store-operated calcium entry-associated regulatory factor isoform 2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| SARAF super family | cl26304 | SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic ... |
1-167 | 3.95e-25 | ||||
SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling. The actual alignment was detected with superfamily member pfam06682: Pssm-ID: 461985 Cd Length: 322 Bit Score: 98.18 E-value: 3.95e-25
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| Name | Accession | Description | Interval | E-value | ||||
| SARAF | pfam06682 | SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic ... |
1-167 | 3.95e-25 | ||||
SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling. Pssm-ID: 461985 Cd Length: 322 Bit Score: 98.18 E-value: 3.95e-25
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| Name | Accession | Description | Interval | E-value | ||||
| SARAF | pfam06682 | SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic ... |
1-167 | 3.95e-25 | ||||
SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling. Pssm-ID: 461985 Cd Length: 322 Bit Score: 98.18 E-value: 3.95e-25
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| Blast search parameters | ||||
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