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Conserved domains on  [gi|665404473|ref|NP_001285647|]
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uncharacterized protein Dmel_CG9021, isoform B [Drosophila melanogaster]

Protein Classification

Ins_allergen_rp domain-containing protein( domain architecture ID 10535966)

Ins_allergen_rp domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
120-292 4.61e-39

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


:

Pssm-ID: 462003  Cd Length: 173  Bit Score: 135.39  E-value: 4.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404473  120 GLTNLVRVARPLLPAATLKNILANGVE-DPQVQELIKLLRSDNFKTQVQLLKATKQHQLLHDYVCRRLkLDPTYYAEYVR 198
Cdd:pfam06757   1 SLREDLQDFLALIPLEKIQDIVARYLLnDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAG-LDIYDYINVLN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404473  199 VFLDLHISDPPTIKlPNRRPGVRGLLQDLREALPRTALRNMYQQLYSSDSELSSAIRLIRGSEFRRLLRDLRQLKEYRSL 278
Cdd:pfam06757  80 DFLGLSGLVPPSST-LLRTGGLRGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERLRASPEVQRL 158
                         170
                  ....*....|....
gi 665404473  279 AADLEKSGVPLRQL 292
Cdd:pfam06757 159 LNKLRAHGVDVDEL 172
 
Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
120-292 4.61e-39

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 135.39  E-value: 4.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404473  120 GLTNLVRVARPLLPAATLKNILANGVE-DPQVQELIKLLRSDNFKTQVQLLKATKQHQLLHDYVCRRLkLDPTYYAEYVR 198
Cdd:pfam06757   1 SLREDLQDFLALIPLEKIQDIVARYLLnDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAG-LDIYDYINVLN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404473  199 VFLDLHISDPPTIKlPNRRPGVRGLLQDLREALPRTALRNMYQQLYSSDSELSSAIRLIRGSEFRRLLRDLRQLKEYRSL 278
Cdd:pfam06757  80 DFLGLSGLVPPSST-LLRTGGLRGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERLRASPEVQRL 158
                         170
                  ....*....|....
gi 665404473  279 AADLEKSGVPLRQL 292
Cdd:pfam06757 159 LNKLRAHGVDVDEL 172
 
Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
120-292 4.61e-39

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 135.39  E-value: 4.61e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404473  120 GLTNLVRVARPLLPAATLKNILANGVE-DPQVQELIKLLRSDNFKTQVQLLKATKQHQLLHDYVCRRLkLDPTYYAEYVR 198
Cdd:pfam06757   1 SLREDLQDFLALIPLEKIQDIVARYLLnDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAG-LDIYDYINVLN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404473  199 VFLDLHISDPPTIKlPNRRPGVRGLLQDLREALPRTALRNMYQQLYSSDSELSSAIRLIRGSEFRRLLRDLRQLKEYRSL 278
Cdd:pfam06757  80 DFLGLSGLVPPSST-LLRTGGLRGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERLRASPEVQRL 158
                         170
                  ....*....|....
gi 665404473  279 AADLEKSGVPLRQL 292
Cdd:pfam06757 159 LNKLRAHGVDVDEL 172
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
224-301 3.50e-06

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 46.41  E-value: 3.50e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665404473  224 LQDLREALPRTALRNMYQQLYSSDSELSSAIRLIRGSEFRRLLRDLRQLKEYRSLAADLEKSGVPLRQLQQLVANALG 301
Cdd:pfam06757   6 LQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDFLG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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