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Conserved domains on  [gi|528078311|ref|NP_001268436|]
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phosphatase and actin regulator 3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 353-506 5.17e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078311  353 LPRKCKKELLAVKLRNRPSKQELEDRnifpRRTDEERQEIRQQIEMKLSKRlsQRPAVEELERRNILKQRNDQTEQEERR 432
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEER----KQAMIEEERKRKLLEKEMEER--QKAIYEEERRREAEEERRKQQEMEERR 552

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528078311  433 EIKQRLTRKLNQRPTVDELRDRKILIRfsDYVEVAKAqdydrRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 506
Cdd:pfam17380 553 RIQEQMRKATEERSRLEAMEREREMMR--QIVESEKA-----RAEYEATTPITTIKPIYRPRISEYQPPDVESH 619
 
Name Accession Description Interval E-value
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 353-506 5.17e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078311  353 LPRKCKKELLAVKLRNRPSKQELEDRnifpRRTDEERQEIRQQIEMKLSKRlsQRPAVEELERRNILKQRNDQTEQEERR 432
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEER----KQAMIEEERKRKLLEKEMEER--QKAIYEEERRREAEEERRKQQEMEERR 552

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528078311  433 EIKQRLTRKLNQRPTVDELRDRKILIRfsDYVEVAKAqdydrRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 506
Cdd:pfam17380 553 RIQEQMRKATEERSRLEAMEREREMMR--QIVESEKA-----RAEYEATTPITTIKPIYRPRISEYQPPDVESH 619
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
399-423 7.52e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 7.52e-04
                           10        20
                   ....*....|....*....|....*
gi 528078311   399 KLSKRLSQRPAVEELERRNILKQRN 423
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
 
Name Accession Description Interval E-value
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 353-506 5.17e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 5.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528078311  353 LPRKCKKELLAVKLRNRPSKQELEDRnifpRRTDEERQEIRQQIEMKLSKRlsQRPAVEELERRNILKQRNDQTEQEERR 432
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEER----KQAMIEEERKRKLLEKEMEER--QKAIYEEERRREAEEERRKQQEMEERR 552

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528078311  433 EIKQRLTRKLNQRPTVDELRDRKILIRfsDYVEVAKAqdydrRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 506
Cdd:pfam17380 553 RIQEQMRKATEERSRLEAMEREREMMR--QIVESEKA-----RAEYEATTPITTIKPIYRPRISEYQPPDVESH 619
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
399-423 7.52e-04

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 7.52e-04
                           10        20
                   ....*....|....*....|....*
gi 528078311   399 KLSKRLSQRPAVEELERRNILKQRN 423
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 399-420 3.15e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 34.94  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|..
gi 528078311  399 KLSKRLSQRPAVEELERRNILK 420
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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