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Conserved domains on  [gi|594190936|ref|NP_001277437|]
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dolichyldiphosphatase 1 isoform b [Mus musculus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 1-82 2.05e-30

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03382:

Pssm-ID: 469784  Cd Length: 159  Bit Score: 106.97  E-value: 2.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936   1 MPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:cd03382   83 MPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157


                 ..
gi 594190936  81 WF 82
Cdd:cd03382  158 WF 159
 
Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 1-82 2.05e-30

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 106.97  E-value: 2.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936   1 MPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:cd03382   83 MPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157


                 ..
gi 594190936  81 WF 82
Cdd:cd03382  158 WF 159
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 1-86 6.14e-08

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 48.19  E-value: 6.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936    1 MPSSHSQFMWFFSVYSFLFLylrmhqtnnaRFLDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:pfam01569  48 FPSGHSATAFALALLLALLL----------RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALL 117


                  ....*.
gi 594190936   81 WFIITQ 86
Cdd:pfam01569 118 VYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
1-82 1.89e-07

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 46.57  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936     1 MPSSHSQFMWFFSVYSFLFLYLRMHqtnnarfldllwRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:smart00014  47 FPSGHTAFAFAFALFLLLYLPARAG------------RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAV 114


                   ..
gi 594190936    81 WF 82
Cdd:smart00014 115 LF 116
PLN02715 PLN02715
lipid phosphate phosphatase
 2-78 2.04e-03

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 36.96  E-value: 2.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594190936   2 PSSHSQfmWFFSVYSFLFLYL--RMHQTNNARFLDLLwrhVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMA 78
Cdd:PLN02715 188 PSGHTS--WSFAGLTFLSLYLsgKIKAFNGEGHVAKL---CLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVA 261
 
Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 1-82 2.05e-30

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 106.97  E-value: 2.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936   1 MPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:cd03382   83 MPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157


                 ..
gi 594190936  81 WF 82
Cdd:cd03382  158 WF 159
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 2-79 8.86e-10

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 53.40  E-value: 8.86e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 594190936   2 PSSHSQFmwffSVYSFLFLYLRMHQTNNARFLDLLwRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAV 79
Cdd:cd03384   75 PSGHASL----SMYAAVFLALYLQARLKLRGSRLL-RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIAL 147
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 1-82 1.78e-08

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 49.38  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936   1 MPSSHSQFMWFFSVYSFLFLYLRmhqtnnarfldlLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:cd01610   53 FPSGHAAFAFALALFLALLLPRR------------LLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALL 120


                 ..
gi 594190936  81 WF 82
Cdd:cd01610  121 VL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 1-86 6.14e-08

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 48.19  E-value: 6.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936    1 MPSSHSQFMWFFSVYSFLFLylrmhqtnnaRFLDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:pfam01569  48 FPSGHSATAFALALLLALLL----------RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALL 117


                  ....*.
gi 594190936   81 WFIITQ 86
Cdd:pfam01569 118 VYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
1-82 1.89e-07

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 46.57  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936     1 MPSSHSQFMWFFSVYSFLFLYLRMHqtnnarfldllwRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMAVA 80
Cdd:smart00014  47 FPSGHTAFAFAFALFLLLYLPARAG------------RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAV 114


                   ..
gi 594190936    81 WF 82
Cdd:smart00014 115 LF 116
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 1-82 6.74e-07

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 46.44  E-value: 6.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936   1 MPSSHSQFMwfFSVYSFLFLYL--RMHQTNNARFLdllWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMA 78
Cdd:cd03390  112 FPSGHSSFA--FAGLGFLSLYLagKLHIFDPRGSS---WRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIA 186


                 ....
gi 594190936  79 VAWF 82
Cdd:cd03390  187 YLSY 190
PLN02715 PLN02715
lipid phosphate phosphatase
 2-78 2.04e-03

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 36.96  E-value: 2.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594190936   2 PSSHSQfmWFFSVYSFLFLYL--RMHQTNNARFLDLLwrhVLSLGLLTAAFLVSYSRVYLLYHTWSQVFYGGVAGSLMA 78
Cdd:PLN02715 188 PSGHTS--WSFAGLTFLSLYLsgKIKAFNGEGHVAKL---CLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PLN02250 PLN02250
lipid phosphate phosphatase
 2-86 7.73e-03

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 35.29  E-value: 7.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594190936   2 PSSHSQfmWFFSVYSFLFLYLrmhqTNNARFLDLLwRHVLSLGL----LTAAFLVSYSRVYLLYHTWSQVFYGGVAGslM 77
Cdd:PLN02250 164 PSGHTS--WSFAGLGFLSLYL----SGKIRVFDRR-GHVAKLCIvflpLLVAALVGVSRVDDYWHHWQDVFAGALIG--L 234


                 ....*....
gi 594190936  78 AVAWFIITQ 86
Cdd:PLN02250 235 TVASFCYLQ 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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