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Conserved domains on  [gi|453232546|ref|NP_001263882|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

G-protein coupled receptor( domain architecture ID 11606548)

G-protein coupled receptor (GPCR) transmits physiological signals from the outside of the cell to the inside by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
54-336 9.71e-68

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


:

Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 219.43  E-value: 9.71e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFLYTRKRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIP--ELTQAPYTTVYTLP 131
Cdd:cd14978    3 YGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsfLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 132 FGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITkEQVIEICP 211
Cdd:cd14978   83 LANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNN-NSYYYVIP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 212 TSLFV--TINSVYNIYMYMVLMTLLPFFFLLCINAIIVK---------RQSKAKTDESAPKNEGTSDDTITMIMVVILFL 280
Cdd:cd14978  162 TLLRQneTYLLKYYFWLYAIFVVLLPFILLLILNILLIRalrkskkrrRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 453232546 281 ACNTLALVVNFIENFTEPS--PVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14978  242 ICNLPAGILNILEAIFGESflSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
54-336 9.71e-68

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 219.43  E-value: 9.71e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFLYTRKRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIP--ELTQAPYTTVYTLP 131
Cdd:cd14978    3 YGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsfLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 132 FGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITkEQVIEICP 211
Cdd:cd14978   83 LANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNN-NSYYYVIP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 212 TSLFV--TINSVYNIYMYMVLMTLLPFFFLLCINAIIVK---------RQSKAKTDESAPKNEGTSDDTITMIMVVILFL 280
Cdd:cd14978  162 TLLRQneTYLLKYYFWLYAIFVVLLPFILLLILNILLIRalrkskkrrRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 453232546 281 ACNTLALVVNFIENFTEPS--PVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14978  242 ICNLPAGILNILEAIFGESflSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
70-325 1.20e-14

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 73.87  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546   70 IINVFLYTRKrLQNSANTYLLFLACSDFMVIVTGLFiFWIDSARSYIPELTQAPYTTVYTLpFGYMAQTCSIYFTVAAAV 149
Cdd:pfam00001   5 VILVILRNKK-LRTPTNIFLLNLAVADLLFSLLTLP-FWLVYYLNHGDWPFGSALCKIVGA-LFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  150 DCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLRKcfNDITKEQVIEICptsLFVTINSVYNIYMYMV 229
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALL---LSLPPLLFGW--TLTVPEGNVTVC---FIDFPEDLSKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  230 LMTLLPFFFLLCINA-----IIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLACNTLALVVNFIENFTEPSPV--L 302
Cdd:pfam00001 154 LISVLGFLLPLLVILvcytlIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsrL 233
                         250       260
                  ....*....|....*....|...
gi 453232546  303 LNFLSDTSNFLVVFNSSVNCIIY 325
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
54-336 9.71e-68

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 219.43  E-value: 9.71e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFLYTRKRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIP--ELTQAPYTTVYTLP 131
Cdd:cd14978    3 YGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsfLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 132 FGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITkEQVIEICP 211
Cdd:cd14978   83 LANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNN-NSYYYVIP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 212 TSLFV--TINSVYNIYMYMVLMTLLPFFFLLCINAIIVK---------RQSKAKTDESAPKNEGTSDDTITMIMVVILFL 280
Cdd:cd14978  162 TLLRQneTYLLKYYFWLYAIFVVLLPFILLLILNILLIRalrkskkrrRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 453232546 281 ACNTLALVVNFIENFTEPS--PVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14978  242 ICNLPAGILNILEAIFGESflSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
54-329 3.60e-25

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 104.68  E-value: 3.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVF-LYTRKRLQNSANTYLLFLACSDFMVivtGLFIFWIDSARSYIPELTQAPYTTVYTLPF 132
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILvILRNRRLRTVTNYFILNLAVADLLV---GLLVIPFSLVSLLLGRWWFGDALCKLLGFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 133 GYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFpqfnlrkCFNDITKEQVIEICPT 212
Cdd:cd00637   78 QSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPL-------LGWGVYDYGGYCCCCL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 213 SLFVTINSVYNIYMYMVLMTLLPFFFLLCINAIIVK--RQSKAKTDESAPKNEGTSDD------TITMIMVVILFLACNT 284
Cdd:cd00637  151 CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRklRRHRRRIRSSSSNSSRRRRRrrerkvTKTLLIVVVVFLLCWL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 453232546 285 LALVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFN 329
Cdd:cd00637  231 PYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
70-325 1.20e-14

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 73.87  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546   70 IINVFLYTRKrLQNSANTYLLFLACSDFMVIVTGLFiFWIDSARSYIPELTQAPYTTVYTLpFGYMAQTCSIYFTVAAAV 149
Cdd:pfam00001   5 VILVILRNKK-LRTPTNIFLLNLAVADLLFSLLTLP-FWLVYYLNHGDWPFGSALCKIVGA-LFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  150 DCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLRKcfNDITKEQVIEICptsLFVTINSVYNIYMYMV 229
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALL---LSLPPLLFGW--TLTVPEGNVTVC---FIDFPEDLSKPVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  230 LMTLLPFFFLLCINA-----IIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLACNTLALVVNFIENFTEPSPV--L 302
Cdd:pfam00001 154 LISVLGFLLPLLVILvcytlIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsrL 233
                         250       260
                  ....*....|....*....|...
gi 453232546  303 LNFLSDTSNFLVVFNSSVNCIIY 325
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
53-336 1.51e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 70.67  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  53 TIILALPVLSVFGVLTNIInVFL--YTRKRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIPeltQAPYTTVYTL 130
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLL-VILavYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWP---FGPVLCRFWI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 131 PFGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKqICISIV-VVSIMYNSLRFPQFNLrkcfnditkEQVIEI 209
Cdd:cd14967   77 ALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRAL-IMIAAVwVYSLLISLPPLVGWRD---------ETQPSV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 210 CPTSLFVTINSVYNIYMYMVLMtLLPFFFLLCINAII---VKRQSKAktdesapknegtsddTITMIMVVILFLACNTLA 286
Cdd:cd14967  147 VDCECEFTPNKIYVLVSSVISF-FIPLLIMIVLYARIfrvARRELKA---------------AKTLAIIVGAFLLCWLPF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 453232546 287 LVVNFIENFTEPSPVLlNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14967  211 FIIYLVSAFCPPDCVP-PILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
54-336 1.11e-10

