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Conserved domains on  [gi|665392156|ref|NP_001285396|]
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vacuolar protein sorting 4, isoform B [Drosophila melanogaster]

Protein Classification

vacuolar protein sorting-associated protein 4( domain architecture ID 15269737)

vacuolar protein sorting-associated protein 4 is an ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain.

CATH:  1.10.8.60
Gene Ontology:  GO:0005524|GO:0016887|GO:0007033|GO:0015031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 126-296 4.02e-124

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 357.25  E-value: 4.02e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 126 KPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSK 205
Cdd:cd19521    1 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEAN-STFFSVSSSDLVSK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 206 WLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSA 285
Cdd:cd19521   80 WMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSA 159

                        170
                 ....*....|.
gi 665392156 286 IRRRFEKRIYI 296
Cdd:cd19521  160 IRRRFEKRIYI 170
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 379-439 2.82e-36

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


:

Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 127.61  E-value: 2.82e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156  379 LVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFG 439
Cdd:pfam09336   1 LTPCSPGDPGAIEMTWMDIPSDKLLEPPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 6-69 7.54e-31

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


:

Pssm-ID: 239141  Cd Length: 75  Bit Score: 113.51  E-value: 7.54e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156   6 TLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGeKAKDSIRAKCLQYLDRAE 69
Cdd:cd02678    2 FLQKAIELVKKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNP-KSKESIRAKCTEYLDRAE 64
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 323-361 6.36e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.39  E-value: 6.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 665392156  323 DLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFK 361
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQE 41
 
Name Accession Description Interval E-value
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 126-296 4.02e-124

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 357.25  E-value: 4.02e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 126 KPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSK 205
Cdd:cd19521    1 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEAN-STFFSVSSSDLVSK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 206 WLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSA 285
Cdd:cd19521   80 WMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSA 159

                        170
                 ....*....|.
gi 665392156 286 IRRRFEKRIYI 296
Cdd:cd19521  160 IRRRFEKRIYI 170
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 112-353 1.69e-89

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 274.96  E-value: 1.69e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 112 KKLQSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEA 189
Cdd:COG1222   58 KRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGIEPP-KGVLLYGPPGTGKTLLAKAVAGEL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 190 NrSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDN-ENDSVRRIKTEFLVQMQGVgNDTD 268
Cdd:COG1222  137 G-APFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDgTSGEVQRTVNQLLAELDGF-ESRG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 269 GILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNtTHVLTEQDLKELAGKTEGYSGADISIVVRDA 346
Cdd:COG1222  215 DVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRD-MPLADDVDLDKLAKLTEGFSGADLKAIVTEA 293


                 ....*..
gi 665392156 347 LMEPVRK 353
Cdd:COG1222  294 GMFAIRE 300
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 122-440 2.89e-69

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 233.26  E-value: 2.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  122 IVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSS 200
Cdd:TIGR01243 443 VLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIrPPKGVLLFGPPGTGKTLLAKAVATESG-ANFIAVRGP 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  201 DLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVR-RIKTEFLVQMQGVgNDTDGILVLGATNIP 279
Cdd:TIGR01243 522 EILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMDGI-QELSNVVVIAATNRP 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  280 WVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLgNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTA 357
Cdd:TIGR01243 601 DILDPALLRpgRFDRLILVPPPDEEARKEIFKIHT-RSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGS 679

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  358 THFKRVSGPSptnhEEIVNDLLvpcspgdqgavemnwmdvpsdklfeppVTMRDMLKSLSRTKPTVNEDDLKKLRKFTED 437
Cdd:TIGR01243 680 PAKEKLEVGE----EEFLKDLK---------------------------VEMRHFLEALKKVKPSVSKEDMLRYERLAKE 728


                  ...
gi 665392156  438 FGQ 440
Cdd:TIGR01243 729 LKR 731
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 123-353 1.17e-65

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 215.47  E-value: 1.17e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 123 VIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFtgKRI---PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSS 199
Cdd:PRK03992 122 VIESPNVTYEDIGGLEEQIREVREAVELPLKKPELF--EEVgiePPKGVLLYGPPGTGKTLLAKAVAHETN-ATFIRVVG 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 200 SDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNEND---SVRRIKTEFLVQMQGVgNDTDGILVLGAT 276
Cdd:PRK03992 199 SELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSgdrEVQRTLMQLLAEMDGF-DPRGNVKIIAAT 277

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 277 NIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNtTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRK 353
Cdd:PRK03992 278 NRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRK-MNLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD 355
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 168-298 5.35e-56

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 181.64  E-value: 5.35e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  168 ILLFGPPGTGKSYLAKAVATEANRsTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNEND 247
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGA-PFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 665392156  248 SVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPL 298
Cdd:pfam00004  80 ESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 379-439 2.82e-36

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 127.61  E-value: 2.82e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156  379 LVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFG 439
Cdd:pfam09336   1 LTPCSPGDPGAIEMTWMDIPSDKLLEPPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 6-69 7.54e-31

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 113.51  E-value: 7.54e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156   6 TLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGeKAKDSIRAKCLQYLDRAE 69
Cdd:cd02678    2 FLQKAIELVKKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNP-KSKESIRAKCTEYLDRAE 64
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 7-69 1.94e-21

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 87.21  E-value: 1.94e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156    7 LQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKyEAQGEKAKDSIRAKCLQYLDRAE 69
Cdd:pfam04212   1 LSKALELVKKAVEEDNAGNYEEALELYKEALDYLLLALK-ETKNEERRELLRAKIAEYLERAE 62
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 164-300 7.63e-21

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 88.58  E-value: 7.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156   164 PWKGILLFGPPGTGKSYLAKAVATEANRST--FFSVSSSDLMS--------------KWLGESEKLVKNLFELARQHKPS 227
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGggVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156   228 IIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGvgndtdGILVLGATNIPWVLDSA-IRRRFEKRIYIPLPE 300
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEK------NLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
5-69 1.28e-18

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 80.04  E-value: 1.28e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665392156     5 TTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEaQGEKAKDSIRAKCLQYLDRAE 69
Cdd:smart00745   3 DYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVE-SDSKRREALKAKAAEYLDRAE 66
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 323-361 6.36e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.39  E-value: 6.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 665392156  323 DLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFK 361
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQE 41
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 168-234 1.03e-06

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 49.39  E-value: 1.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156 168 ILLFGPPGTGKSYLAKAV---ATEANRSTFFsVSSSDLMSKWlgESEKLVKNLFELARQH-KPSIIFIDEI 234
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALgyaACRQGYRVRF-TTAADLVEQL--AQARADGRLGRLLRRLaRYDLLIIDEL 160
 
Name Accession Description Interval E-value
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 126-296 4.02e-124

