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Conserved domains on  [gi|665389943|ref|NP_001284943|]
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NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform B [Drosophila melanogaster]

Protein Classification

GRIM-19 domain-containing protein( domain architecture ID 10533236)

GRIM-19 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GRIM-19 pfam06212
GRIM-19 protein; This family consists of several eukaryotic gene associated with ...
 9-140 2.37e-75

GRIM-19 protein; This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homolog of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localization and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity.


:

Pssm-ID: 461852  Cd Length: 132  Bit Score: 220.58  E-value: 2.37e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389943    9 PPKQDLPPPGGYKKIPFARVPPKSYFTGFTTIGTYVVVTAVGLGIYYLTAKKVKRDEIEMRSAQNVIFPILVAERDREFL 88
Cdd:pfam06212   1 KVKQDMPPPGGYGPINYARNPPKTGLSGYAMLAGGIGVTAVGFYLYYKGNKERRRLRIEMRSARLAILPLLQAERDRRYL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665389943   89 RQLRRNRDEEAELMKNVPGWEVGTWYGEPVFKTLPEDTLVTPIFKEFYAHSD 140
Cdd:pfam06212  81 KQLRKNRDEEAELMKDVPGWEVGTWYGEPVYHTLPKDRWVDPMPEEYYAHSP 132
 
Name Accession Description Interval E-value
GRIM-19 pfam06212
GRIM-19 protein; This family consists of several eukaryotic gene associated with ...
 9-140 2.37e-75

GRIM-19 protein; This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homolog of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localization and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity.


Pssm-ID: 461852  Cd Length: 132  Bit Score: 220.58  E-value: 2.37e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389943    9 PPKQDLPPPGGYKKIPFARVPPKSYFTGFTTIGTYVVVTAVGLGIYYLTAKKVKRDEIEMRSAQNVIFPILVAERDREFL 88
Cdd:pfam06212   1 KVKQDMPPPGGYGPINYARNPPKTGLSGYAMLAGGIGVTAVGFYLYYKGNKERRRLRIEMRSARLAILPLLQAERDRRYL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665389943   89 RQLRRNRDEEAELMKNVPGWEVGTWYGEPVFKTLPEDTLVTPIFKEFYAHSD 140
Cdd:pfam06212  81 KQLRKNRDEEAELMKDVPGWEVGTWYGEPVYHTLPKDRWVDPMPEEYYAHSP 132
 
Name Accession Description Interval E-value
GRIM-19 pfam06212
GRIM-19 protein; This family consists of several eukaryotic gene associated with ...
 9-140 2.37e-75

GRIM-19 protein; This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homolog of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localization and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity.


Pssm-ID: 461852  Cd Length: 132  Bit Score: 220.58  E-value: 2.37e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389943    9 PPKQDLPPPGGYKKIPFARVPPKSYFTGFTTIGTYVVVTAVGLGIYYLTAKKVKRDEIEMRSAQNVIFPILVAERDREFL 88
Cdd:pfam06212   1 KVKQDMPPPGGYGPINYARNPPKTGLSGYAMLAGGIGVTAVGFYLYYKGNKERRRLRIEMRSARLAILPLLQAERDRRYL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665389943   89 RQLRRNRDEEAELMKNVPGWEVGTWYGEPVFKTLPEDTLVTPIFKEFYAHSD 140
Cdd:pfam06212  81 KQLRKNRDEEAELMKDVPGWEVGTWYGEPVYHTLPKDRWVDPMPEEYYAHSP 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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