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Conserved domains on  [gi|665390939|ref|NP_001285159|]
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secretory 16, isoform J [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 1371-1631 2.89e-95

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


:

Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 311.11  E-value: 2.89e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1371 TPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPA 1450
Cdd:cd09233    58 TDIAEQKALNRFRNLLLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRFARSESKLNDPLQTLYQLFSGNSPE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1451 CVSQLRDE------QWGDWRSHLSILVTNKSRQpeYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSAteltt 1524
Cdd:cd09233   138 AITELADNpaeaewALGNWREHLAIILSNRTSN--LDLEALVELGDLLAQRGLVEAAHICYLLAGVPLGPYPSSP----- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1525 ltanvPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARH 1604
Cdd:cd09233   211 -----SSCLLGGAVHNKSPRTFATPEAIQLTEIYEYALSLGNPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASS 285

                         250       260
                  ....*....|....*....|....*....
gi 665390939 1605 IE--LKPESYDSNFIQRVCGLAERLRYHD 1631
Cdd:cd09233   286 LKslTKSPYYDPNLLAQLQDLSERLSGTS 314
DUF4813 super family cl25718
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 279-379 3.50e-06

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


The actual alignment was detected with superfamily member pfam16072:

Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 51.30  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939   279 TSFSAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGigAPPAHLAGVGASPA-PSALVGASPAPIIGVGA 357
Cdd:pfam16072  152 TSAGSGTTVINAGGQQPAAPAAPAYPVAPAAYPAQAPAAAPAPAPG--APQTPLAPLNPVAAaPAAAAGAAAAPVVAAAA 229

                           90       100
                   ....*....|....*....|..
gi 665390939   358 PPVGAPPVGAPPADATTIAPPA 379
Cdd:pfam16072  230 PAAAAPPPPAPAAPPADAAPPA 251
 
Name Accession Description Interval E-value
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 1371-1631 2.89e-95

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 311.11  E-value: 2.89e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1371 TPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPA 1450
Cdd:cd09233    58 TDIAEQKALNRFRNLLLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRFARSESKLNDPLQTLYQLFSGNSPE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1451 CVSQLRDE------QWGDWRSHLSILVTNKSRQpeYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSAteltt 1524
Cdd:cd09233   138 AITELADNpaeaewALGNWREHLAIILSNRTSN--LDLEALVELGDLLAQRGLVEAAHICYLLAGVPLGPYPSSP----- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1525 ltanvPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARH 1604
Cdd:cd09233   211 -----SSCLLGGAVHNKSPRTFATPEAIQLTEIYEYALSLGNPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASS 285

                         250       260
                  ....*....|....*....|....*....
gi 665390939 1605 IE--LKPESYDSNFIQRVCGLAERLRYHD 1631
Cdd:cd09233   286 LKslTKSPYYDPNLLAQLQDLSERLSGTS 314
Sec16_C pfam12931
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ...
 1383-1628 7.75e-39

Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.


Pssm-ID: 432884  Cd Length: 279  Bit Score: 147.32  E-value: 7.75e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  1383 RSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKAND-----PLQTLYQMKSCHTPACVSQL-- 1455
Cdd:pfam12931    2 RALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnksgeSLAALYQVFAGNSEEAVDELvp 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  1456 ----RDEQWGDWRSHLSILVTNksRQPEyDRSSVVALGDTLFQRGDIYAAHFCYLVAQeefgrydssatelttltANVPR 1531
Cdd:pfam12931   82 psknALWALDNWRETLALVLSN--RSPG-DVEALLALGDLLAQYGRTEAAHICFLLAG-----------------LPLSQ 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  1532 LILLGSSHYKHFNEFASN-EAIIMTEIYEYARSLFD--PKFS-IAHFQHYKFLLATRILDYGQHFRCTNYLEQIARHIEL 1607
Cdd:pfam12931  142 TVLLGADHVRFPSTFGNDlESILLTEIYEYALSLSPpqPPFVgLPHLLPYKLQHAAVLAEYGLVSEAQKYCDAITASLKS 221

                          250       260
                   ....*....|....*....|....
gi 665390939  1608 ---KPESYDSNFIQRVCGLAERLR 1628
Cdd:pfam12931  222 ltkKSPYYHPTLLAQLEDLSNRLS 245
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 279-379 3.50e-06