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 357.25  E-value: 4.02e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 126 KPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSK 205
Cdd:cd19521    1 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEAN-STFFSVSSSDLVSK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 206 WLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSA 285
Cdd:cd19521   80 WMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSA 159

                        170
                 ....*....|.
gi 665392156 286 IRRRFEKRIYI 296
Cdd:cd19521  160 IRRRFEKRIYI 170
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 134-296 4.17e-90

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 270.38  E-value: 4.17e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 134 VAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGESEKL 213
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESG-STFFSISASSLVSKWVGESEKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 214 VKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGN-DTDGILVLGATNIPWVLDSAIRRRFEK 292
Cdd:cd19509   80 VRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNkPEDRVLVLGATNRPWELDEAFLRRFEK 159


                 ....
gi 665392156 293 RIYI 296
Cdd:cd19509  160 RIYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 112-353 1.69e-89

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 274.96  E-value: 1.69e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 112 KKLQSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEA 189
Cdd:COG1222   58 KRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGIEPP-KGVLLYGPPGTGKTLLAKAVAGEL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 190 NrSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDN-ENDSVRRIKTEFLVQMQGVgNDTD 268
Cdd:COG1222  137 G-APFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDgTSGEVQRTVNQLLAELDGF-ESRG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 269 GILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNtTHVLTEQDLKELAGKTEGYSGADISIVVRDA 346
Cdd:COG1222  215 DVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRD-MPLADDVDLDKLAKLTEGFSGADLKAIVTEA 293


                 ....*..
gi 665392156 347 LMEPVRK 353
Cdd:COG1222  294 GMFAIRE 300
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 133-296 8.60e-75

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 231.41  E-value: 8.60e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGESEK 212
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECG-TTFFNVSSSTLTSKYRGESEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 213 LVKNLFELARQHKPSIIFIDEIDSMCSAR-SDNENDSVRRIKTEFLVQMQGVGNDTDG------ILVLGATNIPWVLDSA 285
Cdd:cd19522   80 LVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVGGASENddpskmVMVLAATNFPWDIDEA 159

                        170
                 ....*....|.
gi 665392156 286 IRRRFEKRIYI 296
Cdd:cd19522  160 LRRRLEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 113-296 3.09e-73

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 227.95  E-value: 3.09e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 113 KLQSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEAnRS 192
Cdd:cd19525    3 KMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQS-GA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 193 TFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGNDTDG-IL 271
Cdd:cd19525   82 TFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDrIL 161

                        170       180
                 ....*....|....*....|....*
gi 665392156 272 VLGATNIPWVLDSAIRRRFEKRIYI 296
Cdd:cd19525  162 VVGATNRPQEIDEAARRRLVKRLYI 186
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 131-362 3.25e-73

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 235.19  E-value: 3.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 131 WSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPW-KGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSDLMSKWLGE 209
Cdd:COG0464  156 LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPpRGLLLYGPPGTGKTLLARALAGELGLP-LIEVDLSDLVSKYVGE 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 210 SEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVgndTDGILVLGATNIPWVLDSAIRRR 289
Cdd:COG0464  235 TEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL---RSDVVVIAATNRPDLLDPALLRR 311

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665392156 290 FEKRIYIPLPEAHARLVMFKIHLGNtTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQ---TATHFKR 362
Cdd:COG0464  312 FDEIIFFPLPDAEERLEIFRIHLRK-RPLDEDVDLEELAEATEGLSGADIRNVVRRAALQALRLGRepvTTEDLLE 386
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 133-296 1.73e-69

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 217.80  E-value: 1.73e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGESEK 212
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESN-ATFFNISAASLTSKYVGEGEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 213 LVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGV-GNDTDGILVLGATNIPWVLDSAIRRRFE 291
Cdd:cd19524   80 LVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVqSNGDDRVLVMGATNRPQELDDAVLRRFT 159


                 ....*
gi 665392156 292 KRIYI 296
Cdd:cd19524  160 KRVYV 164
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 122-440 2.89e-69

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 233.26  E-value: 2.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  122 IVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSS 200
Cdd:TIGR01243 443 VLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIrPPKGVLLFGPPGTGKTLLAKAVATESG-ANFIAVRGP 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  201 DLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVR-RIKTEFLVQMQGVgNDTDGILVLGATNIP 279
Cdd:TIGR01243 522 EILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTdRIVNQLLTEMDGI-QELSNVVVIAATNRP 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  280 WVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLgNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTA 357
Cdd:TIGR01243 601 DILDPALLRpgRFDRLILVPPPDEEARKEIFKIHT-RSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGS 679

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  358 THFKRVSGPSptnhEEIVNDLLvpcspgdqgavemnwmdvpsdklfeppVTMRDMLKSLSRTKPTVNEDDLKKLRKFTED 437
Cdd:TIGR01243 680 PAKEKLEVGE----EEFLKDLK---------------------------VEMRHFLEALKKVKPSVSKEDMLRYERLAKE 728


                  ...
gi 665392156  438 FGQ 440
Cdd:TIGR01243 729 LKR 731
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 123-353 1.17e-65

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 215.47  E-value: 1.17e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 123 VIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFtgKRI---PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSS 199
Cdd:PRK03992 122 VIESPNVTYEDIGGLEEQIREVREAVELPLKKPELF--EEVgiePPKGVLLYGPPGTGKTLLAKAVAHETN-ATFIRVVG 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 200 SDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNEND---SVRRIKTEFLVQMQGVgNDTDGILVLGAT 276
Cdd:PRK03992 199 SELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSgdrEVQRTLMQLLAEMDGF-DPRGNVKIIAAT 277

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 277 NIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNtTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRK 353
Cdd:PRK03992 278 NRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRK-MNLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD 355
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 111-357 1.75e-57

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 196.74  E-value: 1.75e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  111 KKKLQSKledaiviEKPKVQWSDVAGLDAAKEALKEAVILpIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATE 188
Cdd:TIGR01241  41 KAKLLNE-------EKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTklGAKIP-KGVLLVGPPGTGKTLLAKAVAGE 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  189 ANRStFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSD---NENDSVRRIKTEFLVQMQGVGN 265
Cdd:TIGR01241 112 AGVP-FFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAglgGGNDEREQTLNQLLVEMDGFGT 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  266 dTDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNTThVLTEQDLKELAGKTEGYSGADISIVV 343
Cdd:TIGR01241 191 -NTGVIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDIKGREEILKVHAKNKK-LAPDVDLKAVARRTPGFSGADLANLL 268

                         250
                  ....*....|....
gi 665392156  344 RDALMEPVRKVQTA 357
Cdd:TIGR01241 269 NEAALLAARKNKTE 282
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 133-296 7.02e-57