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 62.29  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFLYTR-KRLQNSANTYLLFLACSDFMVIVTGLfIFWIDSARSYIPELTQAPYTTVYTLpf 132
Cdd:cd15001    2 VIIVYVITFVLGLIGNSLVIFVVARfRRMRSVTNVFLASLATADLLLLVFCV-PLKTAEYFSPTWSLGAFLCKAVAYL-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 133 GYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNS-LRFPQFNLRkcfNDITKEQVIEICP 211
Cdd:cd15001   79 QLLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASpVLFGQGLVR---YESENGVTVYHCQ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 212 TSLfvtINSVYNIYmYMVLMTLLPFFFLLCINAIIVKRQSKAKtdesapknegtsddTITM-IMVVILFLACNTLALVVN 290
Cdd:cd15001  156 KAW---PSTLYSRL-YVVYLAIVIFFIPLIVMTFAYARDTRKQ--------------VIKMlISVVVLFAVCWGPLLIDN 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 453232546 291 FIENF---TEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15001  218 LLVSFdviSTLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
63-333 9.02e-10

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 59.70  E-value: 9.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  63 VFGVLTNIINVF-LYTRKRLQNSANTYLLFLACSDFMVIVTglFIFWIDsarsYIPELTQAPYTTVYTLPFGYMAQT--- 138
Cdd:cd14985   12 LVGLLGNLFVVWvFLFPRGPKRVADIFIANLAAADLVFVLT--LPLWAT----YTANQYDWPFGAFLCKVSSYVISVnmf 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 139 CSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLRKCF--NDITKEQVIEICP-TSLF 215
Cdd:cd14985   86 ASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACL---LSLPTFLLRSLQaiENLNKTACIMLYPhEAWH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 216 VTINSVYNIymymvLMTLLPFFFLLCINAIIvkRQSKAKTDESAPKNEGTSDDTITMIMVVIL-FLAC-------NTLAL 287
Cdd:cd14985  163 FGLSLELNI-----LGFVLPLLIILTCYFHI--ARSLRKRYERTGKNGRKRRKSLKIIFALVVaFLVCwlpfhffKFLDF 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 453232546 288 VVNF-IENFTEPSPVLLNFLSdTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd14985  236 LAQLgAIRPCFWELFLDLGLP-IATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
52-333 2.67e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 58.33  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  52 LTIILALPVLSVFGVLTNIINVFLYtrKRLQNSANTYLLFLACSDFMVivtGLFIFWIDSARS-----YIPELTQAPYTT 126
Cdd:cd15055    4 YIVLSSISLLTVLGNLLVIISISHF--KQLHTPTNLLLLSLAVADFLV---GLLVMPFSMIRSietcwYFGDTFCKLHSS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 127 vytlpFGYMAQTCSIYFTVAAAVDCFVNVCwakQAKHYC---TVRRAKqICISIV-VVSIMYNSLrfpqfnLRKCFNDIT 202
Cdd:cd15055   79 -----LDYILTSASIFNLVLIAIDRYVAVC---DPLLYPtkiTIRRVK-ICICLCwFVSALYSSV------LLYDNLNQP 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 203 KEQVIEICPTSLFVTINSVYNIyMYMVLMTLLPFFFLLCINA---IIVKRQSKA------------KTDESAPKNEGTSD 267
Cdd:cd15055  144 GLIRYNSCYGECVVVVNFIWGV-VDLVLTFILPCTVMIVLYMrifVVARSQARAirshtaqvslegSSKKVSKKSERKAA 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 453232546 268 DTITMIMVVilFLACNTLALVVNFIENFTEPSPVLLNFLSdtsnFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15055  223 KTLGIVVGV--FLLCWLPYYIVSLVDPYISTPSSVFDVLI----WLGYFNSCLNPLIYALFYPWFR 282
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
53-336 2.10e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 55.68  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  53 TIILALPVLSVFGVLTNIINVF-LYTRKRLQNSANTYLLFLACSDFMVIVTGLfifwidsarsyipeltqaPYTTVY--T 129
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAvVLRNKHMRTVTNYFLVNLAVADLLVSLFCM------------------PLTLLEnvY 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 130 LPFGYMAQTC-------------SIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRK 196
Cdd:cd14993   64 RPWVFGEVLCkavpylqgvsvsaSVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEE 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 197 CFNDITKEQVIEIC----PTSLFVTInsvYNIYMYmVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSDDTITM 272
Cdd:cd14993  144 IISSEPGTITIYICtedwPSPELRKA---YNVALF-VVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILR 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 273 ---------IMVVILFLACNTLALVVNFIENFTEPSPVLlnflsDTSNFLVVF---------NSSVNCIIYFIFNTDYRD 334
Cdd:cd14993  220 skkkvarmlIVVVVLFALSWLPYYVLSILLDFGPLSSEE-----SDENFLLILpfaqllgysNSAINPIIYCFMSKKFRR 294

                 ..
gi 453232546 335 VF 336
Cdd:cd14993  295 GF 296
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
54-329 5.08e-08

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 53.97  E-value: 5.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFLYTRKRLqnSANTYLLFLACSDFM-VIVTGLFIFWIdsARSYIPELTQAPYTTVYtlPF 132
Cdd:cd14964    4 ILSLLTCLGLLGNLLVLLSLVRLRKRPR--STRLLLASLAACDLLaSLVVLVLFFLL--GLTEASSRPQALCYLIY--LL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 133 GYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRfpqfnlrkcfndITKEQVIEICPT 212
Cdd:cd14964   78 WYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPP------------LVGKGAIPRYNT 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 213 SLFVTINSVYNIYMYMV---LMTLLPFFFLLCINAIIVKRQS-------KAKTDESAPKNEGTSDDTITMIMVVILFLAc 282
Cdd:cd14964  146 LTGSCYLICTTIYLTWGfllVSFLLPLVAFLVIFSRIVLRLRrrvrairSAASLNTDKNLKATKSLLILVITFLLCWLP- 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 453232546 283 ntlaLVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFN 329
Cdd:cd14964  225 ----FSIVFILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
63-336 6.28e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 54.28  E-value: 6.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  63 VFGVLTNIINVFLYTRKR-LQNSANTYLLFLACSDFMVIVTG----LFIFWidsarSYIPELTQAPYTTVYTLpfgyMAQ 137
Cdd:cd14979   12 VVGIVGNLLTCIVIARHKsLRTTTNYYLFSLAVSDLLILLVGlpveLYNFW-----WQYPWAFGDGGCKLYYF----LFE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 138 TC---SIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSI---MYNSLRFPQFNLRKCFNdiTKEQVIEIC- 210
Cdd:cd14979   83 ACtyaTVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSIlcaIPILFLMGIQYLNGPLP--GPVPDSAVCt 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 211 ---PTSLFVTINSVYNIYMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSD------DTITMI-MVVILFL 280
Cdd:cd14979  161 lvvDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELSLsqqarrQVVKMLgAVVIAFF 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 281 AC----NTLALVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14979  241 VCwlpfHAQRLMFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
60-326 3.03e-07

