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Conserved domains on  [gi|665404394|ref|NP_001285627|]
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H15, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 276-472 5.25e-141

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


:

Pssm-ID: 410319  Cd Length: 190  Bit Score: 408.74  E-value: 5.25e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20193    1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSG----VDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSipgSPKELQDMDHK 435
Cdd:cd20193   77 DPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTA---SLVNLKSEEFR 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 472
Cdd:cd20193  154 TFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
 
Name Accession Description Interval E-value
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 276-472 5.25e-141

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 408.74  E-value: 5.25e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20193    1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSG----VDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSipgSPKELQDMDHK 435
Cdd:cd20193   77 DPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTA---SLVNLKSEEFR 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 472
Cdd:cd20193  154 TFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 278-471 1.65e-110

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 330.29  E-value: 1.65e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394  278 CHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKADP 357
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSG----LDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394  358 PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLshgqsiPGSPKELQDMDHKTF 437
Cdd:pfam00907  75 HSPPRVYIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRV------GGDEPSLPEENVKTF 148

                         170       180       190
                  ....*....|....*....|....*....|....
gi 665404394  438 VFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:pfam00907 149 VFPETEFIAVTAYQNEEITQLKIDNNPFAKGFRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
276-474 1.31e-101

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 307.66  E-value: 1.31e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394   276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSrrYRYAYHRSSWLVAGKA 355
Cdd:smart00425   1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSG----LDPNALYSVLMDLVPVDD--KRYKFNNGKWVVAGKA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394   356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSG--QVVLNSMHRYQPRIHLVRLSHGQSIPGSPKelqdmd 433
Cdd:smart00425  75 EPHMPSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGhlQIILNSMHKYQPRLHIVEVDDISKEILSQF------ 148

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 665404394   434 hKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSR 474
Cdd:smart00425 149 -KTFVFPETQFIAVTAYQNQKITKLKIDNNPFAKGFRDQGR 188
 
Name Accession Description Interval E-value
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 276-472 5.25e-141

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 408.74  E-value: 5.25e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20193    1 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSG----VDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSipgSPKELQDMDHK 435
Cdd:cd20193   77 DPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKKKDHTA---SLVNLKSEEFR 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 472
Cdd:cd20193  154 TFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 190
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 278-471 1.65e-110

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 330.29  E-value: 1.65e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394  278 CHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKADP 357
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSG----LDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394  358 PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLshgqsiPGSPKELQDMDHKTF 437
Cdd:pfam00907  75 HSPPRVYIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRV------GGDEPSLPEENVKTF 148

                         170       180       190
                  ....*....|....*....|....*....|....
gi 665404394  438 VFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:pfam00907 149 VFPETEFIAVTAYQNEEITQLKIDNNPFAKGFRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
276-474 1.31e-101

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 307.66  E-value: 1.31e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394   276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSrrYRYAYHRSSWLVAGKA 355
Cdd:smart00425   1 IKVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSG----LDPNALYSVLMDLVPVDD--KRYKFNNGKWVVAGKA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394   356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSG--QVVLNSMHRYQPRIHLVRLSHGQSIPGSPKelqdmd 433
Cdd:smart00425  75 EPHMPSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGhlQIILNSMHKYQPRLHIVEVDDISKEILSQF------ 148

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 665404394   434 hKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSR 474
Cdd:smart00425 149 -KTFVFPETQFIAVTAYQNQKITKLKIDNNPFAKGFRDQGR 188
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 276-471 4.50e-94

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 288.17  E-value: 4.50e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20187    2 VTVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFG----MDPMADYMLMMDFVPVDDKRYRYAFHSSSWLVAGKA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKElqdmDHK 435
Cdd:cd20187   78 DPAMPGRIHVHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSENSAEE----NFK 153

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20187  154 TFIFPETKFTAVTAYQNHRITQLKIASNPFAKGFRD 189
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 276-471 8.10e-86

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 266.60  E-value: 8.10e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSrrYRYAYHRSSWLVAGKA 355
Cdd:cd20188    3 PKVELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSG----LDKKAKYILLMDIVAADD--CRYKFHNSRWMVAGKA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSpkelqdmDHK 435
Cdd:cd20188   77 DPEMPKRMYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYS-------TFR 149

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20188  150 TYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRD 185
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 276-471 9.59e-86

