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Conserved domains on  [gi|1890265819|ref|NP_001273158|]
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denticleless protein homolog isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-124 4.36e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVSTPwQPP 82
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGA---VTSvAFSPDGKLLASGSDDGTVRLWDLATG-KLL 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1890265819  83 TVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLE 124
Cdd:COG2319   198 RTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKL 238
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-124 4.36e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVSTPwQPP 82
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGA---VTSvAFSPDGKLLASGSDDGTVRLWDLATG-KLL 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1890265819  83 TVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLE 124
Cdd:COG2319   198 RTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKL 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-118 1.73e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGLKTspVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPT 83
Cdd:cd00200   181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLRT-GECVQ 255

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1890265819  84 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWR 118
Cdd:cd00200   256 TLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-117 7.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1890265819   78 PWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 117
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
79-117 1.41e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1890265819  79 WQPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 117
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 5-127 1.77e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   5 SLILDSTGSTLFANCTDDNiymfnmtglKTSPVAIFNGHQNSTFYVKSSL------SPDDQFLVSGSSDEAAYIWKVSTP 78
Cdd:PLN00181  580 SIDYSSADPTLLASGSDDG---------SVKLWSINQGVSIGTIKTKANIccvqfpSESGRSLAFGSADHKVYYYDLRNP 650

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1890265819  79 WQPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNTLKIWRLN---RGLEEKP 127
Cdd:PLN00181  651 KLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDLSmsiSGINETP 700
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-124 4.36e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVSTPwQPP 82
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGA---VTSvAFSPDGKLLASGSDDGTVRLWDLATG-KLL 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1890265819  83 TVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLE 124
Cdd:COG2319   198 RTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKL 238
WD40 COG2319
WD40 repeat [General function prediction only];
12-120 1.61e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  12 GSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQE 91
Cdd:COG2319   300 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGA 374

                          90       100
                  ....*....|....*....|....*....
gi 1890265819  92 VTSVCWCPsDFTKIATCSDDNTLKIWRLN 120
Cdd:COG2319   375 VTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-118 1.73e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGLKTspVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPT 83
Cdd:cd00200   181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLRT-GECVQ 255

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1890265819  84 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWR 118
Cdd:cd00200   256 TLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
12-122 6.32e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 6.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  12 GSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQE 91
Cdd:COG2319   216 GKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGG 290

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1890265819  92 VTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 122
Cdd:COG2319   291 VNSVAFSP-DGKLLASGSDDGTVRLWDLATG 320
WD40 COG2319
WD40 repeat [General function prediction only];
12-124 3.78e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 3.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  12 GSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPwQPPTVLLGHSQE 91
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGA 332

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1890265819  92 VTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLE 124
Cdd:COG2319   333 VRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-122 1.63e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFAnCTDDN-IYMFNMTglKTSPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVSTpWQP 81
Cdd:cd00200    97 SSVAFSPDGRILSS-SSRDKtIKVWDVE--TGKCLTTLRGHTDW---VNSvAFSPDGTFVASSSQDGTIKLWDLRT-GKC 169

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1890265819  82 PTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 122
Cdd:cd00200   170 VATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-122 2.96e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 2.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNstfYVKS-SLSPDDQFLVSGSSDEAAYIWKVSTpWQPP 82
Cdd:cd00200   139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLTGHTG---EVNSvAFSPDGEKLLSSSSDGTIKLWDLST-GKCL 212

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1890265819  83 TVLLGHSQEVTSVCWCPSDFTkIATCSDDNTLKIWRLNRG 122
Cdd:cd00200   213 GTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-122 4.75e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  36 PVAIFNGHQNSTFYVKssLSPDDQFLVSGSSDEAAYIWKVSTPwQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLK 115
Cdd:cd00200     1 LRRTLKGHTGGVTCVA--FSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIR 76


                  ....*..
gi 1890265819 116 IWRLNRG 122
Cdd:cd00200    77 LWDLETG 83
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-122 2.89e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   4 SSLILDSTGSTLFANCTDDNIYMFNMTGlkTSPVAIFNGHQNstFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPwQPPT 83
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRLWDLETG-ECVR 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1890265819  84 VLLGHSQEVTSVCWCPSDFTkIATCSDDNTLKIWRLNRG 122
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETG 125
WD40 COG2319
WD40 repeat [General function prediction only];
34-122 9.40e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 9.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  34 TSPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPwQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNT 113
Cdd:COG2319    68 GALLATLLGHTAAVLSV--AFSPDGRLLASASADGTVRLWDLATG-LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGT 143


                  ....*....
gi 1890265819 114 LKIWRLNRG 122
Cdd:COG2319   144 VRLWDLATG 152
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-117 7.11e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.11e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1890265819   78 PWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 117
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
79-117 1.41e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1890265819  79 WQPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 117
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-126 5.11e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 5.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1890265819  84 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLEEK 126
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR 45
WD40 COG2319
WD40 repeat [General function prediction only];
5-77 5.37e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 5.37e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1890265819   5 SLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVST 77
Cdd:COG2319   335 SVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGA---VTSvAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 5-127 1.77e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819   5 SLILDSTGSTLFANCTDDNiymfnmtglKTSPVAIFNGHQNSTFYVKSSL------SPDDQFLVSGSSDEAAYIWKVSTP 78
Cdd:PLN00181  580 SIDYSSADPTLLASGSDDG---------SVKLWSINQGVSIGTIKTKANIccvqfpSESGRSLAFGSADHKVYYYDLRNP 650

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1890265819  79 WQPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNTLKIWRLN---RGLEEKP 127
Cdd:PLN00181  651 KLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDLSmsiSGINETP 700
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 13-112 1.67e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 40.84  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  13 STLFANCTDDNIYMFNMT----GLKTSPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGH 88
Cdd:PLN00181  673 STLVSSSTDNTLKLWDLSmsisGINETPLHSFMGHTNVKNFV--GLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKT 750

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1890265819  89 ------------SQEVTSVCWCPSDFTKIATCSDDN 112
Cdd:PLN00181  751 idpvsglevddaSQFISSVCWRGQSSTLVAANSTGN 786
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 35-74 3.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1890265819   35 SPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWK 74
Cdd:smart00320   3 ELLKTLKGHTGPVTSV--AFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
52-135 8.22e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 8.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890265819  52 SSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWcPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDK 131
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLLDAAAGALLAT-LLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119


                  ....
gi 1890265819 132 LSTV 135
Cdd:COG2319   120 TGAV 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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