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 184.94  E-value: 7.02e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRI--PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGES 210
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLlqPPKGVLLYGPPGCGKTMLAKATAKEAG-ARFINLQVSSLTDKWYGES 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 211 EKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGND-TDGILVLGATNIPWVLDSAIRRR 289
Cdd:cd19520   80 QKLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDgNCRVIVMGATNRPQDLDEAILRR 159


                 ....*..
gi 665392156 290 FEKRIYI 296
Cdd:cd19520  160 MPKRFHI 166
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 168-298 5.35e-56

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 181.64  E-value: 5.35e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  168 ILLFGPPGTGKSYLAKAVATEANRsTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNEND 247
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGA-PFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 665392156  248 SVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPL 298
Cdd:pfam00004  80 ESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 140-296 6.59e-55

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 179.79  E-value: 6.59e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 140 AKEALKEAVILPIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSDLMSKWLGESEKLVKNL 217
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKrlGIRPP-KGVLLYGPPGCGKTLLAKALASEAGLN-FISVKGPELFSKYVGESERAVREI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 218 FELARQHKPSIIFIDEIDSMCSARSDNENDSVR-RIKTEFLVQMQGVGnDTDGILVLGATNIPWVLDSAIRR--RFEKRI 294
Cdd:cd19511   79 FQKARQAAPCIIFFDEIDSLAPRRGQSDSSGVTdRVVSQLLTELDGIE-SLKGVVVIAATNRPDMIDPALLRpgRLDKLI 157


                 ..
gi 665392156 295 YI 296
Cdd:cd19511  158 YV 159
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 133-296 2.46e-53

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 175.94  E-value: 2.46e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRIPW-KGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGESE 211
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPpRGVLLHGPPGTGKTLLARAVANEAG-ANFLSISGPSIVSKYLGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 212 KLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGNDtDGILVLGATNIPWVLDSAIRR--R 289
Cdd:cd19503   80 KNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMSSR-GKVVVIAATNRPDAIDPALRRpgR 158


                 ....*..
gi 665392156 290 FEKRIYI 296
Cdd:cd19503  159 FDREVEI 165
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 127-422 1.56e-52

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 187.81  E-value: 1.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  127 PKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSK 205
Cdd:TIGR01243 173 PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIePPKGVLLYGPPGTGKTLLAKAVANEAG-AYFISINGPEIMSK 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  206 WLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLDSA 285
Cdd:TIGR01243 252 YYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL-KGRGRVIVIGATNRPDALDPA 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  286 IRR--RFEKRIYIPLPEAHARLVMFKIHLGNTThVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQtathfkrv 363
Cdd:TIGR01243 331 LRRpgRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFI-------- 401

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156  364 sgpsptnheeivndllvpcspgDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPT 422
Cdd:TIGR01243 402 ----------------------REGKINFEAEEIPAEVLKELKVTMKDFMEALKMVEPS 438
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 140-296 1.86e-50

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 168.23  E-value: 1.86e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 140 AKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSDLMSKWLGESEKLVKNLFE 219
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLP-LIVVKLSSLLSKYVGESEKNLRKIFE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 220 LARQHKPSIIFIDEIDSMCSARSDN-ENDSVRRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLDSAIRR--RFEKRIYI 296
Cdd:cd19481   80 RARRLAPCILFIDEIDAIGRKRDSSgESGELRRVLNQLLTELDGV-NSRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 125-353 2.21e-49

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 173.03  E-value: 2.21e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 125 EKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLM 203
Cdd:PTZ00454 138 EKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIdPPRGVLLYGPPGTGKTMLAKAVAHHTT-ATFIRVVGSEFV 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 204 SKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDS---VRRIKTEFLVQMQGVGNDTDgILVLGATNIPW 280
Cdd:PTZ00454 217 QKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGAdreVQRILLELLNQMDGFDQTTN-VKVIMATNRAD 295

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665392156 281 VLDSAIRR--RFEKRIYIPLPEAHARLVMFKIhLGNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRK 353
Cdd:PTZ00454 296 TLDPALLRpgRLDRKIEFPLPDRRQKRLIFQT-ITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 131-294 9.52e-49

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 164.05  E-value: 9.52e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 131 WSDVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGE 209
Cdd:cd19502    2 YEDIGGLDEQIREIREVVELPLKHPELFEELGIePPKGVLLYGPPGTGKTLLAKAVANHTD-ATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 210 SEKLVKNLFELARQHKPSIIFIDEIDSMCSAR------SDNEndsVRRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLD 283
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsgtgGDRE---VQRTMLELLNQLDGF-DPRGNIKVIMATNRPDILD 156

                        170
                 ....*....|...
gi 665392156 284 SAIRR--RFEKRI 294
Cdd:cd19502  157 PALLRpgRFDRKI 169
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 129-296 1.55e-48

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 163.56  E-value: 1.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 129 VQWSDVAGLDAAKEALKEAVILpIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSDLMSKW 206
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTklGAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVP-FFSISGSDFVEMF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 207 LGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNE---NDSVRRIKTEFLVQMQGVGNDTdGILVLGATNIPWVLD 283
Cdd:cd19501   78 VGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLgggHDEREQTLNQLLVEMDGFESNT-GVIVIAATNRPDVLD 156

                        170
                 ....*....|....*
gi 665392156 284 SAIRR--RFEKRIYI 296
Cdd:cd19501  157 PALLRpgRFDRQVYV 171
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
125-339 1.35e-47

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 171.76  E-value: 1.35e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 125 EKPKVQWSDVAGLDAAKEALKEAV-ILpiKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSD 201
Cdd:COG0465  135 DKPKVTFDDVAGVDEAKEELQEIVdFL--KDPEKFTrlGAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVP-FFSISGSD 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 202 LM--------SKwlgeseklVKNLFELARQHKPSIIFIDEIDSMCSARSDNE---NDsvrriktE-------FLVQMQGV 263
Cdd:COG0465  211 FVemfvgvgaSR--------VRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLgggHD-------EreqtlnqLLVEMDGF 275

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 264 GNDTdGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNTThvLTEQ-DLKELAGKTEGYSGADI 339
Cdd:COG0465  276 EGNE-GVIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKVHARKKP--LAPDvDLEVIARRTPGFSGADL 351
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
131-347 8.36e-47