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 266.75  E-value: 9.59e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20191    3 IQVELQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSG----LDPHAQYIVAMDIVPVDNKRYRYVYHSSKWMVAGNA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHG----QSIPGSPKElqd 431
Cdd:cd20191   79 DAPVPPRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRKDSStdlsPKKPVPPGE--- 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665404394 432 mDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20191  156 -GVKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 276-471 5.18e-85

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 264.68  E-value: 5.18e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKA 355
Cdd:cd20189    1 IKVFLENRELWQKFHEVGTEMIITKAGRRMFPSIKVKVTG----LNPKTKYILLMDIVPADDHRYKF--HDSEWVVAGKA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVrlshgQSIPGSPKELQDMDHK 435
Cdd:cd20189   75 EPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDQFGHIILNSMHKYQPRIHIV-----QADDNNAFGSKNTAFS 149

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20189  150 THVFPETAFIAVTAYQNHQITQLKIENNPFAKGFRG 185
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 276-471 1.15e-83

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 261.17  E-value: 1.15e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20682    1 IQVELCSRELWLQFHNLGNEMIITKAGRRMFPALKVKLTG----LDPDKLYIVWVDIVPVDSNRYRYVYHSSKWVVAGSG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKS-GQVVLNSMHRYQPRIHLvrlshgQSIPGSPKELQDM-- 432
Cdd:cd20682   77 DVLPPANRYIHPDSPASGKYWMSQIVSFDKLKLTNNKEPKQkGQISLHSMHKYQPRIHI------QPVEDDGRNVEKAin 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 665404394 433 --DHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20682  151 ssKALSFEFPETSFITVTAYQNQQITKLKIASNPFAKGFRD 191
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 276-471 7.25e-79

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 248.78  E-value: 7.25e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAyHRSSWLVAGKA 355
Cdd:cd20681    1 VKVTLKNRDLWQQFHREGTEMIITKSGRRMFPSLRLSVSG----LEPDARYCVLLEMVLASDCRFKYS-GNGGWVPAGGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DP--PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKelqdmd 433
Cdd:cd20681   76 EPqpPLPRRIYIHPDSPATGDHWMSQPISFSKVKLTNNTLDPQGNIVLTSMHKYQPRIHIVRCSDTLALPWAPT------ 149

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 665404394 434 hKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20681  150 -ASFTFPETEFIAVTAYQNERITKLKIDNNPFAKGFRE 186
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 275-471 1.40e-77

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 245.60  E-value: 1.40e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 275 PVQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGK 354
Cdd:cd20200    2 KVQVELQGSELWKRFHEIGTEMIITKAGRRMFPSVRVKVKG----LDPLKQYYIAMDVVPVDSKRYRYVYHSSQWMVAGN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 355 ADPPP-PSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLV------RLSHGQSIPGSPK 427
Cdd:cd20200   78 TDHSCiTPRLYVHPDSPCSGETWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYKPRVHVIlqdsrfDLSQIQSLPAEGV 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 665404394 428 elqdmdhKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20200  158 -------KTFSFPETEFTTVTAYQNQQITKLKIDRNPFAKGFRD 194
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 276-471 6.77e-76

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 241.49  E-value: 6.77e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVAGKA 355
Cdd:cd20199    4 VRVDLQGADLWKRFHEIGTEMIITKAGRRMFPAMRVKITG----LDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSI-PGSPKELQDmDH 434
Cdd:cd20199   80 DSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKECGEELsPVKPIPSGE-GV 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 665404394 435 KTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20199  159 KAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 195
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 276-471 1.04e-75

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 240.24  E-value: 1.04e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAyhRSSWLVAGKA 355
Cdd:cd20192    1 IRVTLEDRELWKKFHSLTNEMIVTKSGRRMFPVLKVSVSG----LDPNAMYSVLLDFVQVDNHRWKYV--NGEWVPGGKA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNeMDKSGQVVLNSMHRYQPRIHLVRlshgqsipgspkeLQDMDHK 435
Cdd:cd20192   75 EPPPPSSVYVHPDSPNFGAHWMKGPVSFSKVKLTNK-PNGEGQIMLNSLHKYEPRVHIVR-------------VGSNNHE 140

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665404394 436 ----TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20192  141 rlvsTFSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLD 180
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 276-471 3.85e-74

