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Conserved domains on  [gi|442620860|ref|NP_001262909|]
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crumbs, isoform D [Drosophila melanogaster]

Protein Classification

neurexin-3; calcium-binding EGF-like domain-containing protein( domain architecture ID 11363242)

neurexin-3 is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion, and may also mediate intracellular signaling| calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1105-1240 1.30e-36

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1105 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1184
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 442620860  1185 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1240
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1338-1500 2.72e-25

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1338 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1417
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1418 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1493
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 442620860  1494 VSNGSLN 1500
Cdd:pfam00054  125 VNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1642-1778 1.92e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1642 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1719
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442620860  1720 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1778
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 959-995 9.03e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.03e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860  959 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 995
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.12e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442620860  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1851-1887 2.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.45e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860 1851 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1887
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2007-2044 2.52e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.52e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860 2007 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2044
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 780-815 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  780 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 815
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 857-893 1.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860  857 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 893
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1889-1924 2.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860 1889 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1924
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-855 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.68e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860  818 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 855
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 2.79e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1543-1572 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 442620860 1543 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1572
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-778 2.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442620860  728 DVDECLSF-PCLNGATCHNklfffkfgkhrilrQINAYECVCQPGYEGENCE 778
Cdd:cd00054     1 DIDECASGnPCQNGGTCVN--------------TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 689-725 3.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  689 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 725
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 997-1032 1.32e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  997 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1032
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 652-686 1.61e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442620860  652 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 686
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 6.38e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.38e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2046-2083 7.09e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860 2046 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2083
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1266-1296 1.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860  1266 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1296
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2087-2125 3.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860 2087 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2125
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 4.98e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.98e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442620860  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1973-2002 8.72e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.72e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860  1973 CEITPCDNGGLCLTTGAVPMCKCSLGYTGR 2002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1105-1240 1.30e-36

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1105 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1184
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 442620860  1185 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1240
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1338-1500 2.72e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1338 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1417
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1418 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1493
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 442620860  1494 VSNGSLN 1500
Cdd:pfam00054  125 VNGKPLD 131
LamG smart00282
Laminin G domain;
1100-1237 4.87e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.87e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1100 DINLQFRTTLPNGVLAFGTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVFIGS-KLNDSNWHKVFVAINTSHLVLSAN 1178
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLA--LELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442620860   1179 DE--QAIFPVGSYETANnsqpSFPRTYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVNGK 1237
Cdd:smart00282   79 GGnrVSGESPGGLTILN----LDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1086-1235 7.86e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 7.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1086 TSLISVTTEREEG--YDINLQFRTTLPNGVLAFGTTGEKNEpvSYILELINGRLNLHSSLLnkWEGVFIGSK--LNDSNW 1161
Cdd:cd00110     7 SSYVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGD--FLALELEDGRLVLRYDLG--SGSLVLSSKtpLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442620860 1162 HKVFVAINTSHLVLSANDEQAI-FPVGSYETANNSQPSFprtYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVN 1235
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPL---YLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1333-1496 8.06e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.14  E-value: 8.06e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1333 DISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTL 1412
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG--------GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRS 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1413 VQVKLNGTE--YFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPgiipvpgagipiedttvpkeaddsrdyFKGIIQ 1490
Cdd:smart00282   73 VTLSVDGGNrvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPG---------------------------FRGCIR 125


                    ....*.
gi 442620860   1491 DVKVSN 1496
Cdd:smart00282  126 NLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1326-1494 1.16e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1326 RAIRSILDISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGEllVKMQFSGTPEAYTVG-GQKLDNGYNHLI 1404
Cdd:cd00110    16 PAPRTRLSISFSFRTTSPNGLLLYAGSQN--------GGDFLALELEDGR--LVLRYDLGSGSLVLSsKTPLNDGQWHSV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1405 EVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGPAPTRESLLGATtepgiipvpgagipiedttvpkeaddsR 1482
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV---------------------------S 138

                         170
                  ....*....|..
gi 442620860 1483 DYFKGIIQDVKV 1494
Cdd:cd00110   139 PGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1642-1778 1.92e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1642 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1719
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442620860  1720 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1778
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 959-995 9.03e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.03e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860  959 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 995
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.12e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442620860  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1851-1887 2.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.45e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860 1851 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1887
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2007-2044 2.52e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.52e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860 2007 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2044
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG smart00282
Laminin G domain;
1638-1776 3.71e-07