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 161.59  E-value: 8.36e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 131 WSDVAGLDAAKEALKEAVI------LPIKFpqlftgKRIPWKGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSDLMS 204
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKelrrreNLRKF------GLWPPRKILFYGPPGTGKTMLAEALAGELKLP-LLTVRLDSLIG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 205 KWLGESEKLVKNLFELARQHkPSIIFIDEIDSMCSARSD-NENDSVRRIKTEFLVQMqgvGNDTDGILVLGATNIPWVLD 283
Cdd:COG1223   74 SYLGETARNLRKLFDFARRA-PCVIFFDEFDAIAKDRGDqNDVGEVKRVVNALLQEL---DGLPSGSVVIAATNHPELLD 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156 284 SAIRRRFEKRIYIPLPEAHARLVMFKIHLgNTTHVLTEQDLKELAGKTEGYSGADISIVVRDAL 347
Cdd:COG1223  150 SALWRRFDEVIEFPLPDKEERKEILELNL-KKFPLPFELDLKKLAKKLEGLSGADIEKVLKTAL 212
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 133-296 1.08e-45

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 155.81  E-value: 1.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGESEK 212
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLG-ATFLRLRGSTLVAKWAGEGEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 213 LVKNLFELARQHKPSIIFIDEIDSMCSARsDNENDSVRRIKTEFLVQMQGV-GNDTDGILVLGATNIPWVLDSAIRRRFE 291
Cdd:cd19523   80 ILQASFLAARCRQPSVLFISDLDALLSSQ-DDEASPVGRLQVELLAQLDGVlGSGEDGVLVVCTTSKPEEIDESLRRYFS 158


                 ....*
gi 665392156 292 KRIYI 296
Cdd:cd19523  159 KRLLV 163
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 140-296 4.65e-45

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 154.19  E-value: 4.65e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 140 AKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGESEKLVKNLF 218
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLGIrPPKGILLYGPPGTGKTLLAKAVATESN-ANFISVKGPELLSKWVGESEKAIREIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 219 ELARQHKPSIIFIDEIDSMCSAR-SDNENDSVRRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLDSAIRR--RFEKRIY 295
Cdd:cd19529   80 RKARQVAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGL-EEMNGVVVIAATNRPDIIDPALLRagRFDRLIY 158


                 .
gi 665392156 296 I 296
Cdd:cd19529  159 I 159
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 133-297 3.52e-42

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 146.81  E-value: 3.52e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFtgKRI---PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGE 209
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELF--KAIgikPPRGILLYGPPGTGKTLIARAVANETG-AFFFLINGPEIMSKLAGE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 210 SEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGNDTDgILVLGATNIPWVLDSAIRR- 288
Cdd:cd19519   78 SESNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAH-VIVMAATNRPNSIDPALRRf 156

                        170
                 ....*....|
gi 665392156 289 -RFEKRIYIP 297
Cdd:cd19519  157 gRFDREIDIG 166
ftsH CHL00176
cell division protein; Validated
 129-353 4.15e-41

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 154.82  E-value: 4.15e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 129 VQWSDVAGLDAAKEALKEAVILpIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKW 206
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTavGAKIP-KGVLLVGPPGTGKTLLAKAIAGEAE-VPFFSISGSEFVEMF 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 207 LGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDN---ENDSVRRIKTEFLVQMQGVGNDTdGILVLGATNIPWVLD 283
Cdd:CHL00176 257 VGVGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGiggGNDEREQTLNQLLTEMDGFKGNK-GVIVIAATNRVDILD 335

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665392156 284 SAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNTTHVLtEQDLKELAGKTEGYSGADISIVVRDALMEPVRK 353
Cdd:CHL00176 336 AALLRpgRFDRQITVSLPDREGRLDILKVHARNKKLSP-DVSLELIARRTPGFSGADLANLLNEAAILTARR 406
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 141-296 2.25e-40

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 141.88  E-value: 2.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 141 KEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEAnRSTFFSVSSSDLMSKWLGESEKLVKNLFE 219
Cdd:cd19528    2 KRELQELVQYPVEHPDKFLKFGMtPSKGVLFYGPPGCGKTLLAKAIANEC-QANFISVKGPELLTMWFGESEANVRDIFD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 220 LARQHKPSIIFIDEIDSMCSARSDNENDS---VRRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLDSAIRR--RFEKRI 294
Cdd:cd19528   81 KARAAAPCVLFFDELDSIAKARGGNIGDAggaADRVINQILTEMDGM-NTKKNVFIIGATNRPDIIDPAILRpgRLDQLI 159


                 ..
gi 665392156 295 YI 296
Cdd:cd19528  160 YI 161
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
111-352 3.78e-40

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 152.11  E-value: 3.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 111 KKKLQSKLEDAIviekpKVQWSDVAGLDAAKEALKEAVIL---PIKFPQLftGKRIPwKGILLFGPPGTGKSYLAKAVAT 187
Cdd:PRK10733 136 KSKARMLTEDQI-----KTTFADVAGCDEAKEEVAELVEYlrePSRFQKL--GGKIP-KGVLMVGPPGTGKTLLAKAIAG 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 188 EAnRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARS---DNENDSVRRIKTEFLVQMQGV- 263
Cdd:PRK10733 208 EA-KVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGaglGGGHDEREQTLNQMLVEMDGFe 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 264 GNdtDGILVLGATNIPWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLgNTTHVLTEQDLKELAGKTEGYSGADISI 341
Cdd:PRK10733 287 GN--EGIIVIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHM-RRVPLAPDIDAAIIARGTPGFSGADLAN 363

                        250
                 ....*....|.
gi 665392156 342 VVRDALMEPVR 352
Cdd:PRK10733 364 LVNEAALFAAR 374
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 124-346 6.33e-40

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 148.38  E-value: 6.33e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 124 IEK-PKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSD 201
Cdd:PTZ00361 174 VDKaPLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIkPPKGVILYGPPGTGKTLLAKAVANETS-ATFLRVVGSE 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 202 LMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKT---EFLVQMQGVGNDTDgILVLGATNI 278
Cdd:PTZ00361 253 LIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEIQRtmlELLNQLDGFDSRGD-VKVIMATNR 331

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156 279 PWVLDSAIRR--RFEKRIYIPLPEAHARLVMFKIHLGNTThvLTEQ-DLKELAGKTEGYSGADISIVVRDA 346
Cdd:PTZ00361 332 IESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMT--LAEDvDLEEFIMAKDELSGADIKAICTEA 400
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 133-295 7.78e-39

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 138.03  E-value: 7.78e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEANRS----TFFSVSSSDLMSKWL 207
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKItPPRGVLFHGPPGTGKTLMARALAAECSKGgqkvSFFMRKGADCLSKWV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 208 GESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVgnDTDG-ILVLGATNIPWVLDSAI 286
Cdd:cd19517   81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGL--DNRGqVVVIGATNRPDALDPAL 158

                        170
                 ....*....|.
gi 665392156 287 RR--RFEKRIY 295
Cdd:cd19517  159 RRpgRFDREFY 169
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 140-295 5.62e-38