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 52.11  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNI--INVFLYTRKRLqNSANTYLLFLACSDfMVIVTGLfIFWIDSARSYipeltqapyttvYTLPFG---- 133
Cdd:cd15380    9 AICFFGLLGNLfvLFVFLLPRRRL-TIAEIYLANLAASD-LVFVLGL-PFWAENIRNQ------------FNWPFGnflc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 134 YMAQTC-------SIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLR--KCFNDITKE 204
Cdd:cd15380   74 RVISGVikanlfiSIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGL---LSIPTFLFRsvKHVPDLNIS 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 205 QVIEICPTSLFVTINSV-YNIYMYMVLMTLLpFFFLLCINAIIVKRQSKAKTDESAPKNEGTsddTITMIMVVILFLACN 283
Cdd:cd15380  151 ACILLFPHEAWHFARRVeLNIVGFLLPLAAI-VFFNFHIIASLRERTEESRKRCGGLKDTKA---TRLILTLVLMFLVCW 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 453232546 284 TLALVVNFIENFTEPSPV-------LLNFLSDTSNFLVVFNSSVNCIIYF 326
Cdd:cd15380  227 TPYHFFAFLDFLFQVEVIqgcfweeFIDLGLQLANFFAFANSCLNPVIYV 276
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
60-333 1.34e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 49.80  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNIINVFLYTRKR-LQNSANTYLLFLACSD---FMVIVTGLFIFWIDSARSYIPELTQApyttvyTLPFGYM 135
Cdd:cd15928    9 VLMLVGASGNLLTVLVIGRSRdMRTTTNLYLSSLAVSDlliFLVLPLDLYRLWRYRPWRFGDLLCRL------MYFFSET 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 136 AQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITKEQvIEICPTSLF 215
Cdd:cd15928   83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRG-FECTVVNVS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 216 VTINSVyniymyMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSD-------DTITMIMVVIL-FLACNTLAL 287
Cdd:cd15928  162 SGLLSV------MLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASrrdnnhrQTVRMLAVIVLaFVLCWLPFH 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 453232546 288 VVNFIENFTEPSPVLLNFLSDTSNFL--VVF--NSSVNCIIYFIFNTDYR 333
Cdd:cd15928  236 VGRVIFNHSRASTKHLHYVSQYFNLVsfVLFylSAAINPILYNLMSKRYR 285
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
51-336 1.62e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 49.65  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  51 YLTIILALPVLSVFGVLTNIINVFlyTRKRLQNSANTYLLFLACSDFMV--IVTGLFIFW-IDSARSYIPELTQAPYTTv 127
Cdd:cd15053    3 WALFLLLLPLLTVFGNVLVIMSVF--RERSLQTATNYFIVSLAVADLLVaiLVMPFAVYVeVNGGKWYLGPILCDIYIA- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 128 ytlpFGYMAQTCSIYFTVAAAVDCFVNVcwaKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFnlrkCFNDITKEQVI 207
Cdd:cd15053   80 ----MDVMCSTASIFNLCAISIDRYIAV---TQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLL----FGLNNVPYRDP 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 208 EICP--TSLFVTINSVYNIYMYMVLMTLLpffFLLCINAIivKRQSKAktdesapknegtsddTITMIMVVILFLACNTL 285
Cdd:cd15053  149 EECRfyNPDFIIYSSISSFYIPCIVMLLL---YYRIFRAL--RREKKA---------------TKTLAIVLGVFLFCWLP 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 453232546 286 ALVVNFIENFTEPSPVLLNFLSDTSNFLVVF----NSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15053  209 FFTLNILNAICPKLQNQSCHVGPALFSLTTWlgyvNSFLNPIIYTIFNIEFRKAF 263
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
60-285 2.01e-06

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 49.32  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTN--IINVFLYTRKRlQNSANTYLLFLACSDFMVIVTGLF-----------IFWIDSARSYIpeltqapytt 126
Cdd:cd15157    9 IIFVLGVVGNglSIYVFLQPSKK-KTSVNIFMLNLAVSDLMFVSTLPFradyylmgshwVFGDIACRIMS---------- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 127 vYTLpfgYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFpqFNLRKCFNDITKEQV 206
Cdd:cd15157   78 -YSL---YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLL--SKGTSKYNSQTKCLD 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 207 IEICPTSLFVTINSVyniymYMVLMTLLPFFFLLCINAIIVKRQSKAKTDES---APKNEGTSDDTITMIMVVILFLACN 283
Cdd:cd15157  152 LHPSKIDKLLILNYI-----VLVVGFILPFCTLSICYILIIKALLKPRVPQSklrVSHKKALLTIIITLILFLLCFLPYH 226