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 51.30  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939   279 TSFSAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGigAPPAHLAGVGASPA-PSALVGASPAPIIGVGA 357
Cdd:pfam16072  152 TSAGSGTTVINAGGQQPAAPAAPAYPVAPAAYPAQAPAAAPAPAPG--APQTPLAPLNPVAAaPAAAAGAAAAPVVAAAA 229

                           90       100
                   ....*....|....*....|..
gi 665390939   358 PPVGAPPVGAPPADATTIAPPA 379
Cdd:pfam16072  230 PAAAAPPPPAPAAPPADAAPPA 251
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 282-392 2.08e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  282 SAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVG 361
Cdd:PRK07764  399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTA 478

                          90       100       110
                  ....*....|....*....|....*....|.
gi 665390939  362 APPVGAPPADATTIAPPAALPPSIVPSSGSN 392
Cdd:PRK07764  479 APAPAPPAAPAPAAAPAAPAAPAAPAGADDA 509
 
Name Accession Description Interval E-value
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 1371-1631 2.89e-95

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 311.11  E-value: 2.89e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1371 TPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPA 1450
Cdd:cd09233    58 TDIAEQKALNRFRNLLLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRFARSESKLNDPLQTLYQLFSGNSPE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1451 CVSQLRDE------QWGDWRSHLSILVTNKSRQpeYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSAteltt 1524
Cdd:cd09233   138 AITELADNpaeaewALGNWREHLAIILSNRTSN--LDLEALVELGDLLAQRGLVEAAHICYLLAGVPLGPYPSSP----- 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939 1525 ltanvPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARH 1604
Cdd:cd09233   211 -----SSCLLGGAVHNKSPRTFATPEAIQLTEIYEYALSLGNPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASS 285

                         250       260
                  ....*....|....*....|....*....
gi 665390939 1605 IE--LKPESYDSNFIQRVCGLAERLRYHD 1631
Cdd:cd09233   286 LKslTKSPYYDPNLLAQLQDLSERLSGTS 314
Sec16_C pfam12931
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ...
 1383-1628 7.75e-39

Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.


Pssm-ID: 432884  Cd Length: 279  Bit Score: 147.32  E-value: 7.75e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  1383 RSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKAND-----PLQTLYQMKSCHTPACVSQL-- 1455
Cdd:pfam12931    2 RALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnksgeSLAALYQVFAGNSEEAVDELvp 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  1456 ----RDEQWGDWRSHLSILVTNksRQPEyDRSSVVALGDTLFQRGDIYAAHFCYLVAQeefgrydssatelttltANVPR 1531
Cdd:pfam12931   82 psknALWALDNWRETLALVLSN--RSPG-DVEALLALGDLLAQYGRTEAAHICFLLAG-----------------LPLSQ 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  1532 LILLGSSHYKHFNEFASN-EAIIMTEIYEYARSLFD--PKFS-IAHFQHYKFLLATRILDYGQHFRCTNYLEQIARHIEL 1607
Cdd:pfam12931  142 TVLLGADHVRFPSTFGNDlESILLTEIYEYALSLSPpqPPFVgLPHLLPYKLQHAAVLAEYGLVSEAQKYCDAITASLKS 221

                          250       260
                   ....*....|....*....|....
gi 665390939  1608 ---KPESYDSNFIQRVCGLAERLR 1628
Cdd:pfam12931  222 ltkKSPYYHPTLLAQLEDLSNRLS 245
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 279-379 3.50e-06

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 51.30  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939   279 TSFSAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGigAPPAHLAGVGASPA-PSALVGASPAPIIGVGA 357
Cdd:pfam16072  152 TSAGSGTTVINAGGQQPAAPAAPAYPVAPAAYPAQAPAAAPAPAPG--APQTPLAPLNPVAAaPAAAAGAAAAPVVAAAA 229

                           90       100
                   ....*....|....*....|..
gi 665390939   358 PPVGAPPVGAPPADATTIAPPA 379
Cdd:pfam16072  230 PAAAAPPPPAPAAPPADAAPPA 251
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 286-393 6.36e-06

