177 155 GNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFN 231
Cdd:PLN00113 508 ENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-176 2.77e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 2.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 100 LLNLTLAHNAIHTLygDAFVELTRLRYLDLSYNRLEQIDE--HILESNNQLIHLNLEGNKLStlgKGP------ILRSPS 171
Cdd:cd21340  122 LRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC---KKPkyrdkiILASKS 196


                 ....*
gi 665408177 172 LRSLN 176
Cdd:cd21340  197 LEVLD 201
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 74-204 5.37e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 5.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  74 TTVELLDLSYNDITTIDDDSFK------TTIHllNLTLAHNAIHTLYGDAFVE----LTRLRYLDLSYNR-----LEQID 138
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAealtqnTTVT--TLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQigdegVIALA 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665408177 139 EHiLESNNQLIHLNLEGNKLSTlgKGPIL------RSPSLRSLNLRnsqVNQLGTQLLSALPQ-------LRQLDLAQN 204
Cdd:COG5238  258 EA-LKNNTTVETLYLSGNQIGA--EGAIAlakalqGNTTLTSLDLS---VNRIGDEGAIALAEglqgnktLHTLNLAYN 330
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 62-196 1.21e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  62 AKRLISAnIEIPTTVELLDLSYNDITtiDD------DSFKTTIHLLNLTLAHNAIHT----LYGDAFVELTRLRYLDLSY 131
Cdd:COG5238  281 AIALAKA-LQGNTTLTSLDLSVNRIG--DEgaialaEGLQGNKTLHTLNLAYNGIGAqgaiALAKALQENTTLHSLDLSD 357

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665408177 132 NRLEqiDE------HILESNNQLIHLNLEGNKLSTLGKGPI---LRSPSLRSLNLRNsqvNQLGTQLLSALPQL 196
Cdd:COG5238  358 NQIG--DEgaialaKYLEGNTTLRELNLGKNNIGKQGAEALidaLQTNRLHTLILDG---NLIGAEAQQRLEQL 426
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-237 8.76e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 8.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  77 ELLDLSYNDITTIDddSFKTTIHLLNLTLAHNAIHTLygDAFVELTRLRYLDLSYNR-----LEQIDEHILESNNQLIHL 151
Cdd:COG4886  231 ETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQltdlkLKELELLLGLNSLLLLLL 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 152 NLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLNVEENPFN 231
Cdd:COG4886  307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386


                 ....*.
gi 665408177 232 CDRALA 237
Cdd:COG4886  387 LTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-228 3.76e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  65 LISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSynrLEQIDEHILES 144
Cdd:COG4886   18 LELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS---LLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 145 NNQLIHLNLEGNKlstlgkgPILRSPSLRSLNLRNSQVNQLGTQlLSALPQLRQLDLAQNLLLTLsPGDFHAPRNLASLN 224
Cdd:COG4886   95 LTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLD 165


                 ....
gi 665408177 225 VEEN 228
Cdd:COG4886  166 LSNN 169
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-225 1.06e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177 117 AFVELTRLRYLDLSYNRLE-QIDEHILESNNQLIHLNLEGNKLStlgkGPILRS--PSLRSLNLRNSQVNQLGTQLLSAL 193
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT----GSIPRGsiPNLETLDLSNNMLSGEIPNDIGSF 163

                         90       100       110
                 ....*....|....*....|....*....|..
gi 665408177 194 PQLRQLDLAQNLLLTLSPGDFhapRNLASLNV 225
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSL---TNLTSLEF 192
PLN03150 PLN03150
hypothetical protein; Provisional
 99-197 1.41e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  99 HLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLeqiDEHILESNNQLIH---LNLEGNKLStlGKGPilrsPSLRSL 175
Cdd:PLN03150 443 HLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF---NGSIPESLGQLTSlriLNLNGNSLS--GRVP----AALGGR 513

                         90       100
                 ....*....|....*....|..
gi 665408177 176 NLRNSQVNQLGTQLLSALPQLR 197
Cdd:PLN03150 514 LLHRASFNFTDNAGLCGIPGLR 535
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 200-250 1.84e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.22  E-value: 1.84e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 665408177   200 DLAQNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALAKVATGLRQRGVAI 250
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKV 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-230 3.73e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177  75 TVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLE 154
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665408177 155 GNKLSTLGKGPILRSPSLRSLNLRNsqvnqlgTQLLSALPQLRQLDLAQNLLLTLsPGDFHAPRNLASLNVEENPF 230
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148
LRR_9 pfam14580
Leucine-rich repeat;
79-200 3.95e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177   79 LDLSYNDITTIDD-----DSFKTtihllnLTLAHNAIHTLygDAFVELTRLRYLDLSYNRLEQIDEHILESNNQLIHLNL 153
Cdd:pfam14580  24 LDLRGYKIPIIENlgatlDQFDT------IDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELIL 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 665408177  154 EGNKLSTLGK-GPILRSPSLRSLN-LRNSQVNQLGTQLLSA--LPQLRQLD 200
Cdd:pfam14580  96 TNNNLQELGDlDPLASLKKLTFLSlLRNPVTNKPHYRLYVIykVPQLRLLD 146
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 170-208 4.11e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 665408177  170 PSLRSLNLRNSQVNQLgtQLLSALPQLRQLDLAQNLLLT 208
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 69-180 7.37e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 36.75  E-value: 7.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408177   69 NIEIPTTVelldlsyndiTTIDDDSFKTTIHLLNLTLAHNaIHTLYGDAFvELTRLRYLDLSyNRLEQIDEHILESNNQL 148
Cdd:pfam13306  15 SITIPSSL----------TSIGEYAFSNCTSLKSITLPSS-LTSIGSYAF-YNCSLTSITIP-SSLTSIGEYAFSNCSNL 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665408177  149 IHLNLEGNkLSTLGKGPILRSpSLRSLNLRNS 180
Cdd:pfam13306  82 KSITLPSN-LTSIGSYAFSNC-SLKSITIPSS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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