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 135.25  E-value: 5.62e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 140 AKEALKEAVILPIKFPQLFTGKRIPW-KGILLFGPPGTGKSYLAKAVATEANRStFFSVSSSDLMSKWLGESEKLVKNLF 218
Cdd:cd19526    1 VKKALEETIEWPSKYPKIFASSPLRLrSGILLYGPPGCGKTLLASAIASECGLN-FISVKGPELLNKYIGASEQNVRDLF 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 219 ELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLDSAIRR--RFEKRIY 295
Cdd:cd19526   80 SRAQSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGV-EGLDGVYVLAATSRPDLIDPALLRpgRLDKLVY 157
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 137-296 6.97e-38

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 135.31  E-value: 6.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 137 LDAAKEALKEAVILPIKFPQLFT--GKRIPwKGILLFGPPGTGKSYLAKAVATEAnRSTFFSVSSSDLMSKWLGESEKLV 214
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKalGIDLP-TGVLLYGPPGCGKTLLAKAVANES-GANFISVKGPELLNKYVGESERAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 215 KNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGvGNDTDGILVLGATNIPWVLDSAIRR--RFEK 292
Cdd:cd19530   79 RQVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDG-LEERSNVFVIAATNRPDIIDPAMLRpgRLDK 157


                 ....
gi 665392156 293 RIYI 296
Cdd:cd19530  158 TLYV 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 141-296 3.11e-37

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 133.41  E-value: 3.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 141 KEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRsTFFSVSSSDLMSKWLGESEKLVKNLFEL 220
Cdd:cd19527    2 KKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSL-NFLSVKGPELINMYIGESEANVREVFQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 221 ARQHKPSIIFIDEIDSMCSARSdNENDS---VRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSAIRR--RFEKRIY 295
Cdd:cd19527   81 ARDAKPCVIFFDELDSLAPSRG-NSGDSggvMDRVVSQLLAELDGMSSSGQDVFVIGATNRPDLLDPALLRpgRFDKLLY 159


                 .
gi 665392156 296 I 296
Cdd:cd19527  160 L 160
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 133-294 4.80e-37

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 133.30  E-value: 4.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALKEAVILPIKFPQLFTGKRI-PWKGILLFGPPGTGKSYLAKAVATEAnRSTFFSVSSSDLMSKWLGESE 211
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVePPRGVLLHGPPGCGKTMLANAIAGEL-KVPFLKISATEIVSGVSGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 212 KLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGVGN---DTDGILVLGATNIPWVLDSAIRR 288
Cdd:cd19518   80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNektAGGPVLVIGATNRPDSLDPALRR 159


                 ....*...
gi 665392156 289 --RFEKRI 294
Cdd:cd19518  160 agRFDREI 167
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 379-439 2.82e-36

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 127.61  E-value: 2.82e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156  379 LVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFG 439
Cdd:pfam09336   1 LTPCSPGDPGAIEMTWMDIPSDKLLEPPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 6-69 7.54e-31

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 113.51  E-value: 7.54e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156   6 TLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGeKAKDSIRAKCLQYLDRAE 69
Cdd:cd02678    2 FLQKAIELVKKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNP-KSKESIRAKCTEYLDRAE 64
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 135-298 1.84e-28

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 109.54  E-value: 1.84e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 135 AGLDAAKEALKEAVILPikfpqlftgkriPWKGILLFGPPGTGKSYLAKAVATEANRS--TFFSVSSSDLMSKWLGESEK 212
Cdd:cd00009    1 VGQEEAIEALREALELP------------PPKNLLLYGPPGTGKTTLARAIANELFRPgaPFLYLNASDLLEGLVVAELF 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 213 ---LVKNLFELARQHKPSIIFIDEIDSMcsarsdneNDSVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWV--LDSAIR 287
Cdd:cd00009   69 ghfLVRLLFELAEKAKPGVLFIDEIDSL--------SRGAQNALLRVLETLNDLRIDRENVRVIGATNRPLLgdLDRALY 140

                        170
                 ....*....|.
gi 665392156 288 RRFEKRIYIPL 298
Cdd:cd00009  141 DRLDIRIVIPL 151
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 7-69 1.94e-21

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 87.21  E-value: 1.94e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156    7 LQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKyEAQGEKAKDSIRAKCLQYLDRAE 69
Cdd:pfam04212   1 LSKALELVKKAVEEDNAGNYEEALELYKEALDYLLLALK-ETKNEERRELLRAKIAEYLERAE 62
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 164-300 7.63e-21

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 88.58  E-value: 7.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156   164 PWKGILLFGPPGTGKSYLAKAVATEANRST--FFSVSSSDLMS--------------KWLGESEKLVKNLFELARQHKPS 227
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGggVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156   228 IIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGvgndtdGILVLGATNIPWVLDSA-IRRRFEKRIYIPLPE 300
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEK------NLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 166-296 1.02e-19

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 86.00  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 166 KGILLFGPPGTGKSYLAKAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPS--------IIFIDEIDSM 237
Cdd:cd19504   36 KGILLYGPPGTGKTLMARQIGKMLNAREPKIVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156 238 CSARSDNENDSV--RRIKTEFLVQMQGVgNDTDGILVLGATNIPWVLDSAIRR--RFEKRIYI 296
Cdd:cd19504  116 CKQRGSMAGSTGvhDTVVNQLLSKIDGV-EQLNNILVIGMTNRKDLIDEALLRpgRLEVQMEI 177
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
5-69 1.28e-18

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 80.04  E-value: 1.28e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665392156     5 TTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEaQGEKAKDSIRAKCLQYLDRAE 69
Cdd:smart00745   3 DYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVE-SDSKRREALKAKAAEYLDRAE 66
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 7-69 2.09e-18

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 79.28  E-value: 2.09e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156   7 LQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQgEKAKDSIRAKCLQYLDRAE 69
Cdd:cd02656    3 LQQAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKE-PKLRKLLRKKVKEYLDRAE 64
ycf46 CHL00195
Ycf46; Provisional
 110-347 2.69e-16

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 80.83  E-value: 2.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 110 EKKKLQSKLEdaiVIE--KPKVQWSDVAGLDAAKEALKeavilpiKFPQLFTGKRIPW-----KGILLFGPPGTGKSYLA 182
Cdd:CHL00195 207 EKKQIISQTE---ILEfySVNEKISDIGGLDNLKDWLK-------KRSTSFSKQASNYglptpRGLLLVGIQGTGKSLTA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 183 KAVATEANRStFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSmCSARSDNENDS--VRRIKTEFLVQM 260
Cdd:CHL00195 277 KAIANDWQLP-LLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDK-AFSNSESKGDSgtTNRVLATFITWL 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 261 qgvGNDTDGILVLG-ATNIPWVLDSAIRR-RFEKRIYIPLPEAHARLVMFKIHLgNTTHVLTEQ--DLKELAGKTEGYSG 336
Cdd:CHL00195 355 ---SEKKSPVFVVAtANNIDLLPLEILRKgRFDEIFFLDLPSLEEREKIFKIHL-QKFRPKSWKkyDIKKLSKLSNKFSG 430