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 50.31  E-value: 6.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939   286 TAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPpahlagvgASPAPSALVGASPAPiigvGAPPVGAPPV 365
Cdd:pfam07174   22 AVAGASAVAVALPAVAHADPEPAPPPPSTATAPPAPPPPPPAP--------AAPAPPPPPAAPNAP----NAPPPPADPN 89

                           90       100       110
                   ....*....|....*....|....*....|
gi 665390939   366 GA--PPADATTIAPPAALPPSIVPSSGSNP 393
Cdd:pfam07174   90 APppPPADPNAPPPPAVDPNAPEPGRIDNA 119
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 282-392 2.08e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  282 SAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVG 361
Cdd:PRK07764  399 PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTA 478

                          90       100       110
                  ....*....|....*....|....*....|.
gi 665390939  362 APPVGAPPADATTIAPPAALPPSIVPSSGSN 392
Cdd:PRK07764  479 APAPAPPAAPAPAAAPAAPAAPAAPAGADDA 509
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 302-394 2.32e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.25  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  302 SAGVGASPAPPTGVVAPPAhlagiGAPPAhlagvgASPAPSALVGASPAPIIGVGAPPVGAPPVGAPPA--DATTIAPPA 379
Cdd:PRK14951  367 AAAAEAAAPAEKKTPARPE-----AAAPA------AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPApvAAPAAAAPA 435

                          90
                  ....*....|....*
gi 665390939  380 ALPPSIVPSSGSNPF 394
Cdd:PRK14951  436 AAPAAAPAAVALAPA 450
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 288-391 4.49e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  288 VGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHlAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVG----AP 363
Cdd:PRK07764  387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAA-AAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAaapsAQ 465

                          90       100
                  ....*....|....*....|....*...
gi 665390939  364 PVGAPPADATTIAPPAALPPSIVPSSGS 391
Cdd:PRK07764  466 PAPAPAAAPEPTAAPAPAPPAAPAPAAA 493
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
282-394 8.82e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 8.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  282 SAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHlAGVGASPAPSALVGA-------------- 347
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA-APARRSPAPEALAAArqasargpggapap 450

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 665390939  348 --SPAPIIGVGAPPVGAPPVGAPPADATTIAPPAALPPSIVPSSGSNPF 394
Cdd:PRK12323  451 apAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW 499
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 283-382 1.10e-03

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 43.21  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939   283 AQMTAVGSPIYAVGASSAHSAGVGASPAP----PTGVVAP--PAHLAGIGAPPAHLAGVGASPAPSALVGASPAPiigvG 356
Cdd:pfam16072  166 QQPAAPAAPAYPVAPAAYPAQAPAAAPAPapgaPQTPLAPlnPVAAAPAAAAGAAAAPVVAAAAPAAAAPPPPAP----A 241

                           90       100
                   ....*....|....*....|....*.
gi 665390939   357 APpvgaPPVGAPPADATTIAPPAALP 382
Cdd:pfam16072  242 AP----PADAAPPAPGGIICVPVRVP 263
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 293-393 1.81e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  293 YAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSALvgasPAPIIGVGAPPVGAPPVGAPPADA 372
Cdd:PRK07764  387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPA----PAPPSPAGNAPAGGAPSPPPAAAP 462

                          90       100
                  ....*....|....*....|..
gi 665390939  373 T-TIAPPAALPPSIVPSSGSNP 393
Cdd:PRK07764  463 SaQPAPAPAAAPEPTAAPAPAP 484
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
244-383 2.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  244 QSPPELGQEPELDAIVPPQAfqnqpPTAAPPPTSltsfSAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLA 323
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAA-----PAAAAPAPA----APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  324 GIGAPPAHLAGVGASPAPsalvgASPAPIIGVGAPPVGAPPVGAPPADATTIAPPAALPP 383
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPAA-----AARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP 497
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
294-393 2.81e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  294 AVGASSAHSAGVGASPAPPTGVVAPPAHLA---------GIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVGAPP 364
Cdd:PRK07003  402 VTGAAGAALAPKAAAAAAATRAEAPPAAPAppatadrgdDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                          90       100
                  ....*....|....*....|....*....
gi 665390939  365 VGAPPADATTIAPPAALPPSIVPSSGSNP 393
Cdd:PRK07003  482 SDAPPDAAFEPAPRAAAPSAATPAAVPDA 510
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 304-387 3.10e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.96  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  304 GVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSAlVGASPAPIIGVGAPPVGAPPVGAPPADATTIAPPAALPP 383
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPA-AAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                  ....
gi 665390939  384 SIVP 387
Cdd:PRK12270  116 EVTP 119
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 204-393 3.66e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  204 ATSNNVNNNGELPPPANPQSTSLQQQPLNQQSIPllhqQPQSPPELGQEPELDAIVPPQAFQNQPPTAAPPPTSLTSFSA 283
Cdd:PRK07764  589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPA----APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  284 QMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSALVGASPAPiigvGAPPVGAP 363
Cdd:PRK07764  665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPS----PAADDPVP 740

