NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|665391514|ref|NP_001285276|]
View 

uncharacterized protein Dmel_CG15643, isoform B [Drosophila melanogaster]

Protein Classification

SREBP regulating gene protein( domain architecture ID 10562938)

SREBP regulating gene protein positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP

Gene Ontology:  GO:2000640
PubMed:  32111832

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 74-197 1.65e-70

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


:

Pssm-ID: 463004  Cd Length: 128  Bit Score: 210.69  E-value: 1.65e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391514   74 EARCRNSVQGRQWLADERGFVCRREEVLTNGCCN---LELPGIGYYSCRTCNTSTHCCGVYEYCVSCCLHPGQQPLLERV 150
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLSNGCCNttgVNAPTTKRYSCDTCNLSSRCCSVYEYCVSCCLHPDKRPLLEVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 665391514  151 L-QAPNTPKYIFASVTDHFELCLVKCRTNSHSVEHENKYRDPAAKHCY 197
Cdd:pfam10218  81 LkKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 74-197 1.65e-70

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 210.69  E-value: 1.65e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391514   74 EARCRNSVQGRQWLADERGFVCRREEVLTNGCCN---LELPGIGYYSCRTCNTSTHCCGVYEYCVSCCLHPGQQPLLERV 150
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLSNGCCNttgVNAPTTKRYSCDTCNLSSRCCSVYEYCVSCCLHPDKRPLLEVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 665391514  151 L-QAPNTPKYIFASVTDHFELCLVKCRTNSHSVEHENKYRDPAAKHCY 197
Cdd:pfam10218  81 LkKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 74-197 1.65e-70

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 210.69  E-value: 1.65e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391514   74 EARCRNSVQGRQWLADERGFVCRREEVLTNGCCN---LELPGIGYYSCRTCNTSTHCCGVYEYCVSCCLHPGQQPLLERV 150
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLSNGCCNttgVNAPTTKRYSCDTCNLSSRCCSVYEYCVSCCLHPDKRPLLEVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 665391514  151 L-QAPNTPKYIFASVTDHFELCLVKCRTNSHSVEHENKYRDPAAKHCY 197
Cdd:pfam10218  81 LkKARGRTQVLYGSVTDHFELCLAKCRTSSHSVQHENTYRDPDAKHCY 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH