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Conserved domains on  [gi|665389310|ref|NP_001284816|]
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uncharacterized protein Dmel_CG3091, isoform C [Drosophila melanogaster]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10074233)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to Drosophila melanogaster retinol-binding protein pinta, a retinoid-binding protein which shows highest affinity for all-trans retinol

Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729
SCOP:  4003560

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
99-262 4.30e-25

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 98.18  E-value: 4.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  99 LLILPGVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMSDARFTKPDVERETGsgadyvldeadiaegdVQIVDIGGYT 178
Cdd:cd00170   11 IGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGF----------------VVIIDLKGFS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310 179 LRHLAyvSIFVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGMDSLYKEVPRDMLPNE 258
Cdd:cd00170   75 LSNLS--DLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKE 152

                 ....
gi 665389310 259 YGGK 262
Cdd:cd00170  153 LGGT 156
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
99-262 4.30e-25

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 98.18  E-value: 4.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  99 LLILPGVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMSDARFTKPDVERETGsgadyvldeadiaegdVQIVDIGGYT 178
Cdd:cd00170   11 IGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGF----------------VVIIDLKGFS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310 179 LRHLAyvSIFVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGMDSLYKEVPRDMLPNE 258
Cdd:cd00170   75 LSNLS--DLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKE 152

                 ....
gi 665389310 259 YGGK 262
Cdd:cd00170  153 LGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
101-261 2.30e-21

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 88.08  E-value: 2.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  101 ILPGVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMsdarftkpdveretgsgADYVLDEADIA--EGDVQIVDIGGYT 178
Cdd:pfam00650   5 YLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLV-----------------LERALLLMPEGqvEGLTVIIDLKGLS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  179 LRHLAYVSIFVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGMD-SLYKEVPRDMLPN 257
Cdd:pfam00650  68 LSNMDWWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEeELEKYIPPEQLPK 147

                  ....
gi 665389310  258 EYGG 261
Cdd:pfam00650 148 EYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
104-262 1.80e-19

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 83.12  E-value: 1.80e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310   104 GVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMSDarftKPDVERETGSGADYVldeadiaegdVQIVDIGGYTLRHLA 183
Cdd:smart00516  14 GYDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLE----KILQEEKKTGGIEGF----------TVIFDLKGLSMSNPD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310   184 YVsifVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGM-DSLYKEVPRDMLPNEYGGK 262
Cdd:smart00516  80 LS---VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSkEELLEYIDKEQLPEELGGT 156
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
99-262 4.30e-25

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 98.18  E-value: 4.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  99 LLILPGVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMSDARFTKPDVERETGsgadyvldeadiaegdVQIVDIGGYT 178
Cdd:cd00170   11 IGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGF----------------VVIIDLKGFS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310 179 LRHLAyvSIFVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGMDSLYKEVPRDMLPNE 258
Cdd:cd00170   75 LSNLS--DLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEELLEYIDPDQLPKE 152

                 ....
gi 665389310 259 YGGK 262
Cdd:cd00170  153 LGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
101-261 2.30e-21

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 88.08  E-value: 2.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  101 ILPGVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMsdarftkpdveretgsgADYVLDEADIA--EGDVQIVDIGGYT 178
Cdd:pfam00650   5 YLHGRDKEGRPVLYLRLGRHDPKKSSEEELVRFLVLV-----------------LERALLLMPEGqvEGLTVIIDLKGLS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  179 LRHLAYVSIFVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGMD-SLYKEVPRDMLPN 257
Cdd:pfam00650  68 LSNMDWWSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEeELEKYIPPEQLPK 147

                  ....
gi 665389310  258 EYGG 261
Cdd:pfam00650 148 EYGG 151
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
104-262 1.80e-19

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 83.12  E-value: 1.80e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310   104 GVTPQGNKLIFFRMADLDPRTRNSVEETKIFVMMSDarftKPDVERETGSGADYVldeadiaegdVQIVDIGGYTLRHLA 183
Cdd:smart00516  14 GYDKDGRPVLIERAGRFDLKSVTLEELLRYLVYVLE----KILQEEKKTGGIEGF----------TVIFDLKGLSMSNPD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310   184 YVsifVLRVYMKFLQEAYPSRLQAMHVINCPTYLDKLISMMSPFLREEVRNMIRYHTEGM-DSLYKEVPRDMLPNEYGGK 262
Cdd:smart00516  80 LS---VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSkEELLEYIDKEQLPEELGGT 156
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
171-261 7.10e-07

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 47.71  E-value: 7.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389310  171 IVDIGGYTLRHLAYVSiFVLRVYMKFLQeAYPSRLQAMHVINCPTYLDKLIS-MMSPFLREEVRNMIRYHtEGMDSLYKE 249
Cdd:pfam13716  45 VVDHTGVTSENFPSLS-FLKKAYDLLPR-AFKKNLKAVYVVHPSTFLRTFLKtLGSLLGSKKLRKKVHYV-SSLSELWEG 121
                          90
                  ....*....|..
gi 665389310  250 VPRDMLPNEYGG 261
Cdd:pfam13716 122 IDREQLPTELPG 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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