|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
432-574 |
9.11e-31 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 117.04 E-value: 9.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 432 TYDAFVIYSSQDedWVRNELVKNLEEGVPPFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSQHFIQSRWCIFEYE 511
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELV 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648216106 512 IAQTWQFLRSHAGIIFIVLqKLEKSLLRQQVELYRLLSRNTYLEWEDSVLGRhiFWRRLKKAL 574
Cdd:smart00255 78 AALENALEEGGLRVIPIFY-EVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
436-575 |
2.06e-29 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 114.00 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 436 FVIYSS----QDEDWVRNELVKNLeeGVPPFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSQHFIQSRWCIFEYE 511
Cdd:pfam01582 1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 512 IAQTWQfLRSHAGIIFIVLQKLEK-------SLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLKK 572
Cdd:pfam01582 78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156
|
...
gi 648216106 573 ALL 575
Cdd:pfam01582 157 DIS 159
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
65-335 |
9.93e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 95.00 E-value: 9.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 65 LANASVISLLSLNLRGLEALPNDFRWQHLEVVNCKLQQFPALKFNSLKKFVFKDNKHMHTFTEI-NLPNLQFLDLSGNHL 143
Cdd:COG4886 46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELsNLTNLESLDLSGNQL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 144 SFKGccshNEFGT-TKLKHLDLSFNEIITMKSNFMGLEQLEYLDFQHSSLKQANDFsiFLSLRNLHYLDISYTNIHvVFR 222
Cdd:COG4886 126 TDLP----EELANlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQIT-DLP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 223 GIFAGLVSLQTLKMAGNSFQNnlLPDVFTDLTNLILLDLSKCQLEQVSQraFHSLPRLQVLNMSHNRLLFLDTLpyKPLH 302
Cdd:COG4886 199 EPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLT 272
|
250 260 270
....*....|....*....|....*....|...
gi 648216106 303 SLRILDCSYNLIVASKEQELQHLPRSLAFLNLT 335
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
230-290 |
4.69e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.83 E-value: 4.69e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648216106 230 SLQTLKMAGNSFQNnLLPDVFTDLTNLILLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRL 290
Cdd:pfam13855 2 NLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
130-290 |
1.20e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.77 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 130 LPNLQFLDLSGNHLSFKgccSHNEFGT-TKLKHLDLSFNEIITMKSNFMG-LEQLEYLDFQHSSL---------KQANDF 198
Cdd:PLN00113 139 IPNLETLDLSNNMLSGE---IPNDIGSfSSLKVLDLGGNVLVGKIPNSLTnLTSLEFLTLASNQLvgqiprelgQMKSLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 199 SIFLSLRNL--------------HYLDISYTNIHVVFRGIFAGLVSLQTLKMAGNSFQNNLLPDVFtDLTNLILLDLSKC 264
Cdd:PLN00113 216 WIYLGYNNLsgeipyeiggltslNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDN 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 648216106 265 QL-----EQVSQ-------------------RAFHSLPRLQVLNMSHNRL 290
Cdd:PLN00113 295 SLsgeipELVIQlqnleilhlfsnnftgkipVALTSLPRLQVLQLWSNKF 344
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
157-337 |
3.72e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.24 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 157 TKLKHLDLSFNEIITMKsNFMGLEQLEYLDFQHSSLKQANDFSiflSLRNLHYLDISYTNIHVVfRGiFAGLVSLQTLKM 236
Cdd:cd21340 24 KNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVV-EG-LENLTNLEELHI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 237 AGNSFQNN--LLPDVFTdltnliLLDLSKCqleqvsqrafhslprLQVLNMSHNRLLFLDTLpyKPLHSLRILDCSYNLI 314
Cdd:cd21340 98 ENQRLPPGekLTFDPRS------LAALSNS---------------LRVLNISGNNIDSLEPL--APLRNLEQLDASNNQI 154
|
170 180
....*....|....*....|....*
gi 648216106 315 VASKEQE--LQHLPrSLAFLNLTKN 337
Cdd:cd21340 155 SDLEELLdlLSSWP-SLRELDLTGN 178
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
432-574 |
9.11e-31 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 117.04 E-value: 9.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 432 TYDAFVIYSSQDedWVRNELVKNLEEGVPPFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSQHFIQSRWCIFEYE 511
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELV 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648216106 512 IAQTWQFLRSHAGIIFIVLqKLEKSLLRQQVELYRLLSRNTYLEWEDSVLGRhiFWRRLKKAL 574
Cdd:smart00255 78 AALENALEEGGLRVIPIFY-EVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
436-575 |
2.06e-29 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 114.00 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 436 FVIYSS----QDEDWVRNELVKNLeeGVPPFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSQHFIQSRWCIFEYE 511
Cdd:pfam01582 1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 512 IAQTWQfLRSHAGIIFIVLQKLEK-------SLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLKK 572
Cdd:pfam01582 78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156
|
...
