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Conserved domains on  [gi|665391051|ref|NP_001285186|]
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uncharacterized protein Dmel_CG15717, isoform C [Drosophila melanogaster]

Protein Classification

aldehyde dehydrogenase family protein; aldehyde dehydrogenase( domain architecture ID 10538358)

aldehyde dehydrogenase family protein is an NAD(P)(+)-dependent enzyme that may oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and may play an important role in detoxification| aldehyde dehydrogenase catalyzes the oxidation of a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1487 pfam07368
Protein of unknown function (DUF1487); This family consists of several uncharacterized ...
 38-250 4.39e-127

Protein of unknown function (DUF1487); This family consists of several uncharacterized proteins from Drosophila melanogaster. The function of this family is unknown.


:

Pssm-ID: 254173  Cd Length: 215  Bit Score: 358.99  E-value: 4.39e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051   38 QWRSPQLMVVFEDGDLHSARHQLLQSLQNPFAEGSVATLLLQESIADQFVGLVAQDLRPLSQEVSKHPSYTSTLAKIEEL 117
Cdd:pfam07368   1 AWNSPRLMVIFEDGDVNSALHALVESLHNPFAPGAVATVLVQESIRDEFVERVRSRLKPLSERVANHPSYLKTLEKIDEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  118 KAKTVQG--ESLKAGESPVLVYDCVHSYLGNGATGVVTVHTFRTAKEAGQLAKRDPLPYGQVSLWNEKLGCAYELIPRLP 195
Cdd:pfam07368  81 NAKTIHGksEGRPADASPILVCDFPHSFLGGGPTGVVTLHTFRNMKEAVQLHAKEPLPFDSVSIWNEKLAGVYDLAARLN 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 665391051  196 SDIVAINCFNPDLDPIWESFAADRNDVLLAKNYHYESLVVSGKRRIVVFPVGTIF 250
Cdd:pfam07368 161 SDQFFINCFNVDLKPIKKPFAAPKNSVVIARGYHYETLVIGGKRKIIVFPVGTIS 215
 
Name Accession Description Interval E-value
DUF1487 pfam07368
Protein of unknown function (DUF1487); This family consists of several uncharacterized ...
 38-250 4.39e-127

Protein of unknown function (DUF1487); This family consists of several uncharacterized proteins from Drosophila melanogaster. The function of this family is unknown.


Pssm-ID: 254173  Cd Length: 215  Bit Score: 358.99  E-value: 4.39e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051   38 QWRSPQLMVVFEDGDLHSARHQLLQSLQNPFAEGSVATLLLQESIADQFVGLVAQDLRPLSQEVSKHPSYTSTLAKIEEL 117
Cdd:pfam07368   1 AWNSPRLMVIFEDGDVNSALHALVESLHNPFAPGAVATVLVQESIRDEFVERVRSRLKPLSERVANHPSYLKTLEKIDEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  118 KAKTVQG--ESLKAGESPVLVYDCVHSYLGNGATGVVTVHTFRTAKEAGQLAKRDPLPYGQVSLWNEKLGCAYELIPRLP 195
Cdd:pfam07368  81 NAKTIHGksEGRPADASPILVCDFPHSFLGGGPTGVVTLHTFRNMKEAVQLHAKEPLPFDSVSIWNEKLAGVYDLAARLN 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 665391051  196 SDIVAINCFNPDLDPIWESFAADRNDVLLAKNYHYESLVVSGKRRIVVFPVGTIF 250
Cdd:pfam07368 161 SDQFFINCFNVDLKPIKKPFAAPKNSVVIARGYHYETLVIGGKRKIIVFPVGTIS 215
ALDH_F16 cd07111
Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 ...
 44-205 5.22e-08

Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.


