wengen, isoform B [Drosophila melanogaster]
TNFR_c6 domain-containing protein( domain architecture ID 10439907)
TNFR_c6 domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | ||
TNFR_c6 | pfam00020 | TNFR/NGFR cysteine-rich region; |
100-137 | 3.27e-05 | ||
TNFR/NGFR cysteine-rich region; : Pssm-ID: 459633 [Multi-domain] Cd Length: 39 Bit Score: 40.37 E-value: 3.27e-05
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Name | Accession | Description | Interval | E-value | ||
TNFR_c6 | pfam00020 | TNFR/NGFR cysteine-rich region; |
100-137 | 3.27e-05 | ||
TNFR/NGFR cysteine-rich region; Pssm-ID: 459633 [Multi-domain] Cd Length: 39 Bit Score: 40.37 E-value: 3.27e-05
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TNFRSF16 | cd13416 | Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ... |
108-141 | 5.57e-05 | ||
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases. Pssm-ID: 276921 [Multi-domain] Cd Length: 159 Bit Score: 42.29 E-value: 5.57e-05
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TNFR | smart00208 | Tumor necrosis factor receptor / nerve growth factor receptor repeats; Repeats in growth ... |
100-137 | 6.60e-04 | ||
Tumor necrosis factor receptor / nerve growth factor receptor repeats; Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR Pssm-ID: 214558 Cd Length: 39 Bit Score: 36.68 E-value: 6.60e-04
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Name | Accession | Description | Interval | E-value | ||
TNFR_c6 | pfam00020 | TNFR/NGFR cysteine-rich region; |
100-137 | 3.27e-05 | ||
TNFR/NGFR cysteine-rich region; Pssm-ID: 459633 [Multi-domain] Cd Length: 39 Bit Score: 40.37 E-value: 3.27e-05
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TNFRSF16 | cd13416 | Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ... |
108-141 | 5.57e-05 | ||
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases. Pssm-ID: 276921 [Multi-domain] Cd Length: 159 Bit Score: 42.29 E-value: 5.57e-05
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TNFR | smart00208 | Tumor necrosis factor receptor / nerve growth factor receptor repeats; Repeats in growth ... |
100-137 | 6.60e-04 | ||
Tumor necrosis factor receptor / nerve growth factor receptor repeats; Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR Pssm-ID: 214558 Cd Length: 39 Bit Score: 36.68 E-value: 6.60e-04
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TNFRSF16 | cd13416 | Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ... |
107-137 | 9.67e-04 | ||
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases. Pssm-ID: 276921 [Multi-domain] Cd Length: 159 Bit Score: 38.82 E-value: 9.67e-04
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Blast search parameters | ||||
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