gi 648216106 573 ALL 575
Cdd:pfam01582 157 DIS 159
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
65-335 |
9.93e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 95.00 E-value: 9.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 65 LANASVISLLSLNLRGLEALPNDFRWQHLEVVNCKLQQFPALKFNSLKKFVFKDNKHMHTFTEI-NLPNLQFLDLSGNHL 143
Cdd:COG4886 46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELsNLTNLESLDLSGNQL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 144 SFKGccshNEFGT-TKLKHLDLSFNEIITMKSNFMGLEQLEYLDFQHSSLKQANDFsiFLSLRNLHYLDISYTNIHvVFR 222
Cdd:COG4886 126 TDLP----EELANlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQIT-DLP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 223 GIFAGLVSLQTLKMAGNSFQNnlLPDVFTDLTNLILLDLSKCQLEQVSQraFHSLPRLQVLNMSHNRLLFLDTLpyKPLH 302
Cdd:COG4886 199 EPLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLT 272
|
250 260 270
....*....|....*....|....*....|...
gi 648216106 303 SLRILDCSYNLIVASKEQELQHLPRSLAFLNLT 335
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
68-359 |
4.01e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 4.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 68 ASVISLLSLNLRGLEALPNDFRWQHLEVVNCKLQQFPAL--KFNSLKKFVFKDNKhmhtFTEI-----NLPNLQFLDLSG 140
Cdd:COG4886 93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEElaNLTNLKELDLSNNQ----LTDLpeplgNLTNLKSLDLSN 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 141 NHLS-----FKGCcshnefgtTKLKHLDLSFNEIITMKSNFMGLEQLEYLDFQHSSLKqanDFSIFLS-LRNLHYLDISY 214
Cdd:COG4886 169 NQLTdlpeeLGNL--------TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT---DLPEPLAnLTNLETLDLSN 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 215 TNIHVVfrGIFAGLVSLQTLKMAGNSFQNnlLPDvFTDLTNLILLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRLLFLD 294
Cdd:COG4886 238 NQLTDL--PELGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648216106 295 TLPYKPLHSLRILDCSYNLIVASKEQELQHLPRSLAFLNLTKNDFSCACEHQTFLQWVKDQKQLL 359
Cdd:COG4886 313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
436-531 |
1.09e-12 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 65.03 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 436 FVIYSSQDEDWVRnELVKNLEE-GVPPFhlcLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAq 514
Cdd:pfam13676 2 FISYAGEDRAWAE-WLADALEAaGYRVW---LDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75
|
90
....*....|....*..
gi 648216106 515 tWQFLRSHAGIIFIVLQ 531
Cdd:pfam13676 76 -LADPEGRKRLIPVRLE 91
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
13-323 |
7.80e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.18 E-value: 7.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 13 INQLVLGEFKNERNLESFDKSVLEELCNLT-LEQFRIAHfgefpDDVSDLFNCLANASVISLLSLNLRGLEALPNDF-RW 90
Cdd:COG4886 84 LLLLGLTDLGDLTNLTELDLSGNEELSNLTnLESLDLSG-----NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLgNL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 91 QHLEVVNC---KLQQFPA--LKFNSLKKFVFKDNKhmhtFTEI-----NLPNLQFLDLSGNHLS-----FKGCcshnefg 155
Cdd:COG4886 159 TNLKSLDLsnnQLTDLPEelGNLTNLKELDLSNNQ----ITDLpeplgNLTNLEELDLSGNQLTdlpepLANL------- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 156 tTKLKHLDLSFNEIITMkSNFMGLEQLEYLDFQHSSLKqanDFSIFLSLRNLHYLDISYTNIHVVFRGIFAGLVSLQTLK 235
Cdd:COG4886 228 -TNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLT---DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 236 MAGNSFQNNLLPDVFTDLTNLILLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRLLFLDTLPYKPLHSLRILDCSYNLIV 315
Cdd:COG4886 303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
|
....*...
gi 648216106 316 ASKEQELQ 323
Cdd:COG4886 383 ALLLLTLL 390
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
230-290 |
4.69e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.83 E-value: 4.69e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648216106 230 SLQTLKMAGNSFQNnLLPDVFTDLTNLILLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRL 290
Cdd:pfam13855 2 NLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
130-290 |
1.20e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.77 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 130 LPNLQFLDLSGNHLSFKgccSHNEFGT-TKLKHLDLSFNEIITMKSNFMG-LEQLEYLDFQHSSL---------KQANDF 198
Cdd:PLN00113 139 IPNLETLDLSNNMLSGE---IPNDIGSfSSLKVLDLGGNVLVGKIPNSLTnLTSLEFLTLASNQLvgqiprelgQMKSLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 199 SIFLSLRNL--------------HYLDISYTNIHVVFRGIFAGLVSLQTLKMAGNSFQNNLLPDVFtDLTNLILLDLSKC 264
Cdd:PLN00113 216 WIYLGYNNLsgeipyeiggltslNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDN 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 648216106 265 QL-----EQVSQ-------------------RAFHSLPRLQVLNMSHNRL 290
Cdd:PLN00113 295 SLsgeipELVIQlqnleilhlfsnnftgkipVALTSLPRLQVLQLWSNKF 344
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
109-290 |
3.65e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 50.23 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 109 NSLKKFVFKDN----KHMHTFTEinLPNLQFLDLSGNHLSfkGCCSHNEFGTTKLKHLDLSFNEIITMKSNFMGLEQLEY 184
Cdd:PLN00113 404 RSLRRVRLQDNsfsgELPSEFTK--LPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLEN 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 185 LDFQHsslkqaNDFSIFLSLRnlhyldisytnihvvfrgiFAGLVSLQTLKMAGNSFqNNLLPDVFTDLTNLILLDLSKC 264
Cdd:PLN00113 480 LDLSR------NQFSGAVPRK-------------------LGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHN 533
|
170 180
....*....|....*....|....*.
gi 648216106 265 QLEQVSQRAFHSLPRLQVLNMSHNRL 290
Cdd:PLN00113 534 QLSGQIPASFSEMPVLSQLDLSQNQL 559
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
157-337 |
3.72e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.24 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 157 TKLKHLDLSFNEIITMKsNFMGLEQLEYLDFQHSSLKQANDFSiflSLRNLHYLDISYTNIHVVfRGiFAGLVSLQTLKM 236
Cdd:cd21340 24 KNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVV-EG-LENLTNLEELHI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 237 AGNSFQNN--LLPDVFTdltnliLLDLSKCqleqvsqrafhslprLQVLNMSHNRLLFLDTLpyKPLHSLRILDCSYNLI 314
Cdd:cd21340 98 ENQRLPPGekLTFDPRS------LAALSNS---------------LRVLNISGNNIDSLEPL--APLRNLEQLDASNNQI 154
|
170 180
....*....|....*....|....*
gi 648216106 315 VASKEQE--LQHLPrSLAFLNLTKN 337
Cdd:cd21340 155 SDLEELLdlLSSWP-SLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
254-314 |
5.14e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 5.14e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648216106 254 TNLILLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRLLFLDTLPYKPLHSLRILDCSYNLI 314
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
129-288 |
2.97e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 129 NLPNLQFLDLSGNHLSFKGccshNEFGTTKLKHLDLSFNEIITMkSNFMGLEQLE--YLDFQHSSLKQA---NDFSIFLS 203
Cdd:cd21340 44 FLTNLTHLYLQNNQIEKIE----NLENLVNLKKLYLGGNRISVV-EGLENLTNLEelHIENQRLPPGEKltfDPRSLAAL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 204 LRNLHYLDISYTNIhvvfrgifaglVSLQTLKMagnsfqnnllpdvftdLTNLILLDLSKCQLEQVSQ--RAFHSLPRLQ 281
Cdd:cd21340 119 SNSLRVLNISGNNI-----------DSLEPLAP----------------LRNLEQLDASNNQISDLEEllDLLSSWPSLR 171
|
....*..
