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Conserved domains on  [gi|544186069|ref|NP_001269644|]
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olfactomedin-like protein 2A isoform 2 [Homo sapiens]

Protein Classification

olfactomedin domain-containing protein( domain architecture ID 10490292)

olfactomedin domain-containing protein adopts a five-bladed beta-propeller structure, similar to gliomedin that interacts with neuronal cell adhesion molecules such as neurofascin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OLF pfam02191
Olfactomedin-like domain;
185-436 1.31e-122

Olfactomedin-like domain;


:

Pssm-ID: 460482  Cd Length: 246  Bit Score: 356.07  E-value: 1.31e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  185 LRAVDPPVRHHSYGRHEGAWMKDPAARDDRIYVT-NYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFY 263
Cdd:pfam02191   1 LVSVSKPVTVKLSGGKYGAWMKDPLPPSDKIYVTdRGTSGNTLREYASLDDFKNGSPSKKYKLPYPWQGTGHVVYNGSLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  264 YNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDDRdeaqpEVIVLSRLDPGD 343
Cdd:pfam02191  81 YNKYNSRNIVKYDLTTRTVAARRVLPGAGYNNRFPYSWGGHTDIDLAVDENGLWVIYATEENE-----GNIVVSKLDPET 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  344 LSVhrETTWKTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAYAFDTHTGTDARPQLPFLNEHAYTTQIDYNPKERVLYA 423
Cdd:pfam02191 156 LEV--EQTWNTSYPKRSAGNAFMVCGVLYAVRSVNTRREEIFYAFDTYTGKEEAVSIPFPNRYGKISMLDYNPRDKKLYA 233

                         250
                  ....*....|...
gi 544186069  424 WDNGHQLTYTLHF 436
Cdd:pfam02191 234 WDDGYQVTYPVTF 246
 
Name Accession Description Interval E-value
OLF pfam02191
Olfactomedin-like domain;
185-436 1.31e-122

Olfactomedin-like domain;


Pssm-ID: 460482  Cd Length: 246  Bit Score: 356.07  E-value: 1.31e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  185 LRAVDPPVRHHSYGRHEGAWMKDPAARDDRIYVT-NYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFY 263
Cdd:pfam02191   1 LVSVSKPVTVKLSGGKYGAWMKDPLPPSDKIYVTdRGTSGNTLREYASLDDFKNGSPSKKYKLPYPWQGTGHVVYNGSLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  264 YNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDDRdeaqpEVIVLSRLDPGD 343
Cdd:pfam02191  81 YNKYNSRNIVKYDLTTRTVAARRVLPGAGYNNRFPYSWGGHTDIDLAVDENGLWVIYATEENE-----GNIVVSKLDPET 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  344 LSVhrETTWKTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAYAFDTHTGTDARPQLPFLNEHAYTTQIDYNPKERVLYA 423
Cdd:pfam02191 156 LEV--EQTWNTSYPKRSAGNAFMVCGVLYAVRSVNTRREEIFYAFDTYTGKEEAVSIPFPNRYGKISMLDYNPRDKKLYA 233

                         250
                  ....*....|...
gi 544186069  424 WDNGHQLTYTLHF 436
Cdd:pfam02191 234 WDDGYQVTYPVTF 246
OLF smart00284
Olfactomedin-like domains;
183-436 3.67e-71

Olfactomedin-like domains;


Pssm-ID: 128580  Cd Length: 255  Bit Score: 225.10  E-value: 3.67e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069   183 GTLRAVDPPVRHHSYGRHE-GAWMKDPAA---RDDRIYV--TNYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHV 256
Cdd:smart00284   1 GGLAGISKPVTLQTSWKGKsGAWMKDPLWnttKKSLYWYmpLNTRVLRSVREYSSMSDFQMGKNPTDHPLPHAGQGTGVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069   257 VYQGAFYYNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDDRDEaqpevIVL 336
Cdd:smart00284  81 VYNGSLYFNKFNSHDICRFDLTTETYQKEPLLNGAGYNNRFPYAWGGFSDIDLAVDENGLWVIYATEQNAGK-----IVI 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069   337 SRLDPGDLSVhrETTWKTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAYAFDTHTGTDARPQLPFLNEHAYTTQIDYNP 416
Cdd:smart00284 156 SKLNPATLTI--ENTWITTYNKRSASNAFMICGILYVTRSLGSKGEKVFYAYDTNTGKEGHLDIPFENMYEYISMLDYNP 233

