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Conserved domains on  [gi|559098480|ref|NP_001273973|]
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vascular endothelial growth factor A, long form isoform s [Homo sapiens]

Protein Classification

PDGF and VEGF_C domain-containing protein( domain architecture ID 11255541)

PDGF and VEGF_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 22-104 2.83e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 125.61  E-value: 2.83e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480    22 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 101
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 559098480   102 CRP 104
Cdd:smart00141  81 CRP 83
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 115-163 1.56e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


:

Pssm-ID: 405273  Cd Length: 49  Bit Score: 86.97  E-value: 1.56e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 559098480  115 CGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 163
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 22-104 2.83e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 125.61  E-value: 2.83e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480    22 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 101
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 559098480   102 CRP 104
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 22-105 1.98e-33

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 113.23  E-value: 1.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480  22 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPH--QGQHIGEMSFLQHNK 99
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                 ....*.
gi 559098480 100 CECRPK 105
Cdd:cd00135   81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
24-102 2.24e-32

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 110.45  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480   24 CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIK---PHQGQHIGEMSFLQHNKC 100
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 559098480  101 EC 102
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 2-105 3.77e-27

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 99.31  E-value: 3.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480   2 AEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIM-- 79
Cdd:PHA02661  26 GSTGSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVMlt 105

                         90       100
                 ....*....|....*....|....*...
gi 559098480  80 --RIKPHQGQHIGEMSFLQHNKCECRPK 105
Cdd:PHA02661 106 svSGSTGATSNFQTISVEEHTKCKCEFK 133
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 115-163 1.56e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 86.97  E-value: 1.56e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 559098480  115 CGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 163
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 22-104 2.83e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 125.61  E-value: 2.83e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480    22 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 101
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 559098480   102 CRP 104
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 22-105 1.98e-33

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 113.23  E-value: 1.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480  22 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPH--QGQHIGEMSFLQHNK 99
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                 ....*.
gi 559098480 100 CECRPK 105
Cdd:cd00135   81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
24-102 2.24e-32

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 110.45  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480   24 CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIK---PHQGQHIGEMSFLQHNKC 100
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 559098480  101 EC 102
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 2-105 3.77e-27

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 99.31  E-value: 3.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559098480   2 AEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIM-- 79
Cdd:PHA02661  26 GSTGSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVMlt 105

                         90       100
                 ....*....|....*....|....*...
gi 559098480  80 --RIKPHQGQHIGEMSFLQHNKCECRPK 105
Cdd:PHA02661 106 svSGSTGATSNFQTISVEEHTKCKCEFK 133
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 115-163 1.56e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 86.97  E-value: 1.56e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 559098480  115 CGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 163
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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