gi 648216106 282 VLNMSHN 288
Cdd:cd21340 172 ELDLTGN 178
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
132-290 |
3.35e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 47.15 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 132 NLQFLDLSGNHLSFK---GCCSHNEFgtTKLKHLDLSFN-EIITMKSNFMGLEQLEYldfqhsslkQANDFS-----IFL 202
Cdd:PLN00113 357 NLTVLDLSTNNLTGEipeGLCSSGNL--FKLILFSNSLEgEIPKSLGACRSLRRVRL---------QDNSFSgelpsEFT 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 203 SLRNLHYLDISYTNIHVVFRGIFAGLVSLQTLKMAGNSFQNNlLPDVFTDlTNLILLDLSKCQLEQVSQRAFHSLPRLQV 282
Cdd:PLN00113 426 KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG-LPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
....*...
gi 648216106 283 LNMSHNRL 290
Cdd:PLN00113 504 LKLSENKL 511
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
278-339 |
5.53e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 5.53e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648216106 278 PRLQVLNMSHNRLLFLDTLPYKPLHSLRILDCSYNLIVASKEQELQHLPrSLAFLNLTKNDF 339
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
181-241 |
8.44e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 8.44e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648216106 181 QLEYLDFQHSSLKQANDfSIFLSLRNLHYLDISYTNIHVVFRGIFAGLVSLQTLKMAGNSF 241
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
128-340 |
1.02e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.65 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 128 INLPNLQFLDLSGNHLSFKGC-----CSHNEFgttkLKHLDLSFNEIITMKSNFMG------LEQLEYLDFQHSSLKQAN 196
Cdd:cd00116 78 TKGCGLQELDLSDNALGPDGCgvlesLLRSSS----LQELKLNNNGLGDRGLRLLAkglkdlPPALEKLVLGRNRLEGAS 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 197 DFSI---FLSLRNLHYLDISYTNIHVvfRGIfaglvslQTLKMAgnsfqnnllpdvFTDLTNLILLDLSKCQL--EQVSQ 271
Cdd:cd00116 154 CEALakaLRANRDLKELNLANNGIGD--AGI-------RALAEG------------LKANCNLEVLDLNNNGLtdEGASA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 272 --RAFHSLPRLQVLNMSHNRL------LFLDTLPyKPLHSLRILDCSYNLIVASK-EQELQHLP--RSLAFLNLTKNDFS 340
Cdd:cd00116 213 laETLASLKSLEVLNLGDNNLtdagaaALASALL-SPNISLLTLSLSCNDITDDGaKDLAEVLAekESLLELDLRGNKFG 291
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
8-261 |
3.39e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.38 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 8 LAGSKINQL--VLGEFKNernLESFD------KSVLEELCNLT-LEQFRIAH--FGEFPDDVSDLFNclanasvisLLSL 76
Cdd:COG4886 143 LSNNQLTDLpePLGNLTN---LKSLDlsnnqlTDLPEELGNLTnLKELDLSNnqITDLPEPLGNLTN---------LEEL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 77 NLRG--LEALPNDFRW----QHLEVVNCKLQQFPAL-KFNSLKKFVFKDNKHMHTFTEINLPNLQFLDLSGNHLSFKGCC 149
Cdd:COG4886 211 DLSGnqLTDLPEPLANltnlETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLK 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 150 SHNEFGTTKLKHLDLSFNEIITMKSNFMGLEQLEYLDFQHSSLKQANDFSIFLSLRNLHYLDISYTNIHVVFRGIFAGLV 229
Cdd:COG4886 291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370
|
250 260 270
....*....|....*....|....*....|..
