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Conserved domains on  [gi|539848372|ref|NP_001269368|]
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biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 4 [Homo sapiens]

Protein Classification

biogenesis of lysosome-related organelles complex 1 subunit 2( domain architecture ID 10562160)

biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) is a component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BLOC1_2 pfam10046
Biogenesis of lysosome-related organelles complex-1 subunit 2; Members of this family of ...
 42-136 9.81e-34

Biogenesis of lysosome-related organelles complex-1 subunit 2; Members of this family of proteins play a role in cellular proliferation, as well as in the biogenesis of specialized organelles of the endosomal-lysosomal system.


:

Pssm-ID: 462951 [Multi-domain]  Cd Length: 96  Bit Score: 113.45  E-value: 9.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539848372   42 RDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQA 121
Cdd:pfam10046   1 EDMFTKVSKYLEAELEATVEDYKLLEKMNEATSLKYKDMKDVAASLEKELEELNQKYEELQPYLQQIDQIEEQVTKLEET 80

                          90
                  ....*....|....*.
gi 539848372  122 AYKLDAYSKKL-AKYK 136
Cdd:pfam10046  81 VYELDEYSKRLeSKFK 96
 
Name Accession Description Interval E-value
BLOC1_2 pfam10046
Biogenesis of lysosome-related organelles complex-1 subunit 2; Members of this family of ...
 42-136 9.81e-34

Biogenesis of lysosome-related organelles complex-1 subunit 2; Members of this family of proteins play a role in cellular proliferation, as well as in the biogenesis of specialized organelles of the endosomal-lysosomal system.


Pssm-ID: 462951 [Multi-domain]  Cd Length: 96  Bit Score: 113.45  E-value: 9.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539848372   42 RDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQA 121
Cdd:pfam10046   1 EDMFTKVSKYLEAELEATVEDYKLLEKMNEATSLKYKDMKDVAASLEKELEELNQKYEELQPYLQQIDQIEEQVTKLEET 80

                          90
                  ....*....|....*.
gi 539848372  122 AYKLDAYSKKL-AKYK 136
Cdd:pfam10046  81 VYELDEYSKRLeSKFK 96
PRK10807 PRK10807
intermembrane transport protein PqiB;
44-103 1.85e-03

intermembrane transport protein PqiB;


Pssm-ID: 182747 [Multi-domain]  Cd Length: 547  Bit Score: 36.95  E-value: 1.85e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 539848372  44 MFSKMATYLTGELTATSEDYKLLENMNKLTSLKylEMKDIAINISRNLKDLNQKYAGLQP 103
Cdd:PRK10807 437 MIEQATSTLSESQRTMRELQTTLDSLNKITSSQ--SMQQLPADMQKTLRELNRSMQGFQP 494
 
Name Accession Description Interval E-value
BLOC1_2 pfam10046
Biogenesis of lysosome-related organelles complex-1 subunit 2; Members of this family of ...
 42-136 9.81e-34

Biogenesis of lysosome-related organelles complex-1 subunit 2; Members of this family of proteins play a role in cellular proliferation, as well as in the biogenesis of specialized organelles of the endosomal-lysosomal system.


Pssm-ID: 462951 [Multi-domain]  Cd Length: 96  Bit Score: 113.45  E-value: 9.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539848372   42 RDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQA 121
Cdd:pfam10046   1 EDMFTKVSKYLEAELEATVEDYKLLEKMNEATSLKYKDMKDVAASLEKELEELNQKYEELQPYLQQIDQIEEQVTKLEET 80

                          90
                  ....*....|....*.
gi 539848372  122 AYKLDAYSKKL-AKYK 136
Cdd:pfam10046  81 VYELDEYSKRLeSKFK 96
PRK10807 PRK10807
intermembrane transport protein PqiB;
44-103 1.85e-03

intermembrane transport protein PqiB;


Pssm-ID: 182747 [Multi-domain]  Cd Length: 547  Bit Score: 36.95  E-value: 1.85e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 539848372  44 MFSKMATYLTGELTATSEDYKLLENMNKLTSLKylEMKDIAINISRNLKDLNQKYAGLQP 103
Cdd:PRK10807 437 MIEQATSTLSESQRTMRELQTTLDSLNKITSSQ--SMQQLPADMQKTLRELNRSMQGFQP 494
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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