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Conserved domains on  [gi|612407871|ref|NP_001278398|]
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C-C motif chemokine 4-like isoform 2 precursor [Homo sapiens]

Protein Classification

CC family chemokine( domain architecture ID 10640845)

CC family chemokine similar to C-C motif chemokine 23, a chemotactic factor that attracts monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 31-64 7.34e-11

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


:

Pssm-ID: 197570  Cd Length: 59  Bit Score: 51.48  E-value: 7.34e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 612407871   31 PTACCFSYTARKLPRNFVVDYYETSSLCSQPAVV 64
Cdd:smart00199  1 PLRCCLSYTSKKIPLKRIKSYYPTSSHCPKPAVI 34
 
Name Accession Description Interval E-value
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 31-64 7.34e-11

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 51.48  E-value: 7.34e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 612407871   31 PTACCFSYTARKLPRNFVVDYYETSSLCSQPAVV 64
Cdd:smart00199  1 PLRCCLSYTSKKIPLKRIKSYYPTSSHCPKPAVI 34
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 34-64 5.44e-10

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 49.17  E-value: 5.44e-10
                        10        20        30
                ....*....|....*....|....*....|.
gi 612407871 34 CCFSYTARKLPRNFVVDYYETSSLCSQPAVV 64
Cdd:cd00272   1 CCLSYSKKRIPLRVLKSYRRTSSSCSKPAVI 31
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 32-64 3.47e-08

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 44.57  E-value: 3.47e-08
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 612407871  32 TACCFSYTARKLPRNFVVDYYET--SSLCSQPAVV 64
Cdd:pfam00048  1 SDCCLRYSSKPIPLKRVKSYEIQpaSSSCPKPAVI 35
 
Name Accession Description Interval E-value
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 31-64 7.34e-11

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 51.48  E-value: 7.34e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 612407871   31 PTACCFSYTARKLPRNFVVDYYETSSLCSQPAVV 64
Cdd:smart00199  1 PLRCCLSYTSKKIPLKRIKSYYPTSSHCPKPAVI 34
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 34-64 5.44e-10

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 49.17  E-value: 5.44e-10
                        10        20        30
                ....*....|....*....|....*....|.
gi 612407871 34 CCFSYTARKLPRNFVVDYYETSSLCSQPAVV 64
Cdd:cd00272   1 CCLSYSKKRIPLRVLKSYRRTSSSCSKPAVI 31
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 32-64 3.47e-08

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 44.57  E-value: 3.47e-08
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 612407871  32 TACCFSYTARKLPRNFVVDYYET--SSLCSQPAVV 64
Cdd:pfam00048  1 SDCCLRYSSKPIPLKRVKSYEIQpaSSSCPKPAVI 35
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 34-64 2.47e-05

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 37.32  E-value: 2.47e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 612407871 34 CCFSYTARKLPRNFVVDYYETSSL--CSQPAVV 64
Cdd:cd00169   1 CCLKYTSKPIPPKNIKSYRVQEAGghCSIPAVI 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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