gi 648216106 230 SLQTLKMAGNSFQNNLLPDVFTDLTNLILLDL 261
Cdd:COG4886 371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
129-386 |
7.03e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 42.91 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 129 NLPNLQFLDLSGNHLSfkGCCSHNEFGTTKLKHLDLSFNE--------IITMKS---------NFMG--------LEQLE 183
Cdd:PLN00113 258 NLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSlsgeipelVIQLQNleilhlfsnNFTGkipvaltsLPRLQ 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 184 YLDFQhsslkqANDFS--IFLSL---RNLHYLDISYTNIH----------------VVFRGIFAGLV--------SLQTL 234
Cdd:PLN00113 336 VLQLW------SNKFSgeIPKNLgkhNNLTVLDLSTNNLTgeipeglcssgnlfklILFSNSLEGEIpkslgacrSLRRV 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 235 KMAGNSFQNNLlPDVFTDLTNLILLDLSKCQLE-QVSQRAFhSLPRLQVLNMSHNRllFLDTLP-YKPLHSLRILDCSYN 312
Cdd:PLN00113 410 RLQDNSFSGEL-PSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNK--FFGGLPdSFGSKRLENLDLSRN 485
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 648216106 313 LIVASKEQELQHLPRsLAFLNLTKNDFSCACEHQtfLQWVKDQKQLLVGAEQMVCTQPLEMQDLPVLSFRNATC 386
Cdd:PLN00113 486 QFSGAVPRKLGSLSE-LMQLKLSENKLSGEIPDE--LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
131-192 |
1.33e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 1.33e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648216106 131 PNLQFLDLSGNHLSfkGCCSHNEFGTTKLKHLDLSFNEIITMKSN-FMGLEQLEYLDFQHSSL 192
Cdd:pfam13855 1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
159-340 |
3.42e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 40.30 E-value: 3.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 159 LKHLDLSFNEIITMKSNFMGLEQLEYLDFQHSSLKQANDFSIFLSLRNLHYLDISYTNIHVVFRGIFAGLVSLQTLKMAG 238
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 239 NSFQNNLLPDVFTDLTNLILLDLSKCQleqvsqrAFHSLPRLQVLNMSHNRllfLDTLPY--KPLHSLRILDCSYNLIVA 316
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ---LTDLPEelANLTNLKELDLSNNQLTD 150
|
170 180
....*....|....*....|....
gi 648216106 317 SKEqELQHLPrSLAFLNLTKNDFS 340
Cdd:COG4886 151 LPE-PLGNLT-NLKSLDLSNNQLT 172
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
157-217 |
3.73e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.96 E-value: 3.73e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648216106 157 TKLKHLDLSFNEIITM-KSNFMGLEQLEYLDFQHSSLKQANDFSiFLSLRNLHYLDISYTNI 217
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
130-340 |
5.33e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 39.83 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 130 LPNLQFLDLSGNHLSFKgcCSHNEFGTT-KLKHLDLSFNeiitmksNFMG------LEQLEYLDFQHSSL--KQANDFSI 200
Cdd:PLN00113 92 LPYIQTINLSNNQLSGP--IPDDIFTTSsSLRYLNLSNN-------NFTGsiprgsIPNLETLDLSNNMLsgEIPNDIGS 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 201 FLSLRnlhYLDISYTNIHVVFRGIFAGLVSLQTLKMAGNSF--------------------QNNL---LPDVFTDLTNLI 257
Cdd:PLN00113 163 FSSLK---VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqiprelgqmkslkwiylgYNNLsgeIPYEIGGLTSLN 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648216106 258 LLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRLlfldTLPYKP----LHSLRILDCSYNLIVASKEQELQHLpRSLAFLN 333
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL----SGPIPPsifsLQKLISLDLSDNSLSGEIPELVIQL-QNLEILH 314
|
....*..
gi 648216106 334 LTKNDFS 340
Cdd:PLN00113 315 LFSNNFT 321
|
|
| |