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 51.19  E-value: 3.71e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1638 IDIAFRTRAG-GTLLYIDNVDG--FFEIGVNGGRVTITWKLSALHFGESARFEKENtDGEWSRIYLRAHNSKLeggwkgw 1714
Cdd:smart00282    2 ISFSFRTTSPnGLLLYAGSKGGgdYLALELRDGRLVLRYDLGSGPARLTSDPTPLN-DGQWHRVAVERNGRSV------- 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442620860   1715 eSM-VDPTPAFSTDIDQAAfqSLIATSTQVYLGGMPESRQARGSTLSaqqgSQFKGCVGEARV 1776
Cdd:smart00282   74 -TLsVDGGNRVSGESPGGL--TILNLDGPLYLGGLPEDLKLPPLPVT----PGFRGCIRNLKV 129
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 780-815 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  780 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 815
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1638-1776 1.16e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 50.11  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1638 IDIAFRTR-AGGTLLYIDN--VDGFFEIGVNGGRVTITWKLSAlhfgESARFEKENT--DGEWSRIYLRAHNSKLeggwk 1712
Cdd:cd00110    24 ISFSFRTTsPNGLLLYAGSqnGGDFLALELEDGRLVLRYDLGS----GSLVLSSKTPlnDGQWHSVSVERNGRSV----- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442620860 1713 gweSM-VDPTPAFstDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAqqgsQFKGCVGEARV 1776
Cdd:cd00110    95 ---TLsVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP----GFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 857-893 1.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860  857 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 893
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1889-1924 2.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860 1889 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1924
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-855 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.68e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860  818 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 855
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 2.79e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2007-2044 3.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   2007 DINECES-NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE 2044
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
959-995 3.15e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.15e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    959 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFE-GTHCE 995
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1543-1572 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 442620860 1543 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1572
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1540-1570 7.70e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 7.70e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860  1540 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKN 1570
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1851-1887 9.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.28e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   1851 DIDECL-NTECLNNGTCINQVAAFFCQCQPGFE-GQHCE 1887
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
780-816 1.50e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    780 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMT-GRICD 816
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-778 2.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442620860  728 DVDECLSF-PCLNGATCHNklfffkfgkhrilrQINAYECVCQPGYEGENCE 778
Cdd:cd00054     1 DIDECASGnPCQNGGTCVN--------------TVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-855 2.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    818 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE 855
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1889-1925 2.70e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.70e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   1889 NIDECA-DQPCHNGGNCTDLIASYVCDCPEDYM-GPQCD 1925
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 689-725 3.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  689 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 725
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
857-893 4.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    857 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYK-GKNCE 893
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-455 5.43e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.43e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 442620860    425 NVDEC-DKNPCLNGGRCFDTYGWYTCQCLDGW 455
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 997-1032 1.32e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  997 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1032
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
386-423 1.33e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.33e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    386 DTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 652-686 1.61e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442620860  652 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 686
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-778 3.69e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.69e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 442620860    728 DVDECLSF-PCLNGATCHNKlfffkfgkhrilrqINAYECVCQPGYE-GENCE 778
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNT--------------VGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 429-458 4.26e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860   429 CDKNPCLNGGRCFDTYGWYTCQCLDGWGGE 458
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 963-991 5.56e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.56e-04
                           10        20
                   ....*....|....*....|....*....
gi 442620860   963 CDSNPCSKHGNCNDGIGTYTCECEPGFEG 991
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 6.38e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.38e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 861-891 6.44e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.44e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860   861 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 891
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2046-2083 7.09e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860 2046 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2083
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2046-2083 1.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   2046 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPY-CGAYC 2083
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1542-1572 1.07e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.07e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 442620860   1542 KNPCLHNAECRNTWNDYTCKCPNGYK-GKNCQ 1572
Cdd:smart00179    8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1266-1296 1.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860  1266 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1296
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-498 1.93e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.93e-03
                          10        20
                  ....*....|....*....|....*...
gi 442620860  471 CLNGGTCLDKPIGFQCLCPPEYTGELCQ 498
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
689-726 2.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 442620860    689 DVDECTLHPkICGNG-ICKNEKGSYKCYCTPGFT-GVHCD 726
Cdd:smart00179    1 DIDECASGN-PCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 654-685 2.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 442620860   654 CATQPCQNGGECVDLPnGDYECKCTRGWTGRT 685
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
997-1032 3.62e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.62e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 442620860    997 NIDECDRYNPCQRG-TCYDQIDDYDCDCDANY-GGKNC 1032
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2087-2125 3.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860 2087 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2125
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
689-719 3.79e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 442620860   689 DVDECTLHPKIC-GNGICKNEKGSYKCYCTPG 719
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2011-2042 4.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.17e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 442620860  2011 CESNPCQNGGQCKDLVGRYECDCQgTGFEGIR 2042
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 4.98e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.98e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442620860  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1268-1298 7.17e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.17e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442620860 1268 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1298
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
652-686 8.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.44e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 442620860    652 NQCAT-QPCQNGGECVDLPNGdYECKCTRGWT-GRTC 686
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGS-YRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1973-2002 8.72e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.72e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860  1973 CEITPCDNGGLCLTTGAVPMCKCSLGYTGR 2002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1105-1240 1.30e-36

