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Conserved domains on  [gi|519666783|ref|NP_001265539|]
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myb-related protein B isoform 2 [Homo sapiens]

Protein Classification

myb-related protein( domain architecture ID 13851054)

myb-related protein contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain, binds DNA and functions as a transcription factor, such as human myb-related protein A that specifically recognizes the sequence 5'-YAAC[GT]G-3'

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 427-570 5.11e-56

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 187.57  E-value: 5.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  427 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQK-HAAFVTPD-QKYSMDNTPHTPTPFKNALE- 503
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 519666783  504 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGlRRSPIKKVRKSLALDIVDED 570
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKE 150
PLN03091 super family cl33633
hypothetical protein; Provisional
 57-173 4.47e-29

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 120.85  E-value: 4.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  57 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 134
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 519666783 135 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF-------LSESKDCK 173
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdpnthkpLSEVENGE 136
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-70 1.17e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.15  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783   34 WTHEEN-----------------------RTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 70
Cdd:pfam13921   1 WTEEEDekllklvekygndwkqiakelgrRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 427-570 5.11e-56

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 187.57  E-value: 5.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  427 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQK-HAAFVTPD-QKYSMDNTPHTPTPFKNALE- 503
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 519666783  504 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGlRRSPIKKVRKSLALDIVDED 570
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKE 150
PLN03091 PLN03091
hypothetical protein; Provisional
 57-173 4.47e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 120.85  E-value: 4.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  57 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 134
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 519666783 135 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF-------LSESKDCK 173
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdpnthkpLSEVENGE 136
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 56-171 1.46e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 117.20  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  56 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 135
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 519666783 136 IAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKD 171
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 62-120 2.08e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 79.28  E-value: 2.08e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 519666783   62 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 120
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
59-107 3.28e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 75.72  E-value: 3.28e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 519666783    59 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 107
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 61-105 9.94e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.15  E-value: 9.94e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 519666783  61 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 105
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-70 1.17e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.15  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783   34 WTHEEN-----------------------RTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 70
Cdd:pfam13921   1 WTEEEDekllklvekygndwkqiakelgrRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 427-570 5.11e-56

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 187.57  E-value: 5.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  427 FSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQK-HAAFVTPD-QKYSMDNTPHTPTPFKNALE- 503
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKeNTGFRTPNiRRSILETTPRTPTPFKNALAa 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 519666783  504 ---KYGPLKPLPQTP-HLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGlRRSPIKKVRKSLALDIVDED 570
Cdd:pfam09316  81 qekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQE-HRSPNKKVRKSLWLDDWDKE 150
PLN03091 PLN03091
hypothetical protein; Provisional
 57-173 4.47e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 120.85  E-value: 4.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  57 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 134
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 519666783 135 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF-------LSESKDCK 173
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIdpnthkpLSEVENGE 136
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 56-171 1.46e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 117.20  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  56 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 135
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 519666783 136 IAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKD 171
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 59-160 7.26e-26

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 107.09  E-value: 7.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  59 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKG-RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIA 137
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100
                 ....*....|....*....|...
gi 519666783 138 KMLPGRTDNAVKNHWNSTIKRKV 160
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKL 127
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 62-120 2.08e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 79.28  E-value: 2.08e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 519666783   62 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 120
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
59-107 3.28e-17

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 75.72  E-value: 3.28e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 519666783    59 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 107
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 59-105 7.03e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.46  E-value: 7.03e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 519666783   59 KGPWTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHL 105
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 61-105 9.94e-17

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 74.15  E-value: 9.94e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 519666783  61 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 105
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 111-154 8.13e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 71.38  E-value: 8.13e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 519666783  111 KSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNS 154
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 114-153 8.35e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.98  E-value: 8.35e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 519666783 114 WTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWN 153
Cdd:cd00167    2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
111-158 1.19e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 62.63  E-value: 1.19e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 519666783   111 KSCWTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWNSTIKR 158
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 114-165 3.61e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 53.08  E-value: 3.61e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 519666783  114 WTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGF 165
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPW 52
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 2-158 1.51e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.49  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783   2 SRRTRCEDldelhyQDTDSDVPE---QRDSKCKVKWTHeenRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYG 78
Cdd:COG5147   21 GSWKRTED------EDLKALVKKlgpNNWSKVASLLIS---STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  79 TkQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAhKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKR 158
Cdd:COG5147   92 T-QWSTIADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRNEFDKI-DPFNENSARRPDIYEDELLEREVNREASYRLR 169
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 55-101 5.65e-08

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 49.62  E-value: 5.65e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 519666783  55 PDLVKGPWTKEEDQKVIELVKKYGTkQWTLIAKhLKGRLGKQCRERW 101
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLLPT-QWRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 61-103 3.55e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.18  E-value: 3.55e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 519666783  61 PWTKEEDQKVIELVKKYGTKQWTLIAKH---LKGRLGKQCRERWHN 103
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-70 1.17e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.15  E-value: 1.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783   34 WTHEEN-----------------------RTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 70
Cdd:pfam13921   1 WTEEEDekllklvekygndwkqiakelgrRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 107-146 9.61e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 40.37  E-value: 9.61e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 519666783 107 PEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLpGRTDN 146
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 51-157 8.84e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 42.47  E-value: 8.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 519666783  51 RVLNPDLVKGPWTKEEDQKVIELVKKYGtKQWTLIAKhLKGRLGKQCRERWHNHLNP--EVKKSCWT-EEEDRIIC---- 123
Cdd:COG5147  283 RKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDKvvne 360

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 519666783 124 ---EAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIK 157
Cdd:COG5147  361 mrlEAQQSSRILWLLIAQNIRNRLQHHCRDKYGVLIS 397
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 62-112 6.43e-03

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 35.72  E-value: 6.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 519666783  62 WTKEEDQKVI----ELVKKYGTKQ-----WTLIAKHLK----GRLGKQCRERWhNHLNPEVKKS 112
Cdd:cd12203    3 WPREETLSLIrlrrEMESRFQETKskkalWEEIAAKMRelgyNRSAKQCKEKW-ENLNKYYKKV 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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