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 236.28  E-value: 3.85e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSrrYRYAYHRSSWLVAGKA 355
Cdd:cd20197    1 VRASLEDQDLWKKFHQIGTEMIITKSGRRMFPQCKIRVSG----LLPYAKYVMLVDFVPVDN--FRYKWNKDQWEVAGKA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPkelqdmdHK 435
Cdd:cd20197   75 EPQPPCRTYVHPDSPAPGSHWMKQPISFQKLKLTNNTLDQHGHIILHSMHRYQPRFHIVQADDLFNVRWSL-------FQ 147

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20197  148 VFSFPETVFTAVTAYQNEKITKLKIDNNPFAKGFRE 183
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 276-463 4.87e-74

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 235.57  E-value: 4.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGpLrqiQPADRYAVLLDVVPLDSRRYRyaYHRSSWLVAGKA 355
Cdd:cd00182    1 ITVSLRNEELWKKFHELGTEMIVTKSGRRMFPTLEYSVSG-L---DPNKLYSVSLHFERVDNKRYK--FNNGKWVPSGKA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPP-PSRIYAHPDCPLSPEALRKQVVSFEKVKLTNN-EMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKElqdmd 433
Cdd:cd00182   75 EPPPePSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNkEDKKEGHILLHSMHKYIPVLTIYEVDDNGLLSKLVKE----- 149

                        170       180       190
                 ....*....|....*....|....*....|
gi 665404394 434 hktFVFPETVFTAVTAYQNQLITKLKIDSN 463
Cdd:cd00182  150 ---FRFPETEFIAVTAYQNDEITQLKIDNN 176
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 273-471 4.64e-73

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 233.85  E-value: 4.64e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 273 LTPVQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAYHRSSWLVA 352
Cdd:cd20198    4 MEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITG----LDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 353 GKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSI-PGSPKELQD 431
Cdd:cd20198   80 GNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLsPTKPVPTGD 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665404394 432 mDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20198  160 -GVKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 198
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 276-471 5.85e-69

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 222.45  E-value: 5.85e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKA 355
Cdd:cd20190    1 VSLSLEDRELWKEFSSVGTEMIITKSGRRMFPACKVSVTG----LDPEAKYLFLLDVVPVDNARYKW--NKRRWEPSGKA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPgsPKELQdmdhk 435
Cdd:cd20190   75 EPHLPDRVYIHPDSPAPGAHWMRQPISFHKLKLTNNTLDPHGHLILHSMHKYQPRIHLVQSADLCSQH--WGGMA----- 147

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 TFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20190  148 SFRFPETTFIAVTAYQNPQITKLKIAANPFAKGFRE 183
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 276-471 6.04e-67

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 217.43  E-value: 6.04e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKA 355
Cdd:cd20196    1 VRMSLENAELWKQFSSVGTEMIITKAGRRMFPQLRVSVSG----LDPEARYLLLLDVVPVDGSRYRW--QGNSWEASGKA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVR----LSHGQSIpgspkelqd 431
Cdd:cd20196   75 EPRLPDRVYIHPDSPATGAHWMRQPISFHRAKLTNNTLDPHGHIILHSMHRYQPRVHVVRardvLSWGGGC--------- 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665404394 432 mdhKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20196  146 ---ASFTFPETQFITVTAYQNPKITQLKINSNPFAKGFRE 182
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 276-471 4.68e-63

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 206.94  E-value: 4.68e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKA 355
Cdd:cd20194    2 ASVYLCNRDLWLKFHQHQTEMIITKQGRRMFPTLSFNLSG----LDPTAHYNVFVDMVLADPNHWKF--QSGKWVPCGKA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DP-PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQsiPGSPKELQdmdh 434
Cdd:cd20194   76 EGlPQGNRVYVHPDSPNTGAHWMKQEISFSKLKLTNNKGADQGMIVLNSMHKYQPRIHVIEVGGNG--PNEQRNLQ---- 149

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 665404394 435 kTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20194  150 -THSFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRD 185
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 280-471 3.54e-60

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 199.58  E-value: 3.54e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 280 LETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDsrRYRYAYHRSSWLVAGKADPPP 359
Cdd:cd20195    5 LENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISG----LDPDRNYILVMDISPVD--NFRYRWNGRWWEPSGKAEPHV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 360 PSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVrlshgqSIPGSPKELQDMDHK--TF 437
Cdd:cd20195   79 LGRVFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVV------PADKEVDVIQLNGPDvhTF 152