                        250
                 ....*....|.
gi 665392156 337 ADISIVVRDAL 347
Cdd:CHL00195 431 AEIEQSIIEAM 441
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 133-261 8.24e-16

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 74.71  E-value: 8.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 133 DVAGLDAAKEALK--EAVILPikfPQLFTGKRIPwKGILLFGPPGTGKSYLAKAVATEANRsTFFSVSSSDLMSKWLGES 210
Cdd:cd19507    1 DVGGLDNLKDWLKkrKAAFSK---QASAYGLPTP-KGLLLVGIQGTGKSLTAKAIAGVWQL-PLLRLDMGRLFGGLVGES 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665392156 211 EKLVKNLFELARQHKPSIIFIDEIDSmCSARSDNENDS--VRRIKTEFLVQMQ 261
Cdd:cd19507   76 ESRLRQMIQTAEAIAPCVLWIDEIEK-GFSNADSKGDSgtSSRVLGTFLTWLQ 127
MIT_2 cd02684
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 6-69 1.17e-14

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239147  Cd Length: 75  Bit Score: 68.69  E-value: 1.17e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156   6 TLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKaKDSIRAKCLQYLDRAE 69
Cdd:cd02684    2 SLEKAIALVVQAVKKDQRGDAAAALSLYCSALQYFVPALHYETDAQR-KEALRQKVLQYVSRAE 64
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 163-296 1.23e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 66.32  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 163 IPW-KGILLFGPPGTGKSYLAKAVATEAN--------RSTFFSVSSSDLMSKWLGESEKLVKNLF----ELARQHKPSI- 228
Cdd:cd19508   49 ITWnRLVLLHGPPGTGKTSLCKALAQKLSirlssryrYGQLIEINSHSLFSKWFSESGKLVTKMFqkiqELIDDKDALVf 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156 229 IFIDEIDSMCSAR----SDNE-NDSVRRIKTeFLVQMQGVgNDTDGILVLGATNIPWVLDSAIRRRFEKRIYI 296
Cdd:cd19508  129 VLIDEVESLAAARsassSGTEpSDAIRVVNA-VLTQIDRI-KRYHNNVILLTSNLLEKIDVAFVDRADIKQYI 199
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 164-286 1.59e-12

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 65.09  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 164 PWKGILLFGPPGTGKSYLAKAVATEA--------------NRSTFFSVSSSDLMSKWlGESEKLVKNLFELARQHKPSII 229
Cdd:cd19505   11 PSKGILLIGSIETGRSYLIKSLAANSyvplirislnkllyNKPDFGNDDWIDGMLIL-KESLHRLNLQFELAKAMSPCII 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 230 FIDEIDSMCSARSDNENDSVRRIKTEFLV---QMQGVGNDTDGILVLGATNIPWVLDSAI 286
Cdd:cd19505   90 WIPNIHELNVNRSTQNLEEDPKLLLGLLLnylSRDFEKSSTRNILVIASTHIPQKVDPAL 149
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 144-296 3.69e-11

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 61.21  E-value: 3.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 144 LKEAVILPIKFPQLFTGKRIPWK-GILLFGPPGTGKSYLAKAVATEANRSTF-FSVSSSDLmskwlgeSEKLVKNLfeLA 221
Cdd:cd19510    1 IIDDLKDFIKNEDWYNDRGIPYRrGYLLYGPPGTGKSSFIAALAGELDYDICdLNLSEVVL-------TDDRLNHL--LN 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 222 RQHKPSIIFIDEIDSMCSARSDNENdsvRRIKTEFL--VQMQGVGNDTDGI------LVLGATNIPWVLDSAIRR--RFE 291
Cdd:cd19510   72 TAPKQSIILLEDIDAAFESREHNKK---NPSAYGGLsrVTFSGLLNALDGVasseerIVFMTTNHIERLDPALIRpgRVD 148


                 ....*
gi 665392156 292 KRIYI 296
Cdd:cd19510  149 MKIYM 153
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 166-296 1.54e-09

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 56.77  E-value: 1.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 166 KGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMSKWLGES--EKLVKNLFELARQHKPSIIFIDEIDSMCS---A 240
Cdd:cd19506   27 KSLLLAGPSGVGKKMLVHAICTETG-ANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYkkvP 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665392156 241 RSDNENDSvRRIKTEFLVQMQGVGNDtDGILVLGATNIPWVLD-SAIRRRFEKRIYI 296
Cdd:cd19506  106 KTEKQLDP-KRLKKDLPKILKSLKPE-DRVLIVGTTSRPFEADlKSFCKVYNKIILI 160
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 323-361 6.36e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.39  E-value: 6.36e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 665392156  323 DLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFK 361
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQE 41
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 162-294 5.83e-08

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 51.76  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 162 RIPWKGILLFGPPGTGKSYLAKAVATEANRStfFSVSSSDLMSKWLGESEKLVKNLFELARQHKPS-IIFIDEIDSMCSA 240
Cdd:cd19512   19 KGLYRNILFYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAIHKVFDWANTSRRGlLLFVDEADAFLRK 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665392156 241 RSDNE-NDSVRRIKTEFLVQMqgvGNDTDGILVLGATNIPWVLDSAIRRRFEKRI 294
Cdd:cd19512   97 RSTEKiSEDLRAALNAFLYRT---GEQSNKFMLVLASNQPEQFDWAINDRIDEMV 148
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 136-297 6.75e-08

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 54.85  E-value: 6.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  136 GLDAAKE---ALKEAVILPIKfpQLFTGKRIPW--KGILLFGPPGTGKSYLAKAVA------TEANRSTFFSVSSSDLMS 204
Cdd:TIGR03922 280 GLERVKRqvaALKSSTAMALA--RAERGLPVAQtsNHMLFAGPPGTGKTTIARVVAkiycglGVLRKPLVREVSRADLIG 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  205 KWLGESEKLVKNLFELARQhkpSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQgvgNDTDGILVLGA---TNIPWV 281
Cdd:TIGR03922 358 QYIGESEAKTNEIIDSALG---GVLFLDEAYTLVETGYGQKDPFGLEAIDTLLARME---NDRDRLVVIGAgyrKDLDKF 431

                         170
                  ....*....|....*...
gi 665392156  282 LDS--AIRRRFEKRIYIP 297
Cdd:TIGR03922 432 LEVneGLRSRFTRVIEFP 449
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 168-234 1.03e-06