                 ..
gi 453232546 284 TL 285
Cdd:cd15157  227 IL 228
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
63-327 3.61e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 48.42  E-value: 3.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  63 VFGVLTNIIN-VFLYTRKRLQNSANTYLLFLACSDFMVIVTglFIFWID-SARSYIPELTQAPYTTVYTLPFGYMAqtCS 140
Cdd:cd14982   12 ILGLLGNILAlWVFLRKMKKRSPTTIYMINLALADLLFVLT--LPFRIYyYLNGGWWPFGDFLCRLTGLLFYINMY--GS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 141 IYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISI-------VVVSIMYNSLRFPQFNLRKCFNDItkeqvieicptS 213
Cdd:cd14982   88 ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVwilvlvaSVPLLLLRSTIAKENNSTTCFEFL-----------S 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 214 LFVTINSVYNIYMyMVLMTLLPFF-FLLCINAII--VKRQSKAKTDESAPKNegtsddTITMIMVVIL-FLAC-----NT 284
Cdd:cd14982  157 EWLASAAPIVLIA-LVVGFLIPLLiILVCYSLIIraLRRRSKQSQKSVRKRK------ALRMILIVLAvFLVCflpyhVT 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 453232546 285 LALVVNFIENFTEPSPVlLNFLSDTSNF---LVVFNSSVNCIIYFI 327
Cdd:cd14982  230 RILYLLVRLSFIADCSA-RNSLYKAYRItlcLASLNSCLDPLIYYF 274
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
52-336 4.08e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 48.70  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  52 LTIILALPVLSVFGVLTNIINVFLYTRKR-LQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYiPELTQAPYTTVYTL 130
Cdd:cd15357    1 LPMSLVYAVIFVVGVIGNLLVCLVILKHQnMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNY-PFLFGPVGCYFKTA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 131 PFGYMAqTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMY-------NSLRFPQFNLRKCFNDITK 203
Cdd:cd15357   80 LFETVC-FASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFsipntsiHGIKLQYFPNGTLIPDSAT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 204 EQVIEicPTSLFVTINSVYNIYMYMVLMTLLPFffLLCINAIIVKRQSKAKTDESAPKNEGTSDDTIT--MIMVVILFLA 281
Cdd:cd15357  159 CTVVK--PLWIYNLIIQITSLLFYVLPMGVISV--LYYLMGLKLRGDKSLEADEMNVNIQRPSRKSVTkmLFVLVLVFAI 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 453232546 282 C----NTLALVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15357  235 CwapfHVDRLFFSFVVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
54-336 6.35e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 48.12  E-value: 6.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNI-INVFLYTRKRLQNSANTYLLFLACSDFMV--------IVTGLFIFWIDSArsyipeltqaPY 124
Cdd:cd15065    2 IGIFLSLIIVLAIFGNVlVCLAIFTDRRLRKKSNLFIVSLAVADLLVallvmtfaVVNDLLGYWLFGE----------TF 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 125 TTVYtLPFGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFP-------QFNLRKC 197
Cdd:cd15065   72 CNIW-ISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHlgwhrlsQDEIKGL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 198 FNDITKEQVIEICPTSLFVTINSVYNIYMYMVLMTLLpFFFLLCI------NAIIVKRQS------KAKTDESAPKNEGT 265
Cdd:cd15065  151 NHASNPKPSCALDLNPTYAVVSSLISFYIPCLVMLLI-YSRLYLYarkhvvNIKSQKLPSesgskfQVPSLSSKHNNQGV 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 453232546 266 SDD----TITMIMVVilFLACNTLALVVNFIENFTEP--SPVLLNFLSdtsnFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15065  230 SDHkaavTLGIIMGV--FLICWLPFFIINIIAAFCKTciPPKCFKILT----WLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
63-336 9.05e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 47.28  E-value: 9.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  63 VFGVLTNII-NVFLYTRKRLQNSANTYLLFLACSDFMVIV----TGLFIFWIdsarsyiPELTQAPYTTVYTLPF--GYM 135
Cdd:cd14997   12 VVGVLGNVLvGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvcmpVALVETWA-------REPWLLGEFMCKLVPFveLTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 136 AQTcSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNS--LRFPQFNLRKCFNDitkeQVIEICPTS 213
Cdd:cd14997   85 AHA-SVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSpvLFITEFKEEDFNDG----TPVAVCRTP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 214 LFVTINSVYnIYMYMVLMTLLPFFFLLCINAIIVKR------QSKAKTDESAPKNEGTSDDTITM-IMVVILFLACNTLA 286
Cdd:cd14997  160 ADTFWKVAY-ILSTIVVFFVVPLAILSGLYSVICRRlvghpaLESRRADAANRHTLRSRRQVVYMlITVVVLFFVCLLPF 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 453232546 287 LVVNFIENFTePSPVLLNFLSDTSNFLVVF-------NSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14997  239 RVVTLWIIFA-PDEDLQALGLEGYLNLLVFcrvmvylNSALNPILYNLMSTKFRSAF 294
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
51-336 9.26e-06

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 47.23  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  51 YLTIILalpvLSVFGvltNIINVFLYTR-KRLQNSANTYLLFLACSDFMVivtGLFIFwidsarsyipeltqaPYTTVYT 129
Cdd:cd15207    7 YSLIFL----LCVVG---NVLVCLVVAKnPRMRTVTNYFILNLAVSDLLV---GVFCM---------------PFTLVDN 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 130 L----PFG-------YMAQTCSI---YFT-VAAAVDCFVNVCWAKQAKhyCTVRRAKQICISIVVVSIMYNSlrfPQ-FN 193
Cdd:cd15207   62 IltgwPFGdvmcklsPLVQGVSVaasVFTlVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMI---PQaLV 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 194 LRKCFNDITKEQVIEIC----PTSLFVTINSVyniyMYMVLMTLLPffflLCINAI--------IVKRQSKAKTDESAPK 261
Cdd:cd15207  137 LEVKEYQFFRGQTVHICvefwPSDEYRKAYTT----SLFVLCYVAP----LLIIAVlyvrigyrLWFKPVPGGGSASREA 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 262 NEGTSDDTIT----MIMVVILFlACNTLAL-VVNFIENFTEPSP----VLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDY 332
Cdd:cd15207  209 QAAVSKKKVRvikmLIVVVVLF-ALSWLPLhTVTMLDDFGNLSPnqreVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNF 287

                 ....
gi 453232546 333 RDVF 336
Cdd:cd15207  288 RKGF 291
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
56-282 9.79e-06

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 47.21  E-value: 9.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  56 LALPVLS----VFGVLTNIINVFLYT-RKRLQNSANTYLLFLACSDFMVIVTglFIFWIDSAR------SYIPELTQAPY 124
Cdd:cd14984    1 VFLPVLYslvfLLGLVGNSLVLLVLLyYRKLRSMTDVYLLNLALADLLFVLT--LPFWAVYAAdgwvfgSFLCKLVSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 125 TT-VYtlpfgymaqtCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLRKCFNDITK 203
Cdd:cd14984   79 TInFY----------SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALL---LSLPEFIFSQVSEENGS 145
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 453232546 204 EQVIEICPTSLFVTINSVYNIYMyMVLMTLLPFFFLLCINAIIVKRQSKAktdesapKNEGTSDDTITMIMVVILFLAC 282
Cdd:cd14984  146 SICSYDYPEDTATTWKTLLRLLQ-NILGFLLPLLVMLFCYSRIIRTLLRA-------RNHKKHRALRVIFAVVVVFFLC 216
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
60-282 1.25e-05