                        170       180       190
                 ....*....|....*....|....*....|....
gi 665404394 438 VFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20195  153 TFPQTEFFAVTAYQNKQITQLKIDYNPFAKGFRE 186
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 276-471 7.65e-56

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 187.55  E-value: 7.65e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAyhRSSWLVAGKA 355
Cdd:cd20202    2 LKVSLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSG----LDPNAMYSFLLDFVAADNHRWKYV--NGEWVPGGKP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTnNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKelqdmdhk 435
Cdd:cd20202   76 EPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLT-NKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHS-------- 146

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 tfvFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20202  147 ---FPETQFIAVTAYQNEEITALKIKYNPFAKAFLD 179
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 276-471 3.71e-52

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 177.91  E-value: 3.71e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAyhRSSWLVAGKA 355
Cdd:cd20201    6 LQVSLEDAELWQRFKEVTNEMIVTKNGRRMFPVLKISVSG----LDPNAMYSFLLDFAPADGHRWKYV--NGEWVPAGKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTnNEMDKSGQVVLNSMHRYQPRIHLVRLShgqsipGSPKELQDMDhk 435
Cdd:cd20201   80 EPHSHSCVYIHPDSPNFGAHWMKAPISFSKVKLT-NKLNGGGQIMLNSLHKYEPQIHIVRVG------GPHRMVTNCS-- 150

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665404394 436 tfvFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20201  151 ---FPETQFIAVTAYQNEEITALKIKYNPFAKAFLD 183
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 276-471 2.07e-51

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 176.30  E-value: 2.07e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKA 355
Cdd:cd20203    2 LQVLLNNHPLWSKFHKHQTEMIITKQGRRMFPFLSFNLTG----LDPTAHYNVYVDVVLADQHHWRY--QGGKWVQCGKA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 356 DPP-PPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE---MDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKElqd 431
Cdd:cd20203   76 EGNmPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKgasNNVTQMIVLQSLHKYQPRLHIVEVKEGETEEAYSSS--- 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665404394 432 mDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20203  153 -KTHTFTFPETQFIAVTAYQNAEITQLKIDHNPFAKGFRD 191
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 277-471 3.00e-46

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 162.21  E-value: 3.00e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 277 QCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKAD 356
Cdd:cd20204    3 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISG----LDPTAHYNIFVDVILADPNHWRF--QGGKWVPCGKAD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 357 PP-PPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE--MDKSGQ-VVLNSMHRYQPRIHLVRLSH-GQSIPGSPKELQd 431
Cdd:cd20204   77 TNvQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKgaSNNNGQmVVLQSLHKYQPRLHVVEVNEdGTEDTSQPGRVQ- 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665404394 432 mdhkTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20204  156 ----TFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 277-471 3.63e-46

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 162.16  E-value: 3.63e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 277 QCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYayHRSSWLVAGKAD 356
Cdd:cd20205    3 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITG----LNPTAHYNVFVEVVLADPNHWRF--QGGKWVTCGKAD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 357 PP-PPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE---MDKSGQVVLNSMHRYQPRIHLVRLSHGqsipGSPKELQDM 432
Cdd:cd20205   77 NNmQGNKVYVHPESPNTGAHWMRQEISFGKLKLTNNKganNNNTQMIVLQSLHKYQPRLHIVEVSED----GVEDLNDSS 152

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 665404394 433 DHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 471
Cdd:cd20205  153 KTQTFTFPENQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 276-472 2.26e-44

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 157.94  E-value: 2.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 276 VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGplrqIQPADRYAVLLDVVPLDSRRYRYAyhRSSWLVAGK- 354
Cdd:cd20683    1 PQLLLEDADLWAQFHSVQNEMIITKSGRCLFPLLRFRAVN----LDPKALYSIALDIEQVSPNRFRFR--NGRWNPIDKd 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404394 355 --ADPPPPS----------RIYAHPDCPLSPEALRKQVVSFEKVKLTN------------------NEMDKSGQVVLNSM 404
Cdd:cd20683   75 qrGDDAFSSgtadksvllpESYIHPDGPQTGAFWMANGISFAKIKLSNrqpnssdrdgpkenitnsISALPDGHFFLTSF 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665404394 405 HRYQPRIHLVRLSHGQSipgspkelQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDS 472
Cdd:cd20683  155 HKYQPRLHLIQHSAGDH--------DDILSTTFTFEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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