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Conserved domains on  [gi|595763388|ref|NP_001277708|]
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zinc finger protein 879 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-485 1.97e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 1.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 132 KCNICGKVFFHSSSLSKHQRTHTGEKLYKC--QGCRKAFSQRSSLAQHLRVHTGEKPYLCSD----------------CG 193
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasssslssSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 194 KAFSFTTSL---------------IGHQRMHTGERPYE-CKECGKTFKGSSSLH-------------------NHQRIHT 238
Cdd:COG5048  115 SNSNDNNLLsshslppssrdpqlpDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVST 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 239 GEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECSQCGKAFTSISRLSRH------HRVHTGEKPFHCNVCGKVFSYHS 312
Cdd:COG5048  195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSSS 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 313 ALTIHQRTHTG-EKPYACKECGKAFSQSSALTQHQR--IHTGE--KPYKCAE--CGKAFSWLSRLNIHHRIHTGEKPYHC 385
Cdd:COG5048  275 PNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 386 KECGKAFSSHSAVNT-------HRKIHTGEKPYKCSD--CEKAFNQSSALIQHQRIHTGEKP--FNCKVCGKAFRQSSSL 454
Cdd:COG5048  355 KLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434

                        410       420       430
                 ....*....|....*....|....*....|.
gi 595763388 455 MTHMRIHTGERPYRCEACGKaFSQSSSLANH 485
Cdd:COG5048  435 IPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-485 1.97e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 1.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 132 KCNICGKVFFHSSSLSKHQRTHTGEKLYKC--QGCRKAFSQRSSLAQHLRVHTGEKPYLCSD----------------CG 193
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasssslssSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 194 KAFSFTTSL---------------IGHQRMHTGERPYE-CKECGKTFKGSSSLH-------------------NHQRIHT 238
Cdd:COG5048  115 SNSNDNNLLsshslppssrdpqlpDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVST 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 239 GEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECSQCGKAFTSISRLSRH------HRVHTGEKPFHCNVCGKVFSYHS 312
Cdd:COG5048  195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSSS 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 313 ALTIHQRTHTG-EKPYACKECGKAFSQSSALTQHQR--IHTGE--KPYKCAE--CGKAFSWLSRLNIHHRIHTGEKPYHC 385
Cdd:COG5048  275 PNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 386 KECGKAFSSHSAVNT-------HRKIHTGEKPYKCSD--CEKAFNQSSALIQHQRIHTGEKP--FNCKVCGKAFRQSSSL 454
Cdd:COG5048  355 KLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434

                        410       420       430
                 ....*....|....*....|....*....|.
gi 595763388 455 MTHMRIHTGERPYRCEACGKaFSQSSSLANH 485
Cdd:COG5048  435 IPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 1.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 595763388  453 SLMTHMRIHTGERPYRCEACGKAFSQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 409-458 4.79e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 4.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 595763388 409 KPYkCSDCEKAFNQSSALIQHQRIHTgekpFNCKVCGKAFRQSSSLMTHM 458
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
PHA00733 PHA00733
hypothetical protein
 410-458 1.64e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 1.64e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 595763388 410 PYKCSDCEKAFNQSSALIQHQRIHTGEKpfNCKVCGKAFRQSSSLMTHM 458
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-485 1.97e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 1.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 132 KCNICGKVFFHSSSLSKHQRTHTGEKLYKC--QGCRKAFSQRSSLAQHLRVHTGEKPYLCSD----------------CG 193
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasssslssSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 194 KAFSFTTSL---------------IGHQRMHTGERPYE-CKECGKTFKGSSSLH-------------------NHQRIHT 238
Cdd:COG5048  115 SNSNDNNLLsshslppssrdpqlpDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVST 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 239 GEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECSQCGKAFTSISRLSRH------HRVHTGEKPFHCNVCGKVFSYHS 312
Cdd:COG5048  195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSSS 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 313 ALTIHQRTHTG-EKPYACKECGKAFSQSSALTQHQR--IHTGE--KPYKCAE--CGKAFSWLSRLNIHHRIHTGEKPYHC 385
Cdd:COG5048  275 PNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 386 KECGKAFSSHSAVNT-------HRKIHTGEKPYKCSD--CEKAFNQSSALIQHQRIHTGEKP--FNCKVCGKAFRQSSSL 454
Cdd:COG5048  355 KLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434