                          250       260
                   ....*....|....*....|
gi 544186069   417 KERVLYAWDNGHQLTYTLHF 436
Cdd:smart00284 234 NDRKLYAWNNGHLVHYDIAL 253
 
Name Accession Description Interval E-value
OLF pfam02191
Olfactomedin-like domain;
185-436 1.31e-122

Olfactomedin-like domain;


Pssm-ID: 460482  Cd Length: 246  Bit Score: 356.07  E-value: 1.31e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  185 LRAVDPPVRHHSYGRHEGAWMKDPAARDDRIYVT-NYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHVVYQGAFY 263
Cdd:pfam02191   1 LVSVSKPVTVKLSGGKYGAWMKDPLPPSDKIYVTdRGTSGNTLREYASLDDFKNGSPSKKYKLPYPWQGTGHVVYNGSLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  264 YNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDDRdeaqpEVIVLSRLDPGD 343
Cdd:pfam02191  81 YNKYNSRNIVKYDLTTRTVAARRVLPGAGYNNRFPYSWGGHTDIDLAVDENGLWVIYATEENE-----GNIVVSKLDPET 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069  344 LSVhrETTWKTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAYAFDTHTGTDARPQLPFLNEHAYTTQIDYNPKERVLYA 423
Cdd:pfam02191 156 LEV--EQTWNTSYPKRSAGNAFMVCGVLYAVRSVNTRREEIFYAFDTYTGKEEAVSIPFPNRYGKISMLDYNPRDKKLYA 233

                         250
                  ....*....|...
gi 544186069  424 WDNGHQLTYTLHF 436
Cdd:pfam02191 234 WDDGYQVTYPVTF 246
OLF smart00284
Olfactomedin-like domains;
183-436 3.67e-71

Olfactomedin-like domains;


Pssm-ID: 128580  Cd Length: 255  Bit Score: 225.10  E-value: 3.67e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069   183 GTLRAVDPPVRHHSYGRHE-GAWMKDPAA---RDDRIYV--TNYYYGNSLVEFRNLENFKQGRWSNMYKLPYNWIGTGHV 256
Cdd:smart00284   1 GGLAGISKPVTLQTSWKGKsGAWMKDPLWnttKKSLYWYmpLNTRVLRSVREYSSMSDFQMGKNPTDHPLPHAGQGTGVV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069   257 VYQGAFYYNRAFTKNIIKYDLRQRFVASWALLPDVVYEDTTPWKWRGHSDIDFAVDESGLWVIYPAVDDRDEaqpevIVL 336
Cdd:smart00284  81 VYNGSLYFNKFNSHDICRFDLTTETYQKEPLLNGAGYNNRFPYAWGGFSDIDLAVDENGLWVIYATEQNAGK-----IVI 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544186069   337 SRLDPGDLSVhrETTWKTRLRRNSYGNCFLVCGILYAVDTYNQQEGQVAYAFDTHTGTDARPQLPFLNEHAYTTQIDYNP 416
Cdd:smart00284 156 SKLNPATLTI--ENTWITTYNKRSASNAFMICGILYVTRSLGSKGEKVFYAYDTNTGKEGHLDIPFENMYEYISMLDYNP 233

                          250       260
                   ....*....|....*....|
gi 544186069   417 KERVLYAWDNGHQLTYTLHF 436
Cdd:smart00284 234 NDRKLYAWNNGHLVHYDIAL 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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