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Conserved domains on  [gi|508772601|ref|NP_001265320|]
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contactin-associated protein 1 precursor [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 36-167 1.64e-45

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 160.60  E-value: 1.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   36 RSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQG--SFNSWDWVTRYMLLYGDRVDSWTP 113
Cdd:cd00057    12 DQITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 508772601  114 FYQRGHNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGLYG 167
Cdd:cd00057    92 YKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 175-330 1.37e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.37  E-value: 1.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  175 LYFDGDDAISYRFPRGVSRSLwdVFAFSFKTEEKDGLLLHAEGA-QGDYVTIELEGAHLLLHMSLGSspiqprpGHTTVS 253
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 508772601  254 AGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQ-RFILNGDFERLNLDTEMFIGGLVGAARKN-LAYRHNFRGCIENVIFN 330
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1088-1218 1.34e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 1.34e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  1088 FSTSSAPAVLLYVSSFVRDYMAVLIKDdGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1167
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVN-GRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 508772601  1168 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1218
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 362-513 9.02e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 9.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  362 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIaQSGRKKLQFAAGYRLN 440
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508772601  441 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWdCHSNQTAFHGCMELLKVD 513
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 787-937 1.12e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.64  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  787 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPycqwRRPYVRVELNTSRdVVFAFDvgNGDENLTVHS 865
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  866 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWMEYDQPLYVG--------SAELKRRPFVGCLRAMRLN 937
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
4.1m smart00294
putative band 4.1 homologues' binding motif;
1304-1322 2.31e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.31e-05
                            10
                    ....*....|....*....
gi 508772601   1304 FYLQNHRYKGSYHTNEPKA 1322
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 584-616 1.60e-04

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 40.62  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 508772601  584 SCEAYRLSGKT--SGNFTIDPDGSGPLKPFVVYCD 616
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCD 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 544-575 4.69e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 4.69e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 508772601   544 CSPNMCEHDGRCYQSWDDFICYCElTGYKGET 575
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 584-658 5.17e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member cd00087:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 215  Bit Score: 43.00  E-value: 5.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601  584 SC-EAYRLSGKTSGNFTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmerpflgaiQYWNASWEE 658
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 36-167 1.64e-45

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 160.60  E-value: 1.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   36 RSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQG--SFNSWDWVTRYMLLYGDRVDSWTP 113
Cdd:cd00057    12 DQITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 508772601  114 FYQRGHNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGLYG 167
Cdd:cd00057    92 YKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 175-330 1.37e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.37  E-value: 1.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  175 LYFDGDDAISYRFPRGVSRSLwdVFAFSFKTEEKDGLLLHAEGA-QGDYVTIELEGAHLLLHMSLGSspiqprpGHTTVS 253
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 508772601  254 AGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQ-RFILNGDFERLNLDTEMFIGGLVGAARKN-LAYRHNFRGCIENVIFN 330
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
199-332 3.32e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.32e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    199 FAFSFKTEEKDGLLLHAEGAQG-DYVTIELEGAHLLLHMSLGSSPIQPRPGHTTVsaggvlNDQHWHYVRVDRFGRDVNF 277
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601    278 TLDGY-VQRFILNGDFERLNLDTEMFIGGLV-GAARKNLAYRHNFRGCIENVIFNRV 332
Cdd:smart00282   76 SVDGGnRVSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 24-168 3.41e-30

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 116.84  E-value: 3.41e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601     24 GCDEELvGPLYARSLGASSYYsllTAPRFARLHGIS--GWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYM 101
Cdd:smart00231    1 PCNEPL-GLESDSQITASSSY---WAAKIARLNGGSdgGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYKL 76

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601    102 LLYGDRVDsWTPfYQRGHNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGLYGC 168
Cdd:smart00231   77 EYSDDGVN-WTT-YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 203-330 1.39e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 114.44  E-value: 1.39e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   203 FKTEEKDGLLLHAEGAQGDYVTIELEGAHLLLHMSLGSSPIqprpghTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY 282
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 508772601   283 VQRFILN-GDFERLNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN 330
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1088-1218 1.34e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 1.34e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  1088 FSTSSAPAVLLYVSSFVRDYMAVLIKDdGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1167
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVN-GRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 508772601  1168 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1218
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1083-1218 3.44e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.44e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   1083 EVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIKDdGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1161
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRD-GRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601   1162 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1218
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1072-1216 9.19e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.42  E-value: 9.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601 1072 YRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIKDdGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1150
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELED-GRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508772601 1151 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1216
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 362-513 9.02e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 9.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  362 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIaQSGRKKLQFAAGYRLN 440
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508772601  441 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWdCHSNQTAFHGCMELLKVD 513
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 40-165 1.31e-24

