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Conserved domains on  [gi|554506562|ref|NP_001272981|]
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zinc finger protein 595 isoform b [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-60 3.26e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.43  E-value: 3.26e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 554506562     4 VTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLAICSPFSQDLSPV-QGIE 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLeQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-567 2.87e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 166 KPYKCEKCGKAFNRSTSLSKHKRIHTGEKPYTCEECGKAFRRSTVLN--EHKKIHTGEKPYKCEECG---KAFTRSTTLN 240
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 241 EHKKIHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKPYKckECGKAFRQSRSLNEHKNIHTGEkpytcEKCGKAFNQS 320
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 321 SSLIIHRSIHSEQKLYKCEECGkaFTWS-SSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKRIHTGEKPYTCEECGK 399
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLS--SSYSiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 400 AFNQSSTLILHKRIHSG-------QKPYKCEECGKAFTRSTTLNEHK--KIHTGE--KPYKCEE--CGKAFIWSASLNEH 466
Cdd:COG5048  263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 467 KNIHTGEKPYKCK--ECGKAFNQSS-----GLIIHRSIHSEQKLYKCE--ECGKAFTRSTALNEHKKIHSGEKP--YKCK 535
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410       420       430
                 ....*....|....*....|....*....|..
gi 554506562 536 ECGKAYNLSSTLTKHKRIHTGEKPFTCEECGK 567
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 4.84e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 554506562  574 SLTKHKIIHTGEKSYKCEECGKAFNR 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-60 3.26e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.43  E-value: 3.26e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 554506562     4 VTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLAICSPFSQDLSPV-QGIE 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLeQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 2.66e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 95.62  E-value: 2.66e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 554506562    3 LVTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.43e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.83  E-value: 2.43e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 554506562   4 VTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-567 2.87e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 166 KPYKCEKCGKAFNRSTSLSKHKRIHTGEKPYTCEECGKAFRRSTVLN--EHKKIHTGEKPYKCEECG---KAFTRSTTLN 240
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 241 EHKKIHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKPYKckECGKAFRQSRSLNEHKNIHTGEkpytcEKCGKAFNQS 320
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 321 SSLIIHRSIHSEQKLYKCEECGkaFTWS-SSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKRIHTGEKPYTCEECGK 399
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLS--SSYSiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 400 AFNQSSTLILHKRIHSG-------QKPYKCEECGKAFTRSTTLNEHK--KIHTGE--KPYKCEE--CGKAFIWSASLNEH 466
Cdd:COG5048  263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 467 KNIHTGEKPYKCK--ECGKAFNQSS-----GLIIHRSIHSEQKLYKCE--ECGKAFTRSTALNEHKKIHSGEKP--YKCK 535
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410       420       430
                 ....*....|....*....|....*....|..
gi 554506562 536 ECGKAYNLSSTLTKHKRIHTGEKPFTCEECGK 567
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 3.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 554506562  378 HLAKHKRIHTGEKPYTCEECGKAFNQ 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 528-607 2.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 528 GEKPYKCK--ECGKAYNLSSTLtKHKRIHTGEKPFTCEecgkafnwSSSLTKHKIIHTGEKSYKCEECGKAFNRPSTLTV 605
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 554506562 606 HK 607
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 554506562  574 SLTKHKIIHTGEKSYKCEECGKAFNR 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-60 3.26e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.43  E-value: 3.26e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 554506562     4 VTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLAICSPFSQDLSPV-QGIE 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLeQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 2.66e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 95.62  E-value: 2.66e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 554506562    3 LVTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.43e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.83  E-value: 2.43e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 554506562   4 VTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-567 2.87e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 166 KPYKCEKCGKAFNRSTSLSKHKRIHTGEKPYTCEECGKAFRRSTVLN--EHKKIHTGEKPYKCEECG---KAFTRSTTLN 240
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 241 EHKKIHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKPYKckECGKAFRQSRSLNEHKNIHTGEkpytcEKCGKAFNQS 320
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 321 SSLIIHRSIHSEQKLYKCEECGkaFTWS-SSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKRIHTGEKPYTCEECGK 399
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLS--SSYSiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 400 AFNQSSTLILHKRIHSG-------QKPYKCEECGKAFTRSTTLNEHK--KIHTGE--KPYKCEE--CGKAFIWSASLNEH 466
Cdd:COG5048  263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 467 KNIHTGEKPYKCK--ECGKAFNQSS-----GLIIHRSIHSEQKLYKCE--ECGKAFTRSTALNEHKKIHSGEKP--YKCK 535
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410       420       430
                 ....*....|....*....|....*....|..