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 47.05  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNIINVFLYTRKRLQNSA-NTYLLFLACSDFMVIVTGLF--IFWIDSARSYIPEL-----TQAPYTTVYtlp 131
Cdd:cd15158    9 VITVFGLVGNGFALYVLIKTYRQKSAfHIYMLNLAVSDLLCVCTLPLrvVYYVHKGQWLFGDFlcrisSYALYVNLY--- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 132 fgymaqtCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNS------LRFPQFNLRKCFNDITKEQ 205
Cdd:cd15158   86 -------CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSpflmsgSHDTETNKTKCFEPPQSNQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 206 VIeicpTSLFVtINsvyniYMYMVLMTLLPFF-FLLCINAII---VKRQSKAKtdesapKNEGTSDDTITMIMVVIL-FL 280
Cdd:cd15158  159 QL----TKLLV-LN-----YISLVVGFIIPFLvILICYAMIIrtlLKNTMKAR------KQQSSRKKAIRMIIIVLLaFL 222

                 ..
gi 453232546 281 AC 282
Cdd:cd15158  223 VS 224
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
63-336 3.56e-05

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 45.49  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  63 VFGVLTN--IINVFLYTRK-RLQNSANTYLLFLACSDFMVIvtglfIFWIdsarsyipeltqaPY-TTVYTLP------- 131
Cdd:cd15098   12 CLGVLGNslVITVLARVKPgKRRSTTNVFILNLSIADLFFL-----LFCV-------------PFqATIYSLPewvfgaf 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 132 -------FGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSlrfPQFNLRKCFNDITKE 204
Cdd:cd15098   74 mckfvhyFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMAS---PVAVHQDLVHHWTAS 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 205 QVIEICPTSLFVTINSVYnIYMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLAC-- 282
Cdd:cd15098  151 NQTFCWENWPEKQQKPVY-VVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKSERSKKKTAQTVLVVVVVFGISwl 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 453232546 283 --NTLALVVNFIE-NFTEPSPVLLnflsDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15098  230 phHIIHLWVEFGDfPLTQASFVLR----ITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
59-336 4.26e-05

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 45.66  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546   59 PVLSVFGVLTNIINVFLYTRKRLQNSA-NTYLLFLACSDFMVIVTGLFIFWIDSARSYIPE--LTQAPYTTVYTL----P 131
Cdd:pfam10324   4 FILSFIGFIINIFHLIILTRKSMRTSSiNIIMIGIAICDIITMLLTIYNFIPEFIISYENSecIPPDSYLKVLLDwileS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  132 FGYMAQTCSIYFTVAAAVDCFVNV---------CWAKQAKHYCTVrrakqicISIVVVSIMYNSLRFPQFNLRK------ 196
Cdd:pfam10324  84 LQDYSRRCSTWLGVFMALIRTLVVknpmsnkiqKLSKPKFGLIII-------IIVFILSLPISIFYYFRYEIVEvggiwk 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  197 ----C--FNDITKEQVIEICPTSLFVTINS-VYNIYMYMVLMT-------LLPFFFLLCINAIivkRQSKAKTDESAPKN 262
Cdd:pfam10324 157 pppnCagFPPNYTETRYVLVVSELFTANDGlLLKIFLLIDGIFskiipciLLPILTILLIIEL---RKAKKSRKNLSSSS 233
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232546  263 EGTSDDTITMIMVV-ILFLACNTLALVVNFIENFTEPSPVLLNFLSDTSNF---LVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:pfam10324 234 KNKSDRTTKLVIFMtISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIfslLFTINSISHCFICFLMSSQYRKTA 311
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
55-336 7.42e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 44.27  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  55 ILALPVLSVFGVLTNIINVFLYT----RKRLQNSANTYLLFLACSDFMV--IVTGLfifwidsarSYIPELTQ----APY 124
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAaillERSLQGVSNYLILSLAVADLMVavLVMPL---------SAVYEVSQhwflGPE 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 125 TTVYTLPFGYMAQTCSIYFTVAAAVDCFvnvcWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITKE 204
Cdd:cd15331   72 VCDMWISMDVLCCTASILHLVAIALDRY----WAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLDRV 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 205 QVIEICPTS------LFVTINSVYniymymvlmtlLPFFFLLCINAII---VKRQSKAKTdesapknegtsddtiTMIMV 275
Cdd:cd15331  148 LKTGVCLISqdygytIFSTVGAFY-----------VPLLLMIIIYWKIyqaAKRERKAAR---------------TLAII 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 453232546 276 VILFLACNT----LALVVNFIENFTEPSPVLLNFLsdtsnFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15331  202 TGAFVVCWLpfflVALVMPFCGAWQISRFLESFFL-----WLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
63-333 1.67e-04

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 43.59  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  63 VFGVLTNI--INVFLYtRKRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIPelTQAPYTTVYTLPFgYMAQTCS 140
Cdd:cd15373   12 VVGLVLNIlaLYVFLF-RTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWP--FSEALCKIVRFLF-YTNLYCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 141 IYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITKEQVIEICPTSLFVTINS 220
Cdd:cd15373   88 ILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFVVYSS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 221 VyniymYMVLMTLLPFFFLLCINAIIVKRQSKAKTdeSAPKNEGTSDDTITMIMVVILFLACNTLALVVNFIENFTEPSP 300
Cdd:cd15373  168 V-----MLVLLFCVPFVVILVCYALMVRKLLKPSA--GTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRSM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 453232546 301 VL-------LNFLSDTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15373  241 DLscgtlnaINLAYKVTRPLASANSCLDPILYFLAGQSFR 280
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-333 2.01e-04

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 43.22  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNI--INVFLYTRKRLqNSANTYLLFLACSDFmvIVTGLFIFWIDSARSYIPELTQAPYTTVYTLPFgYMAQ 137
Cdd:cd15189    9 SLCLFGLLGNLfvLLVFLLHRRRL-TVAEIYLGNLAAADL--VFVSGLPFWAMNILNQFNWPFGELLCRVVNGVI-KVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 138 TCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLRKcFNDITKEQVIEiCPTSLFVT 217
Cdd:cd15189   85 YTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLL---LSIPTFLLRK-IKAIPDLNITA-CVLLYPHE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 218 INSVYNIYMYMVLMTLLPFFFLLCINAIIVkrQSKAKTDESAPKNEGT-SDDTITMIMVVILFLACNTLALVVNFIENFT 296
Cdd:cd15189  160 AWHFAHIVLLNIVGFLLPLLVITFCNYNIL--QALRTREESTRCEDRNdSKATALVLAVTLLFLVCWGPYHFFTFLDFLF 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 453232546 297 EPSPV-------LLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15189  238 DVGVLdecfwehFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
52-336 3.47e-04