                        410       420       430
                 ....*....|....*....|....*....|.
gi 595763388 455 MTHMRIHTGERPYRCEACGKaFSQSSSLANH 485
Cdd:COG5048  435 IPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-489 1.64e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 143 SSSLSKHQRTHTGE----KLYKCQGCRKAFSQRSSLAQHLRVHTGEKPYLCSDCGKAFSFTTSLIG--HQRMHTGERPYE 216
Cdd:COG5048   14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 217 C--KECGKTFKGSSSLHNHQrIHTGEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECSQC-GKAFTSISRLSRHHRVH 293
Cdd:COG5048   94 NskSLPLSNSKASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 294 TgekpfhcNVCGKVFSYHSALTIHQRTHTGEKPYACKECGKAFSQSSALTQHQRIHTGEKPYKCAECGKAFSWLSRLNIH 373
Cdd:COG5048  173 A-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 374 HRIHTGEKPYHCKECGKAFSSHSAVNTHRKIHTGE-------KPYKCSDCEKAFNQSSALIQHQR--IHTGE--KPFNCK 442
Cdd:COG5048  246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCP 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 595763388 443 V--CGKAFRQSSSLMTHMRIHTGERPYRC--EACGKAFSQSSSLANHQKTH 489
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-490 1.65e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 213 RPYECKECGKTFKGSSSLHNHQRIHTGEKPYKCNECGRA--FSQCSSLIQHHRIHTGEKPYECSQCGKAFTSISRLSRHH 290
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 291 RVHTGE-KPFHCNVCGKVFSYHSALTIHQRTHT---GEKPYACKECGKAFSQSS-------------------ALTQHQR 347
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNslhpplpanslskdpssnlSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 348 IHTGEKPYKCAECGKAFSWLSRLNIHHRIHTGEKPYHCKECGKAFSSHSAVNTHRKIHTGEKPYKCSDCEKAFNQSSALI 427
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 595763388 428 QHQRIHTGE-------KPFNCKVCGKAFRQSSSLMTHMR--IHTGE--RPYRC--EACGKAFSQSSSLANHQKTHY 490
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 1.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 595763388  453 SLMTHMRIHTGERPYRCEACGKAFSQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 407-490 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 407 GEKPYKCS--DCEKAFNQSSALIQHqRIHTGekpfnckvCGKAFRQSSSLMTHMRIHTGERPYRCEACGKAFSQSSSLAN 484
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 595763388 485 HqKTHY 490
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-402 1.90e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 227 SSSLHNHQRIHTGE-----KPYKCNECGRAFSQCSSLIQH--HRIHTGE--KPYEC--SQCGKAFTSISRLSRHHRVHTG 295
Cdd:COG5048  269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 296 EKPFHCNVC-------GKVFSYHSALTIHQRTHTGEKPYAC--KECGKAFSQSSALTQHQRIHTGEKP--YKCAECGKAF 364
Cdd:COG5048  349 ISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 595763388 365 SWLSRLNIHHRIHTGEKPYHCKECGKAFSSHSAVNTHR 402
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-365 3.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.39e-04
                          10        20
                  ....*....|....*....|....*
gi 595763388  341 ALTQHQRIHTGEKPYKCAECGKAFS 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 409-458 4.79e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 4.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 595763388 409 KPYkCSDCEKAFNQSSALIQHQRIHTgekpFNCKVCGKAFRQSSSLMTHM 458
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 213-261 7.02e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 7.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 595763388 213 RPYeCKECGKTFKGSSSLHNHQRIHTgekpYKCNECGRAFSQCSSLIQH 261
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-294 8.02e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 211 GERPYECK--ECGKTFKGSSSL-----HNHQRIHTGEKPykcnecgrafsqcsSLIQHHRIHTGEKPYECSQCGKAFTSI 283
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLkyhmlHGHQNQKLHENP--------------SPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                         90
                 ....*....|.
gi 595763388 284 SRLsRHHRVHT 294
Cdd:COG5189  412 NGL-KYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 8.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 595763388  425 ALIQHQRIHTGEKPFNCKVCGKAFRQ 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 8.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 595763388  313 ALTIHQRTHTGEKPYACKECGKAFSQ 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-373 8.93e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 8.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 214 PYECKECGKTFKGSSSLHNHQR--IHTGE--KPYKCNE--CGRAFSQCSSLIQHHRIHTGEKPYEC--SQCGKAFTSIS- 284
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLn 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 285 ---RLSRHHRVHTGEKPFHCNV---CGKVFSYHSALTIHQRTHTGEKPYACK--ECGKAFSQSSALTQHQRIHTGEKPYK 356
Cdd:COG5048  369 nepPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 595763388 357 CAECGKAFSWLSRLNIH 373
Cdd:COG5048  449 CSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 8.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 595763388  257 SLIQHHRIHTGEKPYECSQCGKAFTS 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 595763388  369 RLNIHHRIHTGEKPYHCKECGKAFSS 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-292 1.17e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 131 CKCNICGKVFFHSSSLSKHQRT--HTGEKLYKCQ----GCRKAFSQRSSLAQHLRVHTGEKPYLCSDCGKAFSFTTSLIG 204
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFScpysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 205 --HQRMH-----TGERPYEC--KECGKTFKGSS--SLHNHQRIHTGEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYEC 273
Cdd:COG5048  370 epPQSLQqykdlKNDKKSETlsNSCIRNFKRDSnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                        170
                 ....*....|....*....
gi 595763388 274 SQCGKaFTSISRLSRHHRV 292
Cdd:COG5048  450 SILKS-FRRDLDLSNHGKD 467
PHA00733 PHA00733
hypothetical protein
 410-458 1.64e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 1.64e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 595763388 410 PYKCSDCEKAFNQSSALIQHQRIHTGEKpfNCKVCGKAFRQSSSLMTHM 458
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-233 1.65e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595763388 155 GEKLYKCQ--GCRKAFSQRSSLAQHlRVHtgekpylcSDCGKAFSFTTSLIGHQRMHTGERPYECKECGKTFKGSSSLHN 232
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 595763388 233 H 233
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 595763388  285 RLSRHHRVHTGEKPFHCNVCGKVFSY 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-254 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|..
gi 595763388  233 HQRIHTGEKPYKCNECGRAFSQ 254
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-225 2.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|.
gi 595763388  205 HQRMHTGERPYECKECGKTFK 225
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-197 2.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.99e-03
                          10        20
                  ....*....|....*....|....*
gi 595763388  173 SLAQHLRVHTGEKPYLCSDCGKAFS 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-422 4.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 595763388  397 AVNTHRKIHTGEKPYKCSDCEKAFNQ 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 439-461 7.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.14e-03
                          10        20
                  ....*....|....*....|...
gi 595763388  439 FNCKVCGKAFRQSSSLMTHMRIH 461
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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