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1105 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1184
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 442620860  1185 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1240
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1338-1500 2.72e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.72e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1338 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1417
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1418 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1493
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 442620860  1494 VSNGSLN 1500
Cdd:pfam00054  125 VNGKPLD 131
LamG smart00282
Laminin G domain;
1100-1237 4.87e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.87e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1100 DINLQFRTTLPNGVLAFGTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVFIGS-KLNDSNWHKVFVAINTSHLVLSAN 1178
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLA--LELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442620860   1179 DE--QAIFPVGSYETANnsqpSFPRTYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVNGK 1237
Cdd:smart00282   79 GGnrVSGESPGGLTILN----LDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1086-1235 7.86e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 7.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1086 TSLISVTTEREEG--YDINLQFRTTLPNGVLAFGTTGEKNEpvSYILELINGRLNLHSSLLnkWEGVFIGSK--LNDSNW 1161
Cdd:cd00110     7 SSYVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGD--FLALELEDGRLVLRYDLG--SGSLVLSSKtpLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442620860 1162 HKVFVAINTSHLVLSANDEQAI-FPVGSYETANNSQPSFprtYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVN 1235
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPL---YLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1105-1237 3.56e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.69  E-value: 3.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1105 FRTTLPNGVLAFgTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVF-IGSKLNDSNWHKVFVAINTSHLVLSANDEQAI 1183
Cdd:pfam02210    1 FRTRQPNGLLLY-AGGGGSDFLA--LELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 442620860  1184 FPVGSYETANNSQPSfpRTYLGGTIPNLksyLRHLTHQPSAFVGCMQDIMVNGK 1237
Cdd:pfam02210   78 SSLPPGESLLLNLNG--PLYLGGLPPLL---LLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1333-1496 8.06e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.14  E-value: 8.06e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1333 DISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTL 1412
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG--------GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRS 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1413 VQVKLNGTE--YFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPgiipvpgagipiedttvpkeaddsrdyFKGIIQ 1490
Cdd:smart00282   73 VTLSVDGGNrvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPG---------------------------FRGCIR 125


                    ....*.
gi 442620860   1491 DVKVSN 1496
Cdd:smart00282  126 NLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1326-1494 1.16e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1326 RAIRSILDISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGEllVKMQFSGTPEAYTVG-GQKLDNGYNHLI 1404
Cdd:cd00110    16 PAPRTRLSISFSFRTTSPNGLLLYAGSQN--------GGDFLALELEDGR--LVLRYDLGSGSLVLSsKTPLNDGQWHSV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1405 EVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGPAPTRESLLGATtepgiipvpgagipiedttvpkeaddsR 1482
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV---------------------------S 138

                         170
                  ....*....|..
gi 442620860 1483 DYFKGIIQDVKV 1494
Cdd:cd00110   139 PGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1642-1778 1.92e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1642 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1719
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442620860  1720 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1778
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 959-995 9.03e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.03e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860  959 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 995
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.12e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442620860  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1338-1496 1.23e-07

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 52.42  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1338 IRTREPTGQVFYLGtdprkaptkNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1417
Cdd:pfam02210    1 FRTRQPNGLLLYAG---------GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860  1418 NG--TEYFRKTLSTTGLLDAQVLYLGGPAPTResllgattepgiipvpgagipiedttvPKEADDSRDYFKGIIQDVKVS 1495
Cdd:pfam02210   72 DGqtVVSSLPPGESLLLNLNGPLYLGGLPPLL---------------------------LLPALPVRAGFVGCIRDVRVN 124


                   .
gi 442620860  1496 N 1496
Cdd:pfam02210  125 G 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1851-1887 2.45e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.45e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860 1851 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1887
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2007-2044 2.52e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.52e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860 2007 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2044
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG smart00282
Laminin G domain;
1638-1776 3.71e-07