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 49.39  E-value: 1.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156 168 ILLFGPPGTGKSYLAKAV---ATEANRSTFFsVSSSDLMSKWlgESEKLVKNLFELARQH-KPSIIFIDEI 234
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALgyaACRQGYRVRF-TTAADLVEQL--AQARADGRLGRLLRRLaRYDLLIIDEL 160
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 168-234 2.46e-06

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 49.31  E-value: 2.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665392156 168 ILLFGPPGTGKSYLAKAVATEANRsTFFSVSSSDlmskwlgESEKLVKNLFELARQH----KPSIIFIDEI 234
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDA-PFEALSAVT-------SGVKDLREVIEEARQRrsagRRTILFIDEI 101
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 168-234 6.16e-06

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 48.13  E-value: 6.16e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156 168 ILLFGPPGTGKSYLAKAVATEANRsTFFSVS--SSdlmskwlGESEklVKNLFELARQH----KPSIIFIDEI 234
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDA-EFVALSavTS-------GVKD--IREVIEEARERraygRRTILFVDEI 114
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 136-217 9.66e-06

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 47.30  E-value: 9.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  136 GLDAAKEALkeAVILpikfpQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRST-FFSVSSSDLMSKWLGESEKLV 214
Cdd:pfam06068  28 GQEKAREAA--GVIV-----EMIKEGKIAGRAVLIAGPPGTGKTALAIAISKELGEDTpFTSISGSEVYSLEMKKTEALT 100


                  ...
gi 665392156  215 KNL 217
Cdd:pfam06068 101 QAF 103
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 167-290 1.08e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.98  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  167 GILLFGPPGTGKSYLAKAVATEANRSTFFSV------SSSDLMSKWLGESEKLVKNLFELARQHKPS-IIFIDEIDsmcS 239
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVqltrdtTEEDLFGRRNIDPGGASWVDGPLVRAAREGeIAVLDEIN---R 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  240 ARSDNEND-----SVRRIKTEFLVQMQGVGNdtDGILVLGATNIP----WVLDSAIRRRF 290
Cdd:pfam07728  78 ANPDVLNSllsllDERRLLLPDGGELVKAAP--DGFRLIATMNPLdrglNELSPALRSRF 135
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 168-235 1.16e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 45.26  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  168 ILLFGPPGTGKSYLAKAVATEAN--RSTFFSVSSSDLM-----SKWLGESEKLVK-----NLFELARQHKPSIIFIDEID 235
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFgdERALIRIDMSEYMeehsvSRLIGAPPGYVGyeeggQLTEAVRRKPYSIVLIDEIE 85
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
166-234 1.27e-05

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 46.31  E-value: 1.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665392156 166 KGILLFGPPGTGKSYLAKAVATEA----NRSTFFSVssSDLMSKWlgESEKLVKNLFELARQ-HKPSIIFIDEI 234
Cdd:COG1484  100 ENLILLGPPGTGKTHLAIALGHEAcragYRVRFTTA--PDLVNEL--KEARADGRLERLLKRlAKVDLLILDEL 169
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 168-368 3.50e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.54  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 168 ILLFGPPGTGKSYLAKAVATEANRStFFSVS-SSDLM-SKWLGES--------EKLVKN-LFElarqhkpSIIFIDEIDs 236
Cdd:COG0714   34 LLLEGVPGVGKTTLAKALARALGLP-FIRIQfTPDLLpSDILGTYiydqqtgeFEFRPGpLFA-------NVLLADEIN- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 237 mcsaRSDnendsvrrIKTE-FLVQ-MQ----GVGNDT----DGILVLgATNIP------WVLDSAIRRRFEKRIYIPLPE 300
Cdd:COG0714  105 ----RAP--------PKTQsALLEaMEerqvTIPGGTyklpEPFLVI-ATQNPieqegtYPLPEAQLDRFLLKLYIGYPD 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665392156 301 AHA--RLVMFK--IHLGNTTHVLTEQDLKELAGKTEgysGADISIVVRDALMEPVRKVQTATHFKRvsGPSP 368
Cdd:COG0714  172 AEEerEILRRHtgRHLAEVEPVLSPEELLALQELVR---QVHVSEAVLDYIVDLVRATREHPDLRK--GPSP 238
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 166-234 4.18e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 45.92  E-value: 4.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 166 KGILLFGPPGTGKSYLAKAVA-----TEANRSTFFSV----SSSDLMskwLGESEKLVKNLFEL-------------ARQ 223
Cdd:COG1401  222 KNVILAGPPGTGKTYLARRLAealggEDNGRIEFVQFhpswSYEDFL---LGYRPSLDEGKYEPtpgiflrfclkaeKNP 298

                         90
                 ....*....|.
gi 665392156 224 HKPSIIFIDEI 234
Cdd:COG1401  299 DKPYVLIIDEI 309
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
166-234 6.32e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 44.93  E-value: 6.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 166 KGILLFGPPGTGKSYLAKAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPsiIFIDEI 234
Cdd:COG1373   21 KAVVITGPRQVGKTTLLKQLAKELENILYINLDDPRLRALAEEDPDDLLEALKELYPGKTY--LFLDEI 87
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
166-213 7.63e-05

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 44.96  E-value: 7.63e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 665392156 166 KGILLFGPPGTGKSYLAKAVATEANRST-FFSVSSSDLMSKWLGESEKL 213
Cdd:COG1224   65 KGILIVGPPGTGKTALAVAIARELGEDTpFVAISGSEIYSAELKKTEFL 113
MIT_SNX15 cd02677
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT ...
 7-69 1.15e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.


Pssm-ID: 239140  Cd Length: 75  Bit Score: 40.41  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156   7 LQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKaKDSIRAKCLQYLDRAE 69
Cdd:cd02677    3 LEQAAELIRLALEKEEEGDYEAAFEFYRAGVDLLLKGVQGDSSPER-REAVKRKIAEYLKRAE 64
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 2-69 1.96e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 39.71  E-value: 1.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665392156   2 AAGTTLQKAIDLvtkateeDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKaKDSIRAKCLQYLDRAE 69
Cdd:cd02683    5 AAKEVLKRAVEL-------DQEGRFQEALVCYQEGIDLLMQVLKGTKDEAK-KKNLRQKISEYMDRAE 64
MIT_calpain7_2 cd02680
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 7-69 2.41e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


Pssm-ID: 239143  Cd Length: 75  Bit Score: 39.60  E-value: 2.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665392156   7 LQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTiKYEAQGEKAKDSIRAKCLQYLDRAE 69
Cdd:cd02680    3 LERAHFLVTQAFDEDEKGNAEEAIELYTEAVELCINT-SNETMDQALQTKLKQLARQALDRAE 64
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 168-257 4.32e-04

