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Conserved domains on  [gi|665389977|ref|NP_001284949|]
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pickled eggs, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 11-163 1.18e-83

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 265.72  E-value: 1.18e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  11 PFKSSEEYLEAMREDLAEWLSTLYPeLSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQARNKSMTrsmtsglagp 90
Cdd:cd21268    1 PFKSSEEYLYAMKEDLAEWLNTLYN-LDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLK---------- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389977  91 ILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGM 163
Cdd:cd21268   70 LPPREVIFYRPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 257-325 5.61e-43

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 150.05  E-value: 5.61e-43
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665389977  257 LDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRC 325
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 11-163 1.18e-83

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 265.72  E-value: 1.18e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  11 PFKSSEEYLEAMREDLAEWLSTLYPeLSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQARNKSMTrsmtsglagp 90
Cdd:cd21268    1 PFKSSEEYLYAMKEDLAEWLNTLYN-LDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLK---------- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389977  91 ILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGM 163
Cdd:cd21268   70 LPPREVIFYRPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 257-325 5.61e-43

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 150.05  E-value: 5.61e-43
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665389977  257 LDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRC 325
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 257-326 4.38e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 133.34  E-value: 4.38e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977   257 LDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCR 326
Cdd:smart00243   3 IDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAK 72
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 24-151 9.79e-08

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 50.78  E-value: 9.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977    24 EDLAEWL-STLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYlarrqarnksmtrsmtsglagpilamgnvhYLPA 102
Cdd:smart00033   1 KTLLRWVnSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDK------------------------------KKVA 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 665389977   103 AKSGTFFARDNVSNFITWCRKsLKIIEClLFETDDLI-MRKNEKHVILCL 151
Cdd:smart00033  51 ASLSRFKKIENINLALSFAEK-LGGKVV-LFEPEDLVeGPKLILGVIWTL 98
SCP1 COG5199
Calponin [Cytoskeleton];
24-168 1.98e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 43.37  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  24 EDLAEWL-STLYPELSINADnFMDRLDTGVALCKHANYVRQAAVDYLARRQarnksmtrsmtsglagpilamgnvhylpa 102
Cdd:COG5199   16 KEVTLWIeTVLGEKFEPPGD-LLSLLKDGVRLCRILNEASPLDIKYKESKM----------------------------- 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665389977 103 aksgTFFARDNVSNFITWCRKsLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAK-----FGMLAPML 168
Cdd:COG5199   66 ----PFVQMENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQKermfsGPFLGPHL 131
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 11-163 1.18e-83

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 265.72  E-value: 1.18e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  11 PFKSSEEYLEAMREDLAEWLSTLYPeLSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQARNKSMTrsmtsglagp 90
Cdd:cd21268    1 PFKSSEEYLYAMKEDLAEWLNTLYN-LDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASPLK---------- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389977  91 ILAMGNVHYLPAAKSGTFFARDNVSNFITWCRKSLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGM 163
Cdd:cd21268   70 LPPREVIFYRPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 16-162 7.27e-49

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 169.37  E-value: 7.27e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  16 EEYLEAMREDLAEWLSTLYPeLSINADNFMDRLDTGVALCKHANYVRQAAVDYLARRQARNKSmtrsmtsglagpilAMG 95
Cdd:cd21204    1 EEALLPMKEDLAEWLNDLLG-DDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKKNGPP--------------PSY 65

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389977  96 NVHYLPAAKSGTFFARDNVSNFITWCRKsLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFG 162
Cdd:cd21204   66 KLKCNENAKPGSFFARDNVANFLRWCRK-LGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 257-325 5.61e-43

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 150.05  E-value: 5.61e-43
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665389977  257 LDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRC 325
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 257-326 4.38e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 133.34  E-value: 4.38e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977   257 LDEMVRDLVEKCTCPSQFPMVRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLSHYLDKHDPCRCR 326
Cdd:smart00243   3 IDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAK 72
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 16-163 4.62e-26