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 51.19  E-value: 3.71e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860   1638 IDIAFRTRAG-GTLLYIDNVDG--FFEIGVNGGRVTITWKLSALHFGESARFEKENtDGEWSRIYLRAHNSKLeggwkgw 1714
Cdd:smart00282    2 ISFSFRTTSPnGLLLYAGSKGGgdYLALELRDGRLVLRYDLGSGPARLTSDPTPLN-DGQWHRVAVERNGRSV------- 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442620860   1715 eSM-VDPTPAFSTDIDQAAfqSLIATSTQVYLGGMPESRQARGSTLSaqqgSQFKGCVGEARV 1776
Cdd:smart00282   74 -TLsVDGGNRVSGESPGGL--TILNLDGPLYLGGLPEDLKLPPLPVT----PGFRGCIRNLKV 129
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 780-815 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  780 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 815
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1638-1776 1.16e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 50.11  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442620860 1638 IDIAFRTR-AGGTLLYIDN--VDGFFEIGVNGGRVTITWKLSAlhfgESARFEKENT--DGEWSRIYLRAHNSKLeggwk 1712
Cdd:cd00110    24 ISFSFRTTsPNGLLLYAGSqnGGDFLALELEDGRLVLRYDLGS----GSLVLSSKTPlnDGQWHSVSVERNGRSV----- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442620860 1713 gweSM-VDPTPAFstDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAqqgsQFKGCVGEARV 1776
Cdd:cd00110    95 ---TLsVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP----GFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 857-893 1.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860  857 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 893
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1889-1924 2.25e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860 1889 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1924
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-855 2.68e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.68e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860  818 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 855
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 2.79e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2007-2044 3.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   2007 DINECES-NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE 2044
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
959-995 3.15e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.15e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    959 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFE-GTHCE 995
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1543-1572 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 442620860 1543 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1572
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1540-1570 7.70e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 7.70e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860  1540 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKN 1570
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1851-1887 9.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.28e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   1851 DIDECL-NTECLNNGTCINQVAAFFCQCQPGFE-GQHCE 1887
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
780-816 1.50e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    780 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMT-GRICD 816
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-778 2.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.32e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442620860  728 DVDECLSF-PCLNGATCHNklfffkfgkhrilrQINAYECVCQPGYEGENCE 778
Cdd:cd00054     1 DIDECASGnPCQNGGTCVN--------------TVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-855 2.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    818 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE 855
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1889-1925 2.70e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.70e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   1889 NIDECA-DQPCHNGGNCTDLIASYVCDCPEDYM-GPQCD 1925
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 689-725 3.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  689 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 725
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
857-893 4.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    857 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYK-GKNCE 893
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-455 5.43e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.43e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 442620860    425 NVDEC-DKNPCLNGGRCFDTYGWYTCQCLDGW 455
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 997-1032 1.32e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442620860  997 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1032
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
386-423 1.33e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.33e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860    386 DTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 652-686 1.61e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442620860  652 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 686
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-778 3.69e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.69e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 442620860    728 DVDECLSF-PCLNGATCHNKlfffkfgkhrilrqINAYECVCQPGYE-GENCE 778
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNT--------------VGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 429-458 4.26e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860   429 CDKNPCLNGGRCFDTYGWYTCQCLDGWGGE 458
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 963-991 5.56e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.56e-04
                           10        20
                   ....*....|....*....|....*....
gi 442620860   963 CDSNPCSKHGNCNDGIGTYTCECEPGFEG 991
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 6.38e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.38e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 861-891 6.44e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.44e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860   861 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 891
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2046-2083 7.09e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442620860 2046 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2083
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2046-2083 1.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442620860   2046 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPY-CGAYC 2083
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1542-1572 1.07e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.07e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 442620860   1542 KNPCLHNAECRNTWNDYTCKCPNGYK-GKNCQ 1572
Cdd:smart00179    8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1266-1296 1.31e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860  1266 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1296
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-498 1.93e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.93e-03
                          10        20
                  ....*....|....*....|....*...
gi 442620860  471 CLNGGTCLDKPIGFQCLCPPEYTGELCQ 498
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
689-726 2.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 442620860    689 DVDECTLHPkICGNG-ICKNEKGSYKCYCTPGFT-GVHCD 726
Cdd:smart00179    1 DIDECASGN-PCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1543-1572 2.28e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.28e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442620860 1543 NPCLHNAECRNTWNDYTCKCPNGYKG-KNCQ 1572
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 654-685 2.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 442620860   654 CATQPCQNGGECVDLPnGDYECKCTRGWTGRT 685
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
997-1032 3.62e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.62e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 442620860    997 NIDECDRYNPCQRG-TCYDQIDDYDCDCDANY-GGKNC 1032
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2087-2125 3.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442620860 2087 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2125
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
689-719 3.79e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 442620860   689 DVDECTLHPKIC-GNGICKNEKGSYKCYCTPG 719
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442620860   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2011-2042 4.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.17e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 442620860  2011 CESNPCQNGGQCKDLVGRYECDCQgTGFEGIR 2042
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 4.98e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.98e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442620860  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 962-995 6.60e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442620860  962 ECD-SNPCSKHGNCNDGIGTYTCECEPGFEG-THCE 995
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1268-1298 7.17e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.17e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442620860 1268 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1298
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
652-686 8.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.44e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 442620860    652 NQCAT-QPCQNGGECVDLPNGdYECKCTRGWT-GRTC 686
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGS-YRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1973-2002 8.72e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.72e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 442620860  1973 CEITPCDNGGLCLTTGAVPMCKCSLGYTGR 2002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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