gi 554506562 536 ECGKAYNLSSTLTKHKRIHTGEKPFTCEECGK 567
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-611 3.23e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 3.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 222 KPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCKECGKAFRWSTSLN--EHKNIHTGEKPYKC-KECGKAFRQSRSLNEH 298
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 299 KNIHTGEKPYTCEKCGKAFNQSSSLIIHRSIHSEQKLYKCEEC-GKAFTWSSSLNKHKRIHTGEKPytceecgKAFYRSS 377
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 378 HLAKHKRIHTGEKPYTCEECGKAFNQSSTLILHKRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCEECGKAF 457
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 458 IWSASLNEHKNIHTGE-------KPYKCKECGKAFNQSSGLIIHR--SIHSEQKLYKCEE----CGKAFTRSTALNEHKK 524
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 525 IHSGEKPYKCKEC-------GKAYNLSSTLTKHKRIHTGEKPFTCE--ECGKAFNWSSSLTKHKIIHTGEKS--YKCEEC 593
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410
                 ....*....|....*...
gi 554506562 594 GKAFNRPSTLTVHKRIHT 611
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-511 6.33e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 111 KIFQCNTCVKVFSKFSNSNKHKIRHTGEKPFKCTECGR--SFYMSH-LTQHTGIHAGEKPYKCEKCGKAFNRSTSLSKHK 187
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLeLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 188 RIHTGE-KPYTCEECGKAF--RRSTVLNEHKKIHTGEKPYKceecGKAFTRSTTLNEHKKIHTGEKPYKCKECGKAFrws 264
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPssRDPQLPDLLSISNLRNNPLP----GNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL--- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 265 tSLNEHKNIHTGEKPYKCKECGKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHRSIHSEQKLYKCEECG-- 342
Cdd:COG5048  185 -SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrs 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 343 ----KAFTWSSSLNKHKRIHTG-EKPYTCEECGKAFYRSSHLAKHKR--IHTGE--KPYTCEE--CGKAFNQSSTLILHK 411
Cdd:COG5048  264 slptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 412 RIHSGQKPYKC--EECGKAFTRSTT------LNEHKKIHTGEKPYKCEECGKAFIWSAS-LNEHKNIHTGEKP--YKCKE 480
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPP 423

                        410       420       430
                 ....*....|....*....|....*....|.
gi 554506562 481 CGKAFNQSSGLIIHRSIHSEQKLYKCEECGK 511
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
333-616 1.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 333 QKLYKCEECGKAFTWSSSLNKHKRIHTGEKPYTC--EECGKAFYRSSHLAKHKRIHTGEKPYTCE-ECGKAFNQSSTLIL 409
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 410 HKRIHSGQKPYKCEECGKAFT--RSTTLNEHKKIHTGEKPYK---------------------CEECGKAFIWSASLNeH 466
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSsrDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLI-S 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 467 KNIHTGEKPYKCKECGKAFNQSSGLIIHRSIHSEQKLYKCEECGKAFTRSTALNEHKKIHSGEKPYKCKECGKAYNLSST 546
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 547 LTKHKRIHTGE-------KPFTCEECGKAFNWSSSLTKHK--IIHTGE--KSYKCEE--CGKAFNRPSTLTVHKRIHTGK 613
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                 ...