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 100.21  E-value: 1.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    40 ASSYYSLLTAPRfARLHGI--SGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWD-WVTRYMLLYGDRVDSWTPFYq 116
Cdd:pfam00754    4 ASSSYSGEGPAA-AALDGDpnTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNgYVTSYKIEYSLDGENWTTVK- 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 508772601   117 rghNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGL 165
Cdd:pfam00754   82 ---DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 787-937 1.12e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.64  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  787 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPycqwRRPYVRVELNTSRdVVFAFDvgNGDENLTVHS 865
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  866 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWMEYDQPLYVG--------SAELKRRPFVGCLRAMRLN 937
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 389-515 1.68e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.11  E-value: 1.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   389 FRTWDLTGLLLFSRlGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 468
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 508772601   469 RVS-YPLLIRTGTSYFFGGCPKPaSRWDCHSNQTAFHGCMELLKVDGQ 515
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
385-515 3.44e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 96.64  E-value: 3.44e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    385 VSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 464
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 508772601    465 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWDcHSNQTAFHGCMELLKVDGQ 515
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 813-939 1.25e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.79  E-value: 1.25e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   813 FRTSAPSGVFLENMGGpycqwRRPYVRVELNTSRdVVFAFDVGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 892
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 508772601   893 HRPWVLRPMPLQTYIwMEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 939
Cdd:pfam02210   73 GQTVVSSLPPGESLL-LNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
808-939 1.24e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.24e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    808 DVSFYFRTSAPSGVFLENMGGPYCQwrrpYVRVELNTSRdVVFAFDVGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 887
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD----YLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    888 RLRVDHRPWVLRPMPLQTYIwMEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 939
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTI-LNLDGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
4.1m smart00294
putative band 4.1 homologues' binding motif;
1304-1322 2.31e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.31e-05
                            10
                    ....*....|....*....
gi 508772601   1304 FYLQNHRYKGSYHTNEPKA 1322
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 584-616 1.60e-04

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 40.62  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 508772601  584 SCEAYRLSGKT--SGNFTIDPDGSGPLKPFVVYCD 616
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCD 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 544-575 4.69e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 4.69e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 508772601   544 CSPNMCEHDGRCYQSWDDFICYCElTGYKGET 575
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 584-658 5.17e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.00  E-value: 5.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601  584 SC-EAYRLSGKTSGNFTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmerpflgaiQYWNASWEE 658
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
581-625 3.78e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.58  E-value: 3.78e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 508772601   581 YKESCEAYRLSGKTSGNFTIDPDGSGplKPFVVYCDIR-ENRAWTV 625
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 542-576 5.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 508772601  542 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGETC 576
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 580-639 7.95e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 39.18  E-value: 7.95e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 508772601    580 LYKESCEAYRLSGKTSGNFTIDPDGSGplKPFVVYCDIRENR-AWTVVRHdrlwttRVTGS 639
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGgGWTVIQR------RMDGS 53
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 36-167 1.64e-45

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 160.60  E-value: 1.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   36 RSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQG--SFNSWDWVTRYMLLYGDRVDSWTP 113
Cdd:cd00057    12 DQITASSSYSSGWEASRARLNSDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTT 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 508772601  114 FYQRGHNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGLYG 167
Cdd:cd00057    92 YKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 175-330 1.37e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 121.37  E-value: 1.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  175 LYFDGDDAISYRFPRGVSRSLwdVFAFSFKTEEKDGLLLHAEGA-QGDYVTIELEGAHLLLHMSLGSspiqprpGHTTVS 253
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGS-------GSLVLS 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 508772601  254 AGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQ-RFILNGDFERLNLDTEMFIGGLVGAARKN-LAYRHNFRGCIENVIFN 330
Cdd:cd00110    73 SKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
199-332 3.32e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.32e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    199 FAFSFKTEEKDGLLLHAEGAQG-DYVTIELEGAHLLLHMSLGSSPIQPRPGHTTVsaggvlNDQHWHYVRVDRFGRDVNF 277
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601    278 TLDGY-VQRFILNGDFERLNLDTEMFIGGLV-GAARKNLAYRHNFRGCIENVIFNRV 332
Cdd:smart00282   76 SVDGGnRVSGESPGGLTILNLDGPLYLGGLPeDLKLPPLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 24-168 3.41e-30

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 116.84  E-value: 3.41e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601     24 GCDEELvGPLYARSLGASSYYsllTAPRFARLHGIS--GWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYM 101
Cdd:smart00231    1 PCNEPL-GLESDSQITASSSY---WAAKIARLNGGSdgGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYKL 76