                         170       180       190
                  ....*....|....*....|....*....|
gi 665390939  364 PVGAPPADATTIAPPAALPPSIVPSSGSNP 393
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 282-384 5.04e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  282 SAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVG 361
Cdd:PRK14951  392 APVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPA 471

                          90       100
                  ....*....|....*....|...
gi 665390939  362 APPVGAPPADATtiaPPAALPPS 384
Cdd:PRK14951  472 VASAAPAPAAAP---AAARLTPT 491
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 303-393 5.72e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.97  E-value: 5.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  303 AGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPA----PSALVGASPAPIIGVG-------APPV----GAPPVGA 367
Cdd:PRK14959  374 SGGGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAagmtPSSAAPATPAPSAAPSprvpwddAPPApprsGIPPRPA 453

                          90       100
                  ....*....|....*....|....*.
gi 665390939  368 PPADATTIAPPAalPPSIVPSSGSNP 393
Cdd:PRK14959  454 PRMPEASPVPGA--PDSVASASDAPP 477
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
289-393 5.77e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  289 GSPIYAVGASSAHSAGVGASPAPPTGVVAPPAhLAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVGAPPVGAP 368
Cdd:PRK07003  383 PGARAAAAVGASAVPAVTAVTGAAGAALAPKA-AAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADS 461

                          90       100
                  ....*....|....*....|....*
gi 665390939  369 PADATTIAPPAALPPSIVPSSGSNP 393
Cdd:PRK07003  462 RCDERDAQPPADSGSASAPASDAPP 486
DUF6153 pfam19650
Family of unknown function (DUF6153); This entry represents a member of a biosynthetic gene ...
 296-384 7.10e-03

Family of unknown function (DUF6153); This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001435) is described by MIBiG as an example of the following biosynthetic classes, polyketide and NRP (non-ribosomal peptide). It includes a member from the ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306 and appears to be predominantly found in Actinobacteria.


Pssm-ID: 466137 [Multi-domain]  Cd Length: 116  Bit Score: 38.45  E-value: 7.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939   296 GASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVGASPApSALVGASPAPIIGVGAPPVGAPPVGAPPADATTI 375
Cdd:pfam19650   20 AAAAGAHAHHAAAAAAAAAAASADDGCAHHDGGGGHAQHADATCA-AAGVAGAPALPALLPDPVAAAPAATAARSAAAAA 98


                   ....*....
gi 665390939   376 APPAALPPS 384
Cdd:pfam19650   99 PDGGRAPPS 107
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 282-384 7.41e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.09  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  282 SAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAG----IGAPPAHLAGVGASPAPSALVGASPAPIIGVGA 357
Cdd:PTZ00436  220 AAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAppakAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAP 299

                          90       100
                  ....*....|....*....|....*....
gi 665390939  358 PPVGAPPVGAPPADATTIAPPA--ALPPS 384
Cdd:PTZ00436  300 AKAAAAPAKAAAAPAKAAAPPAkaAAPPA 328
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 291-415 7.71e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 7.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665390939  291 PIYAVGASSAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAHLAGVgASPAPSALVGASPAPIigvgAPPVGAPPVGAPPA 370
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAA-ASAPAAPPAAAPPAPV----AAPAAAAPAAAPAA 440

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 665390939  371 DATTIAPPAALPPSIVPSSGSNPFKRSTGLNKRVNIMADPAAGAP 415
Cdd:PRK14951  441 APAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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