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 42.29  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  52 LTIILALPVLSVFGVLTNIINVFLyTRKRLQNSANT-YLLFLACSDFMVIVTGLFIFwIDSARSYIPeltqapyttvytl 130
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWV-AGFKMKRTVNTvWFLNLALADFLFCLFLPFLI-VYIAMGHHW------------- 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 131 PFG-----------YMAQTCSIYFTVAAAVD-CFVNVC--WAKQakhYCTVRRAKQICISIVVVSIMynsLRFPQFNLRK 196
Cdd:cd14974   66 PFGsvlcklnsfviSLNMFASVFLLTAISLDrCLLVLHpvWAQN---HRTVRLASVVCVGIWILALV---LSVPYFVFRD 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 197 CFNDITKEQVIEICPTSLFVTINSVYNIY-MYMVLMTLLPF-FFLLCINAIIVKRQSKAKTDESAPKNegtsddtiTMIM 274
Cdd:cd14974  140 TVTHHNGRSCNLTCVEDYDLRRSRHKALTvIRFLCGFLLPLlIIAICYSVIAVKLRRKRLAKSSKPLR--------VLLA 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 453232546 275 VVILFLACNTLALVVNFIENFTEPSPVLLNFLSD-TSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14974  212 VVVAFFLCWLPYHVFALLELVAAAGLPEVVLLGLpLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
48-336 5.17e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 41.96  E-value: 5.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  48 WANYLTIILALpVLSVFGVLTNIINVFLYtrKRLQNSANTYLLFLACSDFMVivtGLFIFWIDSARS-----YIPELTQA 122
Cdd:cd15312    1 VAMYLFMAGAI-LLTVFGNLMVIISISHF--KQLHSPTNFLILSLAITDFLL---GFLVMPYSMVRSvescwYFGDLFCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 123 PYTTvytlpFGYMAQTCSIYFTVAAAVDCFVNVCwakQAKHYC---TVRRAKQ-ICISIVVVSIMYNSLRFPQFNLrkcf 198
Cdd:cd15312   75 IHSS-----LDMMLSTTSIFHLCFIAVDRYYAVC---DPLHYRtkiTTPVIKVfLVISWSVPCLFAFGVVFSEVNL---- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 199 nDITKEQVIEI-CPTSLFVTINSVYNiymymVLMTLLPFF----FLLCINA-----------IIVKRQSKAKTDE---SA 259
Cdd:cd15312  143 -EGIEDYVALVsCTGSCVLIFNKLWG-----VIASLIAFFipgtVMIGIYIkiffvarkhakVINNRPSVTKGDSknkLS 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 453232546 260 PKNEGTSDDTITMIMVVILF--LACNTLALVVNFIeNFTEPSPVLlnflsDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15312  217 KKKERKAAKTLSIVMGVFLLcwLPFFVATLIDPFL-NFSTPVDLF-----DALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
60-336 8.56e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 41.13  E-value: 8.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNIINVFLYTRK-RLQNSANTYLLFLACSDFMVIVTGLFIfwidsARSYIPEltqapyttvyTLPFG----- 133
Cdd:cd14970    9 VVCVVGLTGNSLVIYVILRYsKMKTVTNIYILNLAVADELFLLGLPFL-----ATSYLLG----------YWPFGevmck 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 134 ------YMAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYnSLRFPQFNLRKCFNDITKEQVI 207
Cdd:cd14970   74 ivlsvdAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVL-GLPVIIFARTLQEEGGTISCNL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 208 EI-CPTSLFVTINSVYNIymymVLMTLLPF-FFLLCINAIIVKRQSKAKTDESAPKNEGTSDDTIT--MIMVVILFLACN 283
Cdd:cd14970  153 QWpDPPDYWGRVFTIYTF----VLGFAVPLlVITVCYSLIIRRLRSSRNLSTSGAREKRRARRKVTrlVLVVVAVFVVCW 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 453232546 284 T---LALVVNFIENFTEPSPVLLNFLsdTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14970  229 LpfhVFQIVRLLIDPPETLTVVGVFL--FCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
55-336 1.54e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 40.39  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  55 ILALPVLSVFGVLTNIINVF----LYTRKRLQNSANTYLLFLACSDFMVIVTGLfifwidsarsyipeltqaPYTTVYTL 130
Cdd:cd15064    1 VLISVLLSLIILATILGNALviaaILLTRKLHTPANYLIASLAVADLLVAVLVM------------------PLSAVYEL 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 131 P----FGY-----------MAQTCSIYFTVAAAVDCFvnvcWA-KQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNL 194
Cdd:cd15064   63 TgrwiLGQvlcdiwisldvTCCTASILHLCVIALDRY----WAiTDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 195 RKcfnditKEQVIEicPTSLFVTINSVYNIYMymvlmTLLPFFFLLCINAIIVKRQSKAKTDE-SAPKNEGtsddtITMI 273
Cdd:cd15064  139 WR------TPDSED--PSECLISQDIGYTIFS-----TFGAFYIPLLLMLILYWKIYRAAARErKAAKTLG-----IILG 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 453232546 274 MVVILFLACNTLALVVNFIENFTEPSPVllnflSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15064  201 AFIVCWLPFFLVALIVPLCSHCWIPLAL-----KSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
53-336 1.56e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 40.45  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  53 TIILALPVLSVFGVLTNIINVFL-YTRKRLQNSANTYLLFLACSDFMVIVTglfifwidSARSYIPELTQAPYTTVY--- 128
Cdd:cd14995    2 VATFLVLLICGVGIVGNIMVVLVvLRTRHMRTPTNCYLVSLAVADLMVLVA--------AGLPNEIESLLGPDSWIYgya 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 129 ------TLPF-GYMAQTCSIyftVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKcfnDI 201
Cdd:cd14995   74 gcllitYLQYlGINASSLSI---TAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSI---KH 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 202 TKEQVIEICPtslFVTINSVYNIY--MYMVLMTLLPFFFLLCINAIIVKRQSKAKTDEsapknegtsddTITMIMVVILF 279
Cdd:cd14995  148 YGDDIVVRCG---YKVSRHYYLPIylADFVLFYVIPLLLAIVLYGLIGRILFSSRKQV-----------TKMLAVVVVLF 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 453232546 280 LAC----NTLALVVNFIEN-FTEPSPVLLnflsdtSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14995  214 ALLwmpyRTLVVYNSFASPpYLDLWFLLF------CRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
54-336 1.57e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 40.42  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFL-YTRKRLQNSANTYLLFLACSD-FMVIVTGLFIFWIDSARSYIPELTQAPYTTVYtlp 131
Cdd:cd15392    3 IILMYSTIFVLAVGGNGLVCYIvVSYPRMRTVTNYFIVNLALSDiLMAVFCVPFSFIALLILQYWPFGEFMCPVVNY--- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 132 FGYMAQTCSIYFTVAAAVDCFVNVCWAKQAKhyCTVRRAKQICISIVVVSIMYnSLRFPQFNlrKCFNDITKEQVIEICP 211
Cdd:cd15392   80 LQAVSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALAT-ALPIAITS--RLFEDSNASCGQYICT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 212 TSLFVTINSVYNIYMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNegtSDDTIT---------MIMVVILFLAC 282
Cdd:cd15392  155 ESWPSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENN---RDQRMAeskrklvkmMITVVAIFALC 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 453232546 283 ----NTLALVVNFIENFTEPSPvlLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15392  232 wlplNILNLVGDHDESIYSWPY--IPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
54-336 2.25e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 39.72  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  54 IILALPVLSVFGVLTNIINVFLYtrKRLQNSANTYLLFLACSDFMVivtGLFIFWIDSARSYIPELTQAPYTTVYTLPFG 133
Cdd:cd15060    6 LLSVIIAFTIVGNILVILSVFTY--RPLRIVQNFFIVSLAVADLAV---AIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 134 YMAQTCSIYFTVAAAVDCFvnvcWA-KQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQ-FNLRKCFNDITKEQVIEICP 211
Cdd:cd15060   81 ILCCTASILNLCAIALDRY----WAiHDPINYAQKRTLKRVLLMIVVVWALSALISVPPlIGWNDWPENFTETTPCTLTE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 212 TSLFVTINSVYNIYMYMVLMTLlpfffllcINAIIVKRQSKAKtdeSAPKNEGtsddtITMIMVVILFLACNTLALVVNF 291
Cdd:cd15060  157 EKGYVIYSSSGSFFIPLLIMTI--------VYVKIFIATSKER---RAARTLG-----IIMGVFVVCWLPFFLMYVILPF 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 453232546 292 IENfTEPSPVLLNFLSdtsnFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15060  221 CET-CSPSAKVVNFIT----WLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
60-333 2.85e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 39.76  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNIINVflYTRKRLQNSANTYLLFLACSDFMVIVTG-----LFIFWIDSARSYIpeltqapYTTVYTLPFGy 134
Cdd:cd15209   12 VVDVLGNLLVILSV--LRNKKLRNAGNIFVVSLSVADLVVAIYPyplilHAIFHNGWTLGQL-------HCQASGFIMG- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 135 MAQTCSIYFTVAAAVDCFVNVCwakQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRkcfndiTKEQVIEICPTSL 214
Cdd:cd15209   82 LSVIGSIFNITAIAINRYCYIC---HSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIG------SLQYDPRIYSCTF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 215 FVTINSVYNI---YMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLAC----NTLAL 287
Cdd:cd15209  153 AQTVSTVYTItvvVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVLFAVCwaplNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 453232546 288 VVNFieNFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15209  233 AVAI--NPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
58-329 3.59e-03

