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Conserved domains on  [gi|525314307|ref|NP_001265992|]
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transcription factor MYB75 [Solanum lycopersicum]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 1000535)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may be involved in the regulation of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
 3-123 1.15e-52

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 171.80  E-value: 1.15e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525314307   3 TPMCASLGVRKGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGLNRCRKSCRLRWLNYLRPHIKRGDFAPDEVDLILRLHK 82
Cdd:PLN03212  15 TPCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHR 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 525314307  83 LLGNRWSLIAGRLPGRTANDVKNYWNTHFHKKL--SIIAPHLH 123
Cdd:PLN03212  95 LLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKLlrQGIDPQTH 137
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 3-123 1.15e-52

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 171.80  E-value: 1.15e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525314307   3 TPMCASLGVRKGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGLNRCRKSCRLRWLNYLRPHIKRGDFAPDEVDLILRLHK 82
Cdd:PLN03212  15 TPCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHR 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 525314307  83 LLGNRWSLIAGRLPGRTANDVKNYWNTHFHKKL--SIIAPHLH 123
Cdd:PLN03212  95 LLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKLlrQGIDPQTH 137
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-108 1.26e-14

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 73.28  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525314307  13 KGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGLnRCRKSCRLRWLNYLRPHIKRGDFAPDEVDLILRLHKLLGNRWSLIA 92
Cdd:COG5147   20 GGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIA 98

                         90
                 ....*....|....*.
gi 525314307  93 GRLPGRTANDVKNYWN 108
Cdd:COG5147   99 DYKDRRTAQQCVERYV 114
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 66-111 5.54e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 61.75  E-value: 5.54e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 525314307   66 RGDFAPDEVDLILRLHKLLGNRWSLIAGRLPGRTANDVKNYWNTHF 111
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
13-62 7.74e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.08  E-value: 7.74e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 525314307    13 KGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGlNRCRKSCRLRWLNYLRP 62
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 15-60 4.86e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 53.73  E-value: 4.86e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 525314307  15 SWTEQEDSLLRDCIQKYGEGKWHLVPARAGlNRCRKSCRLRWLNYL 60
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 3-123 1.15e-52

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 171.80  E-value: 1.15e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525314307   3 TPMCASLGVRKGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGLNRCRKSCRLRWLNYLRPHIKRGDFAPDEVDLILRLHK 82
Cdd:PLN03212  15 TPCCTKMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHR 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 525314307  83 LLGNRWSLIAGRLPGRTANDVKNYWNTHFHKKL--SIIAPHLH 123
Cdd:PLN03212  95 LLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKLlrQGIDPQTH 137
PLN03091 PLN03091
hypothetical protein; Provisional
 6-123 1.18e-41

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 148.59  E-value: 1.18e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525314307   6 CASLGVRKGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGLNRCRKSCRLRWLNYLRPHIKRGDFAPDEVDLILRLHKLLG 85
Cdd:PLN03091   7 CYKQKLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 525314307  86 NRWSLIAGRLPGRTANDVKNYWNTHFHKKLSI--IAPHLH 123
Cdd:PLN03091  87 NRWSQIAAQLPGRTDNEIKNLWNSCLKKKLRQrgIDPNTH 126
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-108 1.26e-14

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 73.28  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525314307  13 KGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGLnRCRKSCRLRWLNYLRPHIKRGDFAPDEVDLILRLHKLLGNRWSLIA 92
Cdd:COG5147   20 GGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWSTIA 98

                         90
                 ....*....|....*.
gi 525314307  93 GRLPGRTANDVKNYWN 108
Cdd:COG5147   99 DYKDRRTAQQCVERYV 114
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 66-111 5.54e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 61.75  E-value: 5.54e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 525314307   66 RGDFAPDEVDLILRLHKLLGNRWSLIAGRLPGRTANDVKNYWNTHF 111
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 13-60 2.19e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 57.51  E-value: 2.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 525314307   13 KGSWTEQEDSLLRDCIQKYGeGKWHLVPARAGlNRCRKSCRLRWLNYL 60
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP-GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
13-62 7.74e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.08  E-value: 7.74e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 525314307    13 KGSWTEQEDSLLRDCIQKYGEGKWHLVPARAGlNRCRKSCRLRWLNYLRP 62
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 15-60 4.86e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 53.73  E-value: 4.86e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 525314307  15 SWTEQEDSLLRDCIQKYGEGKWHLVPARAGlNRCRKSCRLRWLNYL 60
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
66-113 3.08e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 51.84  E-value: 3.08e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 525314307    66 RGDFAPDEVDLILRLHKLLG-NRWSLIAGRLPGRTANDVKNYWNTHFHK 113
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 71-111 5.88e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.04  E-value: 5.88e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 525314307  71 PDEVDLILRLHKLLG-NRWSLIAGRLPGRTANDVKNYWNTHF 111
Cdd:cd00167    4 EEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 16-74 4.35e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.15  E-value: 4.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 525314307   16 WTEQEDSLLRDCIQKYGeGKWHLVpARAGLNRCRKSCRLRWLNYLRPHIKRGDFAPDEV 74
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQI-AKELGRRTPKQCFDRWRRKLNPKISRGPWSKEED 57
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 69-116 1.15e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 41.91  E-value: 1.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 525314307   69 FAPDEVDLILRLHKLLGNRWSLIAGRLPGRTANDVKNYWNTHFHKKLS 116
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKIS 48
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 16-36 2.88e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 34.85  E-value: 2.88e-03
                         10        20
                 ....*....|....*....|.
gi 525314307  16 WTEQEDSLLRDCIQKYGEGKW 36
Cdd:cd11660    3 WTDEEDEALVEGVEKYGVGNW 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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