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 104.25  E-value: 4.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  16 EEYLEAMREDLAEWLSTLYPElSINADNFMDRLDTGVALCKHANYVRQaavdylarrqarnKSMTRSMTSGLAGPILAMG 95
Cdd:cd21267    2 EASLLPMKEDLALWLTNLLGK-EITAESFMEKLDNGALLCQLAETLQE-------------KFKENSADANKPGKSLPVR 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665389977  96 NVHYLPAAKSGTFFARDNVSNFITWCRKsLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFGM 163
Cdd:cd21267   68 KIPCRANAPSGSFFARDNTANFLSWCRD-VGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 16-162 2.43e-23

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 96.45  E-value: 2.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  16 EEYLEAMREDLAEWLSTLYPElSINADNFMDRLDTGVALCKHANyVRQAAVdylarRQARNKSMTRSMTsglagpilaMG 95
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGK-EVKAERFMEELDNGVLLCQLIG-VLQSKI-----KECCSTEELKHFP---------MR 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389977  96 NVHYLPAAKSGTFFARDNVSNFITWCRkSLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAKFG 162
Cdd:cd21269   65 KVPCKKDAPSGSFFARDNTANFLSWCR-AIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 23-156 1.95e-11

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 61.59  E-value: 1.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  23 REDLAEWL-STLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYlarrqARNKSMTRsmtsglagpilamgnvhylp 101
Cdd:cd00014    1 EEELLKWInEVLGEELPVSITDLFESLRDGVLLCKLINKLSPGSIPK-----INKKPKSP-------------------- 55

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665389977 102 aaksgtFFARDNVSNFITWCRKsLKIIECLLFETDDLIMRKNEKHVILCLLEVAR 156
Cdd:cd00014   56 ------FKKRENINLFLNACKK-LGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 24-151 9.79e-08

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 50.78  E-value: 9.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977    24 EDLAEWL-STLYPELSINADNFMDRLDTGVALCKHANYVRQAAVDYlarrqarnksmtrsmtsglagpilamgnvhYLPA 102
Cdd:smart00033   1 KTLLRWVnSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDK------------------------------KKVA 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 665389977   103 AKSGTFFARDNVSNFITWCRKsLKIIEClLFETDDLI-MRKNEKHVILCL 151
Cdd:smart00033  51 ASLSRFKKIENINLALSFAEK-LGGKVV-LFEPEDLVeGPKLILGVIWTL 98
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 28-151 3.57e-06

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 46.84  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  28 EWLSTLYPELSINADNFMDRLDTGVALCKHANYVrqaavdylarrqarnksmtrsmtsglaGPILAmgnVHYLPAAKSGT 107
Cdd:cd21206   15 QWIEACLNEELPPTTEFEEELRNGVVLAKLANKF---------------------------APKLV---PLKKIYDVGLQ 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 665389977 108 FFARDNVSNFITWCrKSLKIIECLLFETDDLIMRKNEKHVILCL 151
Cdd:cd21206   65 FRHTDNINHFLRAL-KKIGLPKIFHFETTDLYEKKNIPKVIYCL 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 22-156 4.63e-05

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 43.12  E-value: 4.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  22 MREDLAEWLSTLYPElSINADNFMDRLDTGVALCKHANYVRQAavdylarrqarnksMTRSMTSGlagpilAMgnvhylp 101
Cdd:cd21210    1 AEQEAREWIEEVLGE-KLAQGDLLDALKDGVVLCKLANRILPA--------------DIRKYKES------KM------- 52

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665389977 102 aaksgTFFARDNVSNFITWCRKsLKIIECLLFETDDLIMRKNEKHVILCLLEVAR 156
Cdd:cd21210   53 -----PFVQMENISAFLNAARK-LGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
SCP1 COG5199
Calponin [Cytoskeleton];
24-168 1.98e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 43.37  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389977  24 EDLAEWL-STLYPELSINADnFMDRLDTGVALCKHANYVRQAAVDYLARRQarnksmtrsmtsglagpilamgnvhylpa 102
Cdd:COG5199   16 KEVTLWIeTVLGEKFEPPGD-LLSLLKDGVRLCRILNEASPLDIKYKESKM----------------------------- 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665389977 103 aksgTFFARDNVSNFITWCRKsLKIIECLLFETDDLIMRKNEKHVILCLLEVARRGAK-----FGMLAPML 168
Cdd:COG5199   66 ----PFVQMENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQKermfsGPFLGPHL 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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