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 39.45  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  58 LPVL--SVF--GVLTNIINV-FLYTRKRLQNSANTYLLFLACSDFMVIVTglFIFWIDSarsyipELTQAPYTTVYTLPF 132
Cdd:cd15194    3 LPILycLVFlvGAVGNAILMgALVFKRGVRRLIDIFISNLAASDFIFLVT--LPLWVDK------EVVLGPWRSGSFLCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 133 G--YMAQT---CSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMynsLRFPQFNLRKCFNDITKEQVI 207
Cdd:cd15194   75 GssYIISVnmyCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCL---LGLPTLLSRELKKYEEKEYCN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 208 EICPTSLFVTINSVYNIYMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESAPKnegtSDDTITMIMVVILF--LACNT- 284
Cdd:cd15194  152 EDAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLRK----SIKIVFIVVAAFVFswMPFNLf 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 453232546 285 --LALVVNFIENFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFN 329
Cdd:cd15194  228 kaLAIASGLQVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFD 274
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
217-333 3.60e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 39.45  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 217 TINSVYNIYM----YMVLMTLLPFFFLLcINAIIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLAC----NTLALV 288
Cdd:cd15400  155 TASSSYTIAVvvihFIVPITVVSFCYLR-IWVLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVIFAICwaplNLIGLA 233
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 453232546 289 VNFieNFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15400  234 VAI--NPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
65-333 4.47e-03

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 39.00  E-value: 4.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  65 GVLTNIINVFL-YTRKRLQNSANTYLLFLACSDFMVIVT---GLFIFWIDSARSYIPELTQAPYTTVYtlpfgyMAQTCS 140
Cdd:cd15199   14 GLPGNAIALWTfIFRLKVWKPYAVYLLNLVLADVLLLIClpfKAYFYLNGNRWSLGGGTCKALLFMLS------LSRGVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 141 IYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQIC--ISIVVVSIMYNSLRFPQfnlrkcfnditkEQVIEICPTSLFVTI 218
Cdd:cd15199   88 IAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISflVWLLLVGLTIPTLLASQ------------PKNFTECNSFSPKDD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 219 NSVYNIYMYMVLMT--LLPFFFLLCINAIIVKRQSKAKTDESAPKNEGTSDDTITMIMVV--ILFLACnTLALVVNFIEN 294
Cdd:cd15199  156 EDFSDTWQEAVFFLqfLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQRAMALVTSVVVVfgFCFLPC-FLARVLMLIFQ 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 453232546 295 FTEpSPVLLNF---LSDTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15199  235 NKE-SCNALNIavhTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
52-336 4.89e-03