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601    102 LLYGDRVDsWTPfYQRGHNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNprGKIGLRLGLYGC 168
Cdd:smart00231   77 EYSDDGVN-WTT-YKDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 203-330 1.39e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 114.44  E-value: 1.39e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   203 FKTEEKDGLLLHAEGAQGDYVTIELEGAHLLLHMSLGSSPIqprpghTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY 282
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPE------SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 508772601   283 VQRFILN-GDFERLNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN 330
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLlPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1088-1218 1.34e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 1.34e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  1088 FSTSSAPAVLLYVSSFVRDYMAVLIKDdGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQ 1167
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVN-GRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 508772601  1168 KFSLLVDsQLDSPKALYLGRVMETgviDPEIQRYNTPGFSGCLSGVRFNNV 1218
Cdd:pfam02210   80 LPPGESL-LLNLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1083-1218 3.44e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 107.81  E-value: 3.44e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   1083 EVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIKDdGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDY 1161
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRD-GRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601   1162 FPLTEQKfSLLVDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFNNV 1218
Cdd:smart00282   80 GNRVSGE-SPGGLTILNLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1072-1216 9.19e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.42  E-value: 9.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601 1072 YRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVR-DYMAVLIKDdGTLQLRYQLGTSPYVYQlTTRPVTDGQPHSVNITR 1150
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELED-GRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508772601 1151 VYRNLFIQVDYFPLTEQKFSLLvDSQLDSPKALYLGRVMETGVIDPEIqryNTPGFSGCLSGVRFN 1216
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGG-SALLNLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 362-513 9.02e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 9.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  362 PINFGGPHnFVQVPGFPR-RGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIaQSGRKKLQFAAGYRLN 440
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 508772601  441 DGFWHEVNFVAQENHAVISIDD---VEGAEVRVSYPLLirTGTSYFFGGCPKPASRWdCHSNQTAFHGCMELLKVD 513
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGervVESGSPGGSALLN--LDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDLKVN 151
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 40-165 1.31e-24