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.79  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 168 ILLFGPPGTGKSYLAKAVATEANRSTFFSVSSSDLmskwlgesEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNEND 247
Cdd:cd01120    1 ILITGPPGSGKTTLLLQFAEQALLSDEPVIFISFL--------DTILEAIEDLIEEKKLDIIIIDSLSSLARASQGDRSS 72

                         90
                 ....*....|
gi 665392156 248 SVRRIKTEFL 257
Cdd:cd01120   73 ELLEDLAKLL 82
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 168-234 4.48e-04

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 41.66  E-value: 4.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  168 ILLFGPPGTGKSYLAKAVATEANR---STFFsVSSSDLMSKwLGESEKLVKNLFELARQHKPSIIFIDEI 234
Cdd:pfam01695  95 VVLLGPPGVGKTHLAIALGVEACRagySVRF-TSAADLVNQ-LKRAHGDGKLTRKLQQLLKPDVLILDEW 162
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 166-250 1.23e-03

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 39.67  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 166 KGILLFGPPGTGKSYLAKAVATEANrSTFFSVSSSDLMS-KWLG-ESEKLVKNLFElarqhkpSIIFIDEIDSMCSARSD 243
Cdd:cd19498   47 KNILMIGPTGVGKTEIARRLAKLAG-APFIKVEATKFTEvGYVGrDVESIIRDLVE-------GIVFIDEIDKIAKRGGS 118


                 ....*..
gi 665392156 244 NENDSVR 250
Cdd:cd19498  119 SGPDVSR 125
AAA_22 pfam13401
AAA domain;
168-237 1.27e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  168 ILLFGPPGTGKSYLAKAVA---TEANRSTFF-----SVSSSDLMSKWLGE---------SEKLVKNLFE--LARQHKPSI 228
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLeqlPEVRDSVVFvdlpsGTSPKDLLRALLRAlglplsgrlSKEELLAALQqlLLALAVAVV 87


                  ....*....
gi 665392156  229 IFIDEIDSM 237
Cdd:pfam13401  88 LIIDEAQHL 96
PRK08116 PRK08116
hypothetical protein; Validated
 167-188 1.87e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 40.00  E-value: 1.87e-03
                         10        20
                 ....*....|....*....|..
gi 665392156 167 GILLFGPPGTGKSYLAKAVATE 188
Cdd:PRK08116 116 GLLLWGSVGTGKTYLAACIANE 137
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 131-187 2.59e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.06  E-value: 2.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156  131 WSDVAGLDAAKEALKEAVIlpikfpqlftgkripwkG---ILLFGPPGTGKSYLAKAVAT 187
Cdd:pfam01078   2 LADVKGQEQAKRALEIAAA-----------------GghnLLMIGPPGSGKTMLAKRLPG 44
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 168-236 4.29e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 37.61  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 168 ILLFGPPGTGKSYLAKAVATEANRS----TFFSVSSSDLMSKWL------------GESEKLvknlfELARQ--HKPSII 229
Cdd:cd00267   28 VALVGPNGSGKSTLLRAIAGLLKPTsgeiLIDGKDIAKLPLEELrrrigyvpqlsgGQRQRV-----ALARAllLNPDLL 102


                 ....*..
gi 665392156 230 FIDEIDS 236
Cdd:cd00267  103 LLDEPTS 109
PRK04195 PRK04195
replication factor C large subunit; Provisional
 132-235 5.17e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 39.13  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 132 SDVAGLDAAKEALKEAVIlpiKFPqlftgKRIPWKGILLFGPPGTGKSYLAKAVAT-------EANRStffSVSSSDLMS 204
Cdd:PRK04195  14 SDVVGNEKAKEQLREWIE---SWL-----KGKPKKALLLYGPPGVGKTSLAHALANdygweviELNAS---DQRTADVIE 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 665392156 205 KWLGESEKlVKNLFELARQhkpsIIFIDEID 235
Cdd:PRK04195  83 RVAGEAAT-SGSLFGARRK----LILLDEVD 108
PRK13341 PRK13341
AAA family ATPase;
169-243 6.24e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 38.88  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 169 LLFGPPGTGKSYLAKAVATEAnRSTFFSVSS-----SDLMSKwlgeseklVKNLFELARQH-KPSIIFIDEIDSMCSARS 242
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANHT-RAHFSSLNAvlagvKDLRAE--------VDRAKERLERHgKRTILFIDEVHRFNKAQQ 126


                 .
gi 665392156 243 D 243
Cdd:PRK13341 127 D 127
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
130-186 7.18e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 38.25  E-value: 7.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 130 QWSDVAGLDAAKEALKEAVilpikfpqlfTGKRIP--WkgiLLFGPPGTGKSYLAKAVA 186
Cdd:COG2812    8 TFDDVVGQEHVVRTLKNAL----------ASGRLAhaY---LFTGPRGVGKTTLARILA 53
MCM pfam00493
MCM P-loop domain;
142-200 8.09e-03

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 37.51  E-value: 8.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665392156  142 EALKEAVILpikfpQLFTG--KRIPWKG-------ILLFGPPGTGKSYLAKAVATEANRSTFFSVSSS 200
Cdd:pfam00493  30 EDVKKAILL-----QLFGGvkKILPDGTrlrgdinVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGS 92
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 142-237 8.31e-03

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 38.20  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 142 EALKEAVILpikfpQLFTG--KRIPWKG-------ILLFGPPGTGKSYLAKAVATEANRSTFFS------------VSSS 200
Cdd:cd17761   15 EDVKEAIAL-----QLFGGvpKVLPDGTrirgdihILLVGDPGTAKSQLLKYVSKVAPRAVYTTgkgstaagltaaVVRD 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 665392156 201 DLMSKWLGESEKLVknlfeLARQhkpSIIFIDEIDSM 237
Cdd:cd17761   90 EGTGEWYLEAGALV-----LADK---GIAVVDEIDKM 118
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 169-307 9.58e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 38.28  E-value: 9.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392156 169 LLFGPPGTGKSYLAKAVA---TEAN------RSTFFSVSSSDLM--SKWLGESEKLVKNLFELARQHKPSIIFIDEIDSM 237
Cdd:PRK11034 211 LLVGESGVGKTAIAEGLAwriVQGDvpevmaDCTIYSLDIGSLLagTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTI 290

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665392156 238 --CSARSDNENDSVRRIKTEFlvqmqgvgnDTDGILVLGAT------NIpWVLDSAIRRRFEK-RIYIPLPEAHARLVM 307
Cdd:PRK11034 291 igAGAASGGQVDAANLIKPLL---------SSGKIRVIGSTtyqefsNI-FEKDRALARRFQKiDITEPSIEETVQIIN 359
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 168-188 9.75e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 35.66  E-value: 9.75e-03
                          10        20
                  ....*....|....*....|.
gi 665392156  168 ILLFGPPGTGKSYLAKAVATE 188
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARA 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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