gi 554506562 614 EHS 616
Cdd:COG5048  350 SPA 352
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 416-499 1.14e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 416 GQKPYKCE--ECGKAFTRSTTLNEHKKiHTGEKPYKCEecgkafiwSASLNEHKNIHTGEKPYKCKECGKAFNQSSGLII 493
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 554506562 494 HRSiHS 499
Cdd:COG5189  417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 3.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 554506562  378 HLAKHKRIHTGEKPYTCEECGKAFNQ 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-235 3.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.76e-04
                          10        20
                  ....*....|....*....|....*
gi 554506562  211 LNEHKKIHTGEKPYKCEECGKAFTR 235
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 472-551 5.37e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 472 GEKPYKCK--ECGKAFNQSSGLIIHRsihseqklyKCEECGKAFTRSTALNEHKKIHSGEKPYKCKECGKAYNLSSTLTK 549
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 554506562 550 HK 551
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 164-244 7.81e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 164 GEKPYKCE--KCGKAFNRSTSLsKHKRIHTGEKPYTCEECGKafrrstvlNEHKKIHTGEKPYKCEECGKAFTRSTTLNE 241
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 554506562 242 HKK 244
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-261 7.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.94e-04
                          10        20
                  ....*....|....*....|...
gi 554506562  239 LNEHKKIHTGEKPYKCKECGKAF 261
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
182-207 8.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 554506562  182 SLSKHKRIHTGEKPYTCEECGKAFRR 207
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 8.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 554506562  462 SLNEHKNIHTGEKPYKCKECGKAFNQ 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 9.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 554506562  350 SLNKHKRIHTGEKPYTCEECGKAFYR 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-457 9.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.56e-04
                          10        20
                  ....*....|....*....|...
gi 554506562  435 LNEHKKIHTGEKPYKCEECGKAF 457
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 248-331 1.22e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 248 GEKPYKCK--ECGKAFRWSTSLNEHKnihtgekpyKCKECGKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLII 325
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 554506562 326 HRSiHS 331
Cdd:COG5189  417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-291 1.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 554506562  266 SLNEHKNIHTGEKPYKCKECGKAFRQ 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-570 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....
gi 554506562  547 LTKHKRIHTGEKPFTCEECGKAFN 570
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-439 2.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 278 KPYKCKECGKAFRQSRSLNEHKN--IHTGE--KPYTC--EKCGKAFNQSSSLIIHRSIHSEQKLYKC--EECGKAFT--- 346
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 347 ---WSSSLNKHKRIHTGEKPYTCE-ECGKAFYRSSHLAKHKRIHTGEKPYTCE--ECGKAFNQSSTLILHKRIHSGQKPY 420
Cdd:COG5048  368 nnePPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 554506562 421 KCEECGKAFTRSTTLNEHK 439
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 528-607 2.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 528 GEKPYKCK--ECGKAYNLSSTLtKHKRIHTGEKPFTCEecgkafnwSSSLTKHKIIHTGEKSYKCEECGKAFNRPSTLTV 605
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 554506562 606 HK 607
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 304-387 2.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 304 GEKPYTCE--KCGKAFNQSSSLIIHRsihseqklyKCEECGKAFTWSSSLNKHKRIHTGEKPYTCEECGKAfYRSSHLAK 381
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKR-YKNLNGLK 415


                 ....*.
gi 554506562 382 HKRIHT 387
Cdd:COG5189  416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-542 3.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.53e-03
                          10        20
                  ....*....|....*....|....*
gi 554506562  518 ALNEHKKIHSGEKPYKCKECGKAYN 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 554506562  294 SLNEHKNIHTGEKPYTCEKCGKAFNQ 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-431 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*
gi 554506562  407 LILHKRIHSGQKPYKCEECGKAFTR 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 554506562  574 SLTKHKIIHTGEKSYKCEECGKAFNR 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 444-527 5.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554506562 444 GEKPYKCE--ECGKAFIWSASLNEHKnihtgekpyKCKECGKAFNQSSGLIIHRSIHSEQKLYKCEECGKAFTRSTALNE 521
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 554506562 522 HKKiHS 527
Cdd:COG5189  417 HRK-HS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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