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Conserved domains on  [gi|665404536|ref|NP_001285660|]
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uncharacterized protein Dmel_CG9147, isoform D [Drosophila melanogaster]

Protein Classification

glutaredoxin family protein( domain architecture ID 10530477)

glutaredoxin/thioredoxin family protein functions as a thiol disulfide oxidoreductase that catalyzes the oxidation or reduction of protein thiol or disulfide bonds using an active site disulfide or dithiol, present in a CXXC motif

CATH:  3.40.30.10
PubMed:  11441809|11012661|14713336
SCOP:  4000237

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glrx-like pfam05768
Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This ...
 314-388 1.93e-17

Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.


:

Pssm-ID: 399055  Cd Length: 80  Bit Score: 76.18  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404536  314 LTLYTREPCPLCDDLVEQLEQ-GFAGQYRLEKVYIDRKENvrFLRLFRHDIPVLFFNG------QFLCMHRLNEEALRER 386
Cdd:pfam05768   1 LTLYGKPGCGLCEGAEEVLEPlALELGFELEVIDIDGDPE--LLAKYGLEIPVLAFVGiskffnLEILSWRLDEEQLAAE 78


                  ..
gi 665404536  387 LE 388
Cdd:pfam05768  79 LE 80
PaaJ super family cl43052
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 31-69 7.68e-03

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


The actual alignment was detected with superfamily member COG0183:

Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 38.12  E-value: 7.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665404536  31 VVIAAAVRTPSAPF-------RAEEqrLAGLVVDELVKRTSVPREE 69
Cdd:COG0183    4 VVIVDAVRTPFGRFggaladvRADD--LGAAVIKALLERAGLDPEA 47
 
Name Accession Description Interval E-value
Glrx-like pfam05768
Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This ...
 314-388 1.93e-17

Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.


Pssm-ID: 399055  Cd Length: 80  Bit Score: 76.18  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404536  314 LTLYTREPCPLCDDLVEQLEQ-GFAGQYRLEKVYIDRKENvrFLRLFRHDIPVLFFNG------QFLCMHRLNEEALRER 386
Cdd:pfam05768   1 LTLYGKPGCGLCEGAEEVLEPlALELGFELEVIDIDGDPE--LLAKYGLEIPVLAFVGiskffnLEILSWRLDEEQLAAE 78


                  ..
gi 665404536  387 LE 388
Cdd:pfam05768  79 LE 80
GrxC COG0695
Glutaredoxin [Posttranslational modification, protein turnover, chaperones];
314-388 2.98e-04

Glutaredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440459 [Multi-domain]  Cd Length: 74  Bit Score: 39.03  E-value: 2.98e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665404536 314 LTLYTREPCPLCDDLVEQLEQ-GFAgqyrLEKVYIDRKENVR--FLRLF-RHDIPVLFFNGQFlcMHRLNEEALRERLE 388
Cdd:COG0695    2 VTLYTTPGCPYCARAKRLLDEkGIP----YEEIDVDEDPEAReeLRERSgRRTVPVIFIGGEH--LGGFDEGELDALLA 74
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 31-69 7.68e-03

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 38.12  E-value: 7.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665404536  31 VVIAAAVRTPSAPF-------RAEEqrLAGLVVDELVKRTSVPREE 69
Cdd:COG0183    4 VVIVDAVRTPFGRFggaladvRADD--LGAAVIKALLERAGLDPEA 47
 
Name Accession Description Interval E-value
Glrx-like pfam05768
Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This ...
 314-388 1.93e-17

Glutaredoxin-like domain (DUF836); These proteins are related to the pfam00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterized member is G4L from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L.


Pssm-ID: 399055  Cd Length: 80  Bit Score: 76.18  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404536  314 LTLYTREPCPLCDDLVEQLEQ-GFAGQYRLEKVYIDRKENvrFLRLFRHDIPVLFFNG------QFLCMHRLNEEALRER 386
Cdd:pfam05768   1 LTLYGKPGCGLCEGAEEVLEPlALELGFELEVIDIDGDPE--LLAKYGLEIPVLAFVGiskffnLEILSWRLDEEQLAAE 78


                  ..
gi 665404536  387 LE 388
Cdd:pfam05768  79 LE 80
GrxC COG0695
Glutaredoxin [Posttranslational modification, protein turnover, chaperones];
314-388 2.98e-04

Glutaredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440459 [Multi-domain]  Cd Length: 74  Bit Score: 39.03  E-value: 2.98e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665404536 314 LTLYTREPCPLCDDLVEQLEQ-GFAgqyrLEKVYIDRKENVR--FLRLF-RHDIPVLFFNGQFlcMHRLNEEALRERLE 388
Cdd:COG0695    2 VTLYTTPGCPYCARAKRLLDEkGIP----YEEIDVDEDPEAReeLRERSgRRTVPVIFIGGEH--LGGFDEGELDALLA 74
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 31-69 7.68e-03

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 38.12  E-value: 7.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665404536  31 VVIAAAVRTPSAPF-------RAEEqrLAGLVVDELVKRTSVPREE 69
Cdd:COG0183    4 VVIVDAVRTPFGRFggaladvRADD--LGAAVIKALLERAGLDPEA 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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