NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|577861020|ref|NP_001276779|]
View 

cytochrome c oxidase subunit 6B2 isoform 3 [Mus musculus]

Protein Classification

cytochrome c oxidase subunit 6B family protein( domain architecture ID 7495)

cytochrome c oxidase subunit 6B family protein similar to cytochrome c oxidase subunit 6B (also known as subunit VIb), which is a component of cytochrome c oxidase, the terminal oxidase in the respiratory chains of eukaryotes and most bacteria which catalyzes the reduction of O2 and simultaneously pumps protons across the membrane; subunit 6B may bind heme

CATH:  1.10.10.140
Gene Ontology:  GO:0045333|GO:0004129
PubMed:  20233836

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Cyt_c_Oxidase_VIb super family cl02794
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
15-48 1.42e-14

Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIb is one of three mammalian subunits that lacks a transmembrane region. It is located on the cytosolic side of the membrane and helps form the dimer interface with the corresponding subunit on the other monomer complex.


The actual alignment was detected with superfamily member cd00926:

Pssm-ID: 445926  Cd Length: 75  Bit Score: 61.17  E-value: 1.42e-14
                        10        20        30
                ....*....|....*....|....*....|....
gi 577861020 15 TTPPFDPRFPNQNQTRNCYQNFLDYHRCVKTMNR 48
Cdd:cd00926   6 TTAPFDPRFPNQNQTKHCWQRYVDYHRCIKAKGE 39
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIb cd00926
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
15-48 1.42e-14

Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIb is one of three mammalian subunits that lacks a transmembrane region. It is located on the cytosolic side of the membrane and helps form the dimer interface with the corresponding subunit on the other monomer complex.


Pssm-ID: 238466  Cd Length: 75  Bit Score: 61.17  E-value: 1.42e-14
                        10        20        30
                ....*....|....*....|....*....|....
gi 577861020 15 TTPPFDPRFPNQNQTRNCYQNFLDYHRCVKTMNR 48
Cdd:cd00926   6 TTAPFDPRFPNQNQTKHCWQRYVDYHRCIKAKGE 39
COX6B pfam02297
Cytochrome oxidase c subunit VIb; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
21-56 6.73e-10

Cytochrome oxidase c subunit VIb; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.


Pssm-ID: 426708  Cd Length: 65  Bit Score: 48.89  E-value: 6.73e-10
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 577861020  21 PRFPNQNQTRNCYQNFLDYHRCvktMNRRGKSTQPC 56
Cdd:pfam02297  1 PRFPNQNQRKHCWQARDDFFKC---LDKNGIDNSPC 33
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIb cd00926
Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
15-48 1.42e-14

Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIb is one of three mammalian subunits that lacks a transmembrane region. It is located on the cytosolic side of the membrane and helps form the dimer interface with the corresponding subunit on the other monomer complex.


Pssm-ID: 238466  Cd Length: 75  Bit Score: 61.17  E-value: 1.42e-14
                        10        20        30
                ....*....|....*....|....*....|....
gi 577861020 15 TTPPFDPRFPNQNQTRNCYQNFLDYHRCVKTMNR 48
Cdd:cd00926   6 TTAPFDPRFPNQNQTKHCWQRYVDYHRCIKAKGE 39
COX6B pfam02297
Cytochrome oxidase c subunit VIb; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
21-56 6.73e-10

Cytochrome oxidase c subunit VIb; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.


Pssm-ID: 426708  Cd Length: 65  Bit Score: 48.89  E-value: 6.73e-10
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 577861020  21 PRFPNQNQTRNCYQNFLDYHRCvktMNRRGKSTQPC 56
Cdd:pfam02297  1 PRFPNQNQRKHCWQARDDFFKC---LDKNGIDNSPC 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH