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Conserved domains on  [gi|453232216|ref|NP_001263783|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

serpentine receptor domain-containing protein( domain architecture ID 27798)

serpentine receptor domain-containing protein which belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srh super family cl11665
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-259 5.19e-76

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10327:

Pssm-ID: 416353  Cd Length: 303  Bit Score: 234.36  E-value: 5.19e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216    6 QILSLLADAQTTLLMQPVYILPIIGGYTNGLLWQVFRLSSHIQMAMFLLLLYLQVASIVCAIVTKYHVVSNIGKL-SDRS 84
Cdd:pfam10327  51 QISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKhVIPK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216   85 ILFWIFVIVYHGCAFVITGFFSVSCLARQEEENLIKTKFPNAISVF-TLENVAIYDLqvNKWMMITTILFAFMLTSSIVI 163
Cdd:pfam10327 131 WLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEYVKENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLI 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216  164 SFYFSVRLLKTLPSKRNTISARSFRGHQIAVTSLMAQATVPFlVLIIPIGTIVYLFVHVLPNAQEISNIMMAVYSFHASL 243
Cdd:pfam10327 209 LVYLTVDMFRMLKRLRKKISAQTYQKHRAALRSLIAQFATSP-VCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSV 287

                         250
                  ....*....|....*.
gi 453232216  244 STFVMIISTPQYRKMI 259
Cdd:pfam10327 288 NSIVLILTTPPYRKFL 303
 
Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 6-259 5.19e-76

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 234.36  E-value: 5.19e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216    6 QILSLLADAQTTLLMQPVYILPIIGGYTNGLLWQVFRLSSHIQMAMFLLLLYLQVASIVCAIVTKYHVVSNIGKL-SDRS 84
Cdd:pfam10327  51 QISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKhVIPK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216   85 ILFWIFVIVYHGCAFVITGFFSVSCLARQEEENLIKTKFPNAISVF-TLENVAIYDLqvNKWMMITTILFAFMLTSSIVI 163
Cdd:pfam10327 131 WLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEYVKENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLI 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216  164 SFYFSVRLLKTLPSKRNTISARSFRGHQIAVTSLMAQATVPFlVLIIPIGTIVYLFVHVLPNAQEISNIMMAVYSFHASL 243
Cdd:pfam10327 209 LVYLTVDMFRMLKRLRKKISAQTYQKHRAALRSLIAQFATSP-VCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSV 287

                         250
                  ....*....|....*.
gi 453232216  244 STFVMIISTPQYRKMI 259
Cdd:pfam10327 288 NSIVLILTTPPYRKFL 303
 
Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 6-259 5.19e-76

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 234.36  E-value: 5.19e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216    6 QILSLLADAQTTLLMQPVYILPIIGGYTNGLLWQVFRLSSHIQMAMFLLLLYLQVASIVCAIVTKYHVVSNIGKL-SDRS 84
Cdd:pfam10327  51 QISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKhVIPK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216   85 ILFWIFVIVYHGCAFVITGFFSVSCLARQEEENLIKTKFPNAISVF-TLENVAIYDLqvNKWMMITTILFAFMLTSSIVI 163
Cdd:pfam10327 131 WLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEYVKENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLI 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216  164 SFYFSVRLLKTLPSKRNTISARSFRGHQIAVTSLMAQATVPFlVLIIPIGTIVYLFVHVLPNAQEISNIMMAVYSFHASL 243
Cdd:pfam10327 209 LVYLTVDMFRMLKRLRKKISAQTYQKHRAALRSLIAQFATSP-VCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSV 287

                         250
                  ....*....|....*.
gi 453232216  244 STFVMIISTPQYRKMI 259
Cdd:pfam10327 288 NSIVLILTTPPYRKFL 303
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 17-264 9.19e-19

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 84.13  E-value: 9.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216   17 TLLMQPVYILPIIGGYTNGLLwQVFRLSSHIQMAMFLLLLYLQVASIVCAIVTKYHVVSNIGKLSDRSILFWIFVIVYH- 95
Cdd:pfam10318  58 SFLTIPYIFLPALAGYPLGLL-SYLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYi 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216   96 -GCAFVITGFFSVsclARQEEE-NLIKTKFPNAIS-VFTLENVAIYDLQvNKWMMITTILFAFMLTSSIVISFYFSVRLL 172
Cdd:pfam10318 137 iALLFLIPIYLNI---PDQEAAkLKVLKKLPCLPPeFFDNPPVFVLAID-STYFLICIVLLILILIIQILFFVFLTIYYL 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216  173 ktLPSKRNTISARSFRGHQIAVTSLMAQATVPFLVLIIPIGTIVYLFVHVLPNaQEISNIMMAVYSFHASLSTFVMIIST 252
Cdd:pfam10318 213 --FKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVH 289

                         250
                  ....*....|..
gi 453232216  253 PQYRKMIRRGFR 264
Cdd:pfam10318 290 KPYRKFVLSLFK 301
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 147-260 9.18e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 40.13  E-value: 9.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232216  147 MITTILFAFMLTSSIVISFYFSVRLLKTLPSKRNTISARSFRGHQIAVTSLMAQATVPFLVLIIPIGTIVYL-FVHVlpN 225
Cdd:pfam10326 195 LIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLpLFNI--E 272

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 453232216  226 AQEISNIMMAVYSFHASLSTFVMIISTPQYRKMIR 260
Cdd:pfam10326 273 IGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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