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 100.21  E-value: 1.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    40 ASSYYSLLTAPRfARLHGI--SGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWD-WVTRYMLLYGDRVDSWTPFYq 116
Cdd:pfam00754    4 ASSSYSGEGPAA-AALDGDpnTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNgYVTSYKIEYSLDGENWTTVK- 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 508772601   117 rghNSTFFGNVNESALVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGL 165
Cdd:pfam00754   82 ---DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 787-937 1.12e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.64  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  787 TISFHTGAALRFPPIRAN-HSLDVSFYFRTSAPSGVFLENMGGPycqwRRPYVRVELNTSRdVVFAFDvgNGDENLTVHS 865
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGR-LVLRYD--LGSGSLVLSS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  866 DDfEFNDDEWHLVRAEINVKQARLRVDHRPWVlRPMPLQTYIWMEYDQPLYVG--------SAELKRRPFVGCLRAMRLN 937
Cdd:cd00110    74 KT-PLNDGQWHSVSVERNGRSVTLSVDGERVV-ESGSPGGSALLNLDGPLYLGglpedlksPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 389-515 1.68e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.11  E-value: 1.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   389 FRTWDLTGLLLFSRlGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEV 468
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 508772601   469 RVS-YPLLIRTGTSYFFGGCPKPaSRWDCHSNQTAFHGCMELLKVDGQ 515
Cdd:pfam02210   80 LPPgESLLLNLNGPLYLGGLPPL-LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
385-515 3.44e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 96.64  E-value: 3.44e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    385 VSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDve 464
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG-- 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 508772601    465 GAEVRVSYPL---LIRTGTSYFFGGCPKPASRWDcHSNQTAFHGCMELLKVDGQ 515
Cdd:smart00282   80 GNRVSGESPGgltILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 813-939 1.25e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.79  E-value: 1.25e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   813 FRTSAPSGVFLENMGGpycqwRRPYVRVELNTSRdVVFAFDVGNGDENLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 892
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG-----GSDFLALELVNGR-LVLRYDLGSGPESLLSSGK--NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 508772601   893 HRPWVLRPMPLQTYIwMEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 939
Cdd:pfam02210   73 GQTVVSSLPPGESLL-LNLNGPLYLGglppllllPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
808-939 1.24e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.02  E-value: 1.24e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    808 DVSFYFRTSAPSGVFLENMGGPYCQwrrpYVRVELNTSRdVVFAFDVGNGDENLTvhSDDFEFNDDEWHLVRAEINVKQA 887
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD----YLALELRDGR-LVLRYDLGSGPARLT--SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601    888 RLRVDHRPWVLRPMPLQTYIwMEYDQPLYVG--------SAELKRRPFVGCLRAMRLNGV 939
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTI-LNLDGPLYLGglpedlklPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
203-334 8.70e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 83.91  E-value: 8.70e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   203 FKTEEKDGLLLH-AEGAQGDYVTIELEGAHLLLHMSLGSSPIqprpghtTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDG 281
Cdd:pfam00054    1 FRTTEPSGLLLYnGTQTERDFLALELRDGRLEVSYDLGSGAA-------VVRSGDKLNDGKWHSVELERNGRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 508772601   282 yVQRFILN---GDFERLNLDTEMFIGGL--VGAARKNLAYRHNFRGCIENVIFNRVNI 334
Cdd:pfam00054   74 -EARPTGEsplGATTDLDVDGPLYVGGLpsLGVKKRRLAISPSFDGCIRDVIVNGKPL 130
Laminin_G_1 pfam00054
Laminin G domain;
389-518 3.01e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 65.03  E-value: 3.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   389 FRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGyRLNDGFWHEVNFVAQENHAVISIDDveGAEV 468
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTLSVDG--EARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 508772601   469 RVSYPL----LIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVN 518
Cdd:pfam00054   78 TGESPLgattDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1088-1218 3.88e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 3.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601  1088 FSTSSAPAVLLYVSSFV-RDYMAVLIKDdGTLQLRYQLGTSPyVYQLTTRPVTDGQPHSVNITRVYRNLFIQVD--YFPL 1164
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELRD-GRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVDgeARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 508772601  1165 TEQKFSllVDSQLDSPKALYLGRvMETGVIDPEIQRyNTPGFSGCLSGVRFNNV 1218
Cdd:pfam00054   79 GESPLG--ATTDLDVDGPLYVGG-LPSLGVKKRRLA-ISPSFDGCIRDVIVNGK 128
Laminin_G_1 pfam00054
Laminin G domain;
813-942 1.56e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.41  E-value: 1.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508772601   813 FRTSAPSGVFLENMGGPycqwRRPYVRVELNTSRdVVFAFDVGNGDEnLTVHSDdfEFNDDEWHLVRAEINVKQARLRVD 892
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQT----ERDFLALELRDGR-LEVSYDLGSGAA-VVRSGD--KLNDGKWHSVELERNGRSGTLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 508772601   893 HRPWVLRPMPLQTYIWMEYDQPLYVGSA----ELKRR-----PFVGCLRAMRLNGVTLN 942
Cdd:pfam00054   73 GEARPTGESPLGATTDLDVDGPLYVGGLpslgVKKRRlaispSFDGCIRDVIVNGKPLD 131
4.1m smart00294
putative band 4.1 homologues' binding motif;
1304-1322 2.31e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.13  E-value: 2.31e-05
                            10
                    ....*....|....*....
gi 508772601   1304 FYLQNHRYKGSYHTNEPKA 1322
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 584-616 1.60e-04

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 40.62  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 508772601  584 SCEAYRLSGKT--SGNFTIDPDGSGPLKPFVVYCD 616
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCD 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 544-575 4.69e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 4.69e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 508772601   544 CSPNMCEHDGRCYQSWDDFICYCElTGYKGET 575
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 584-658 5.17e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.00  E-value: 5.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 508772601  584 SC-EAYRLSGKTSGNFTIDPDGSgpLKPFVVYCDIR-ENRAWTVVRHdrlwttRVTGSsmerpflgaiQYWNASWEE 658
Cdd:cd00087     5 DCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDtDGGGWTVIQR------RGDGS----------VDFYRSWKE 63
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
581-625 3.78e-03

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 40.58  E-value: 3.78e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 508772601   581 YKESCEAYRLSGKTSGNFTIDPDGSGplKPFVVYCDIR-ENRAWTV 625
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGAT--KPFEVYCDMEtDGGGWTV 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 542-576 5.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 508772601  542 DRC-SPNMCEHDGRCYQSWDDFICYCeLTGYKGETC 576
Cdd:cd00054     3 DECaSGNPCQNGGTCVNTVGSYRCSC-PPGYTGRNC 37
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 580-639 7.95e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 39.18  E-value: 7.95e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 508772601    580 LYKESCEAYRLSGKTSGNFTIDPDGSGplKPFVVYCDIRENR-AWTVVRHdrlwttRVTGS 639
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGgGWTVIQR------RMDGS 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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