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Conserved domains on  [gi|525507388|ref|NP_001267489|]
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acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
41-104 2.76e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.76e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507388  41 FKELEFLSMANVELSSLAR-LPSLNKLRKLELSDNIISGGLEVLAeKCPNLTYLNLSGNKIKDLS 104
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLP 221
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-104 2.76e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.76e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507388  41 FKELEFLSMANVELSSLAR-LPSLNKLRKLELSDNIISGGLEVLAeKCPNLTYLNLSGNKIKDLS 104
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLP 221
FBXL18_LRR pfam19729
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ...
 48-96 1.17e-03

F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes.


Pssm-ID: 466163 [Multi-domain]  Cd Length: 594  Bit Score: 38.18  E-value: 1.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 525507388   48 SMANVELSSLAR-LPSLNKLRKLElsDNIISGGLEVLAEKCPNLTYLNLS 96
Cdd:pfam19729 261 SLVSLNLSGCVHcLLPDSLLRKAE--DDIDSSIVETLVACCPNLRHLNLS 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-98 1.62e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 525507388  44 LEFLSMANVELSSLARLPSLNKLRKLELSDNIISGG--LEVLAEKCPNLTYLNLSGN 98
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-104 2.76e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.76e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507388  41 FKELEFLSMANVELSSLAR-LPSLNKLRKLELSDNIISGGLEVLAeKCPNLTYLNLSGNKIKDLS 104
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLP 221
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-104 4.09e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 4.09e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525507388  41 FKELEFLSMANVELSSL-ARLPSLNKLRKLELSDNIISGGLEVLAeKCPNLTYLNLSGNKIKDLS 104
Cdd:COG4886  112 LTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP 175
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-109 8.44e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 8.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 525507388  42 KELEFLSMANVELSSLAR-LPSLNKLRKLELSDNIISGgLEVLAeKCPNLTYLNLSGNKIKDLSTVEAL 109
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEpLANLTNLETLDLSNNQLTD-LPELG-NLTNLEELDLSNNQLTDLPPLANL 271
FBXL18_LRR pfam19729
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ...
 48-96 1.17e-03

F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes.


Pssm-ID: 466163 [Multi-domain]  Cd Length: 594  Bit Score: 38.18  E-value: 1.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 525507388   48 SMANVELSSLAR-LPSLNKLRKLElsDNIISGGLEVLAEKCPNLTYLNLS 96
Cdd:pfam19729 261 SLVSLNLSGCVHcLLPDSLLRKAE--DDIDSSIVETLVACCPNLRHLNLS 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-98 1.62e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 525507388  44 LEFLSMANVELSSLARLPSLNKLRKLELSDNIISGG--LEVLAEKCPNLTYLNLSGN 98
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-104 1.76e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 1.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 525507388  41 FKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLaeKCPNLTYLNLSGNKIKDLS 104
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-109 1.91e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.61  E-value: 1.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 525507388  42 KELEFLSMANVELSSLAR-LPSLNKLRKLELSDNIISGGLEVLAeKCPNLTYLNLSGNKIKDLSTVEAL 109
Cdd:COG4886  182 TNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLPELGNL 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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