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 38.73  E-value: 4.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  52 LTIILAlpVLSVFGVLTNIINVFLYTRKR-LQNSANTYLLFLACSDFMVIVTGLFIFWIDSAR---SYIPELTQAPYTTV 127
Cdd:cd14969    3 LAVYLS--LIGVLGVVLNGLVIIVFLKKKkLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSgrwSFGDPGCVIYGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 128 YTLPFgymaqtCSIYFTVAAAVDCFVNVCWAKQAKHYCTvRRAKQICISIVVVSIMYNSlrFPQFNlrkcFNDITKEQVI 207
Cdd:cd14969   81 TFLGL------VSISTLAALAFERYLVIVRPLKAFRLSK-RRALILIAFIWLYGLFWAL--PPLFG----WSSYVPEGGG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 208 EIC-PTSLFVTINSVYNIYMYMVLMTLLPF----FFLLCINAIIVKRQSKAKTDESAPKNEGT----SDDTITMIMVVIL 278
Cdd:cd14969  148 TSCsVDWYSKDPNSLSYIVSLFVFCFFLPLaiiiFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaeKKVAKMVLVMIVA 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 453232546 279 FLACNTLALVVNFIENFTEPSPVLLNFLSDTSNFL---VVFNSsvncIIYFIFNTDYRDVF 336
Cdd:cd14969  228 FLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAkssTIYNP----IIYVFMNKQFRRAL 284
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
55-336 6.96e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 38.45  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  55 ILALPVLSVFGVLTNI-INVFLYTRKRLQNSANTYLLFLACSDFMVivtGLFIFWIdsarSYIPELtqapYTTVYTLPFG 133
Cdd:cd15052    4 ALLLLLLVIATIGGNIlVCLAISLEKRLQNVTNYFLMSLAIADLLV---GLLVMPL----SILTEL----FGGVWPLPLV 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 134 YMA--QTCSIYFTVAAAVdcfvnvcwakqakHYCTVRRAKQICISivvvsimyNSLRFPQFNLR-KCFNDITKEQVIEIC 210
Cdd:cd15052   73 LCLlwVTLDVLFCTASIM-------------HLCTISLDRYMAIR--------YPLRTRRNKSRtTVFLKIAIVWLISIG 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 211 ------------PTSLFVTINSVYNIYMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDE-SAPKNEGTsddtitmimVVI 277
Cdd:cd15052  132 isspipvlgiidTTNVLNNGTCVLFNPNFVIYGSIVAFFIPLLIMVVTYALTIRLLSNEqKASKVLGI---------VFA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 278 LFLACNTLALVVNFIENF-TEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15052  203 VFVICWCPFFITNILTGLcEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
60-282 7.66e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 38.25  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  60 VLSVFGVLTNIINVFLYTRK-RLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIPELTQAPYTTVYTLpfgYMAQT 138
Cdd:cd15921    9 LIFILGLTGNSISVYVFLSQyRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVL---YVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 139 CSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLrfpqfnlrkcFNDITKEQVIEICPTSLFVTI 218
Cdd:cd15921   86 SSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSP----------LLFAKSKQHDEGSTRCLELAH 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 453232546 219 NSVYNI----YMYMVLMTLLPFFFLLCINAIIVKRQSKAKTDESapKNEGTSDDTITMIMVV-ILFLAC 282
Cdd:cd15921  156 DAVDKLllinYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALG--RTRPSRRKACALIIISlGIFLVC 222
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
52-333 8.24e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 37.95  E-value: 8.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  52 LTIILALPVLSVFGVLTNIINVFLYTR--KRLQNSANTYLLFLACSDFMVIVTGLFIFWIDSARSYIPELTQAPYTTVYT 129
Cdd:cd15919    1 FVPVIYYSLLLCLGLPANILTVIILSQlvARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNKQMPQVLDKIIEV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 130 LPFGymAQTCSIYFTVAAAVDCFVNVCWAKQAKHYCTVRRAKQICISIVVVSIMYNSLRFPQFNLRKCFNDITKEQVIEi 209
Cdd:cd15919   81 LEFS--SIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWIEDYTSTSMHHVL- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 210 cptslfvtinsvynIYMYMVLMTLLPFFFLLCINAIIVKRQSKaktdESAPKNEGTSDDTITMIMVVILFLACNTLALVV 289
Cdd:cd15919  158 --------------IWIHCFTVYLVPCSIFFVLNSIIVYKLRR----KSNFRLRGYSTGKTTAILFTITSIFAILWAPRI 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 453232546 290 NFIENFTEPSPV----LLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYR 333
Cdd:cd15919  220 IMILYHLYVSPInnswLVHIVSDIANMLALLNTAINFFLYCFISKRFR 267
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
217-336 9.12e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 37.97  E-value: 9.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 217 TINSVYNIYM----YMVLMTLLPFFFLLcINAIIVKRQSKAKTDESAPKNEGTSDDTITMIMVVILFLAC----NTLALV 288
Cdd:cd15401  155 TVSSSYTITVvvvhFIVPLSIVTFCYLR-IWVLVIQVKHRVRQDSKQKLKANDIRNFLTMFVVFVLFAVCwgplNFIGLA 233
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 453232546 289 VNFieNFTEPSPVLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd15401  234 VAI--NPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
55-336 9.81e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 38.13  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546  55 ILALPVLSVFGVLTN--IINVFLYTRKRlQNSANTYLLFLACSDFMVIVTGLF--IFWIDSARSYIPEL--TQAPYTTVY 128
Cdd:cd14986    4 VAVLGVLFVFTLVGNglVILVLRRKRKK-RSRVNIFILNLAIADLVVAFFTVLtqIIWEATGEWVAGDVlcRIVKYLQVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 129 TLpfgymaqTCSIYFTVAAAVD-CFVNVCWAKQAKHYCTVRRAkqicisIVVVSIMYNSLRFPQFNLrkcFNDITKEQVI 207
Cdd:cd14986   83 GL-------FASTYILVSMSLDrYQAIVKPMSSLKPRKRARLM------IVVAWVLSFLFSIPQLVI---FVERELGDGV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232546 208 EICpTSLFVTI--NSVYNIYMyMVLMTLLPFFFLLCINAIIVK---RQSKAKTDESAPKNEGTSDD-------------- 268
Cdd:cd14986  147 HQC-WSSFYTPwqRKVYITWL-ATYVFVIPLIILSYCYGRILRtiwIRSRQKTDRPIAPTAMSCRSvscvssrvslisra 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 453232546 269 ---TITMIMVVIL-FLACNTLALVVNFIENFTEPSPvLLNFLSDTSNFLVVFNSSVNCIIYFIFNTDYRDVF 336
Cdd:cd14986  225 kikTIKMTLVIILaFILCWTPYFIVQLLDVYAGMQQ-LENDAYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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