Pssm-ID: 143429 [Multi-domain]  Cd Length: 480  Bit Score: 53.17  E-value: 5.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  44 LMVVFEDGDLHSARHQLLQSLQnpFAEGSVAT----LLLQESIADQFVGLVAQDLRPL--SQEVSKHPSYTSTLAKIEEL 117
Cdd:cd07111  261 PFIVFDDADLDSAVEGIVDAIW--FNQGQVCCagsrLLVQESVAEELIRKLKERMSHLrvGDPLDKAIDMGAIVDPAQLK 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051 118 KAKTVQGESLKAGESPVLVYDCVHS----YLGNGATGVVTVH---------------TFRTAKEAGQLAKRDplPYG-QV 177
Cdd:cd07111  339 RIRELVEEGRAEGADVFQPGADLPSkgpfYPPTLFTNVPPASriaqeeifgpvlvvlTFRTAKEAVALANNT--PYGlAA 416

                        170       180
                 ....*....|....*....|....*...
gi 665391051 178 SLWNEKLGCAYELIPRLPSDIVAINCFN 205
Cdd:cd07111  417 SVWSENLSLALEVALSLKAGVVWINGHN 444
 
Name Accession Description Interval E-value
DUF1487 pfam07368
Protein of unknown function (DUF1487); This family consists of several uncharacterized ...
 38-250 4.39e-127

Protein of unknown function (DUF1487); This family consists of several uncharacterized proteins from Drosophila melanogaster. The function of this family is unknown.


Pssm-ID: 254173  Cd Length: 215  Bit Score: 358.99  E-value: 4.39e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051   38 QWRSPQLMVVFEDGDLHSARHQLLQSLQNPFAEGSVATLLLQESIADQFVGLVAQDLRPLSQEVSKHPSYTSTLAKIEEL 117
Cdd:pfam07368   1 AWNSPRLMVIFEDGDVNSALHALVESLHNPFAPGAVATVLVQESIRDEFVERVRSRLKPLSERVANHPSYLKTLEKIDEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  118 KAKTVQG--ESLKAGESPVLVYDCVHSYLGNGATGVVTVHTFRTAKEAGQLAKRDPLPYGQVSLWNEKLGCAYELIPRLP 195
Cdd:pfam07368  81 NAKTIHGksEGRPADASPILVCDFPHSFLGGGPTGVVTLHTFRNMKEAVQLHAKEPLPFDSVSIWNEKLAGVYDLAARLN 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 665391051  196 SDIVAINCFNPDLDPIWESFAADRNDVLLAKNYHYESLVVSGKRRIVVFPVGTIF 250
Cdd:pfam07368 161 SDQFFINCFNVDLKPIKKPFAAPKNSVVIARGYHYETLVIGGKRKIIVFPVGTIS 215
ALDH_F16 cd07111
Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 ...
 44-205 5.22e-08

Aldehyde dehydrogenase family 16A1-like; Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.


Pssm-ID: 143429 [Multi-domain]  Cd Length: 480  Bit Score: 53.17  E-value: 5.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  44 LMVVFEDGDLHSARHQLLQSLQnpFAEGSVAT----LLLQESIADQFVGLVAQDLRPL--SQEVSKHPSYTSTLAKIEEL 117
Cdd:cd07111  261 PFIVFDDADLDSAVEGIVDAIW--FNQGQVCCagsrLLVQESVAEELIRKLKERMSHLrvGDPLDKAIDMGAIVDPAQLK 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051 118 KAKTVQGESLKAGESPVLVYDCVHS----YLGNGATGVVTVH---------------TFRTAKEAGQLAKRDplPYG-QV 177
Cdd:cd07111  339 RIRELVEEGRAEGADVFQPGADLPSkgpfYPPTLFTNVPPASriaqeeifgpvlvvlTFRTAKEAVALANNT--PYGlAA 416

                        170       180
                 ....*....|....*....|....*...
gi 665391051 178 SLWNEKLGCAYELIPRLPSDIVAINCFN 205
Cdd:cd07111  417 SVWSENLSLALEVALSLKAGVVWINGHN 444
ALDH_BADH-GbsA cd07119
Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Included in this CD is ...
 46-206 1.26e-05

Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Included in this CD is the NAD+-dependent, betaine aldehyde dehydrogenase (BADH, GbsA, EC=1.2.1.8) of Bacillus subtilis involved in the synthesis of the osmoprotectant glycine betaine from choline or glycine betaine aldehyde.


Pssm-ID: 143437  Cd Length: 482  Bit Score: 45.76  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  46 VVFEDGDLHSARHQLLQSLQnpFAEGSV----ATLLLQESIADQFVGLVAQDL------RPLSQEVSKHP-SYTSTLAKI 114
Cdd:cd07119  251 IVFADADFETAVDQALNGVF--FNAGQVcsagSRLLVEESIHDKFVAALAERAkkiklgNGLDADTEMGPlVSAEHREKV 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051 115 EEL-------KAKTVQGESLKAGES--------PVLVYDCVHSY-------LGNgatgVVTVHTFRTAKEAGQLAkrDPL 172
Cdd:cd07119  329 LSYiqlgkeeGARLVCGGKRPTGDElakgyfvePTIFDDVDRTMrivqeeiFGP----VLTVERFDTEEEAIRLA--NDT 402

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 665391051 173 PYG-QVSLWNEKLGCAYELIPRLPSDIVAINCFNP 206
Cdd:cd07119  403 PYGlAGAVWTKDIARANRVARRLRAGTVWINDYHP 437
ALDH cd07078
NAD(P)+ dependent aldehyde dehydrogenase family; The aldehyde dehydrogenase family (ALDH) of ...
 45-205 1.73e-04

NAD(P)+ dependent aldehyde dehydrogenase family; The aldehyde dehydrogenase family (ALDH) of NAD(P)+ dependent enzymes, in general, oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes to their corresponding carboxylic acids and play an important role in detoxification. Besides aldehyde detoxification, many ALDH isozymes possess multiple additional catalytic and non-catalytic functions such as participating in metabolic pathways, or as binding proteins, or as osmoregulants, to mention a few. The enzyme has three domains, a NAD(P)+ cofactor-binding domain, a catalytic domain, and a bridging domain; and the active enzyme is generally either homodimeric or homotetrameric. The catalytic mechanism is proposed to involve cofactor binding, resulting in a conformational change and activation of an invariant catalytic cysteine nucleophile. The cysteine and aldehyde substrate form an oxyanion thiohemiacetal intermediate resulting in hydride transfer to the cofactor and formation of a thioacylenzyme intermediate. Hydrolysis of the thioacylenzyme and release of the carboxylic acid product occurs, and in most cases, the reduced cofactor dissociates from the enzyme. The evolutionary phylogenetic tree of ALDHs appears to have an initial bifurcation between what has been characterized as the classical aldehyde dehydrogenases, the ALDH family (ALDH) and extended family members or aldehyde dehydrogenase-like (ALDH-like) proteins. The ALDH proteins are represented by enzymes which share a number of highly conserved residues necessary for catalysis and cofactor binding and they include such proteins as retinal dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, delta(1)-pyrroline-5-carboxylate dehydrogenases, alpha-ketoglutaric semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, coniferyl aldehyde dehydrogenase and succinate-semialdehyde dehydrogenase. Included in this larger group are all human, Arabidopsis, Tortula, fungal, protozoan, and Drosophila ALDHs identified in families ALDH1 through ALDH22 with the exception of families ALDH18, ALDH19, and ALDH20 which are present in the ALDH-like group.


Pssm-ID: 143397 [Multi-domain]  Cd Length: 432  Bit Score: 42.20  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051  45 MVVFEDGDLHSARHQLLQSLqnpFAEG-----SVATLLLQESIADQFVGLVAQDLR------PLSQEV------SKHpSY 107
Cdd:cd07078  212 LIVFDDADLDAAVKGAVFGA---FGNAgqvctAASRLLVHESIYDEFVERLVERVKalkvgnPLDPDTdmgpliSAA-QL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391051 108 TSTLAKIEELKAK----TVQGESLKAGE----SPVLVYDCVHSYL-------GNgatgVVTVHTFRTAKEAGQLAKRdpL 172
Cdd:cd07078  288 DRVLAYIEDAKAEgaklLCGGKRLEGGKgyfvPPTVLTDVDPDMPiaqeeifGP----VLPVIPFKDEEEAIELAND--T 361

                        170       180       190
                 ....*....|....*....|....*....|....
gi 665391051 173 PYG-QVSLWNEKLGCAYELIPRLPSDIVAINCFN 205
Cdd:cd07078  362 EYGlAAGVFTRDLERALRVAERLEAGTVWINDYS 395
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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